Cardiovascular System: Vessels and Anatomy

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Questions and Answers

Which layer of a blood vessel is primarily responsible for vasoconstriction and vasodilation?

  • Vasa vasorum
  • Tunica intima
  • Tunica media (correct)
  • Tunica externa

What structural feature distinguishes arteries from veins in terms of their ability to maintain shape?

  • Arteries have more elastic collagen fibers. (correct)
  • Arteries have a thicker tunica externa.
  • Veins have more elastic collagen fibers.
  • Veins have a thicker tunica media.

Elastic arteries, such as the aorta, contain a large proportion of elastic fibers in all tunics. What is a benefit of this?

  • Equalization of blood pressure before reaching smaller arteries (correct)
  • Promotion of vasoconstriction
  • Prevention of backflow
  • Regulation of blood flow into capillaries

Which type of artery is most directly involved in regulating blood flow to different parts of the body through vasoconstriction and vasodilation?

<p>Arterioles (B)</p> Signup and view all the answers

What anatomical adaptation in veins helps counteract low blood pressure and gravity, particularly in the limbs?

<p>One-way valves located in the tunica intima (A)</p> Signup and view all the answers

What is the primary function of capillaries in the cardiovascular system?

<p>To facilitate the exchange of nutrients and waste products between blood and tissues (C)</p> Signup and view all the answers

What is the role of precapillary sphincters in capillary beds?

<p>They control blood flow into the true capillaries. (D)</p> Signup and view all the answers

Which structural feature is characteristic of continuous capillaries, allowing them to form a complete, uninterrupted vessel wall?

<p>Complete continuous vessel (C)</p> Signup and view all the answers

In a portal system, blood flows through two capillary beds before returning to the heart. What is the functional significance of this pathway?

<p>It allows hormones/nutrients picked up in first capillary bed to be delivered efficiently to cells surrounding second capillary bed before returning to heart. (B)</p> Signup and view all the answers

Which component of blood is primarily responsible for transporting oxygen and carbon dioxide?

<p>Erythrocytes (B)</p> Signup and view all the answers

How does the composition of plasma differ from that of interstitial fluid, and what is the functional consequence of this variance?

<p>Plasma has a higher concentration of dissolved oxygen and a greater concentration of dissolved oxygen. (A)</p> Signup and view all the answers

What structural adaptation of erythrocytes enhances their ability to efficiently transport oxygen and carbon dioxide?

<p>Biconcave shape (B)</p> Signup and view all the answers

What cellular process enables leukocytes to move from the bloodstream into tissues in response to inflammation or infection?

<p>Diapedesis (A)</p> Signup and view all the answers

An elevated number of leukocytes (leukocytosis) in a blood sample is most likely indicative of which condition?

<p>Inflammatory reaction (C)</p> Signup and view all the answers

How do the actions of histamines and heparin released by basophils contribute to the body's response to inflammation and allergic reactions?

<p>Histamines promote inflammation, while heparin inhibits blood clotting. (B)</p> Signup and view all the answers

What is the role of monocytes once they migrate from the bloodstream into tissues?

<p>Becoming macrophages that phagocytize bacteria, cell fragments, and debris (C)</p> Signup and view all the answers

Megakaryocytes are responsible for producing which formed element of the blood?

<p>Platelets (D)</p> Signup and view all the answers

During hemopoiesis, hemocytoblasts can differentiate into progenitor cells of the myeloid line. Which blood cells can these cells produce?

<p>Erythrocytes, megakaryocytes/platelets, and all leukocytes (B)</p> Signup and view all the answers

What is the function of blood in the context of regulation?

<p>Mainly through the plasma (C)</p> Signup and view all the answers

Which one of the followings is NOT a function of the blood?

<p>Excretion (A)</p> Signup and view all the answers

What type of cells is extremely motile and called to tissues by chemotaxis process?

<p>Leukocytes (B)</p> Signup and view all the answers

Which cells are produced in red bone marrow by megakaryocytes?

<p>Thrombocytes (A)</p> Signup and view all the answers

Which tunic of the vein contains valves?

<p>Tunica intima (B)</p> Signup and view all the answers

Which of the following best describes the function of elastic fibers in arteries?

<p>Enabling the vessel to stretch and recoil, maintaining blood pressure (C)</p> Signup and view all the answers

Which of the following is the correct order of blood flow through a capillary bed?

<p>Arteriole → metarteriole → true capillaries → thoroughfare channel (B)</p> Signup and view all the answers

What is the main difference between continuous and fenestrated capillaries?

<p>Fenestrated capillaries have small pores for increased permeability, while continuous do not. (B)</p> Signup and view all the answers

In the context of blood vessels, what is 'vasa vasorum' and where is it found?

<p>A network of small capillaries supplying blood to the walls of large vessels. (A)</p> Signup and view all the answers

How do arteries withstand high blood pressure compared to veins?

<p>Thicker walls, especially tunica media with more smooth muscle and elastic fibers (C)</p> Signup and view all the answers

If a patient is diagnosed with leukopenia, which of the following conditions might be suspected?

<p>Viral infection or bone marrow disorder (D)</p> Signup and view all the answers

Which white blood cell is the most abundant and first to respond during a bacterial infection?

<p>Neutrophils (B)</p> Signup and view all the answers

Which vessel is responsible for carrying blood away from the heart?

<p>Arteries (A)</p> Signup and view all the answers

Which of the following is a characteristic of arteries?

<p>No valves (D)</p> Signup and view all the answers

Which of the following the thickest layer in arteries?

<p>Tunica media (C)</p> Signup and view all the answers

Walls of veins are thin and collapse when not filled with blood. Most veins contain:

<p>Valves (D)</p> Signup and view all the answers

Which vessels are only comprised of tunica intima?

<p>Capillaries (C)</p> Signup and view all the answers

The tunica media in muscular arteries play an important role in:

<p>Autonomic nervous system (A)</p> Signup and view all the answers

What percent of the blood does Veins hold?

<p>60% (D)</p> Signup and view all the answers

Which of the following formed elements is responsible for aiding in clot formation?

<p>Platelets (C)</p> Signup and view all the answers

If a researcher is studying the rate of oxygen diffusion from the blood into the surrounding tissues, which type of capillary would be most suitable for examination?

<p>Fenestrated capillaries, because of their openings that enhance material exchange. (D)</p> Signup and view all the answers

A patient's blood test reveals an elevated count of leukocytes. This condition most likely indicates the body is:

<p>Responding to an infection or inflammation. (B)</p> Signup and view all the answers

A researcher is investigating a blood vessel in a tissue sample and observes that it has a thick tunica media with a large proportion of elastic fibers. Which type of vessel is the researcher most likely examining?

<p>An elastic artery, which needs to withstand high pressure. (D)</p> Signup and view all the answers

During a physiology lab, a student observes a blood vessel under a microscope. The vessel has thin walls composed of only the tunica intima. What type of blood vessel is the student most likely observing?

<p>A capillary facilitating nutrient and waste exchange. (C)</p> Signup and view all the answers

In a patient experiencing edema (swelling) due to fluid accumulation in the interstitial space, which component of the blood is most relevant to the regulation of fluid levels between blood vessels and tissues?

<p>Plasma, due to its protein composition and osmotic properties. (B)</p> Signup and view all the answers

Which of the following statements is correct regarding systemic blood vessels in the head, neck, and upper limb?

<p>Most arteries and veins are paired and share the same name, except for the largest vessels. (A)</p> Signup and view all the answers

The superficial structures of the neck, face, and scalp receive their primary blood supply from which artery?

<p>External carotid artery (B)</p> Signup and view all the answers

What is the structure formed by the internal carotid and basilar arteries that supplies blood to the brain?

<p>Cerebral arterial circle (Circle of Willis) (A)</p> Signup and view all the answers

Which artery provides the main blood supply to the brainstem and cerebellum?

<p>Basilar artery (B)</p> Signup and view all the answers

Which cerebral artery is most frequently occluded during a stroke, potentially affecting motor and sensory functions?

<p>Middle cerebral artery (C)</p> Signup and view all the answers

The right and left brachiocephalic veins drain blood from the head, neck, and upper limbs into which major vein?

<p>Superior vena cava (D)</p> Signup and view all the answers

What is the function of dural venous sinuses?

<p>Venous drainage for the cranial vault (A)</p> Signup and view all the answers

Which sinus receives blood from the ophthalmic vein and is clinically significant for its potential role in spreading infections?

<p>Cavernous sinus (D)</p> Signup and view all the answers

After the dural venous sinuses, what are the tributaries of the internal jugular and vertebral veins?

<p>Occipital sinus and inferior petrosal sinus (D)</p> Signup and view all the answers

What veins do the face, scalp, and neck drain into? These veins also exhibit a great degree of of anastomoses.

<p>Internal and external jugular veins (B)</p> Signup and view all the answers

What is a reason infections can pass from extracranial sites into intracranial sites?

<p>The cavernous sinus's connections (B)</p> Signup and view all the answers

After the subclavian artery passes the first rib, what does it become?

<p>Axillary artery (A)</p> Signup and view all the answers

What is supplied by branches of the thyrocervical trunk and axillary artery?

<p>Superior thoracic wall, axilla, and shoulder joint (B)</p> Signup and view all the answers

What does a Collateral Brachial Arterial Branch do?

<p>Travels distally, &quot;side branch&quot; (B)</p> Signup and view all the answers

What vessels are bounded by the inferior margin of the teres major muscle and the division of radial and ulnar vessels in the cubital fossa?

<p>Brachial a/v (C)</p> Signup and view all the answers

Which of the following is not a location to measure pulse in the upper limb?

<p>Brachiocephalic artery (B)</p> Signup and view all the answers

What artery is typically used to measure blood pressure?

<p>Brachial artery (C)</p> Signup and view all the answers

What is a result of an anterior dislocation of the humeral head?

<p>Axillary compression (B)</p> Signup and view all the answers

What is the superficial vein that drains into the axillary vein?

<p>Cephalic vein (D)</p> Signup and view all the answers

What artery is not part of the Circle of Willis?

<p>External Carotid artery (C)</p> Signup and view all the answers

What can Anterior dislocation of the humeral head damage?

<p>Group of nerves in the region (D)</p> Signup and view all the answers

What artery supplies the Brainstem and cerebellum?

<p>Basilar artery (C)</p> Signup and view all the answers

What does the Profunda brachii a. run with?

<p>Radial nerve (A)</p> Signup and view all the answers

What is the primary drainage for the cranial vault?

<p>Dural venous sinuses (B)</p> Signup and view all the answers

What runs through the Carotid canal?

<p>Internal carotid a. (A)</p> Signup and view all the answers

Except for the largest vessels, arteries and veins...

<p>share the same name (A)</p> Signup and view all the answers

What happens after the subclavian artery passes the lateral margin of rib I?

<p>changes to axillary artery (D)</p> Signup and view all the answers

What is the primary source of blood to the neck, face and scalp?

<p>External carotid artery (B)</p> Signup and view all the answers

Cerebral arterial circle (or Circle of Willis) formed by the internal carotid aa. And basilar a supplies which of the following?

<p>the brain (C)</p> Signup and view all the answers

During a stroke which of cerebral artery is the largest and most often occluded?

<p>The middle cerebral artery (B)</p> Signup and view all the answers

The dural venous sinuses drain into:

<p>Internal jugular vein (B)</p> Signup and view all the answers

Inferior petrosal sinus drains into:

<p>Internal jugular vein (C)</p> Signup and view all the answers

Which one of the followings does the cavernous sinus does NOT receives blood from?

<p>the median cubital v. (C)</p> Signup and view all the answers

What does the Axillary artery supply once past rib I?

<p>superior thoracic structures (D)</p> Signup and view all the answers

Which one of the following statements describe the collateral brachial artery ?

<p>Travels distally as a side branch. (B)</p> Signup and view all the answers

Which one of the following arteries can be used to measure blood pressure?

<p>Brachial artery (A)</p> Signup and view all the answers

Anterior dislocation of the humerus can lead to compression of which vessel?

<p>Axillary artery (A)</p> Signup and view all the answers

Which Superficial veins drains into the axillary veins?

<p>Cephalic v (B)</p> Signup and view all the answers

Following a traumatic injury to the neck, a patient presents with impaired blood flow to the brain. Which of the following arteries is least likely to be directly involved in this patient's condition?

<p>Axillary artery (C)</p> Signup and view all the answers

A surgeon is planning to perform a carotid endarterectomy to improve blood flow to the brain. During the procedure, which initial arterial branch off the external carotid artery should the surgeon be mindful of to avoid complications?

<p>Superior thyroid artery (C)</p> Signup and view all the answers

A patient exhibits signs of a stroke affecting the lower limb and anterior aspect of the frontal lobe. Which artery is most likely occluded?

<p>Anterior cerebral artery (A)</p> Signup and view all the answers

A trauma patient has a fractured clavicle, resulting in compression of the subclavian artery. Which of the following arteries would not receive diminished blood flow as a direct result of this compression?

<p>Common carotid artery (B)</p> Signup and view all the answers

A patient presents with an infection that has spread from the face to the cavernous sinus. Which venous structure provides the most likely route for this spread?

<p>Facial vein (C)</p> Signup and view all the answers

Which of the following lists the correct boundaries of the superior thoracic aperture?

<p>1st thoracic vertebra, 1st rib, manubrium of sternum (A)</p> Signup and view all the answers

At which thoracic level does the inferior vena cava pass through the diaphragm via the caval opening?

<p>8th thoracic level (A)</p> Signup and view all the answers

At which thoracic level does the aorta pass behind the diaphragm via the aortic hiatus?

<p>12th thoracic level (C)</p> Signup and view all the answers

Which of the following arteries is NOT found in the thoracic cavity?

<p>Femoral artery (D)</p> Signup and view all the answers

Which of the following vessels is part of the venous system of the thoracic cavity?

<p>Azygos vein (A)</p> Signup and view all the answers

The celiac trunk is a major branch of the abdominal aorta. Which of the following organs does it not directly supply?

<p>Kidney (D)</p> Signup and view all the answers

Which of the following is supplied by the superior mesenteric artery?

<p>Duodenum, jejunum and ileum (A)</p> Signup and view all the answers

Which of the following accurately describes the venous drainage system of the abdomen?

<p>Most organs in the abdomen drain into the hepatic portal system before reaching the inferior vena cava. (B)</p> Signup and view all the answers

Which of the following organs drains directly into the inferior vena cava?

<p>Kidney (A)</p> Signup and view all the answers

What veins merge to form the portal vein?

<p>Splenic and superior mesenteric veins (A)</p> Signup and view all the answers

The anterior intercostal arteries arise from which artery?

<p>Internal thoracic artery (A)</p> Signup and view all the answers

Which of the following is a characteristic of a retroperitoneal organ?

<p>An organ that is located behind the peritoneum. (C)</p> Signup and view all the answers

If a thrombus (blood clot) blocks the inferior mesenteric artery, which portion of the digestive system would be most directly affected?

<p>Descending colon and sigmoid colon (A)</p> Signup and view all the answers

Which of the following veins does NOT directly drain into the inferior vena cava?

<p>Gastric vein (C)</p> Signup and view all the answers

After passing through the liver sinusoids, where does the blood from the hepatic portal vein enter next?

<p>Inferior vena cava (C)</p> Signup and view all the answers

Which of the following is the correct order of blood flow through the hepatic portal system?

<p>Spleen → Hepatic portal vein → Liver → Hepatic vein → Inferior vena cava (D)</p> Signup and view all the answers

In a patient with cirrhosis of the liver, which of the following vascular changes would you NOT expect to observe?

<p>Decreased blood pressure in the hepatic portal vein (B)</p> Signup and view all the answers

A surgeon is performing an abdominal aortic aneurysm repair and needs to clamp the aorta temporarily. Which major arterial branch, if clamped, would directly cause ischemia (lack of blood supply) to the small intestine?

<p>Superior mesenteric artery (B)</p> Signup and view all the answers

Collateral circulation can compensate for blockages in major arteries. If the inferior mesenteric artery is blocked, which of the following arterial anastomoses (connections) would be most important for maintaining blood supply to the rectum?

<p>Superior rectal artery and middle rectal artery (A)</p> Signup and view all the answers

What is the clinical significance of knowing the location of abdominal organs in relation to major blood vessels?

<p>It provides critical information for diagnosing and planning interventions for vascular and organ-related diseases. (B)</p> Signup and view all the answers

A patient presents with abdominal pain and imaging reveals a compression of the celiac trunk by the median arcuate ligament. Which of the following organs is least likely to be directly affected by reduced blood flow due to this compression?

<p>Kidney (B)</p> Signup and view all the answers

A patient has a tumor that is compressing the inferior vena cava in the abdomen. Which of the following clinical signs would you least likely expect to observe?

<p>Jaundice (yellowing of the skin) (D)</p> Signup and view all the answers

After a blunt force trauma to the chest, a patient's anterior intercostal arteries are damaged. Which artery would be recruited to maintain blood flow to the anterior chest wall?

<p>Internal thoracic artery (C)</p> Signup and view all the answers

Where does the portal vein carry blood from?

<p>From digestive organs to the liver (C)</p> Signup and view all the answers

What vessel provides blood to the anterior abdominal wall besides the superficial system?

<p>Internal Thoracic Artery (D)</p> Signup and view all the answers

Which is NOT a characteristic of the Vessels of the Posterior Abdomen?

<p>Series of branches from the renal arteries (A)</p> Signup and view all the answers

Where does blood from the splenic vein directly drain into?

<p>Portal Vein (D)</p> Signup and view all the answers

What is the correct order in which the blood flows?

<p>Portal Vein -&gt; Hepatic Sinusoids -&gt; Hepatic Vein -&gt; Inf. Vena Cava (A)</p> Signup and view all the answers

Which of the following locations is the diaphragm attached to?

<p>All of the above (D)</p> Signup and view all the answers

Why is it useful to understand where the intercostal arteries run?

<p>To avoid vessels during chest tube insertion (D)</p> Signup and view all the answers

Where does the azygos vein drain into?

<p>SVC (D)</p> Signup and view all the answers

What is the esophageal hiatus?

<p>Opening in diaphragm for esophagus (D)</p> Signup and view all the answers

Which of the following vessels is used to hold blood when someone is bleeding profusely in the abdomen?

<p>Abdominal Aorta (B)</p> Signup and view all the answers

A surgeon needs to access the spleen for a splenectomy. What artery does he need to be especially careful of when the vessels are close by?

<p>Splenic artery (A)</p> Signup and view all the answers

A complication post appendectomy is appendicitis. What is the source of the appendicular artery?

<p>Superior mesenteric artery (C)</p> Signup and view all the answers

A patient had a severe obstruction in the superior mesenteric artery. How would the blood be able to reach the splenic flexure of the large intestine?

<p>SMA - Right Colic a. - Marginal a. - Left Colic a. - IMA (A)</p> Signup and view all the answers

Which of the following statements about is FALSE?

<p>Sup rectal v. drains to the IMA then to the portal system. (B)</p> Signup and view all the answers

What vessel is most important to keep patent for a patient to have a good kidney transplant outcome? (Assume standard transplant)

<p>External and Internal Iliac and renal vessels (D)</p> Signup and view all the answers

Which of the following are areas drained by lumbar veins?

<p>All of the above (D)</p> Signup and view all the answers

What is this? (Insanely Difficult Question)

<p>A question! (C)</p> Signup and view all the answers

Which of the following is a direct branch of the common iliac artery?

<p>Internal iliac artery (B), External iliac artery (D)</p> Signup and view all the answers

The external iliac artery exits the pelvis through the inguinal canal to become:

<p>The femoral artery (C)</p> Signup and view all the answers

Which region does the anterior trunk of the internal iliac artery NOT directly supply?

<p>Lower posterior abdominal wall (D)</p> Signup and view all the answers

Which artery listed is NOT a direct continuation or branch of the external iliac artery?

<p>Internal iliac artery (A)</p> Signup and view all the answers

What is the name of the artery just distal to the popliteal artery in the lower extremity?

<p>Anterior tibial artery (D)</p> Signup and view all the answers

After a traumatic injury, a patient has impaired blood flow in the profunda femoris artery. Which artery would primarily provide collateral circulation to the thigh?

<p>Femoral artery (D)</p> Signup and view all the answers

Which vein in the lower limb directly drains into the femoral vein?

<p>Great saphenous vein (A)</p> Signup and view all the answers

Which of the following describes a vascular anastomosis?

<p>The fusion of two or more blood vessels, providing alternate routes for blood flow. (C)</p> Signup and view all the answers

Which of the following is the clinical significance of collateral circulation via vascular anastomoses?

<p>Maintaining blood supply to tissues during vascular blockages or injuries (D)</p> Signup and view all the answers

Which vessels are involved in creating the cerebral arterial circle (Circle of Willis)?

<p>Anterior communicating artery, anterior cerebral arteries, posterior communicating arteries, and posterior cerebral arteries (B)</p> Signup and view all the answers

What is the primary clinical importance of the cerebral arterial circle (Circle of Willis)?

<p>Maintaining blood supply to the brain during occlusions or strokes (A)</p> Signup and view all the answers

What vessels are involved in the Azygos System?

<p>Azygos vein, hemiazygos vein and accessory hemiazygos vein (B)</p> Signup and view all the answers

What is the clinical importance of the Azygos system?

<p>Returning venous blood from the lower part of the body to the heart if the inferior vena cava is blocked. (A)</p> Signup and view all the answers

The pancreaticoduodenal arteries provide a critical anastomosis between which two major arteries?

<p>Celiac trunk and superior mesenteric artery (B)</p> Signup and view all the answers

Clinical blockages to the celiac trunk can be offset by?

<p>The anastomosis the pancreaticoduodenal arteries provide between the celiac trunk and the SMA. (A)</p> Signup and view all the answers

The marginal artery of Drummond provides an anastomosis between the:

<p>Superior mesenteric artery (SMA) and inferior mesenteric artery (IMA) (C)</p> Signup and view all the answers

Which of the following anastomoses is most crucial for maintaining blood supply to the intestine if the superior mesenteric artery (SMA) is blocked?

<p>The anastomosis at the arc of Riolan and marginal artery of Drummond. (D)</p> Signup and view all the answers

In the upper limb, the suprascapular artery forms an anastomosis with which other artery?

<p>Axillary artery (via circumflex scapular a.) (B)</p> Signup and view all the answers

What is the clinical significance of the anastomoses around the shoulder?

<p>Maintain blood supply to the upper limb during traumatic vascular injuries or limb ischemia. (B)</p> Signup and view all the answers

Damage to the femoral artery superior to the adductor canal would affect what anastomoses?

<p>The genicular anastomosis. (B)</p> Signup and view all the answers

What arteries are connected in the genicular anastomosis?

<p>Femoral, popliteal, and geniculate aa. (A)</p> Signup and view all the answers

What vessels are connected to the external ilica a./v. in anastomoses?

<p>Deep circumflex iliac a./v. (C)</p> Signup and view all the answers

What vessels drain venous blood into the portacaval system?

<p>All of the above (E)</p> Signup and view all the answers

A patient with cirrhosis develops esophageal varices. Which portosystemic anastomosis is most directly involved in the formation of these varices?

<p>Left gastric vein and esophageal veins (C)</p> Signup and view all the answers

Which of the following is the adult derivative of the sixth pharyngeal arch?

<p>Ligamentum arteriosum (C)</p> Signup and view all the answers

Which adult structure is derived from the fourth aortic arch on the LEFT side?

<p>Aortic arch (B)</p> Signup and view all the answers

A newborn presents with a congenital defect where the ductus arteriosus failed to close. Which of the following structures is directly affected by this incomplete closure?

<p>Ligamentum arteriosum (C)</p> Signup and view all the answers

In fetal circulation, highly oxygenated blood returns from the placenta via the umbilical vein. What is the initial destination of approximately half of this blood?

<p>Ductus venosus (A)</p> Signup and view all the answers

What best describes the role of the foramen ovale in fetal circulation?

<p>The foramen ovale shunts blood from the right atrium to the left atrium, bypassing the lungs. (A)</p> Signup and view all the answers

What occurs at birth that causes the foramen ovale to close?

<p>Increased pressure in the left atrium causes the valve to close. (B)</p> Signup and view all the answers

What event results in blood entering the fetal systemic system (where it enter the fetal tissue)?

<p>Passing through the fetal aorta. (B)</p> Signup and view all the answers

Ligamentum teres is the remnant of what?

<p>Umbilical vein. (D)</p> Signup and view all the answers

After birth of a new born, several structures no longer needed include the ductus venosus, foramen ovale, etc. Which of the following closes by a muscular contraction?

<p>Ductus venosus. (B)</p> Signup and view all the answers

A newborn infant presents with cyanosis (bluish skin) shortly after birth. An echocardiogram reveals a patent ductus arteriosus (PDA). Which of the following best explains the physiological consequence of a PDA in this neonate? (Insanely Difficult Question)

<p>Shunting of deoxygenated blood from the pulmonary artery to the aorta, bypassing the pulmonary circulation; resulting in a mixing of oxygenated and deoxygenated blood. (A)</p> Signup and view all the answers

A researcher discovers a novel genetic mutation that disrupts the normal development of the aortic arches in utero. Which of the following scenarios would be least likely to occur as a direct consequence of this mutation? (Insanely Difficult Question)

<p>Persistent patency of the ductus venosus, leading to abnormal shunting blood flow. (D)</p> Signup and view all the answers

Which of the following best describes the primary function of the endocrine system?

<p>To regulate body functions through the release of hormones. (C)</p> Signup and view all the answers

How do endocrine glands primarily communicate with their target organs?

<p>By releasing hormones into the bloodstream. (B)</p> Signup and view all the answers

Which characteristic distinguishes endocrine communication from nervous system communication?

<p>Speed and duration of effects. (A)</p> Signup and view all the answers

Which of the following organs or glands is NOT exclusively part of the endocrine system?

<p>Sweat gland. (C)</p> Signup and view all the answers

How does the hypothalamus exert control over the endocrine system?

<p>Through its influence on the pituitary gland. (D)</p> Signup and view all the answers

Hormones synthesized in the hypothalamus are stored and released from which of the following?

<p>Posterior pituitary gland (C)</p> Signup and view all the answers

Which regulatory mechanism directly involves the hypothalamus secreting hormones that influence the anterior pituitary?

<p>Release of inhibiting and releasing hormones. (C)</p> Signup and view all the answers

Where is the pituitary gland located in relation to the hypothalamus?

<p>Inferior (A)</p> Signup and view all the answers

What anatomical structure protects the pituitary gland?

<p>The sella turcica. (D)</p> Signup and view all the answers

The anterior pituitary originates embryologically from which of the following?

<p>Roof of the pharynx. (C)</p> Signup and view all the answers

Which part of the anterior pituitary is the anterior-most portion?

<p>Pars distalis (A)</p> Signup and view all the answers

How do regulatory hormones from the hypothalamus reach the anterior pituitary?

<p>Through the hypothalamo-hypophyseal portal system. (B)</p> Signup and view all the answers

From what embryonic tissue does the posterior pituitary derive?

<p>Neural tissue of the diencephalon (C)</p> Signup and view all the answers

What is the primary arterial blood supply to the posterior pituitary gland?

<p>Inferior hypophyseal artery (B)</p> Signup and view all the answers

Which of the following is a key characteristic of the posterior pituitary's function?

<p>Releasing hormones produced in the hypothalamus. (B)</p> Signup and view all the answers

The parathyroid glands receive their arterial blood supply from which of the following arteries?

<p>Inferior thyroid arteries. (A)</p> Signup and view all the answers

How does the secretion of hormones from the adrenal medulla differ from that of the adrenal cortex?

<p>The medulla secretes hormones in response to sympathetic nervous system stimulation. (B)</p> Signup and view all the answers

Excluding the adrenal glands, where is the adrenal medulla specialized?

<p>It secretes hormones into the bloodstream in the sympathetic nervous system (D)</p> Signup and view all the answers

Which of the following describes the location of the thyroid gland?

<p>Anterior to the larynx (D)</p> Signup and view all the answers

What anatomical feature connects the left and right lobes of the thyroid gland?

<p>The isthmus (C)</p> Signup and view all the answers

From where does the thyroid gland derive?

<p>An epithelia outpouching of the endoderm in the floor of the foregut (A)</p> Signup and view all the answers

Which artery typically does NOT provide arterial supply to the adrenal glands?

<p>Esophageal Artery. (A)</p> Signup and view all the answers

What is the venous drainage of the adrenal glands?

<p>The right and left suprarenal veins. (A)</p> Signup and view all the answers

Which layer of the adrenal cortex is primarily responsible for producing mineralocorticoids, such as aldosterone?

<p>Zona glomerulosa (C)</p> Signup and view all the answers

What is the key hormone produced by the zona fasciculata of the adrenal glands, and what is its primary function?

<p>Cortisol; regulates glucose metabolism and inflammation. (C)</p> Signup and view all the answers

Hormone synthesis in the zona reticularis is stimulated by ACTH. What is the function of this hormone?

<p>It exerts masculinizing effects and promotes protein anabolism and growth (B)</p> Signup and view all the answers

What is the primary hormone secreted by the pineal gland?

<p>Melatonin (C)</p> Signup and view all the answers

What is a primary function of the thymus gland?

<p>Maturation and differentiation of T-lymphocytes. (C)</p> Signup and view all the answers

Which of the following hormones is produced by the kidneys and stimulates red blood cell production?

<p>Erythropoetin (D)</p> Signup and view all the answers

What hormone is produced by the heart in response to increased stretching of the atrial walls, and what is its effect?

<p>Atriopeptin; causes water loss and excretes sodium in the urine (D)</p> Signup and view all the answers

Which of the following hormones is produced by alpha cells of the pancreatic islets?

<p>Glucagon (B)</p> Signup and view all the answers

The delta cells of the pancreatic islets produce which hormone?

<p>Somatostatin (A)</p> Signup and view all the answers

In the context of endocrine function, what role do the gonads play?

<p>Secretion of reproductive hormones (C)</p> Signup and view all the answers

What can be identified with the cells of the colloid in the thyroid?

<p>Thyroglobulin (C)</p> Signup and view all the answers

In a histological sample of the pituitary gland, which structure is characterized by unmyelinated axons extending from the hypothalamus?

<p>Infundibular stalk of the posterior pituitary (B)</p> Signup and view all the answers

A histological slide of the adrenal gland shows a region composed of clusters of endocrine cells arranged in spherical or ovoid groups, surrounded by a thin capsule. What type of adrenal cortex is this?

<p>Zona glomerulosa (B)</p> Signup and view all the answers

During an autopsy, an abnormality is detected in a patient's thyroid gland. Upon microscopic examination, a remnant of tubular structure is observed from the inferior aspect of the tongue to the superior aspect of the thyroid gland. What is the most likely embryonic origin of this remnant structure?

<p>Persistent thyroglossal duct. (B)</p> Signup and view all the answers

A researcher is studying the histology of endocrine tissues and observes a gland with cords and clusters of cuboidal epithelium and fenestrated capillaries. Which of the following glands is the researcher most likely examining?

<p>Pituitary gland (B)</p> Signup and view all the answers

In a pituitary histology, which structure is characterized by hormone-secreting cells that release hormones into the general system?

<p>Acidophils (A)</p> Signup and view all the answers

A histological section of the pancreas reveals a cluster of cells with prominent secretory granules near blood capillaries. Immunohistochemical staining shows these cells are producing insulin. In which region of the pancreas are these insulin-producing cells located?

<p>Islets of Langerhans (D)</p> Signup and view all the answers

Clinical researchers discover a novel genetic mutation that affects the development of the Rathke's pouch. Which of the following endocrine glands will most likely be directly affected by this mutation?

<p>Anterior pituitary (C)</p> Signup and view all the answers

How are the hormones synthesized in the posterior pituitary transported from the hypothalamus?

<p>Axonally through the hypothalamo-hypophyseal tract (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of endocrine glands?

<p>They have ducts that carry secretions to a specific location (A)</p> Signup and view all the answers

What feature of target cells allows them to respond to specific hormones?

<p>Target cells have specific receptors that bind to the hormone (D)</p> Signup and view all the answers

The anterior pituitary (adenohypophysis) originates embryologically from which of the following?

<p>An outpouching from the roof of the pharynx (D)</p> Signup and view all the answers

Name the structure that connects the left and right lobes of the thyroid gland.

<p>Isthmus (B)</p> Signup and view all the answers

Which of the following best describes the function of the pancreatic acini?

<p>Producing alkaline pancreatic juices to aid digestion (D)</p> Signup and view all the answers

The adrenal medulla is specialized in secreting hormones in response to what?

<p>Sympathetic nervous system stimulation (C)</p> Signup and view all the answers

A medical student studying histology observes a thyroid gland sample and notes a remnant of the thyroglossal duct. What embryologic process does this structure represent if it remains patent (open)?

<p>Incomplete closure of the thyroglossal duct during development (D)</p> Signup and view all the answers

A researcher is investigating the effects of a novel compound on endocrine function and discovers it selectively inhibits the action of hypothalamic hormones on the anterior pituitary. Which of the following mechanisms would be most directly affected by this compound?

<p>Secretion of regulatory hormones into the hypophyseal portal veins (D)</p> Signup and view all the answers

During an exceptionally rare autopsy, a histologist discovers that a patient has an anatomical variation where their suprarenal gland lacks a cortex but the medulla is present and appears normal. Assuming the patient was alive, which symptom/hormone imbalance would most likely describe the patient?

<p>Inability to regulate electrolyte balance and stress response but normal sympathetic response to acute stressors (D)</p> Signup and view all the answers

Flashcards

Arteries carry blood...

Away from the heart

Veins carry blood...

To the heart

Capillary Beds

Where oxygen, nutrients, and waste are exchanged

Anastomosis definition

Location where two or more blood vessels converge to supply the same body region

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Companion Vessels

Artery and veins that travel together sharing the same name

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Tunics

Three layers surrounding the lumen of blood vessels

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Tunica Intima

Innermost layer of a blood vessel, made of endothelium and areolar CT

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Tunica Media

Middle layer of a blood vessel, made of smooth muscle

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Tunica Externa

Outer layer of a blood vessel, made of areolar CT

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Vasa Vasorum

Network of blood vessels in the tunica externa of a blood vessel

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Thickest tunic layer in arteries

Arteries have a thicker...

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Thickest layer in arteries

The tunica media is the thickest.

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Thickest tunic layer in veins

Veins have a thicker...

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Vein wall thickness

Veins have thin walls because...

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Valves

Prevent backflow of blood

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Capillaries composition

Only comprised of tunica intima

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Arteries

Thick-walled vessels carrying blood away from the heart

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Types of arteries

Elastic, Muscular, Arterioles

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Elastic fibers in arteries

Elastic arteries have a large...

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Elastic artery example

The aorta

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Muscular arteries

Controls blood flow

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Arterioles

Smallest arteries (1-6 layers of smooth muscle in tunica media)

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Veins

Thin-walled vessels returning blood to the heart

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Types of veins

Veins and Venules

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Skeletal muscle pump

Skeletal muscles also help move blood

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Venules size

Smallest veins

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Smallest venules

Primary location for diapedesis

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Capillaries

Smallest blood vessels, allowing for optimal diffusion of nutrients and gasses

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Capillary bed

Allows for better gas and nutrient exchange due to slow and continuous flow

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Capillary beds

Functional unit of the cardiovascular system

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Metarteriole definition

Blood enters capillary bed here

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Thoroughfare channel definition

Travel through this channel

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Postcapillary venule definition

Leaves capillary bed here

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Precapillary sphincters definition

Control blood flow in true capillaries

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Continuous Capillaries

Most common capillary type

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Fenestrated capillaries

Openings within endothelial cells but basement membrane is continuous

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Sinusoids

Large gaps in both endothelial cells and basement membrane

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Microvascular pathways

Pathways of blood vessels vary to accommodate specialized functions of certain tissues in organs

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Simple pathway

Blood flow from arteries, capillary beds, and veins

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Arteriovenous shunt

arterioles connect directly to venules

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Portal system

Blood flows through two capillary beds separated by a portal vein

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Blood

Comprised of liquid and cellular components

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Erythrocytes

Red blood cells

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Leukocytes

White blood cells

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Plasma

55% of blood (extracellular matrix)

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Transportation (blood function)

Transports elements and compounds throughout body

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Systemic Blood Vessels Pairing

Arteries and veins that are usually paired and share the same name, excluding the largest vessels.

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Blood Vessel Naming

Arteries are named based on the region they supply or traverse.

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Right Common Carotid Artery

Supplies the right side of the head.

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Left Common Carotid Artery

Supplies the left side of the head.

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Right Subclavian Artery

Supplies the right thoracic wall and upper limb.

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Left Subclavian Artery

Supplies the left thoracic wall and upper limb.

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External Carotid Artery

Located more anteriorly in the neck.

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Internal Carotid Artery

Located more posteriorly in the neck.

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Superior Thyroid Artery

Supplies the thyroid gland and larynx.

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Ascending Pharyngeal Artery

Supplies the pharynx.

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Lingual Artery

Supplies the tongue.

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Facial Artery

Supplies the face.

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Maxillary Artery

Supplies the teeth, gums, nasal cavity, and meninges.

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Superficial Temporal Artery

Supplies the lateral head and parotid gland.

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Occipital and Posterior Auricular Artery

Supplies the scalp.

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Basilar Artery

Supplies the brainstem and cerebellum.

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Internal Carotid Arteries and Vertebral Arteries

Supplies the brain.

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Internal Jugular Vein and Vertebral Vein

Dural venous sinuses drain into the...

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Brachiocephalic Veins

Drains the head, neck, and upper limbs into the superior vena cava.

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Cavernous Sinus

Receives blood from ophthalmic v., pterygoid plexus, and dural sinuses; pathway for infections to pass into intracranial locations.

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Superior, middle, and inferior thyroid vein

Drains the thyroid gland and larynx.

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Lingual Vein

Vein that drains the tongue.

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Facial vein

Vein that drains the face.

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Pterygoid plexus

Veins that drains the teeth, gums, nasal cavity, paranasal sinuses, and nasopharynx

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Superficial temporal vein

Vein on the surface that drains the lateral side of the head.

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Upper Limb Arteries

Arteries paired with brachial, radial, and ulnar names.

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Subclavian, Axillary, and Brachial Arteries

Provides blood supply to superior thoracic structures, arm structures, and divides in cubital fossa.

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Clinical Application of Humerus

Anterior dislocation of the humerus

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Cephalic Vein

Drains into the axillary vein.

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Basilic Vein

Superficial veins run near surface

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Cardiovascular structures

The structures that allow for the exchange of gases and nutrients throughout the body by tracing blood flow and identifying related structures.

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Superior thoracic aperture and boundaries

Vessels from mediastinum to head and neck exit here, 1st thoracic vertebra, 1st rib, and manubrium of sternum

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Inferior thoracic cavity boundary

Descending thoracic aorta and inferior vena cava pass through diaphragm to supply abdomen, pelvis, and lower limbs.

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IVC- caval opening

At 8th thoracic level

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Aorta- aortic hiatus

At 12th thoracic level

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Brachial artery

Provides blood to arm; continuation of axillary artery.

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Ulnar artery

Located in forearm on medial aspect.

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Thoracic Cavity Arteries

Thoracic aorta and subclavian artery

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Aorta's arterial branching

Aorta gives rise to anterior, lateral and posterior branches to supply the body.

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Thoracic Cavity Veins

External jugular vein, brachiocephalic vein, and subclavian vein

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arterial naming

Arteries are named based on the region they supply

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Drainage

Veins with same names drain area

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Diaphragm

The boundary between the thoracic and abdominal cavities.

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Anterior Arteries of Abdominal Aorta

Celiac trunk, superior mesenteric, inferior mesenteric arteries

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Celiac trunk

Abdominal esophagus, stomach, proximal portion of small intestine (duodenum), pancreases, liver, gallbladder, spleen

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Superior mesenteric

Most of small intestines: Duodenum, jejunum, ileum and Proximal ½ of Ascending colon, ½ of transverse colon

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Inferior mesenteric

½ of transverse colon, descending colon, sigmoid colon and rectum

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Venous Drainage of the Abdomen

Hepatic portal system and Inferior vena cava drainage

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Hepatic portal system

Most organs in abdomen, GI trac

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Inferior vena cava drainage

Kidney/renal, Adrenal (suprarenal), Gonadal, Pelvis, Lower limb

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Portal vein

Drains blood from the stomach, spleen, pancreas, gallbladder and abdominal part of the GI tract

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Formed by union of

The union of Splenic v. and Superior mesenteric v.

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Pelvic Cavity Vessels

Arteries and veins in the pelvic region.

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Common Iliac vessels

The aorta and inferior vena cava split into these.

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External Iliac vessels

Exits the pelvis via the inguinal canal to become the femoral artery/vein.

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Vessels of the Lower Limb

Blood vessels found in your leg.

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External Iliac (lower limb)

Branches include profunda femoris (deep femoral)

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Profunda Femoris Artery

A branch of the external iliac artery that contains circumflex and perforating vessels.

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Popliteal Artery

Artery that branches into posterior and anterior tibial arteries.

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Paired veins with shared name

Veins that have valves and share a name with an artery.

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Unpaired superficial v.

Unpaired superficial vein.

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Femoral vein

The great saphenous vein drains into this larger vein

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Vascular Anastomoses

Connections between blood vessels that provide alternate routes for blood flow.

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Coronary Anastomoses

Anastomoses for right and left coronary arteries.

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Cerebral Anastomoses

Anterior communicating artery connected with anterior cerebral arteries.

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Azygos System Anastomosis

Capable of returning venous blood if the IVC is blocked.

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Celiac Trunk to SMA Anastomosis

Pancreaticoduodenal arteries communicate and supply the pancreas and duodenum.

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SMA to IMA Anastomosis

Anastomoses at the marginal artery of Drummond and the arc of Riolan.

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Upper Limb Anastomoses

Anastomoses between suprascapular and subscapular arteries (via circumflex scapular artery).

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Lower Limb Anastomoses

Genicular anastomoses involving the femoral, popliteal, and geniculate arteries.

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Internal/External Iliac Arteries Anastomoses

External iliac a./v. ↔ deep circumflex iliac a./v.

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Hepatic Portal Anastomoses

Left gastric v ↔ Esophageal vv.

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Cardiovascular Embryology

Development of the heart & blood vessels during early development.

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Pharyngeal Arch Arteries

Originate from aortic sac.

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Aortic Arches

The fate of these determine adult vascular structures.

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Fetal Circulation

Designed for prenatal needs, modifies at birth.

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Umbilical Veins

Carry high-oxygen blood from placenta to fetus.

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Foramen Ovale

Blood flow bypasses the lungs, skipping pulmonary circulation.

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Umbilical Arteries

Blood shunt to placenta for oxygen.

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Ductus Venosus

Closes at birth, becomes ligamentum venosum.

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Foramen Ovale (after birth)

First breath causes lungs to expand, and pressure changes.

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Ductus Arteriosus

Closes shortly after birth, converts to ligamentum arteriosum

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Umbilical Vessels

Occlude when umbilical cord is tied, and form ligaments.

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Endocrine System

Regulatory system using hormones for control.

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Endocrine glands

Ductless organs secreting molecular products into bloodstream.

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Endocrine System Role

Controls metabolism, growth, tissue function, sleep, and mood via hormones.

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Endocrine and Nervous system

Works with nervous system to maintain body's internal equilibrium.

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Endocrine/Nervous Differences

Communication methods, range, response time, and recovery time.

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Endocrine Glands List

Pituitary, thyroid, adrenals, pancreas, pineal, thymus, parathyroid.

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Endocrine Communication

Releases hormones into the bloodstream.

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Target cells/organs

Specific cells/organs with matching hormone receptors.

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Hypothalamus

The master control center of the endocrine system.

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Pituitary Gland Interactions

Anterior and posterior lobes.

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Hypothalamic Regulation ways

Anterior pituitary : releasing/inhibiting hormones. Posterior pituitary: storing/releasing hormones.

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Adrenal Medulla Role

Specialized to secrete hormones in response to sympathetic nervous system.

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Hypothalamus limitations

Does not control all endocrine cells; some release without input.

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Pituitary Gland

Also known as the hypophysis.

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Infundibulum Function

Connects hypothalamus to pituitary.

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Anterior/Posterior Pituitary Origin

Derived from different embryonic structures.

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Anterior Pituitary Development

Grows from roof of pharynx

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Posterior Pituitary

Forms from the inferior portion of the diencephalon.

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Anterior Pituitary Role

Produces and secretes hormones in response to hypothalamus

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Anterior Pituitary Parts

Pars distalis, intermedia and tuberalis.

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Pars tuberalis function

Hugs the infundibulum.

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Posterior Pituitary Role

Stores hormones produced by hypothalamus.

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Posterior Pituitary components

Pars nervosa and infundibular stalk.

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Hypothalamo-hypophyseal tract

Neural connection between hypothalamus and posterior pituitary

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Hypothalamo-hypophyseal

Regulatory hormones travel here to anterior pituitary.

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Thyroid and Parathyroid arteries

Inferior thyroid arteries.

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Thyroid Gland location

Anterior to trachea, inferior to thyroid cartilage, butterfly shape.

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Parathyroid Gland Location

Posterior surface of thyroid gland.

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Thyroid development

Derived from an epithelial outpouching on the floor of the foregut.

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Adrenal Arterial Supply

Superior, middle and inferior suprarenal arteries.

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Adrenal Gland placement

Superior surface of each kidney.

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Adrenal Gland parts

Outer cortex and inner medulla.

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Zona glomerulosa

Regulates electrolytes.

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Zona fasciculata

stimulates metabolism of lipids and proteins, regulates glucose levels

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Zona Reticularis

exerts masculinizing effects and promote protein anabolism and growth

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Adrenal Medulla Cells

Modified ganglionic cells stimulated by the sympathetic division of the ANS.

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Medulla Secretions

Epinephrine (adrenaline).

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Pancreatic islets

Clusters of endocrine cells.

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Pancreatic acini

Clusters of cells that produce alkaline pancreatic juices

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Alpha cell pancreas

Secrete glucagon.

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Beta cells pancreas

Secrete insulin.

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Delta cells pancreas

Secrete somatostatin controls function with inislin and Glucagon .

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F cells- pancrease

Secrete pancreatic polypeptide.

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Pineal Gland Location

Posterior region of epithalamus.

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Melatonin role.

Circadian rhythm regulation by increasing synthesis at night

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Thymus location

Located in the mediastinum superior to the heart

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Thymus role

stimulates and promotes differentiation, growth, and maturation of T-lymphocytes

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Forth pharyngeal pouch give rise to superior parathyroid glands

give rise to superior parathyroid glands

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Kidneys role

Help regulate the concentration of electrolytes in body fluids, rate of red blood cell production

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Atriopeptin hormone.

Produced by modified cardiac muscle cells in wall of right atrium

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Study Notes

Endocrine Communication

  • The endocrine system uses hormones released into the bloodstream to communicate.
  • Hormones affect specific organs/cells by binding to receptors Organs, tissues, or cells that lack receptors for hormones will not be affected

Endocrine System Introduction

  • A regulatory system produces hormones to control metabolism, growth, development, tissue function, sexual function, sleep, and mood.
  • This system is composed of endocrine glands and endocrine cells within other organs.
  • Endocrine glands are ductless organs that secrete their molecular products directly into the bloodstream.
  • Works with the nervous system to maintain homeostasis in the body
  • Both systems target specific organs
  • Communication methods, range and target of effects, response time/duration, and recovery time distinguish the two systems

Endocrine System Glands

  • Pituitary gland (anterior and posterior)
  • Thyroid gland
  • Parathyroid glands
  • Adrenal glands
  • Pancreas
  • Pineal gland
  • Thymus
  • Kidneys, heart, GI tract, and gonads also contain endocrine cells

Hypothalamic Control of Endocrine System

  • The hypothalamus controls the endocrine system
  • The hypothalamus is the master control center of the endocrine system
  • This system interacts with the pituitary gland
  • Anterior Pituitary (adenohypophysis)
  • Posterior Pituitary (neurohypophysis)
  • Regulation happens in three ways

Hypothalamus Regulation of Endocrine System

  • The hypothalamus secretes regulatory hormones into the blood
  • These hormones influence the secretory activity of the anterior pituitary gland
  • Releasing hormones stimulate production and secretion
  • Inhibiting hormones inhibit production and secretion
  • The hypothalamus produces two hormones transported and stored in the posterior pituitary gland
  • Antidiuretic Hormone (ADH)
  • Oxytocin (OT)
  • The posterior pituitary does not create hormones, instead it only stores/releases them

Hypothalamic Control of Adrenal Medulla

  • Hypothalamus oversees the stimulation and hormone secretion of the adrenal medulla.
  • Adrenal medulla specializes in secreting hormones into the bloodstream in response to the sympathetic nervous system.
  • Parathyroid glands respond to concentrations of chemical levels in the bloodstream

Pituitary Gland Anatomy

  • Another designation for the pituitary gland is the hypophysis
  • The pituitary lays inferior to the hypothalamus
  • Part of the pituitary is the diencephalon
  • The infundibulum is a thin stalk that connects the hypothalamus to the pituitary gland
  • Projects from the median eminence of the hypothalamus
  • Within, and protected by, the sella turcica of the sphenoid bone
  • Partitioned structurally and functionally into the anterior (AP) and posterior (PP) pituitary, from different structures

Development of the Pituitary Gland

  • In the 3rd week of development, the Anterior pituitary grows superiorly as a hypophyseal pouch from the roof of the pharynx
  • Also at week 3, the Posterior pituitary has is forming with the neurohypophyseal bud from the inferior portion of the diencephalon
  • During week 8, the hypophyseal pouch detaches from the roof of pharynx
  • The structure merges with the neurohypophyseal bud
  • The Anterior Pituitary releases and secretes hormones in response to the hypothalamus
  • Is divided into the pars distalis (anterior most), pars intermedia (between the distalis and posterior pituitary), and the pars tuberalis (that hugs the infundibulum0
  • Regulatory hormones reach the anterior pituitary from the hypothalamus through the hypothalamo-hypophyseal portal system
  • The Posterior Pituitary stores hormones synthesized by the hypothalamus
  • Is composed of the pars nervosa and the infundibular stalk
  • Derived from nervous tissue at the base of the diencephalon

Hypothalamo-Hypophyseal Tract

  • A neural connection between hypothalamus and posterior pituitary
  • It contains unmyelinated axons extending from neurosecretory cells in the hypothalamus
  • Hormones are created by neurosecretory cells and transported through the tract
  • The hormones are then temporarily housed in the posterior pituitary and and released directly into the bloodstream by nerve impulses.

Hypothalamo-Hypophyseal Portal System Circulation

  • Blood enters via the internal carotid artery and the superior hypophyseal artery (SHA)
  • Primary plexus which are capillaries located around the median eminence and infundibulum, then drains into the hypophyseal portal veins (HPV)
  • Hypophyseal portal veins extend inferiorly, carrying the hypothalamic hormones to the secondary plexus
  • Hormones released communicate into the interstitial space, and with the anterior pituitary
  • Hormones travel from the anterior pituitary via the hypophyseal veins, eventually to the heart for systemic circulation
  • The arterial supply for the Posterior Pituitary is the inferior hypophyseal artery from the internal carotid artery
  • Consists of a Capillary bed surrounding the Posterior Pituitary
  • The venous drainage is the hypophyseal veins
  • The thyroid gland is anterior to the trachea and inferior of the thyroid cartilage
  • Deep to infrahyoid muscles
  • Right and left Butterfly shaped lobes connects via the isthmus

Parathyroid Glands

  • This series of approximately four small nodules on the posterior surface of the thyroid gland
  • The number and location may vary
  • Derived from pharyngeal pouches, the glands migrate to adult locations
  • Arterial supply comes from the inferior thyroid arteries, venous drainage the same as the thyroid gland

The Thyroid

  • The thyroid develops from an epithelial outpouching of the endoderm
  • The floor of the foregut features the thyroid diverticulum
  • It migrates caudally into a position anterior to the trachea, and a patent thyroglossal duct remains during development
  • The throglossal duct normally closes, with remains located on the posterior tongue, foramen cecum
  • Vascularization devoted to endocrine activities
  • Ext. carotid a. supplies the superior thyroid a., and the subclavian a. supplies the thyrocervical trunk, and the inferior thyroid a.
  • Superior and middle thyroid vv. drain into the internal jugular v., and inferior thyroid v. drains into the brachiocephalic v.

Development of the Thymus and Parathyroid Glands

  • From the third pharyngeal pouch comes the thymus and inferior parathyroid glands
  • The Glands separate from a pouch, migrates caudally, and the inferior parathyroids separate/attach to thymus
  • From the forth pharyngeal pouch superior parathyroid glands comes along, migrates a short distance alone to the thyroid gland

Adrenal Glands

  • Anchored on the superior surface of each kidney, glands are paired and triangular shaped
  • They are retroperitoneal, embedded in fat and fascia to minimize movement
  • Feature an outer adrenal cortex and inner adrenal medulla

Adrenal Gland Blood Supply

  • The arteries come from the superior, middle, and inferior suprarenal artery branches.
  • Veins drain into the right and left suprarenal veins.

The Adrenal Cortex

  • This region separated into three distinct layers Each layer produces its own hormones, originating from mesoderm
  • Zona Glomerulosa, outermost layer that synthesizes mineralocorticoids that regulate electrolyte composition/concentration
  • Zona Fasciculata, middle/thickest layer
  • This synthesizes glucocorticoids to stimulate metabolism of lipids/proteins, and regulate glucose
  • The Zona Reticularis is the innermost layer
  • Synthesizes small amount of gonadocorticoids exerting masculinizing effects/promoting anabolism and growth
  • The Adrenocorticotropic hormone (ACTH) stimulates the adrenal cortex to produce/secrete its own hormones (corticosteroids)
  • The Adrenal Medulla forms the inner core of the adrenal gland
  • It is innervated by the sympathetic nervous system, and the lesser splanchnic nerve
  • Also by the Aorticorenal ganglia
  • Releases neurotransmitters directly into the circulatory system for a widespread response

Adrenal Medulla Cell Production

  • Extensively vascularized and composed of chromaffin cells
  • Formed from neural crest cells which are modified ganglionic cells of the sympathetic division of the ANS Norpeinephrine and Dopamine Production
  • Secrete epinephrine (adrenaline)
  • Prepares the body for fight-or-flight responses
  • Prolongs the effects of sympathetic stimulation

Pancreas Summary

  • Heterocrine glands perform both the endocrine and exocrine actions
  • Exocrine Function: Aids digestion and secretes pancreatic juices into the duodenum
  • Groups of cells that produce alkaline pancreatic juices, Pancreatic acini
  • Endocrine Functions: Pancreatic islets are a cluster of endocrine cells and four types of cells that produce four hormones
  • Alpha, Beta, Delta, F cells

Pancreas - Type of Cells

  • Alpha cells secrete glucagon, which is stimulated by low levels of blood glucose
  • Beta cells secrete insulin, which is stimulated when levels of glucose are elevated
  • Delta cells secrete somatostatin, which is stimulated by high levels of nutrients in the bloodstream
  • F cells secrete polypeptide
  • F cells are stimulated by protein digestion in the GI tract

Pineal Gland and Function

  • Small structure attached to the posterior portion of structures in the epithalamus
  • Secretes Melotonin from Pinealocytes which helps circadian rhythms at night
  • It also affects the synthesis of hypothalamic regulatory hormones for FSH and LH to produce sexual hormones
  • Decreases in size with age
  • The Thymus is superior towards the heart, produces thymopoietin and thymosins
  • It works with the lymphatic system to regulate/maintain body of immunity
  • Stimulates and promotes differentiation, growth, and maturation of T-lymphocytes

Development of Thymus and Parathyroid Glands

  • Third pharyngeal pouch creates the thymus and inferior parathyroid glands
  • Glands here separate from the pouch and migrates down
  • Inferior parathyroid separates and attach to thymus
  • Fourth Pharyngeal pouch forms the thymus and inferior parathyroid gland
  • The Fourth pharyngeal pouch migrate a short distance to the thyroid gland

Endocrine Function of Organs

  • The kidneys help regulate the concentration of electrolytes in body fluids, and the rate of red blood cell production
  • It also increases blood volume and pressure
  • The Kidney Secretes Calcitriol, Erythropoietin and Renin, which contribute to increase electrolyte blood concentration
  • The heart responds to excessive stretching in walls due to the elevated blood pressure
  • Atriopeptin is created for cardiac muscle cells and is produced by the modified cardiac muscle cells
  • Causes loss of water and some amount of sodium excretion from blood into urine to reduce blood volume
  • The gastrointestinal tract produce hormones for accessory organs and tract that contributes to produce digestive activities

Hormones Produced in the GI Tract

  • Stimulates the river, gallbladde, and pancreas to produced secretions when needed

Types of Gonads

  • The Gonads ovaries produce estrogen and progesterone
  • The Testes produce androgens mostly converted into testosterone
  • Inhibins have the ability to release hormones for follicle creations and promote stimulation

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