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Causes of anaemia Cause Clinical features ______ Intrinsic abnormalities of red cells: hereditary membrane defects, enzyme defects,haemoglobinpathies acquired paroxysmal noctural haemoglobinuriaExtrinsic abnormalities of red cells: Antibody-mediated red cell destruction Mechanical trauma to red cells hypersplenism Impaired red cellproduction Deficiency of haematinics megaloblastic anaemia: lack of B12 or folate iron deficiency anaemia dyserythropoisis (production of defective cells) anaemia of chronic disorders myelodysplasia sideroblastic anaemia hypoplasia of marrow (failure to produce cells) aplastic anaemia red cell aplasia invasion of marrow by malignant cells leukaemia myeloproliferative diseases non-haematological malignancies.
Causes of anaemia Cause Clinical features ______ Intrinsic abnormalities of red cells: hereditary membrane defects, enzyme defects,haemoglobinpathies acquired paroxysmal noctural haemoglobinuriaExtrinsic abnormalities of red cells: Antibody-mediated red cell destruction Mechanical trauma to red cells hypersplenism Impaired red cellproduction Deficiency of haematinics megaloblastic anaemia: lack of B12 or folate iron deficiency anaemia dyserythropoisis (production of defective cells) anaemia of chronic disorders myelodysplasia sideroblastic anaemia hypoplasia of marrow (failure to produce cells) aplastic anaemia red cell aplasia invasion of marrow by malignant cells leukaemia myeloproliferative diseases non-haematological malignancies.
Increased red cell loss, Blood loss lysis or polling Haemolysis
Intrinsic abnormalities of red cells: hereditary membrane defects, enzyme defects,haemoglobinpathies acquired paroxysmal noctural haemoglobinuriaExtrinsic abnormalities of red cells: Antibody-mediated red cell destruction Mechanical trauma to red cells hypersplenism
Deficiency of haematinics megaloblastic anaemia: lack of B12 or folate iron deficiency anaemia dyserythropoisis (production of defective cells)
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