17 Questions
What effect does lactate have on human cytotoxic T lymphocytes (CTLs)?
Inhibits proliferation and cytokine production by 95%
How does the acidic external environment in tumors impact T-cells?
Makes it difficult for T-cells to survive
What is a mechanism by which tumor cells escape immune detection?
Upregulation of classical MHC I molecules
What role do tumor-associated macrophages play in the inactivation of T-cells?
Inactivate T-cells
How do cells in the tumor microenvironment contribute to apoptosis of activated T lymphocytes?
By expressing Fas-ligands & PD1 ligands
What effect does aerobic glycolysis have on T-cells in the context of tumor metabolic reprogramming?
Leads to T-cells being in nutrient scarcity
What is the role of Catuxomomab qAnti-EpCAM qAnti-CD3 qFc in recognizing different receptors on immune cells?
Recognizing Fc-gamma receptors on macrophages, dendritic cells, and NK cells
What can the cleavage of EpCAM lead to, according to the text?
Promoting oncogenic potential
Which proteins form a complex with EpICD inside the nucleus?
FHL2, β-catenin, and Lef
What is the mechanism by which Irinotecan is activated in Colorectal Cancer Therapy?
By hydrolysis to SN-38 by carboxylesterase
What can the amount of β-catenin in the nucleus modulate?
The expression level of EpCAM
How does cleaved EpEX stimulate a positive feedback loop according to the text?
By stimulating the cleavage of additional EpCAM molecules
What is the mechanism of action of SN-38, the active metabolite that inhibits topoisomerase I?
Inhibition of DNA replication and transcription
What is the ultimate result of T-cells becoming progressively sensitive to Fas-mediated apoptosis during activation?
Activation-induced cell death (AICD)
Which type of therapy involves antibodies that target vascular endothelial growth factor and its receptors?
Inhibition of angiogenesis
What is the mechanism of action of Tositumomab in cancer therapy?
Binds to CD20 antigen and is combined with radioisotope iodine 131
Which process does angiogenesis promote in rapidly growing tumor cells?
New blood vessel development for nutrient and growth factor supply
Test your knowledge on the mechanism of action of Catuxomomab, a drug that targets multiple receptors in the body for disease treatment. Explore how Catuxomomab binds to different Fc-gamma receptors and activates various immune cells for therapeutic effects.
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