Cardiovascular Pharmacology: DRUG LIST

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Questions and Answers

Which drug is used to treat hypertension by functioning as an alpha-2 adrenergic receptor agonist?

  • Metoprolol
  • Losartan
  • Prazosin
  • Clonidine (correct)

Which of the following drugs decreases calcium ion conductance and is used in the treatment of arrhythmias?

  • Lidocaine
  • Verapamil (correct)
  • Amiodarone
  • Quinidine

A patient with hypertension is prescribed losartan. What is the mechanism of action of this medication?

  • ACE inhibitor
  • AT1 receptor antagonist (correct)
  • Beta-1 adrenergic antagonist
  • Diuretic promoting Na+ & H2O excretion

Which of the following best describes the mechanism by which sodium nitroprusside lowers blood pressure?

<p>Increasing cellular levels of cGMP (C)</p> Signup and view all the answers

Which drug is recognized as a cardiac glycoside that inhibits the Na+/K+ ATPase pump?

<p>Digoxin (D)</p> Signup and view all the answers

A patient is prescribed hydrochlorothiazide for hypertension. How does this drug lower blood pressure?

<p>By increasing Na+ and H2O excretion (D)</p> Signup and view all the answers

Which of the following medications used to treat hypertension also has a contraindication when used with sildenafil?

<p>Nitroglycerin (C)</p> Signup and view all the answers

A patient is prescribed amiodarone for the treatment of arrhythmias. What is the primary mechanism of action of this drug?

<p>Blocks potassium channels (D)</p> Signup and view all the answers

Which of the following drugs is classified as a beta-1 adrenergic antagonist?

<p>Metoprolol (D)</p> Signup and view all the answers

Enalapril is prescribed for a patient with congestive heart failure. What is its mechanism of action?

<p>ACE inhibitor (A)</p> Signup and view all the answers

Which of the following medications would be most appropriate for a patient experiencing both hypertension and angina?

<p>Verapamil (A)</p> Signup and view all the answers

A patient is prescribed quinidine. What is its primary mechanism of action in treating arrhythmias?

<p>Inhibits sodium conductance (D)</p> Signup and view all the answers

Which drug is a non-selective beta-blocker, antagonizing both beta-1 and beta-2 adrenergic receptors?

<p>Propranolol (C)</p> Signup and view all the answers

Which of the following drugs used for congestive heart failure acts as a diuretic, increasing sodium and water excretion?

<p>Hydrochlorothiazide (B)</p> Signup and view all the answers

A patient is experiencing angina. Which of these medications increases cGMP levels to cause vasodilation and relieve chest pain?

<p>Nitroglycerin (D)</p> Signup and view all the answers

Which of the following drugs, used to treat hypertension, functions as an alpha-1 adrenergic receptor antagonist?

<p>Prazosin (D)</p> Signup and view all the answers

A patient with hypertension also has a history of asthma. Which antihypertensive medication should be used with caution?

<p>Propranolol (A)</p> Signup and view all the answers

Which of the following diuretics is often used in the treatment of hypertension, promoting the excretion of sodium and water?

<p>Furosemide (C)</p> Signup and view all the answers

A patient with congestive heart failure is prescribed digoxin. What change in cardiac function is expected due to this medication?

<p>Increased cardiac contractility (A)</p> Signup and view all the answers

Which of the following drugs is correctly paired with its primary mechanism of action?

<p>Lidocaine: Decreases sodium conductance (C)</p> Signup and view all the answers

Flashcards

Hypertension Sympatholytics

Drugs like clonidine, metoprolol, propranolol, and prazosin used to treat hypertension.

Hypertension Vasodilators

Drugs like sodium nitroprusside and verapamil that widen blood vessels to reduce blood pressure.

Hypertension ACE Inhibitors

Drugs like enalapril that inhibit angiotensin-converting enzyme to lower blood pressure.

Hypertension AT1-antagonists

Drugs like losartan that block angiotensin II receptors to lower blood pressure.

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Hypertension Diuretics

Drugs like hydrochlorothiazide and furosemide that increase urine production to lower blood pressure.

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Angina Vasodilators

Drugs like nitroglycerin and verapamil that widen blood vessels to reduce chest pain.

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Angina Sympatholytics

Drugs like propranolol and metoprolol that slow heart rate and reduce chest pain.

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CHF Sympatholytics

Drugs like metoprolol and propranolol that reduce heart rate in heart failure.

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CHF Vasodilators

Drugs like nitroglycerin that dilate blood vessels to alleviate heart failure symptoms.

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CHF ACE Inhibitors

Drugs like enalapril that inhibit ACE to manage heart failure.

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CHF AT1-antagonists

Drugs like losartan that block angiotensin II receptors in heart failure.

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CHF Diuretics

Drugs like hydrochlorothiazide and furosemide that reduce fluid overload in heart failure.

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CHF Cardiac Glycosides

Drugs like digoxin enhance heart contraction in heart failure.

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Arrhythmias Sympatholytics

Drugs like propranolol and metoprolol used to control heart rhythm.

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Arrhythmias Na+ Channel Blockers

Drugs like quinidine and lidocaine that affect sodium channels to stabilize heart rhythm.

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Arrhythmias K+ Channel Blockers

The drug amiodarone that affects potassium channels to manage arrhythmias.

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Arrhythmias Ca+2 Channel Blockers

The drug verapamil that affects calcium channels to control heart rhythm.

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Clonidine's Action

A drug that acts as an alpha 2 agonist.

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Prazosin's Action

A drug that acts as an alpha 1 antagonist.

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Nitric Oxide Mechanism

Drugs like sodium nitroprusside and nitroglycerin that increase cGMP levels.

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Study Notes

  • Cardiovascular pharmacology involves the use of drugs to treat various heart conditions.

Hypertension

  • Sympatholytics like clonidine, metoprolol, propranolol, and prazosin can be used.
  • Vasodilators like sodium nitroprusside and verapamil are options.
  • ACE Inhibitors like enalapril are effective.
  • AT1-antagonists like losartan can be prescribed.
  • Diuretics such as hydrochlorothiazide and furosemide are also used.

Angina

  • Vasodilators like nitroglycerin and verapamil are treatment options.
  • Sympatholytics such as propranolol and metoprolol are other drug options.

Congestive Heart Failure

  • Sympatholytics like metoprolol and propranolol can be used.
  • Vasodilators such as nitroglycerin are another option.
  • ACE Inhibitors like enalapril can be prescribed.
  • AT1-antagonists like losartan are also used.
  • Diuretics such as hydrochlorothiazide and furosemide are effective.
  • Cardiac glycosides like digoxin are another option for treatment.

Arrhythmias

  • Sympatholytics like propranolol, and metoprolol can be used.
  • Na+ channel blockers like quinidine and lidocaine are effective.
  • K+ channel blockers such as amiodarone are another option for treatment.
  • Ca+2 channel blockers such as verapamil can also be used.

Drug Actions

  • Clonidine functions as an α2 agonist.
  • Prazosin functions as an α1 antagonist.
  • Metoprolol functions as a β1 antagonist.
  • Propranolol functions as a β1, β2 antagonist.
  • Sodium nitroprusside increases NO to cGMP.
  • Nitroglycerin increases NO to cGMP.
  • Verapamil decreases Ca+2 conductance.
  • Enalapril is an ACE inhibitor.
  • Losartan functions as an AT1 receptor antagonist.
  • Hydrochlorothiazide increases Na+ and H2O excretion.
  • Furosemide increases Na+ and H2O excretion.
  • Digoxin inhibits the Na+/K+ ATPase.
  • Quinidine decreases Na+ conductance.
  • Lidocaine decreases Na+ conductance.
  • Amiodarone decreases K+ conductance, also affecting other ion channels.

Drug Interaction

  • Nitroglycerin and sildenafil (Viagra) have a significant drug interaction, and patients should be counselled about this.

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