Causes and Clinical Features of Anaemia

Causes of anaemia Cause Clinical features ______  Intrinsic abnormalities of red cells: hereditary membrane defects, enzyme defects,haemoglobinpathies acquired paroxysmal noctural haemoglobinuriaExtrinsic abnormalities of red cells: Antibody-mediated red cell destruction Mechanical trauma to red cells hypersplenism Impaired red cellproduction Deficiency of haematinics  megaloblastic anaemia: lack of B12 or folate  iron deficiency anaemia dyserythropoisis (production of defective cells)  anaemia of chronic disorders  myelodysplasia  sideroblastic anaemia hypoplasia of marrow (failure to produce cells)  aplastic anaemia  red cell aplasia invasion of marrow by malignant cells  leukaemia  myeloproliferative diseases  non-haematological malignancies.