Cardiovascular Physiology Quiz

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Questions and Answers

What primarily regulates arterial pressure in the steady state?

  • Changes in heart rate (HR)
  • Translocation of blood volume into the thorax
  • Modulation of peripheral vasoconstriction (correct)
  • Sustained changes in stroke volume (SV)

What happens to cardiac output (CO) due to rapid changes in heart rate during exercise?

  • CO fluctuates but is not affected by workload
  • CO remains unaffected by HR changes
  • CO increases consistently with HR
  • CO may decrease due to reciprocal changes in SV (correct)

What is the effect of hypotensive challenges on the arterial baroreflex response?

  • It enhances stroke volume output
  • It decreases overall cardiac output
  • It allows the baroreflex to buffer arterial pressure (correct)
  • It amplifies heart rate responses

What was the major finding of Melcher and Donald's study on carotid sinus?

<p>Isolated carotid sinus preparation increases total vascular conductance (D)</p> Signup and view all the answers

What is a key consideration when assessing the strength of baroreflex responses?

<p>The effectiveness in altering cardiac output (A)</p> Signup and view all the answers

What physiological response was specifically heightened during hypnotic suggestion according to the information provided?

<p>Effort sense (C)</p> Signup and view all the answers

In the experimental setup, what was the primary purpose of passive cycling (PC)?

<p>To activate only the mechanoreflex (A)</p> Signup and view all the answers

Which of the following measurements was used to assess heart rate during the experiments?

<p>EKG (C)</p> Signup and view all the answers

What was the workload used in active cycling during the experiments?

<p>80% of peak workload (D)</p> Signup and view all the answers

Which factor was likely increased due to higher muscle activation during the experiments?

<p>Central motor drive (A)</p> Signup and view all the answers

What was a potential method used to simulate active cycling in some subjects?

<p>Electrical stimulation (D)</p> Signup and view all the answers

What type of muscle fibers were attenuated in feedback during the responses stated?

<p>Type III fibers (A), Type IV fibers (D)</p> Signup and view all the answers

What was the purpose of using an adapted tandem bicycle in this study?

<p>To separate central command and mechanoreflex contributions (D)</p> Signup and view all the answers

What effect did hyperoxic saline infusion have on muscle sympathetic activity at rest?

<p>It did not change muscle sympathetic activity. (D)</p> Signup and view all the answers

During exercise, what was the observed effect of hyperoxia on muscle sympathetic nerve activity?

<p>MSNA decreased by 35%. (D)</p> Signup and view all the answers

What method was used to inhibit carotid chemoreceptors during the studies?

<p>Inhalation of hyperoxic gas. (A)</p> Signup and view all the answers

What aspect of exercise is primarily examined in Schork's study?

<p>Oxygen uptake during graded exercise (A)</p> Signup and view all the answers

What is examined as a key factor influencing cardiovascular responses to exercise by Lewis et al.?

<p>Relative and absolute workload (C)</p> Signup and view all the answers

What was the primary finding regarding blood flow during mild exercise when carotid chemoreceptors were inhibited?

<p>Blood flow increased in skeletal muscle. (B)</p> Signup and view all the answers

What type of exercise was used in the study to explore the function of carotid chemoreceptors?

<p>Isometric handgrip exercise. (D)</p> Signup and view all the answers

In the study by Crisafulli et al., what physiological change is noted during exercise-induced atrioventricular block?

<p>Altered venous return (C)</p> Signup and view all the answers

What was controlled during the inhalation of hyperoxic gas in the study?

<p>Breathing rate, tidal volume, and end tidal partial pressure of CO2. (B)</p> Signup and view all the answers

Which mechanism is discussed by Plotnick et al. as relevant during submaximal activity?

<p>Frank-Starling mechanism (D)</p> Signup and view all the answers

What is the primary role of the central command during dynamic exercise?

<p>It establishes a basal level of sympathetic activity linked to exercise intensity. (D)</p> Signup and view all the answers

What role does the muscle pump play according to Laughlin's study?

<p>Facilitating skeletal muscle blood flow during exercise (B)</p> Signup and view all the answers

What was the primary role identified for carotid chemoreceptors during exercise?

<p>To restrain blood flow to skeletal muscles. (D)</p> Signup and view all the answers

What common variable was kept constant during the experiments involving exercise and inhalation of hyperoxic gas?

<p>End tidal partial pressure of CO2. (C)</p> Signup and view all the answers

Which mechanism is commonly known as the 'exercise pressor reflex'?

<p>The modulation of sympathetic tone by peripheral signals from mechanoreceptors and metaboreceptors. (D)</p> Signup and view all the answers

Yamaguchi et al. discuss intersubject variability in what relationship during exercise?

<p>Cardiac output and oxygen uptake (A)</p> Signup and view all the answers

What physiological element is emphasized by Wasserman in relation to exercise?

<p>The wisdom of the body in cellular respiration (B)</p> Signup and view all the answers

How does sympathetic activation during exercise primarily affect cardiovascular function?

<p>It enhances heart rate, myocardial contractility, and venous return. (A)</p> Signup and view all the answers

Which factor was highlighted by Nóbrega et al. in mechanisms for increasing stroke volume?

<p>Muscle contraction patterns (D)</p> Signup and view all the answers

What is meant by 'neural occlusion' in the context of cardiovascular regulation?

<p>The phenomenon where the effects of reflexes do not sum together. (C)</p> Signup and view all the answers

Which brain region is primarily responsible for cardiovascular control according to the document?

<p>The medulla. (A)</p> Signup and view all the answers

What role do baroreflexes play during exercise?

<p>They reset to prevent mismatches between vascular resistance and cardiac output. (A)</p> Signup and view all the answers

Who first proposed the concept of central command in relation to autonomic responses?

<p>Zuntz and Geppert in 1886. (A)</p> Signup and view all the answers

What primary factor modulates sympathetic activation during exercise?

<p>Peripheral signals from mechanoreceptors and metaboreceptors. (D)</p> Signup and view all the answers

What role do carotid chemoreceptors primarily serve in the body?

<p>They act as the major O2 sensor. (A)</p> Signup and view all the answers

What occurs following bilateral carotid body tumor resection in humans?

<p>Ventilatory drive to normocapnic hypoxia is abolished. (A)</p> Signup and view all the answers

How does baroreceptor denervation affect mean arterial pressure (MAP) during exercise?

<p>It leads to a fall in MAP at the onset of exercise. (C)</p> Signup and view all the answers

What triggers powerful reflexes from skeletal muscle during increasing workload?

<p>Activation of skeletal muscle afferents. (A)</p> Signup and view all the answers

What may happen to patients with cardiopulmonary disease during exercise?

<p>They can develop hypoxia and hypercapnia. (A)</p> Signup and view all the answers

What might unbuffered sympathoactivation during exercise cause?

<p>Vasoconstriction in active skeletal muscle. (C)</p> Signup and view all the answers

What physiological response occurs during exposure to high altitude in healthy subjects?

<p>Development of hypoxia during rest and exercise. (D)</p> Signup and view all the answers

What is one of the primary effects of the activation of arterial baroreflex during exercise?

<p>Prevention of excessive sympathoactivation. (A)</p> Signup and view all the answers

Flashcards

Central Command

A neural signal originating from the brain that activates both motor units and cardiovascular control centers, leading to increased sympathetic activity during exercise.

How does Central Command regulate cardiovascular responses?

The mechanism by which the brain adjusts cardiovascular responses based on the intensity of exercise.

Mechano- and Metaboreceptors

Specialized sensory receptors within muscles that detect changes in mechanical stress (tension) and metabolic byproducts like lactate.

Exercise Pressor Reflex

A reflex triggered by mechano- and metaboreceptors in muscles, leading to an increase in sympathetic activity and cardiovascular function during exercise.

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Cardiovascular Response to Exercise

The autonomic nervous system's response to exercise, characterized by increased heart rate, contractility, and venous return, all aimed at increasing cardiac output.

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Central command's role in exercise

The mechanism by which the brain adjusts cardiovascular responses based on the intensity of exercise. It activates both motor units and cardiovascular control centers, leading to increased sympathetic activity.

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Baroreflexes

The regulation of heart rate and blood pressure in response to changes in blood pressure detected by baroreceptors, which act as sensors in the circulatory system.

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Redundancy in Cardiovascular Regulation

The ability of the cardiovascular system to adapt to changing demands, such as those imposed by exercise, through multiple redundant mechanisms.

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Baroreflex Function

The ability of the body to maintain a stable blood pressure despite changes in heart rate.

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Reciprocal SV Changes Compensate for HR Changes

Even though heart rate may change, blood pressure stays stable thanks to changes in blood volume within the body.

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Baroreflex's Main Mechanism is Vasoconstriction

The baroreflex primarily regulates blood pressure by changing the width and resistance of blood vessels, not just by changing heart rate.

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Blood Flow Redistribution during Exercise

As we exercise, the body prioritizes blood flow to the working muscles, so blood pressure regulation becomes more complex.

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Transient HR Changes, Sustained Vasoconstriction

Changes in heart rate in response to baroreflex stimulation are temporary and the main effect on blood pressure comes from adjustments in blood vessel size.

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Effort Sense

The feeling of effort during exercise. It's influenced by how hard your muscles are working and how your body is managing exertion.

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Muscle Afferents

The signals sent from the muscles to the brain about the level of muscle activity and force. This information helps your brain adjust how hard your muscles work and control movement.

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Type III and IV Muscle Fibers

A type of muscle fiber linked to a specific type of muscle afferent, sensitive to changes in muscle tension and length. They play a role in how much force is generated.

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Insular Cortex

The brain area responsible for processing information from your body, including feelings of effort, pain, and internal sensations. It plays a critical role in regulating how your body responds to exercise.

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Mechanoreflex

The feedback signals sent from your muscles to your brain through muscle afferents. These signals help your brain regulate how hard your muscles are working.

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Cardiorespiratory Responses

The ability of the body to adjust physiological responses during exercise to maintain a stable internal environment. This includes things like regulating heart rate, breathing, and blood pressure.

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Hypnotic Suggestion

A technique that uses suggestive language and imagery to influence a person's thoughts, feelings, and actions, leading to changes in how the body responds to exercise.

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Carotid Chemoreceptors

Specialized sensory receptors located in the carotid artery that detect changes in blood oxygen levels.

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Baroreflex Resetting

The process of resetting the body's blood pressure control system (baroreflex) during exercise.

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Carotid Body and Carotid Sinus

The carotid body is key for responding to oxygen changes, while the carotid sinus responds to blood pressure fluctuations.

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Skeletal Muscle Afferents

Nerves that carry signals from the muscles to the brain.

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Arterial Baroreflex

A mechanism that helps maintain blood pressure stability during exercise.

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Permissive Baroreflex

A change in the setpoint of the baroreflex during exercise, allowing for higher blood pressure.

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Unrestrained Vasodilation

A significant decrease in blood pressure that can occur at the onset of exercise if the baroreflex is not functioning normally.

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Sympathoactivation

The activation of sympathetic nerves, which can lead to vasoconstriction and increased heart rate.

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What are carotid chemoreceptors?

Carotid chemoreceptors are sensory receptors located in the carotid artery that detect changes in blood oxygen and carbon dioxide levels. They play a role in regulating breathing and blood pressure.

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How do carotid chemoreceptors affect muscle blood flow during exercise?

Inhibition of carotid chemoreceptors during exercise causes vasodilation in skeletal muscles, allowing for increased blood flow.

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How can carotid chemoreceptors be inhibited?

Hyperoxia, or high oxygen levels, can be used to inhibit carotid chemoreceptor activity. This is achieved by inhaling a gas mixture with a high oxygen concentration.

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How does carotid chemoreceptor inhibition affect MSNA during exercise?

During exercise, inhibition of carotid chemoreceptors leads to a decrease in muscle sympathetic nerve activity (MSNA).

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How was carotid chemoreceptor inhibition achieved in the study?

The study involved infusing hyperoxic saline or dopamine into the carotid arteries of dogs to inhibit carotid chemoreceptors. This was done transiently to avoid systemic effects and compensatory mechanisms.

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What was the effect of carotid chemoreceptor inhibition on muscle blood flow?

The study found that inhibition of carotid chemoreceptors during exercise caused a significant vasodilation in the hindlimb of dogs.

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How were the findings from dogs applied to humans?

These findings were translated to healthy human subjects, confirming that carotid chemoreceptors play a functional role in regulating circulation during exercise.

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What is the carotid chemoreflex?

The carotid chemoreflex is a mechanism that contributes to the neural control of circulation during exercise, helping to regulate blood flow to muscles.

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VO2-CO Relationship

The relationship between the amount of oxygen consumed (VO2) and cardiac output (CO) during exercise, illustrating how the heart pumps more blood to deliver oxygen to working muscles.

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Stroke Volume

The volume of blood ejected by the heart with each beat.

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Cardiac Output

The amount of blood pumped by the heart per minute, calculated by multiplying heart rate and stroke volume.

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Baroreceptors

Specialized sensors in blood vessels that detect changes in blood pressure, triggering reflexes to adjust heart rate and blood pressure.

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Frank-Starling Mechanism

A mechanism that alters the force of heart contraction based on the amount of blood returning to the heart, contributing to increased stroke volume during exercise.

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Muscle Pump

The increased blood flow to working muscles during exercise, primarily facilitated by the muscle pump.

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Study Notes

Neural Regulation of Cardiovascular Response to Exercise

  • Cardiovascular regulation during exercise involves providing sufficient oxygen to working muscles and regulating blood pressure to maintain adequate perfusion of vital organs.
  • Exercise causes a rise in cardiac output (CO) directly correlated to oxygen uptake.
  • Dynamic exercise results in a small increase in mean arterial pressure (MAP) despite metabolic vasodilation in muscles.
  • Skeletal muscles release vasodilators (potassium, adenosine, etc.) during contraction.
  • Cardiovascular responses are regulated by mechanical and nervous systems.
  • Mechanical mechanisms (respiratory and skeletal muscle pumps) enhance stroke volume and CO.
  • Nervous mechanisms involve parasympathetic withdrawal and sympathetic activation, adjusting heart rate, contractility, and vascular resistance.
  • "Central command" activates cardiovascular control areas in the medulla during exercise.
  • Exercise pressor reflex (a peripheral mechanism) reflexively modulates sympathetic tone based on muscle activity and metabolic conditions.
  • Baroreflexes regulate muscle vasodilation and cardiac function to maintain blood pressure.
  • Arterial chemoreceptors contribute to sympathetic modulation during exercise.

Central Command

  • Central command involves regions of the brain involved in motor control activating cardiovascular control areas in the medulla.
  • The mechanism was first proposed in connection to ventilation control, later extended to circulation control.
  • Research suggests central command can operate independently of muscle activation, depending on perceived effort.
  • Inputs from muscle receptors can modulate central command intensity.

Baroreflex

  • Baroreflexes maintain balance between vascular resistance and CO, preventing excessive blood pressure fluctuations.
  • Gain of baroreflexes is largely maintained during exercise, but the relationship between heart rate and arterial pressure shifts (resets) to a higher pressure range during exercise.
  • The primary mechanism of the reflex is peripheral vasoconstriction to increase arterial pressure.

Carotid Chemoreflex

  • Carotid chemoreceptors monitor arterial blood gas composition and hydrogen ion concentration.
  • Peripheral chemoreceptors in the carotid sinus and aortic arch detect hypoxia and hypercapnia.
  • Central chemoreceptors located in the brain stem respond to hypercapnia.
  • Chemoreflexes play a role in autonomic adjustments during exercise, though their exact contribution during normal exercise in normoxia has been less studied.

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