Podcast
Questions and Answers
What is the main function of the cardiovascular system in relation to chemical exchanges within the body?
What is the main function of the cardiovascular system in relation to chemical exchanges within the body?
- To facilitate gas exchange across the epithelium of the lungs.
- To excrete waste products through feces and urine.
- To serve as a rapid transport network for substances throughout the body. (correct)
- To directly absorb nutrients from the digestive tract.
Which component of blood, as a connective tissue, consists of a watery matrix?
Which component of blood, as a connective tissue, consists of a watery matrix?
- Plasma (correct)
- Ground substance
- Specialized cells
- Extracellular protein fibers
By what week of embryonic life does the heart typically begin to beat?
By what week of embryonic life does the heart typically begin to beat?
- End of the third week (correct)
- End of the first week
- End of the second week
- End of the fourth week
What critical role does the cardiovascular system start serving when an embryo reaches a few millimeters in length?
What critical role does the cardiovascular system start serving when an embryo reaches a few millimeters in length?
Why is the cardiovascular system unnecessary in the earliest stages of embryonic development?
Why is the cardiovascular system unnecessary in the earliest stages of embryonic development?
In comparing the cardiovascular system to the cooling system of a car, what corresponds to the blood vessels in the cardiovascular system?
In comparing the cardiovascular system to the cooling system of a car, what corresponds to the blood vessels in the cardiovascular system?
Which statement accurately describes the role of plasma proteins in blood?
Which statement accurately describes the role of plasma proteins in blood?
What is the immediate effect on an embryo's nutrient use after its heart begins to beat and blood starts circulating?
What is the immediate effect on an embryo's nutrient use after its heart begins to beat and blood starts circulating?
What is the approximate percentage of plasma in whole blood?
What is the approximate percentage of plasma in whole blood?
Which of the following is a primary difference between plasma and interstitial fluid?
Which of the following is a primary difference between plasma and interstitial fluid?
What is the term for the percentage of whole blood volume contributed by formed elements?
What is the term for the percentage of whole blood volume contributed by formed elements?
In adult males, what is the normal hematocrit (packed cell volume)?
In adult males, what is the normal hematocrit (packed cell volume)?
Which of the following formed elements is most abundant in the blood?
Which of the following formed elements is most abundant in the blood?
Through which process are formed elements produced?
Through which process are formed elements produced?
Which of the following stem cell types is responsible for the production of formed elements?
Which of the following stem cell types is responsible for the production of formed elements?
Which of the following proteins is most abundant in plasma?
Which of the following proteins is most abundant in plasma?
Which plasma protein is important for maintaining osmotic pressure?
Which plasma protein is important for maintaining osmotic pressure?
Antibodies are a type of:
Antibodies are a type of:
Which type of plasma protein includes transport proteins?
Which type of plasma protein includes transport proteins?
Which plasma protein functions in blood clotting?
Which plasma protein functions in blood clotting?
What insoluble protein forms the basic framework for a blood clot?
What insoluble protein forms the basic framework for a blood clot?
Which sex hormone stimulates red blood cell production?
Which sex hormone stimulates red blood cell production?
What percentage of plasma is made up of proteins?
What percentage of plasma is made up of proteins?
Which formed element accounts for approximately 99.9% of all formed elements in the blood?
Which formed element accounts for approximately 99.9% of all formed elements in the blood?
Which of the following is NOT a primary function of plasma proteins?
Which of the following is NOT a primary function of plasma proteins?
Which plasma protein is most abundant and significantly contributes to the osmotic pressure of plasma?
Which plasma protein is most abundant and significantly contributes to the osmotic pressure of plasma?
Which of the following plasma proteins plays a crucial role in the formation of blood clots?
Which of the following plasma proteins plays a crucial role in the formation of blood clots?
What is the primary function of erythrocytes?
What is the primary function of erythrocytes?
What is the approximate red blood cell count in one microliter of whole blood in adult males?
What is the approximate red blood cell count in one microliter of whole blood in adult males?
What is the term for the percentage of whole blood volume occupied by formed elements?
What is the term for the percentage of whole blood volume occupied by formed elements?
How does the biconcave disc shape of red blood cells enhance their function?
How does the biconcave disc shape of red blood cells enhance their function?
What cellular components do red blood cells lack upon maturation that prevents them from synthesizing proteins?
What cellular components do red blood cells lack upon maturation that prevents them from synthesizing proteins?
Which of the following conditions would likely result in an increased hematocrit?
Which of the following conditions would likely result in an increased hematocrit?
From which two populations of stem cells are the formed elements produced?
From which two populations of stem cells are the formed elements produced?
Which of the following organic nutrients is NOT used for ATP production, growth, and maintenance of cells?
Which of the following organic nutrients is NOT used for ATP production, growth, and maintenance of cells?
Which of the following electrolytes is NOT a major plasma electrolytes?
Which of the following electrolytes is NOT a major plasma electrolytes?
Which of the following is NOT an example oforganic wastes?
Which of the following is NOT an example oforganic wastes?
What is the role of transport globulins within blood plasma?
What is the role of transport globulins within blood plasma?
Which of the following is NOT a primary function of blood?
Which of the following is NOT a primary function of blood?
Which characteristic of blood contributes to its high viscosity?
Which characteristic of blood contributes to its high viscosity?
What is the approximate normal pH range of blood?
What is the approximate normal pH range of blood?
Why is venipuncture a common technique for obtaining blood samples?
Why is venipuncture a common technique for obtaining blood samples?
Which of the following is NOT a component of blood plasma?
Which of the following is NOT a component of blood plasma?
What is the primary function of albumins in blood plasma?
What is the primary function of albumins in blood plasma?
Which type of plasma protein includes antibodies?
Which type of plasma protein includes antibodies?
What role does fibrinogen play in the blood?
What role does fibrinogen play in the blood?
Which of the following best describes the function of blood in stabilizing body temperature?
Which of the following best describes the function of blood in stabilizing body temperature?
What is the term for the procedure of collecting fresh whole blood from a superficial vein?
What is the term for the procedure of collecting fresh whole blood from a superficial vein?
Which of the following would be transported by lipoproteins?
Which of the following would be transported by lipoproteins?
Considering the role of blood in regulating pH, what would happen if blood could not neutralize acids generated by active tissues?
Considering the role of blood in regulating pH, what would happen if blood could not neutralize acids generated by active tissues?
What is the main reason an arterial puncture is performed instead of a venipuncture?
What is the main reason an arterial puncture is performed instead of a venipuncture?
How does blood help defend against pathogens?
How does blood help defend against pathogens?
What is the average temperature of blood in degrees Fahrenheit?
What is the average temperature of blood in degrees Fahrenheit?
What happens to an erythroblast after roughly four days of differentiation?
What happens to an erythroblast after roughly four days of differentiation?
How can reticulocytes be identified in a blood smear?
How can reticulocytes be identified in a blood smear?
What percentage of circulating erythrocytes do reticulocytes normally account for?
What percentage of circulating erythrocytes do reticulocytes normally account for?
What occurs to reticulocytes after 24 hours in circulation?
What occurs to reticulocytes after 24 hours in circulation?
What effect would significant blood loss have on hematocrit levels?
What effect would significant blood loss have on hematocrit levels?
What organic compound, responsible for the greenish color sometimes observed in bruises, is derived from heme?
What organic compound, responsible for the greenish color sometimes observed in bruises, is derived from heme?
In adults, where does erythropoiesis exclusively occur?
In adults, where does erythropoiesis exclusively occur?
What is the role of erythropoietin (EPO) in erythropoiesis?
What is the role of erythropoietin (EPO) in erythropoiesis?
Under which of the following conditions is erythropoietin (EPO) released?
Under which of the following conditions is erythropoietin (EPO) released?
In addition to EPO, which of the following hormones stimulates erythropoiesis?
In addition to EPO, which of the following hormones stimulates erythropoiesis?
Which condition results from a lack of vitamin $B_{12}$ due to the absence of intrinsic factor?
Which condition results from a lack of vitamin $B_{12}$ due to the absence of intrinsic factor?
What is the ultimate source of all formed elements of blood cells?
What is the ultimate source of all formed elements of blood cells?
What is characterized by abnormal hemoglobin?
What is characterized by abnormal hemoglobin?
What is the result of the various forms of thalassemia?
What is the result of the various forms of thalassemia?
What occurs when defective hemoglobin gives up enough of its bound oxygen in individuals with sickle cell anemia (SCA)?
What occurs when defective hemoglobin gives up enough of its bound oxygen in individuals with sickle cell anemia (SCA)?
What is the average total body iron content in women, and approximately how much of it is bound to the hemoglobin of circulating RBCs?
What is the average total body iron content in women, and approximately how much of it is bound to the hemoglobin of circulating RBCs?
What can result from the buildup of too much iron in cardiac muscle tissue?
What can result from the buildup of too much iron in cardiac muscle tissue?
Where are the primary sites of blood formation during the first eight weeks of embryonic development?
Where are the primary sites of blood formation during the first eight weeks of embryonic development?
What pigments are produced from bilirubin in the large intestine and contribute to the color of urine and feces?
What pigments are produced from bilirubin in the large intestine and contribute to the color of urine and feces?
What happens if the bile ducts are blocked or the liver cannot absorb or excrete bilirubin?
What happens if the bile ducts are blocked or the liver cannot absorb or excrete bilirubin?
What crucial characteristic of RBCs ensures that oxygen is delivered to peripheral tissues rather than consumed within the cells themselves?
What crucial characteristic of RBCs ensures that oxygen is delivered to peripheral tissues rather than consumed within the cells themselves?
What accounts for more than 95 percent of an RBC’s intracellular proteins?
What accounts for more than 95 percent of an RBC’s intracellular proteins?
What is the function of heme within a hemoglobin molecule?
What is the function of heme within a hemoglobin molecule?
Which event triggers hemoglobin to release oxygen and bind carbon dioxide?
Which event triggers hemoglobin to release oxygen and bind carbon dioxide?
What condition results from blood with a low hematocrit or reduced hemoglobin content?
What condition results from blood with a low hematocrit or reduced hemoglobin content?
Why do red blood cells have a relatively short lifespan of approximately 120 days?
Why do red blood cells have a relatively short lifespan of approximately 120 days?
What triggers the phagocytosis of red blood cells?
What triggers the phagocytosis of red blood cells?
How are the amino acids resulting from hemoglobin breakdown utilized?
How are the amino acids resulting from hemoglobin breakdown utilized?
What plasma transport protein binds and transports iron in the bloodstream?
What plasma transport protein binds and transports iron in the bloodstream?
What happens to hemoglobin that is released into the bloodstream due to hemolysis and not phagocytized?
What happens to hemoglobin that is released into the bloodstream due to hemolysis and not phagocytized?
What condition is indicated if the urine turns red or brown due to a large number of RBCs breaking down in the bloodstream?
What condition is indicated if the urine turns red or brown due to a large number of RBCs breaking down in the bloodstream?
How does the structure of a mature RBC support its function?
How does the structure of a mature RBC support its function?
What is the primary advantage of the weak iron-oxygen interaction in hemoglobin?
What is the primary advantage of the weak iron-oxygen interaction in hemoglobin?
How do RBCs respond when they reach the lungs where there is high oxygen concentration and low carbon dioxide concentration?
How do RBCs respond when they reach the lungs where there is high oxygen concentration and low carbon dioxide concentration?
What is the significance of RBCs being squeezed through tiny capillaries during circulation?
What is the significance of RBCs being squeezed through tiny capillaries during circulation?
Flashcards
Cardiovascular system
Cardiovascular system
The internal transport network of the body, responsible for circulating blood throughout the body.
Plasma
Plasma
The watery fluid component of blood, containing dissolved substances and proteins.
Diffusion
Diffusion
The process by which substances move from an area of high concentration to low concentration across a membrane.
Cardiovascular system development
Cardiovascular system development
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Diffusion limitation
Diffusion limitation
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Blood components
Blood components
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Heart beating
Heart beating
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Rapid transport
Rapid transport
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Albumins
Albumins
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Globulins
Globulins
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Fibrinogen
Fibrinogen
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Venipuncture
Venipuncture
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Blood smear
Blood smear
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Arterial puncture
Arterial puncture
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Gas transport
Gas transport
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Nutrient transport
Nutrient transport
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Hormone transport
Hormone transport
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Waste transport
Waste transport
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pH and ion regulation
pH and ion regulation
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Fluid loss restriction
Fluid loss restriction
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Defense against toxins and pathogens
Defense against toxins and pathogens
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What is plasma?
What is plasma?
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What is fibrinogen's role in blood clotting?
What is fibrinogen's role in blood clotting?
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What is hematocrit?
What is hematocrit?
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What is hemopoiesis?
What is hemopoiesis?
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What are formed elements?
What are formed elements?
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What are platelets?
What are platelets?
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What are white blood cells?
What are white blood cells?
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What are red blood cells?
What are red blood cells?
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What are albumins?
What are albumins?
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What are globulins?
What are globulins?
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What are lipoproteins?
What are lipoproteins?
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What is the continuous exchange between blood plasma and interstitial fluid?
What is the continuous exchange between blood plasma and interstitial fluid?
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What are the key differences between plasma and interstitial fluid?
What are the key differences between plasma and interstitial fluid?
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What are androgens?
What are androgens?
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What are estrogens?
What are estrogens?
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What is fibrinogen?
What is fibrinogen?
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What happens if the amount of plasma proteins decreases?
What happens if the amount of plasma proteins decreases?
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What is hemoglobin?
What is hemoglobin?
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What is a unique feature of red blood cells?
What is a unique feature of red blood cells?
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What is erythropoiesis?
What is erythropoiesis?
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What is erythropoietin (EPO)?
What is erythropoietin (EPO)?
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Why can't mature red blood cells divide?
Why can't mature red blood cells divide?
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What happens to worn-out red blood cells?
What happens to worn-out red blood cells?
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What are reticulocytes, and what is their role in the blood?
What are reticulocytes, and what is their role in the blood?
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How would a significant blood loss affect hematocrit?
How would a significant blood loss affect hematocrit?
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How can liver damage affect bilirubin levels?
How can liver damage affect bilirubin levels?
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How would a blockage in renal arteries affect hematocrit?
How would a blockage in renal arteries affect hematocrit?
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What is hemoglobin and what is its function?
What is hemoglobin and what is its function?
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RBC energy source
RBC energy source
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RBC lifespan
RBC lifespan
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Hemoglobin function
Hemoglobin function
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Hemoglobin structure
Hemoglobin structure
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Blood color
Blood color
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Hemoglobin and gas exchange
Hemoglobin and gas exchange
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Anemia
Anemia
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RBC removal
RBC removal
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Hemoglobin breakdown
Hemoglobin breakdown
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Hemoglobin amino acid fate
Hemoglobin amino acid fate
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Iron transport
Iron transport
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Iron storage
Iron storage
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Hemoglobinuria
Hemoglobinuria
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RBC turnover
RBC turnover
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Phagocytosis
Phagocytosis
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Thalassemia
Thalassemia
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Sickle Cell Anemia
Sickle Cell Anemia
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Biliverdin
Biliverdin
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Bilirubin
Bilirubin
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Hematopoiesis
Hematopoiesis
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Iron deficiency Anemia
Iron deficiency Anemia
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Erythropoiesis
Erythropoiesis
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Erythropoietin (EPO)
Erythropoietin (EPO)
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Hypoxia
Hypoxia
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Red Bone Marrow
Red Bone Marrow
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Yellow Bone Marrow
Yellow Bone Marrow
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Erythroblast
Erythroblast
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Myeloid Tissue
Myeloid Tissue
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Heme Catabolism
Heme Catabolism
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Hyperbilirubinemia
Hyperbilirubinemia
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Study Notes
Blood: Composition, Function, and Formation
- Blood is a fluid connective tissue, composed of specialized cells, extracellular protein fibers, and a fluid ground substance (plasma)
- Plasma proteins (primarily albumins, globulins, and fibrinogen)
- Crucial for maintaining osmotic pressure
- Albumins: most abundant, maintain osmotic pressure
- Globulins: antibodies (attack pathogens) and transport proteins (binding ions, hormones, lipids)
- Lipoproteins: transport insoluble lipids
- Fibrinogen: clotting, forms fibrin strands
- Blood functions:
- Transport: gases, nutrients, hormones, wastes
- Regulation: pH and ion composition of interstitial fluids
- Restriction of fluid loss: clotting at injury sites
- Defense: white blood cells fight infection, antibodies attack pathogens
- Temperature regulation: absorbs and distributes heat
Physical Characteristics of Blood
- Temperature: approximately 38°C (100.4°F)
- Viscosity: five times thicker than water, due to interactions of plasma proteins, formed elements, and water
- pH: slightly alkaline, between 7.35 and 7.45 (average: 7.4)
Blood Collection and Analysis
- Venipuncture: common technique for obtaining blood from superficial veins (median cubital vein)
- Convenient location, thin vein walls, low pressure
- Capillary puncture: used for preparing blood smears (fingertip, earlobe)
- Arterial puncture: used for evaluating gas exchange at lungs (radial or brachial artery)
Formed Elements in Blood
- Formed elements: cells and cell fragments (platelets, white blood cells, red blood cells)
- Hematocrit: percentage of whole blood volume occupied by formed elements
- Adult male: ~46%
- Adult female: ~42%
- Impacts of dehydration, erythropoietin stimulation, bleeding, blood cell formation
Red Blood Cells (RBCs)
- Structure: biconcave disc, large surface area to volume ratio for efficient gas exchange; flexible for movement through narrow capillaries
- Components:
- Hemoglobin (Hb): ~95% of intracellular protein, binds and transports oxygen and carbon dioxide.
- Complex quaternary structure: 4 globular protein subunits, each with heme molecule containing iron that combines with oxygen.
- Binding of oxygen changes color of blood (bright red with oxygen, dark red without)
- Hemoglobin (Hb): ~95% of intracellular protein, binds and transports oxygen and carbon dioxide.
- Function: carry oxygen and carbon dioxide
- Anaerobic metabolism: energy source, rely on glucose from plasma
- Life span: ~120 days
- Formation (Erythropoiesis):
- Occurs in red bone marrow, myeloid tissue
- Regulated by erythropoietin (EPO) in response to low oxygen levels (hypoxia)
Hemoglobin Recycling
- Macrophages (in liver, spleen, red bone marrow): engulf damaged RBCs
- Breakdown:
- Globin into amino acids
- Heme into iron and bilirubin
- Iron binds to transferrin for reuse
- Bilirubin: processed by liver, excreted in bile (giving feces their color)
- Anemia: low hematocrit or reduced hemoglobin content, leads to reduced oxygen capacity.
- Hemoglobinuria: large numbers of damaged RBCs leads to red or brown blood
Clinical Note: Abnormal Hemoglobin
- Thalassemia: insufficient production of hemoglobin proteins
- Sickle cell anemia (SCA): mutation in hemoglobin affecting RBC shape and flexibility, causing blockages.
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