Causes and Clinical Features of Anaemia

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Causes of anaemia Cause Clinical features ______  Intrinsic abnormalities of red cells: hereditary membrane defects, enzyme defects,haemoglobinpathies acquired paroxysmal noctural haemoglobinuriaExtrinsic abnormalities of red cells: Antibody-mediated red cell destruction Mechanical trauma to red cells hypersplenism Impaired red cellproduction Deficiency of haematinics  megaloblastic anaemia: lack of B12 or folate  iron deficiency anaemia dyserythropoisis (production of defective cells)  anaemia of chronic disorders  myelodysplasia  sideroblastic anaemia hypoplasia of marrow (failure to produce cells)  aplastic anaemia  red cell aplasia invasion of marrow by malignant cells  leukaemia  myeloproliferative diseases  non-haematological malignancies.

Increased red cell loss, Blood loss lysis or polling Haemolysis


Intrinsic abnormalities of red cells: hereditary membrane defects, enzyme defects,haemoglobinpathies acquired paroxysmal noctural haemoglobinuriaExtrinsic abnormalities of red cells: Antibody-mediated red cell destruction Mechanical trauma to red cells hypersplenism


Deficiency of haematinics  megaloblastic anaemia: lack of B12 or folate  iron deficiency anaemia dyserythropoisis (production of defective cells)


anaemia of chronic disorders  myelodysplasia  sideroblastic anaemia hypoplasia of marrow (failure to produce cells)  aplastic anaemia  red cell aplasia invasion of marrow by malignant cells


leukaemia  myeloproliferative diseases  non-haematological malignancies

Learn about the causes and clinical features of anaemia, including increased red cell loss, haemolysis, and impaired red cell production. Explore intrinsic and extrinsic abnormalities of red cells, as well as deficiencies of haematinics such as B12, folate, and iron.

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