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Questions and Answers
What triggers the assembly of adaptor proteins carrying multiple binding sites for the caspase amino-terminal domain?
What triggers the assembly of adaptor proteins carrying multiple binding sites for the caspase amino-terminal domain?
- DNA replication signals
- Apoptotic signals (correct)
- Cell proliferation signals
- Cell differentiation signals
What happens to the initiator caspases upon binding to the adaptor proteins?
What happens to the initiator caspases upon binding to the adaptor proteins?
- They become inactive
- They dissociate from the adaptor proteins
- They dimerize and are activated (correct)
- They undergo conformational changes
What happens to the executioner caspases upon cleavage at a site in the protease domain by an initiator caspase?
What happens to the executioner caspases upon cleavage at a site in the protease domain by an initiator caspase?
- They undergo an activating conformational change (correct)
- They bind to DNA
- They dissociate from the cell
- They become inactive
What happens to the protease domain of the initiator caspases after activation?
What happens to the protease domain of the initiator caspases after activation?
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What is the initial form of executioner caspases?
What is the initial form of executioner caspases?
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