Cardiovascular System Quiz

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Questions and Answers

What is the main function of the cardiovascular system in relation to chemical exchanges within the body?

  • To facilitate gas exchange across the epithelium of the lungs.
  • To excrete waste products through feces and urine.
  • To serve as a rapid transport network for substances throughout the body. (correct)
  • To directly absorb nutrients from the digestive tract.

Which component of blood, as a connective tissue, consists of a watery matrix?

  • Plasma (correct)
  • Ground substance
  • Specialized cells
  • Extracellular protein fibers

By what week of embryonic life does the heart typically begin to beat?

  • End of the third week (correct)
  • End of the first week
  • End of the second week
  • End of the fourth week

What critical role does the cardiovascular system start serving when an embryo reaches a few millimeters in length?

<p>Serving as a rapid-transport system for oxygen, nutrients, and waste products. (D)</p> Signup and view all the answers

Why is the cardiovascular system unnecessary in the earliest stages of embryonic development?

<p>Diffusion across exposed surfaces is sufficient for meeting metabolic demands. (A)</p> Signup and view all the answers

In comparing the cardiovascular system to the cooling system of a car, what corresponds to the blood vessels in the cardiovascular system?

<p>Radiator hoses (D)</p> Signup and view all the answers

Which statement accurately describes the role of plasma proteins in blood?

<p>They are dissolved in the plasma and typically do not form insoluble fibers. (D)</p> Signup and view all the answers

What is the immediate effect on an embryo's nutrient use after its heart begins to beat and blood starts circulating?

<p>Nutrient use will be more efficient (A)</p> Signup and view all the answers

What is the approximate percentage of plasma in whole blood?

<p>55 percent (D)</p> Signup and view all the answers

Which of the following is a primary difference between plasma and interstitial fluid?

<p>Concentration of dissolved proteins (C)</p> Signup and view all the answers

What is the term for the percentage of whole blood volume contributed by formed elements?

<p>Hematocrit (A)</p> Signup and view all the answers

In adult males, what is the normal hematocrit (packed cell volume)?

<p>46 (C)</p> Signup and view all the answers

Which of the following formed elements is most abundant in the blood?

<p>Red blood cells (D)</p> Signup and view all the answers

Through which process are formed elements produced?

<p>Hemopoiesis (C)</p> Signup and view all the answers

Which of the following stem cell types is responsible for the production of formed elements?

<p>Myeloid stem cells (A)</p> Signup and view all the answers

Which of the following proteins is most abundant in plasma?

<p>Albumins (D)</p> Signup and view all the answers

Which plasma protein is important for maintaining osmotic pressure?

<p>Albumins (D)</p> Signup and view all the answers

Antibodies are a type of:

<p>Globulins (B)</p> Signup and view all the answers

Which type of plasma protein includes transport proteins?

<p>Globulins (A)</p> Signup and view all the answers

Which plasma protein functions in blood clotting?

<p>Fibrinogen (D)</p> Signup and view all the answers

What insoluble protein forms the basic framework for a blood clot?

<p>Fibrin (A)</p> Signup and view all the answers

Which sex hormone stimulates red blood cell production?

<p>Androgens (B)</p> Signup and view all the answers

What percentage of plasma is made up of proteins?

<p>7% (D)</p> Signup and view all the answers

Which formed element accounts for approximately 99.9% of all formed elements in the blood?

<p>Red blood cells (A)</p> Signup and view all the answers

Which of the following is NOT a primary function of plasma proteins?

<p>Oxygen transport (A)</p> Signup and view all the answers

Which plasma protein is most abundant and significantly contributes to the osmotic pressure of plasma?

<p>Albumins (B)</p> Signup and view all the answers

Which of the following plasma proteins plays a crucial role in the formation of blood clots?

<p>Fibrinogen (C)</p> Signup and view all the answers

What is the primary function of erythrocytes?

<p>Transporting oxygen and carbon dioxide (B)</p> Signup and view all the answers

What is the approximate red blood cell count in one microliter of whole blood in adult males?

<p>5.4 million (D)</p> Signup and view all the answers

What is the term for the percentage of whole blood volume occupied by formed elements?

<p>Hematocrit (B)</p> Signup and view all the answers

How does the biconcave disc shape of red blood cells enhance their function?

<p>It provides a larger surface area for gas exchange. (B)</p> Signup and view all the answers

What cellular components do red blood cells lack upon maturation that prevents them from synthesizing proteins?

<p>Nuclei &amp; ribosomes (D)</p> Signup and view all the answers

Which of the following conditions would likely result in an increased hematocrit?

<p>Dehydration (A)</p> Signup and view all the answers

From which two populations of stem cells are the formed elements produced?

<p>Myeloid and lymphoid stem cells (A)</p> Signup and view all the answers

Which of the following organic nutrients is NOT used for ATP production, growth, and maintenance of cells?

<p>Urea (A)</p> Signup and view all the answers

Which of the following electrolytes is NOT a major plasma electrolytes?

<p>Ag+ (B)</p> Signup and view all the answers

Which of the following is NOT an example oforganic wastes?

<p>Globulin (D)</p> Signup and view all the answers

What is the role of transport globulins within blood plasma?

<p>Binding small ions, hormones, and other compounds (A)</p> Signup and view all the answers

Which of the following is NOT a primary function of blood?

<p>Producing red blood cells. (A)</p> Signup and view all the answers

Which characteristic of blood contributes to its high viscosity?

<p>Interactions among dissolved proteins, formed elements, and water molecules. (C)</p> Signup and view all the answers

What is the approximate normal pH range of blood?

<p>7.35 - 7.45 (B)</p> Signup and view all the answers

Why is venipuncture a common technique for obtaining blood samples?

<p>Superficial veins are easy to locate, have thinner walls than arteries, and have relatively low blood pressure. (A)</p> Signup and view all the answers

Which of the following is NOT a component of blood plasma?

<p>Formed elements (D)</p> Signup and view all the answers

What is the primary function of albumins in blood plasma?

<p>Maintaining osmotic pressure. (C)</p> Signup and view all the answers

Which type of plasma protein includes antibodies?

<p>Globulins (A)</p> Signup and view all the answers

What role does fibrinogen play in the blood?

<p>Facilitating blood clotting. (B)</p> Signup and view all the answers

Which of the following best describes the function of blood in stabilizing body temperature?

<p>It redistributes heat from active muscles to other tissues and directs blood flow to the skin to lose heat. (C)</p> Signup and view all the answers

What is the term for the procedure of collecting fresh whole blood from a superficial vein?

<p>Venipuncture (D)</p> Signup and view all the answers

Which of the following would be transported by lipoproteins?

<p>Lipids like Cholesterol (B)</p> Signup and view all the answers

Considering the role of blood in regulating pH, what would happen if blood could not neutralize acids generated by active tissues?

<p>Local pH imbalances would occur, potentially affecting cellular function. (B)</p> Signup and view all the answers

What is the main reason an arterial puncture is performed instead of a venipuncture?

<p>To evaluate the efficiency of gas exchange at the lungs (B)</p> Signup and view all the answers

How does blood help defend against pathogens?

<p>By transporting white blood cells and antibodies. (A)</p> Signup and view all the answers

What is the average temperature of blood in degrees Fahrenheit?

<p>100.4°F (B)</p> Signup and view all the answers

What happens to an erythroblast after roughly four days of differentiation?

<p>It sheds its nucleus and becomes a reticulocyte (C)</p> Signup and view all the answers

How can reticulocytes be identified in a blood smear?

<p>By using a stain that only combines with RNA (B)</p> Signup and view all the answers

What percentage of circulating erythrocytes do reticulocytes normally account for?

<p>0.8 percent (C)</p> Signup and view all the answers

What occurs to reticulocytes after 24 hours in circulation?

<p>They complete their maturation and resemble mature RBCs (C)</p> Signup and view all the answers

What effect would significant blood loss have on hematocrit levels?

<p>It would decrease hematocrit due to reduced red blood cell volume (B)</p> Signup and view all the answers

What organic compound, responsible for the greenish color sometimes observed in bruises, is derived from heme?

<p>Biliverdin (C)</p> Signup and view all the answers

In adults, where does erythropoiesis exclusively occur?

<p>Red bone marrow (A)</p> Signup and view all the answers

What is the role of erythropoietin (EPO) in erythropoiesis?

<p>Directly stimulates erythropoiesis (C)</p> Signup and view all the answers

Under which of the following conditions is erythropoietin (EPO) released?

<p>Decreased oxygen content of the blood (C)</p> Signup and view all the answers

In addition to EPO, which of the following hormones stimulates erythropoiesis?

<p>Thyroxine (C)</p> Signup and view all the answers

Which condition results from a lack of vitamin $B_{12}$ due to the absence of intrinsic factor?

<p>Pernicious anemia (C)</p> Signup and view all the answers

What is the ultimate source of all formed elements of blood cells?

<p>Hemocytoblasts (C)</p> Signup and view all the answers

What is characterized by abnormal hemoglobin?

<p>Inherited disorders (D)</p> Signup and view all the answers

What is the result of the various forms of thalassemia?

<p>Inability to produce adequate amounts of the globular proteins (A)</p> Signup and view all the answers

What occurs when defective hemoglobin gives up enough of its bound oxygen in individuals with sickle cell anemia (SCA)?

<p>Hemoglobin molecules interact and cells become stiff and curved (B)</p> Signup and view all the answers

What is the average total body iron content in women, and approximately how much of it is bound to the hemoglobin of circulating RBCs?

<p>2.4 g total iron; 1.9 g in RBCs (A)</p> Signup and view all the answers

What can result from the buildup of too much iron in cardiac muscle tissue?

<p>Heart disease (B)</p> Signup and view all the answers

Where are the primary sites of blood formation during the first eight weeks of embryonic development?

<p>Embryonic yolk sac (C)</p> Signup and view all the answers

What pigments are produced from bilirubin in the large intestine and contribute to the color of urine and feces?

<p>Urobilins and stercobilins (B)</p> Signup and view all the answers

What happens if the bile ducts are blocked or the liver cannot absorb or excrete bilirubin?

<p>Bilirubin levels rise in the bloodstream (C)</p> Signup and view all the answers

What crucial characteristic of RBCs ensures that oxygen is delivered to peripheral tissues rather than consumed within the cells themselves?

<p>The reliance on anaerobic metabolism due to the absence of mitochondria. (B)</p> Signup and view all the answers

What accounts for more than 95 percent of an RBC’s intracellular proteins?

<p>Hemoglobin (D)</p> Signup and view all the answers

What is the function of heme within a hemoglobin molecule?

<p>To hold an iron ion that can reversibly bind to an oxygen molecule. (C)</p> Signup and view all the answers

Which event triggers hemoglobin to release oxygen and bind carbon dioxide?

<p>A localized rise in carbon dioxide levels and a decline in oxygen levels within peripheral tissues. (D)</p> Signup and view all the answers

What condition results from blood with a low hematocrit or reduced hemoglobin content?

<p>Anemia (C)</p> Signup and view all the answers

Why do red blood cells have a relatively short lifespan of approximately 120 days?

<p>They lack the organelles necessary for repair. (D)</p> Signup and view all the answers

What triggers the phagocytosis of red blood cells?

<p>Damage to the plasma membrane. (D)</p> Signup and view all the answers

How are the amino acids resulting from hemoglobin breakdown utilized?

<p>They are metabolized by the cell or released into the bloodstream for use by other cells. (C)</p> Signup and view all the answers

What plasma transport protein binds and transports iron in the bloodstream?

<p>Transferrin (D)</p> Signup and view all the answers

What happens to hemoglobin that is released into the bloodstream due to hemolysis and not phagocytized?

<p>It breaks down, and the polypeptide chains are filtered by the kidneys and lost in urine. (D)</p> Signup and view all the answers

What condition is indicated if the urine turns red or brown due to a large number of RBCs breaking down in the bloodstream?

<p>Hemoglobinuria. (C)</p> Signup and view all the answers

How does the structure of a mature RBC support its function?

<p>The lack of a nucleus and most organelles maximizes space for hemoglobin. (D)</p> Signup and view all the answers

What is the primary advantage of the weak iron-oxygen interaction in hemoglobin?

<p>It enables easy separation of oxygen from hemoglobin in tissues. (C)</p> Signup and view all the answers

How do RBCs respond when they reach the lungs where there is high oxygen concentration and low carbon dioxide concentration?

<p>They absorb oxygen and release carbon dioxide. (B)</p> Signup and view all the answers

What is the significance of RBCs being squeezed through tiny capillaries during circulation?

<p>It contributes to wear and tear on the RBCs, leading to damage and eventual removal. (A)</p> Signup and view all the answers

Flashcards

Cardiovascular system

The internal transport network of the body, responsible for circulating blood throughout the body.

Plasma

The watery fluid component of blood, containing dissolved substances and proteins.

Diffusion

The process by which substances move from an area of high concentration to low concentration across a membrane.

Cardiovascular system development

The first organ system to develop in an embryo, responsible for transporting oxygen, nutrients, and waste products.

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Diffusion limitation

The point at which diffusion becomes too slow to meet the needs of the growing embryo, leading to the development of the cardiovascular system.

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Blood components

The specialized cells, extracellular protein fibers, and ground substance found in blood, similar to other connective tissues.

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Heart beating

The process by which the heart begins to beat, marking the start of blood circulation.

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Rapid transport

The ability to move substances throughout the body efficiently, enabled by the cardiovascular system.

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Albumins

The primary type of plasma protein, responsible for maintaining osmotic pressure.

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Globulins

A type of plasma protein that includes antibodies and transport proteins.

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Fibrinogen

A plasma protein involved in blood clotting.

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Venipuncture

The process of drawing blood from a vein, usually for testing.

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Blood smear

A thin film of blood spread on a microscope slide, stained to reveal various blood components.

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Arterial puncture

The process of drawing blood from an artery, often to assess lung function.

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Gas transport

The ability of blood to carry oxygen from the lungs to tissues and carbon dioxide back to the lungs.

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Nutrient transport

The ability of blood to carry nutrients absorbed by the digestive system or released from storage.

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Hormone transport

The ability of blood to carry hormones from endocrine glands to target cells.

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Waste transport

The ability of blood to carry waste products produced by cells to the kidneys for excretion.

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pH and ion regulation

The ability of blood to regulate the pH and ion composition of interstitial fluids.

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Fluid loss restriction

The ability of blood to help stop bleeding through the process of blood clotting.

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Defense against toxins and pathogens

The ability of blood to defend against toxins and pathogens through white blood cells and antibodies.

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What is plasma?

The liquid portion of blood, containing dissolved substances and proteins like albumins, globulins, and fibrinogen.

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What is fibrinogen's role in blood clotting?

A key protein in plasma that helps form blood clots by forming insoluble strands of fibrin.

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What is hematocrit?

The percentage of blood volume occupied by formed elements like red blood cells, white blood cells, and platelets.

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What is hemopoiesis?

It's the process of forming new blood cells and cell fragments.

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What are formed elements?

These are the blood cells and cell fragments suspended in plasma, making up 45% of blood volume. They include platelets, white blood cells, and red blood cells.

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What are platelets?

These cells, involved in blood clotting, are tiny fragments of larger cells.

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What are white blood cells?

These cells are responsible for the body's immune defense.

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What are red blood cells?

These cells carry oxygen throughout the body.

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What are albumins?

These are the most abundant plasma proteins, important for maintaining the osmotic pressure of blood.

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What are globulins?

They're a diverse group of plasma proteins, including antibodies and transport proteins.

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What are lipoproteins?

These plasma proteins bind to and transport lipids like triglycerides, fatty acids, and cholesterol in the blood.

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What is the continuous exchange between blood plasma and interstitial fluid?

The process of exchanging water, ions, and small solutes between plasma and interstitial fluid across capillary walls.

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What are the key differences between plasma and interstitial fluid?

These are the primary differences between the composition of plasma and interstitial fluid.

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What are androgens?

They are hormones that stimulate red blood cell production.

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What are estrogens?

They are female hormones that do not stimulate red blood cell production.

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What is fibrinogen?

A plasma protein involved in blood clotting, forming insoluble strands of fibrin to create a clot.

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What happens if the amount of plasma proteins decreases?

A decrease in plasma proteins can lead to reduced osmotic pressure in blood, potentially causing fluid to leak out of blood vessels, resulting in edema.

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What is hemoglobin?

The red pigment found in red blood cells that binds and transports oxygen and carbon dioxide.

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What is a unique feature of red blood cells?

Red blood cells are unique because they lack nuclei and most organelles, allowing them to carry more oxygen effectively.

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What is erythropoiesis?

It refers to the formation of red blood cells, a process that occurs in the bone marrow.

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What is erythropoietin (EPO)?

A hormone produced by the kidneys that stimulates the production of red blood cells in response to low oxygen levels in the blood.

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Why can't mature red blood cells divide?

Red blood cells lack nuclei and ribosomes, preventing them from dividing or producing proteins.

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What happens to worn-out red blood cells?

Old, worn-out red blood cells are broken down in the spleen and liver, where their components are recycled.

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What are reticulocytes, and what is their role in the blood?

A reticulocyte is an immature red blood cell that is still capable of synthesizing proteins and has a distinct RNA content. It is released from the bone marrow and is important for the formation of mature red blood cells.

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How would a significant blood loss affect hematocrit?

Hematocrit is the percentage of red blood cells in the blood. After significant blood loss, the hematocrit value would decrease because the proportion of red blood cells in the blood volume would be lower.

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How can liver damage affect bilirubin levels?

A disease that causes liver damage can impair the liver's ability to process bilirubin, a waste product of red blood cell breakdown. This leads to an accumulation of bilirubin in the blood, resulting in jaundice.

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How would a blockage in renal arteries affect hematocrit?

A blockage in renal arteries would reduce blood flow to the kidneys, which can lead to the kidneys producing a hormone called erythropoietin (EPO) that stimulates red blood cell production. This would cause the hematocrit to increase.

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What is hemoglobin and what is its function?

Hemoglobin is the oxygen-carrying protein found in red blood cells. It binds to oxygen in the lungs and releases it to the tissues, facilitating oxygen transport throughout the body.

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RBC energy source

Red blood cells (RBCs) lack mitochondria, the powerhouses of cells, and rely on anaerobic metabolism for energy.

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RBC lifespan

RBCs have a short lifespan of about 120 days due to their inability to repair damage caused by constant circulation.

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Hemoglobin function

Hemoglobin, a protein within RBCs, binds to and transports oxygen throughout the body.

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Hemoglobin structure

Hemoglobin is composed of four protein subunits, each containing a heme molecule that binds an iron ion, which in turn interacts with an oxygen molecule.

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Blood color

Oxygenated blood, with hemoglobin bound to oxygen, is bright red, while deoxygenated blood is darker, almost burgundy.

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Hemoglobin and gas exchange

Hemoglobin can bind to both oxygen and carbon dioxide, releasing oxygen in tissues where it is needed and picking up carbon dioxide.

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Anemia

Low levels of red blood cells or reduced hemoglobin content in the blood lead to anemia, resulting in decreased oxygen-carrying capacity.

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RBC removal

Macrophages, specialized cells that engulf and break down old or damaged cells, play a key role in the removal and recycling of RBCs.

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Hemoglobin breakdown

The heme molecule is broken down, releasing iron, which is either stored or released into the bloodstream for use by new RBCs.

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Hemoglobin amino acid fate

Amino acids from the broken-down hemoglobin molecule are either used by the macrophage or released into the bloodstream for other cells.

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Iron transport

Transferrin, a plasma protein, binds to iron and transports it in the bloodstream for new RBC production.

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Iron storage

Excess transferrin is removed in the liver and spleen, where iron is stored in protein-iron complexes, ensuring a reserve for future RBC production.

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Hemoglobinuria

The breakdown of large numbers of RBCs in the bloodstream can lead to hemoglobinuria, resulting in red or brown urine.

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RBC turnover

The recycling of hemoglobin and the turnover of RBCs ensure a continuous supply of oxygen-carrying cells in the blood.

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Phagocytosis

Phagocytosis, also known as cell eating, is a process where cells engulf and digest solid particles, such as bacteria or cellular debris.

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Thalassemia

A genetic condition where the body can't produce enough hemoglobin, leading to fewer red blood cells and reduced oxygen-carrying capacity.

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Sickle Cell Anemia

A genetic disorder where red blood cells become stiff and curved, blocking blood flow and leading to tissue oxygen starvation.

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Biliverdin

The green pigment produced from heme breakdown, visible in bruises.

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Bilirubin

The orange-yellow pigment formed from biliverdin, released into the bloodstream.

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Hematopoiesis

The process of red blood cell formation and differentiation, primarily occurring in red bone marrow.

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Iron deficiency Anemia

A condition caused by inadequate iron intake, leading to reduced hemoglobin production and symptoms like fatigue and weakness.

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Erythropoiesis

A process in which stem cells in red bone marrow divide and mature into red blood cells.

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Erythropoietin (EPO)

A hormone produced by the kidneys and liver that stimulates red blood cell production.

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Hypoxia

Low oxygen levels in tissues, which triggers the release of erythropoietin.

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Red Bone Marrow

A type of bone marrow found in the center of certain bones, responsible for blood cell production.

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Yellow Bone Marrow

A type of bone marrow found in the shafts of long bones, primarily composed of fat.

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Erythroblast

An immature red blood cell actively synthesizing hemoglobin.

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Myeloid Tissue

The primary site of red blood cell production, found in various bones.

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Heme Catabolism

The process of breaking down heme from hemoglobin.

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Hyperbilirubinemia

A condition where the liver cannot properly absorb or excrete bilirubin, causing its accumulation in the blood.

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Study Notes

Blood: Composition, Function, and Formation

  • Blood is a fluid connective tissue, composed of specialized cells, extracellular protein fibers, and a fluid ground substance (plasma)
  • Plasma proteins (primarily albumins, globulins, and fibrinogen)
    • Crucial for maintaining osmotic pressure
    • Albumins: most abundant, maintain osmotic pressure
    • Globulins: antibodies (attack pathogens) and transport proteins (binding ions, hormones, lipids)
      • Lipoproteins: transport insoluble lipids
    • Fibrinogen: clotting, forms fibrin strands
  • Blood functions:
    • Transport: gases, nutrients, hormones, wastes
    • Regulation: pH and ion composition of interstitial fluids
    • Restriction of fluid loss: clotting at injury sites
    • Defense: white blood cells fight infection, antibodies attack pathogens
    • Temperature regulation: absorbs and distributes heat

Physical Characteristics of Blood

  • Temperature: approximately 38°C (100.4°F)
  • Viscosity: five times thicker than water, due to interactions of plasma proteins, formed elements, and water
  • pH: slightly alkaline, between 7.35 and 7.45 (average: 7.4)

Blood Collection and Analysis

  • Venipuncture: common technique for obtaining blood from superficial veins (median cubital vein)
    • Convenient location, thin vein walls, low pressure
  • Capillary puncture: used for preparing blood smears (fingertip, earlobe)
  • Arterial puncture: used for evaluating gas exchange at lungs (radial or brachial artery)

Formed Elements in Blood

  • Formed elements: cells and cell fragments (platelets, white blood cells, red blood cells)
  • Hematocrit: percentage of whole blood volume occupied by formed elements
    • Adult male: ~46%
    • Adult female: ~42%
    • Impacts of dehydration, erythropoietin stimulation, bleeding, blood cell formation

Red Blood Cells (RBCs)

  • Structure: biconcave disc, large surface area to volume ratio for efficient gas exchange; flexible for movement through narrow capillaries
  • Components:
    • Hemoglobin (Hb): ~95% of intracellular protein, binds and transports oxygen and carbon dioxide.
      • Complex quaternary structure: 4 globular protein subunits, each with heme molecule containing iron that combines with oxygen.
      • Binding of oxygen changes color of blood (bright red with oxygen, dark red without)
  • Function: carry oxygen and carbon dioxide
    • Anaerobic metabolism: energy source, rely on glucose from plasma
    • Life span: ~120 days
  • Formation (Erythropoiesis):
    • Occurs in red bone marrow, myeloid tissue
    • Regulated by erythropoietin (EPO) in response to low oxygen levels (hypoxia)

Hemoglobin Recycling

  • Macrophages (in liver, spleen, red bone marrow): engulf damaged RBCs
  • Breakdown:
    • Globin into amino acids
    • Heme into iron and bilirubin
    • Iron binds to transferrin for reuse
    • Bilirubin: processed by liver, excreted in bile (giving feces their color)
  • Anemia: low hematocrit or reduced hemoglobin content, leads to reduced oxygen capacity.
  • Hemoglobinuria: large numbers of damaged RBCs leads to red or brown blood

Clinical Note: Abnormal Hemoglobin

  • Thalassemia: insufficient production of hemoglobin proteins
  • Sickle cell anemia (SCA): mutation in hemoglobin affecting RBC shape and flexibility, causing blockages.

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