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Questions and Answers
Which of the following factors directly influences cardiac output?
Which of the following factors directly influences cardiac output?
Which of the following hormones increases contractility?
Which of the following hormones increases contractility?
What is the primary role of the parasympathetic nervous system in regulating heart rate?
What is the primary role of the parasympathetic nervous system in regulating heart rate?
Which of the following factors contributes to increased stroke volume?
Which of the following factors contributes to increased stroke volume?
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What is the role of the cardioinhibitory center (CIC) in regulating heart rate?
What is the role of the cardioinhibitory center (CIC) in regulating heart rate?
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Which of the following is NOT a factor that decreases contractility?
Which of the following is NOT a factor that decreases contractility?
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What is the relationship between stroke volume and cardiac output?
What is the relationship between stroke volume and cardiac output?
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Which of the following factors does NOT directly affect stroke volume?
Which of the following factors does NOT directly affect stroke volume?
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Which of the following structures is responsible for anchoring the AV valves to the papillary muscles?
Which of the following structures is responsible for anchoring the AV valves to the papillary muscles?
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What is the main function of the pulmonary circuit?
What is the main function of the pulmonary circuit?
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Which of the following statements accurately describes the function of the left ventricle?
Which of the following statements accurately describes the function of the left ventricle?
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What is the name of the layer of tissue that forms the bulk of the heart wall?
What is the name of the layer of tissue that forms the bulk of the heart wall?
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The structure that separates the left and right atria is called the:
The structure that separates the left and right atria is called the:
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Which type of muscle tissue is found in the heart?
Which type of muscle tissue is found in the heart?
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What is the name of the fluid-filled space between the parietal and visceral layers of the pericardium?
What is the name of the fluid-filled space between the parietal and visceral layers of the pericardium?
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Which of the following valves prevents backflow of blood from the right ventricle into the right atrium?
Which of the following valves prevents backflow of blood from the right ventricle into the right atrium?
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What is the name of the specialized cells in the heart that initiate and conduct electrical impulses?
What is the name of the specialized cells in the heart that initiate and conduct electrical impulses?
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The coronary circulation is responsible for:
The coronary circulation is responsible for:
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Which of the following statements is TRUE about the cardiac action potential plateau phase?
Which of the following statements is TRUE about the cardiac action potential plateau phase?
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Which of the following components of the heart is NOT directly involved in the conduction system?
Which of the following components of the heart is NOT directly involved in the conduction system?
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What is the name of the vessel that carries deoxygenated blood from the lower body to the right atrium?
What is the name of the vessel that carries deoxygenated blood from the lower body to the right atrium?
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Which of the following statements is TRUE regarding the differences between cardiac muscle and skeletal muscle?
Which of the following statements is TRUE regarding the differences between cardiac muscle and skeletal muscle?
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Which of the following structures are responsible for increasing the surface area of the atria?
Which of the following structures are responsible for increasing the surface area of the atria?
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What is the term used to describe the ability of the heart to beat without external stimulation?
What is the term used to describe the ability of the heart to beat without external stimulation?
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Which of the following is NOT a factor that contributes to congestive heart failure (CHF)?
Which of the following is NOT a factor that contributes to congestive heart failure (CHF)?
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The Atrial (Bainbridge) reflex is initiated by:
The Atrial (Bainbridge) reflex is initiated by:
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Which of the following statements is TRUE regarding heart rate regulation?
Which of the following statements is TRUE regarding heart rate regulation?
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The Carotid Sinus Reflex primarily functions to:
The Carotid Sinus Reflex primarily functions to:
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What is the primary effect of epinephrine and thyroxine on heart rate?
What is the primary effect of epinephrine and thyroxine on heart rate?
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What is the term for the sequence of events associated with blood flow through the heart?
What is the term for the sequence of events associated with blood flow through the heart?
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Which phase of the cardiac cycle marks the beginning of ventricular relaxation?
Which phase of the cardiac cycle marks the beginning of ventricular relaxation?
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What is the name of the brief rise in aortic pressure caused by the backflow of blood rebounding off the semilunar valves?
What is the name of the brief rise in aortic pressure caused by the backflow of blood rebounding off the semilunar valves?
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What is the amount of blood remaining in a ventricle after contraction called?
What is the amount of blood remaining in a ventricle after contraction called?
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What does the QRS complex on an electrocardiogram (ECG) correspond to?
What does the QRS complex on an electrocardiogram (ECG) correspond to?
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Which of the following is NOT a component of the cardiac cycle?
Which of the following is NOT a component of the cardiac cycle?
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Which statement accurately describes the Frank-Starling Law of the Heart?
Which statement accurately describes the Frank-Starling Law of the Heart?
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What is meant by the term 'afterload' in the context of the heart?
What is meant by the term 'afterload' in the context of the heart?
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Which of the following accurately describes the role of the atrioventricular (AV) node in the cardiac conduction system?
Which of the following accurately describes the role of the atrioventricular (AV) node in the cardiac conduction system?
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What causes the rapid depolarization of the membrane potential in the initial phase of the action potential?
What causes the rapid depolarization of the membrane potential in the initial phase of the action potential?
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What is the primary reason for the plateau phase in the action potential?
What is the primary reason for the plateau phase in the action potential?
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What is the primary mechanism responsible for repolarization of the membrane potential?
What is the primary mechanism responsible for repolarization of the membrane potential?
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What is the role of the absolute refractory period in the action potential?
What is the role of the absolute refractory period in the action potential?
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Why is the membrane potential more positive during the plateau phase?
Why is the membrane potential more positive during the plateau phase?
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What is the significance of the tension development phase in the action potential?
What is the significance of the tension development phase in the action potential?
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What would happen if the K+ channels failed to open during repolarization?
What would happen if the K+ channels failed to open during repolarization?
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What is the primary difference between the absolute refractory period and the relative refractory period?
What is the primary difference between the absolute refractory period and the relative refractory period?
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Flashcards
Positive Feedback Cycle
Positive Feedback Cycle
A process that amplifies signals, leading to rapid opening of Na+ channels.
Membrane Potential (mV)
Membrane Potential (mV)
The electrical charge difference across a cell membrane.
Ca2+ Influx
Ca2+ Influx
Movement of calcium ions into the cell, crucial for depolarization.
Plateau Phase
Plateau Phase
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Repolarization
Repolarization
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K+ Efflux
K+ Efflux
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Channel Inactivation
Channel Inactivation
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Absolute Refractory Period
Absolute Refractory Period
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Sinoatrial (SA) Node
Sinoatrial (SA) Node
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Atrioventricular (AV) Node
Atrioventricular (AV) Node
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QRS Complex
QRS Complex
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Cardiac Cycle
Cardiac Cycle
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Systole
Systole
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Diastole
Diastole
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Stroke Volume (SV)
Stroke Volume (SV)
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Cardiac Output (CO)
Cardiac Output (CO)
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Preload
Preload
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Frank-Starling Law
Frank-Starling Law
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Pericardium
Pericardium
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Epicardium
Epicardium
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Myocardium
Myocardium
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Endocardium
Endocardium
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Atria
Atria
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Ventricles
Ventricles
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Atrioventricular valves
Atrioventricular valves
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Semilunar valves
Semilunar valves
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Coronary circulation
Coronary circulation
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Cardiac muscle
Cardiac muscle
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Autorhythmicity
Autorhythmicity
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Pacemaker cells
Pacemaker cells
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Action potential
Action potential
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Intercalated discs
Intercalated discs
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Atrial (Bainbridge) Reflex
Atrial (Bainbridge) Reflex
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Carotid Sinus Reflex
Carotid Sinus Reflex
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Chemical Regulation of the Heart
Chemical Regulation of the Heart
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Tachycardia
Tachycardia
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Congestive Heart Failure (CHF)
Congestive Heart Failure (CHF)
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Contractility
Contractility
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Factors increasing contractility
Factors increasing contractility
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Factors decreasing contractility
Factors decreasing contractility
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Sympathetic Nervous System (SNS)
Sympathetic Nervous System (SNS)
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Parasympathetic Nervous System (PNS)
Parasympathetic Nervous System (PNS)
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Cardioacceleratory Center (CAC)
Cardioacceleratory Center (CAC)
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Cardioinhibitory Center (CIC)
Cardioinhibitory Center (CIC)
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Regulation of Heart Rate
Regulation of Heart Rate
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Study Notes
Heart Anatomy
- The heart is located in the mediastinum, between the lungs.
- It's positioned behind the sternum and above the diaphragm.
- The apex of the heart points towards the left hip.
- The heart is enclosed in a double-walled sac called the pericardium.
- The inner layer, the epicardium, is a part of this sac.
- The outer layer, the parietal pericardium, forms the outer protective barrier.
- Fluid within the pericardial cavity minimizes friction during heart movements.
Structure of the Heart Wall
- The wall of the heart comprises three layers:
- The epicardium (visceral pericardium). The outermost layer.
- The myocardium. The middle layer forming most of the heart, containing cardiac muscle tissue.
- The endocardium. The thin lining of the inner myocardial surface, continuous with the cardiovascular system's endothelium.
- The fibrous skeleton of the heart is a fibrous connective tissue layer encircling the cardiac muscle.
Heart Chambers
- The heart has four chambers: two atria and two ventricles.
- The atria receive blood returning to the heart.
- The ventricles pump blood out of the heart.
- Pectinate muscles are ridges within the right atrium.
Heart Valves
- Heart valves ensure unidirectional blood flow.
- The atrioventricular valves (AV valves) are between the atria and ventricles.
- The right AV valve is tricuspid, with three flaps.
- The left AV valve is bicuspid (mitral) with two flaps.
- Chordae tendineae connect the AV valve cusps to the papillary muscles.
- Semilunar valves (SL valves) are between the ventricles and arteries leaving the heart.
- The pulmonary semilunar valve is between the right ventricle and the pulmonary artery.
- The aortic semilunar valve is between the left ventricle and the aorta.
Blood Pathway Through the Heart and Lungs
- Deoxygenated blood arrives at the right atrium via superior and inferior vena cava.
- It then flows through the tricuspid valve to the right ventricle.
- The right ventricle pumps blood through the pulmonary semilunar valve to the pulmonary artery towards the lungs.
- In the lungs, blood is oxygenated.
- Oxygenated blood returns to the left atrium through pulmonary veins.
- It passes through the bicuspid valve to the left ventricle.
- The left ventricle pumps blood through the aortic semilunar valve to the aorta and onward to systemic circulation.
Heart Valves Function
- AV valves open when atrial pressure exceeds ventricular pressure, allowing blood flow into the ventricles.
- AV valves close when ventricular pressure exceeds atrial pressure to prevent backflow.
- SL valves open when ventricular pressure exceeds arterial pressure, allowing blood ejection into the arteries.
- SL valves close when ventricular pressure falls below arterial pressure to prevent backflow into the ventricles.
Coronary Circulation
- This is the functional blood supply to the heart muscle itself.
- Coronary arteries branch from the aorta and supply oxygenated blood to the myocardium.
- Coronary veins collect deoxygenated blood and return it to the coronary sinus, which empties into the right atrium.
Cardiac Muscle
- Cardiac muscle is striated, branched, and interconnected.
- Cardiac muscle cells are uni- or binucleate.
- Intercalated discs join cardiac cells and transmit impulses between cells, allowing for synchronized contraction.
- Cardiac muscle contracts as a functional syncytium.
- Cardiac muscle tissue is self-excitable (autorhythmic).
Cardiac Muscle Contraction
- Depolarization leads to Ca2+ influx, a prolonged process generating a plateau phase.
- Repolarization results from inactivation of Ca2+ channels and opening of voltage-gated K+ channels.
- Cardiac muscle action potentials last much longer than skeletal muscle potentials.
Heart Physiology: Intrinsic Conduction System
- The intrinsic conduction system is the specialized network that coordinates the heartbeat.
- Autorhythmic cells have unstable resting potentials called pacemaker potentials.
- The SA node (sinoatrial node), the heart's pacemaker, initiates action potentials.
Heart Physiology: Sequence of Excitation
- The SA node generates electrical impulses, initiating atrial depolarization approximately 75 times per minute.
- The AV node delays the impulse approximately 0.1 second.
- The impulse then travels to the AV bundle, which branches into the bundle branches and Purkinje fibers in the interventricular septum and walls.
Electrocardiography (ECG)
- ECG records the electrical activity of the heart.
- The P wave represents atrial depolarization, QRS represents ventricular depolarization, and the T wave represents ventricular repolarization.
- Atrial repolarization is obscured by the QRS complex.
Cardiac Cycle
- The cardiac cycle includes all events associated with blood flow through the heart. It contains electrical, mechanical events and phases such as systole and diastole.
- Phases of the cardiac cycle include: ventricular filling, atrial systole, ventricular systole, and isovolumetric relaxation.
Cardiac Output (CO)
- Cardiac output (CO) is the amount of blood pumped out by each ventricle in one minute.
- CO is directly correlated to the product of heart rate (HR) and stroke volume (SV).
Stroke Volume (SV)
- SV is the volume of blood pumped out of one ventricle per contraction.
- SV is determined by the difference between end-diastolic volume (EDV) and end-systolic volume (ESV).
Factors Affecting Stroke Volume
- Preload is the amount of stretching of the cardiac muscle cells before contraction (related to EDV).
- Contractility is the force of contraction independent of stretch.
- Afterload is the resistance against which the ventricles pump blood during systole.
- Increased sympathetic stimulation and certain hormones increase contractility, whereas acidosis and increased extracellular K+ decrease it.
Regulation of Heart Rate-Autonomic Nervous System
- The autonomic nervous system (ANS) governs heart rate.
- The sympathetic nervous system increases heart rate (accelerates).
- The parasympathetic nervous system decreases heart rate (inhibits), mediated by acetylcholine.
Extrinsic Factors Affecting Cardiac Output
- Various factors, like exercise, body temperature, age, and gender affect the heart rate.
Homeostatic Imbalance
- Tachycardia is an abnormally fast heart rate.
- Bradycardia is an abnormally slow heart rate.
Congestive Heart Failure (CHF)
- Congestive heart failure (CHF) is a condition in which the pumping efficiency of the heart is impaired.
- CHF can be brought on from several factors, including coronary atherosclerosis, persistent high blood pressure and others.
Cardiac Conditioning
- Exercise increases cardiac muscle mass.
- Cardiac muscle mass increase contributes to increased strength of contraction
- Increased conditioning results in less frequent heartbeat and a greater resting period.
Special Cardiovascular Reflexes
- Atrial (Bainbridge) reflex is a sympathetic reflex initiated by increased blood volume within the atria.
- Carotid sinus reflex and aortic sinus reflex control blood flow to the brain and systemic circulation using baroreceptors.
Chemical Regulation of the Heart
- Hormones like epinephrine and thyroxine can directly influence heart rate among other factors.
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Description
Test your knowledge of the cardiovascular system with this quiz focused on cardiac output, contractility, heart rate regulation, and more. Dive into the roles of various hormones and nervous system influences on heart function. Perfect for students of anatomy and physiology!