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Cardiovascular Disease Prevention

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Questions and Answers

At what age should atorvastatin 20 mg be considered for the primary prevention of cardiovascular disease?

85 years or older (correct)

75 years or older

65 years or older

70 years or older

What is the primary mechanism of action of statins in reducing cholesterol synthesis?

Blocking the conversion of HMG CoA to mevalonic acid (correct)

Inhibiting the production of bile-acid binding resins

Enhancing the activity of fibrates

Increasing the production of omega fatty acids

What is the primary advantage of rosuvastatin compared to other statins?

It has a longer half-life

It is more effective at reducing LDL cholesterol

It is less likely to cause drug interactions (correct)

It is more soluble in water

What is the primary effect of statins on LDL receptor synthesis?

It upregulates LDL receptor synthesis Signup and view all the answers

What is the primary goal of a cardioprotective diet in the treatment of dyslipidaemia?

To reduce the intake of saturated fats and cholesterol Signup and view all the answers

What is the primary indication for the use of fibrates in the treatment of dyslipidaemia?

Secondary hyperlipidaemia due to diabetes mellitus Signup and view all the answers

What is the primary mechanism of action of Fibrates on lipid metabolism?

Agonist at peroxisome proliferator-activated receptor (PPAR-alpha) nuclear receptor Signup and view all the answers

What is the effect of Fibrates on LDL cholesterol levels?

Modest reduction of 10% Signup and view all the answers

What is the primary clinical use of Cholesterol Absorption Inhibitors?

Primary hypercholesterolemia Signup and view all the answers

What is the effect of Fibrates on triglyceride levels?

Reduction of 20-30% Signup and view all the answers

What is the mechanism of action of Cholestyramine?

Binds bile acid in gut, preventing reabsorption and increasing LDL receptors Signup and view all the answers

What is the common adverse effect of Cholestyramine?

Constipation Signup and view all the answers