5 Questions
What triggers the assembly of adaptor proteins carrying multiple binding sites for the caspase amino-terminal domain?
Apoptotic signals
What happens to the initiator caspases upon binding to the adaptor proteins?
They dimerize and are activated
What happens to the executioner caspases upon cleavage at a site in the protease domain by an initiator caspase?
They undergo an activating conformational change
What happens to the protease domain of the initiator caspases after activation?
It is rearranged into a large and small subunit
What is the initial form of executioner caspases?
Inactive dimers
Test your knowledge of caspase activation during apoptosis in this quiz. Explore the structure and activation of initiator caspases, and understand how apoptotic signals trigger their assembly with adaptor proteins. Enhance your understanding of this critical process in cell death.
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