Catuxomomab Mechanism of Action Quiz
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Questions and Answers

What effect does lactate have on human cytotoxic T lymphocytes (CTLs)?

  • Increases mTOR signaling
  • Inhibits proliferation and cytokine production by 95% (correct)
  • Promotes T-cell activation
  • Enhances cytotoxic activity by 50%

    • How does the acidic external environment in tumors impact T-cells?

  • Enhances T-cell proliferation
  • Makes it difficult for T-cells to survive (correct)
  • Makes it easier for T-cells to survive
  • Creates a nutrient-rich environment for T-cells

    • What is a mechanism by which tumor cells escape immune detection?

  • Upregulation of classical MHC I molecules (correct)
  • Enhanced recruitment of T cells to the tumor
  • Inhibition of regulatory T cells
  • Downregulation of non-classical MHC I molecules

    • What role do tumor-associated macrophages play in the inactivation of T-cells?

    <p>Inactivate T-cells</p> Signup and view all the answers

    How do cells in the tumor microenvironment contribute to apoptosis of activated T lymphocytes?

    <p>By expressing Fas-ligands &amp; PD1 ligands</p> Signup and view all the answers

    What effect does aerobic glycolysis have on T-cells in the context of tumor metabolic reprogramming?

    <p>Leads to T-cells being in nutrient scarcity</p> Signup and view all the answers

    What is the role of Catuxomomab qAnti-EpCAM qAnti-CD3 qFc in recognizing different receptors on immune cells?

    <p>Recognizing Fc-gamma receptors on macrophages, dendritic cells, and NK cells</p> Signup and view all the answers

    What can the cleavage of EpCAM lead to, according to the text?

    <p>Promoting oncogenic potential</p> Signup and view all the answers

    Which proteins form a complex with EpICD inside the nucleus?

    <p>FHL2, β-catenin, and Lef</p> Signup and view all the answers

    What is the mechanism by which Irinotecan is activated in Colorectal Cancer Therapy?

    <p>By hydrolysis to SN-38 by carboxylesterase</p> Signup and view all the answers

    What can the amount of β-catenin in the nucleus modulate?

    <p>The expression level of EpCAM</p> Signup and view all the answers

    How does cleaved EpEX stimulate a positive feedback loop according to the text?

    <p>By stimulating the cleavage of additional EpCAM molecules</p> Signup and view all the answers

    What is the mechanism of action of SN-38, the active metabolite that inhibits topoisomerase I?

    <p>Inhibition of DNA replication and transcription</p> Signup and view all the answers

    What is the ultimate result of T-cells becoming progressively sensitive to Fas-mediated apoptosis during activation?

    <p>Activation-induced cell death (AICD)</p> Signup and view all the answers

    Which type of therapy involves antibodies that target vascular endothelial growth factor and its receptors?

    <p>Inhibition of angiogenesis</p> Signup and view all the answers

    What is the mechanism of action of Tositumomab in cancer therapy?

    <p>Binds to CD20 antigen and is combined with radioisotope iodine 131</p> Signup and view all the answers

    Which process does angiogenesis promote in rapidly growing tumor cells?

    <p>New blood vessel development for nutrient and growth factor supply</p> Signup and view all the answers

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