12 Questions
At what age should atorvastatin 20 mg be considered for the primary prevention of cardiovascular disease?
85 years or older
What is the primary mechanism of action of statins in reducing cholesterol synthesis?
Blocking the conversion of HMG CoA to mevalonic acid
What is the primary advantage of rosuvastatin compared to other statins?
It is less likely to cause drug interactions
What is the primary effect of statins on LDL receptor synthesis?
It upregulates LDL receptor synthesis
What is the primary goal of a cardioprotective diet in the treatment of dyslipidaemia?
To reduce the intake of saturated fats and cholesterol
What is the primary indication for the use of fibrates in the treatment of dyslipidaemia?
Secondary hyperlipidaemia due to diabetes mellitus
What is the primary mechanism of action of Fibrates on lipid metabolism?
Agonist at peroxisome proliferator-activated receptor (PPAR-alpha) nuclear receptor
What is the effect of Fibrates on LDL cholesterol levels?
Modest reduction of 10%
What is the primary clinical use of Cholesterol Absorption Inhibitors?
Primary hypercholesterolemia
What is the effect of Fibrates on triglyceride levels?
Reduction of 20-30%
What is the mechanism of action of Cholestyramine?
Binds bile acid in gut, preventing reabsorption and increasing LDL receptors
What is the common adverse effect of Cholestyramine?
Constipation
This quiz covers the primary prevention of cardiovascular disease, including the use of statins, such as atorvastatin, to reduce the risk of non-fatal myocardial infarction. Learn about the role of dietary and genetic factors in dyslipidaemia and familial hypercholesterolaemia. Test your knowledge of guidelines for statin treatment in different age groups.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
