Podcast
Questions and Answers
What effect does lactate have on human cytotoxic T lymphocytes (CTLs)?
What effect does lactate have on human cytotoxic T lymphocytes (CTLs)?
- Increases mTOR signaling
- Inhibits proliferation and cytokine production by 95% (correct)
- Promotes T-cell activation
- Enhances cytotoxic activity by 50%
How does the acidic external environment in tumors impact T-cells?
How does the acidic external environment in tumors impact T-cells?
- Enhances T-cell proliferation
- Makes it difficult for T-cells to survive (correct)
- Makes it easier for T-cells to survive
- Creates a nutrient-rich environment for T-cells
What is a mechanism by which tumor cells escape immune detection?
What is a mechanism by which tumor cells escape immune detection?
- Upregulation of classical MHC I molecules (correct)
- Enhanced recruitment of T cells to the tumor
- Inhibition of regulatory T cells
- Downregulation of non-classical MHC I molecules
What role do tumor-associated macrophages play in the inactivation of T-cells?
What role do tumor-associated macrophages play in the inactivation of T-cells?
How do cells in the tumor microenvironment contribute to apoptosis of activated T lymphocytes?
How do cells in the tumor microenvironment contribute to apoptosis of activated T lymphocytes?
What effect does aerobic glycolysis have on T-cells in the context of tumor metabolic reprogramming?
What effect does aerobic glycolysis have on T-cells in the context of tumor metabolic reprogramming?
What is the role of Catuxomomab qAnti-EpCAM qAnti-CD3 qFc in recognizing different receptors on immune cells?
What is the role of Catuxomomab qAnti-EpCAM qAnti-CD3 qFc in recognizing different receptors on immune cells?
What can the cleavage of EpCAM lead to, according to the text?
What can the cleavage of EpCAM lead to, according to the text?
Which proteins form a complex with EpICD inside the nucleus?
Which proteins form a complex with EpICD inside the nucleus?
What is the mechanism by which Irinotecan is activated in Colorectal Cancer Therapy?
What is the mechanism by which Irinotecan is activated in Colorectal Cancer Therapy?
What can the amount of β-catenin in the nucleus modulate?
What can the amount of β-catenin in the nucleus modulate?
How does cleaved EpEX stimulate a positive feedback loop according to the text?
How does cleaved EpEX stimulate a positive feedback loop according to the text?
What is the mechanism of action of SN-38, the active metabolite that inhibits topoisomerase I?
What is the mechanism of action of SN-38, the active metabolite that inhibits topoisomerase I?
What is the ultimate result of T-cells becoming progressively sensitive to Fas-mediated apoptosis during activation?
What is the ultimate result of T-cells becoming progressively sensitive to Fas-mediated apoptosis during activation?
Which type of therapy involves antibodies that target vascular endothelial growth factor and its receptors?
Which type of therapy involves antibodies that target vascular endothelial growth factor and its receptors?
What is the mechanism of action of Tositumomab in cancer therapy?
What is the mechanism of action of Tositumomab in cancer therapy?
Which process does angiogenesis promote in rapidly growing tumor cells?
Which process does angiogenesis promote in rapidly growing tumor cells?
