Podcast
Questions and Answers
What is the main mechanism of action of Quinidine as an antiarrhythmic drug?
What is the main mechanism of action of Quinidine as an antiarrhythmic drug?
- Binds to open and inactivated Na+ channels (correct)
- Blocks Ca2+ channels
- Inhibits K+ channels
- Shortens phase 3 repolarization
How do Class IB antiarrhythmic drugs, like lidocaine and mexiletine, differ from Class IA drugs?
How do Class IB antiarrhythmic drugs, like lidocaine and mexiletine, differ from Class IA drugs?
- Block Ca2+ channels
- Increase refractoriness
- Shorten phase 3 repolarization (correct)
- Contribute to negative inotropy
Which drug is used as an alternative for ventricular arrhythmias and may cause nausea, vomiting, and dyspepsia?
Which drug is used as an alternative for ventricular arrhythmias and may cause nausea, vomiting, and dyspepsia?
- Procainamide
- Quinidine
- Mexiletine (correct)
- Amiodarone
What are the typical CNS effects associated with the use of Lidocaine?
What are the typical CNS effects associated with the use of Lidocaine?
What is the A/E (adverse effect) associated with Quinidine known as 'cinchonism'?
What is the A/E (adverse effect) associated with Quinidine known as 'cinchonism'?
Which antiarrhythmic drug has mostly replaced Procainamide for electrical cardioversion or defibrillation in clinical practice?
Which antiarrhythmic drug has mostly replaced Procainamide for electrical cardioversion or defibrillation in clinical practice?
What is the primary therapeutic use of Quinidine among patients with atherosclerotic heart disease or systolic heart failure?
What is the primary therapeutic use of Quinidine among patients with atherosclerotic heart disease or systolic heart failure?
'VT storms' can be managed using which antiarrhythmic drug often used in combination with Amiodarone?
'VT storms' can be managed using which antiarrhythmic drug often used in combination with Amiodarone?
'Nystagmus' can be considered an early indicator of toxicity associated with which antiarrhythmic drug?
'Nystagmus' can be considered an early indicator of toxicity associated with which antiarrhythmic drug?
Among Class IB antiarrhythmic drugs, which one decreases the duration of the action potential?
Among Class IB antiarrhythmic drugs, which one decreases the duration of the action potential?
