Cardiac Physiology: Excitation and Contraction

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Questions and Answers

How does heart muscle differ from skeletal muscle in terms of stimulation and contraction?

  • Heart muscle contraction is significantly faster than skeletal muscle contraction.
  • Heart muscle requires direct nerve stimulation for each contraction, unlike skeletal muscle.
  • Heart muscle has a short refractory period compared to the long refractory period of skeletal muscle.
  • Heart muscle is self-excitable (automaticity) and contracts as a unit, whereas skeletal muscle requires nerve stimulation. (correct)

Why is the long absolute refractory period in cardiac muscle important?

  • It speeds up the rate of contraction in the heart.
  • It prevents tetanus, ensuring the heart relaxes between contractions. (correct)
  • It allows the heart to contract more forcefully.
  • It makes the heart muscle more sensitive to nerve stimulation.

What is the primary function of the sinoatrial (SA) node in the heart?

  • To carry the impulse to the heart apex and ventricular walls.
  • To generate impulses and set the pace for the heart. (correct)
  • To delay the impulse from the atria to the ventricles.
  • To carry the impulse towards the apex of the heart.

What role does the atrioventricular (AV) node play in the cardiac cycle?

<p>It delays the impulse briefly to allow the atria to contract completely before the ventricles. (C)</p> Signup and view all the answers

Which of the following accurately describes the sequence of impulse conduction after it leaves the AV node?

<p>Bundle of His → Bundle branches → Purkinje fibers (A)</p> Signup and view all the answers

What is a key characteristic of autorhythmic cells that distinguishes them from other cardiac cells?

<p>They have unstable resting potentials called pacemaker potentials. (D)</p> Signup and view all the answers

Which ion is primarily responsible for the rising phase of the action potential in autorhythmic cells?

<p>Calcium (Ca2+) (A)</p> Signup and view all the answers

During which phase of the cardiac action potential does rapid depolarization occur?

<p>Phase 0 (C)</p> Signup and view all the answers

What ionic movement is primarily associated with Phase 1 (early repolarization) of the cardiac action potential?

<p>Efflux of K+ ions (A)</p> Signup and view all the answers

What is the primary ionic basis for the plateau phase (Phase 2) of the cardiac action potential?

<p>Influx of calcium ions and decreased potassium permeability. (A)</p> Signup and view all the answers

Which ionic movement is predominantly responsible for the rapid repolarization phase (Phase 3) of the cardiac action potential?

<p>Efflux of K+ ions (D)</p> Signup and view all the answers

What does the QRS complex on an electrocardiogram (ECG) represent in relation to the cardiac action potential?

<p>Depolarization of the ventricles (B)</p> Signup and view all the answers

What part of the electrocardiogram (ECG) relates to the repolarization phase of the action potential?

<p>T wave (C)</p> Signup and view all the answers

What is the typical range for the number of action potentials generated per minute in the heart, under normal conditions?

<p>75-80 AP (C)</p> Signup and view all the answers

How does the sympathetic nervous system influence cardiac function?

<p>It stimulates the heart by activating the cardioacceleratory center. (C)</p> Signup and view all the answers

Which of the following describes the effect of the parasympathetic nervous system on heart function?

<p>Inhibition of the heart via the cardioinhibitory center, slowing the heart rate. (A)</p> Signup and view all the answers

What is a key limitation of the nervous system's ability to influence cardiac action potentials?

<p>It cannot elicit action potentials; these must originate within the SA node. (B)</p> Signup and view all the answers

What is the primary role of calcium channels open as shown in the diagram?

<p>Triggering muscle contaction (A)</p> Signup and view all the answers

How would the cardiac cycle be affected if the AV node was damaged?

<p>The atria and ventricles would contract independently (B)</p> Signup and view all the answers

The normal resting membrane potential is around -80mV, but the action potential from the diagram goes significantly higher, up to +40mV. Where does that extra +120mV potential come from?

<p>Sodium(Na+) rush in to depolarize the cell (C)</p> Signup and view all the answers

Heart muscle is stimulated by nerves and is ______ (automaticity).

<p>self-excitable</p> Signup and view all the answers

Heart muscle contracts as a ______, ensuring coordinated pumping action.

<p>unit</p> Signup and view all the answers

Cardiac muscle has a long (250 ms) absolute ______ period, preventing tetanus.

<p>refractory</p> Signup and view all the answers

The ______ node generates impulses at approximately 75 times per minute.

<p>Sinoatrial (SA)</p> Signup and view all the answers

The Atrioventricular (AV) node delays the impulse approximately ______ seconds.

<p>0.1</p> Signup and view all the answers

Impulses pass from atria to ventricles via the ______ of His.

<p>bundle</p> Signup and view all the answers

The Bundle of His splits into two pathways in the interventricular septum called ______.

<p>bundle branches</p> Signup and view all the answers

[Blank] carry the impulse to the heart apex and ventricular walls.

<p>Purkinje fibers</p> Signup and view all the answers

[Blank] cells initiate action potentials in the heart.

<p>Autorhythmic</p> Signup and view all the answers

The unstable resting potentials in autorhythmic cells are called ______ potentials.

<p>pacemaker</p> Signup and view all the answers

Autorhythmic cells use ______ influx (rather than sodium) for the rising phase of the action potential.

<p>calcium</p> Signup and view all the answers

The time course of the intracellular action potential has been superimposed on the ______.

<p>electrocardiogram (ECG)</p> Signup and view all the answers

The ______ phase of action potential coincides with the QRS complex on an ECG.

<p>depolarization</p> Signup and view all the answers

The repolarization phase of the action potential coincides with the ______ wave on an ECG.

<p>T</p> Signup and view all the answers

The nervous system ______ elicits cardiac action potentials; this can only happen via the SA node.

<p>cannot</p> Signup and view all the answers

Heart is ______ by the sympathetic cardioacceleratory centre.

<p>stimulated</p> Signup and view all the answers

Heart is ______ by the parasympathetic cardioinhibitory centre.

<p>inhibited</p> Signup and view all the answers

Phase 2 of the cardiac cycle is also known as the ______.

<p>plateau</p> Signup and view all the answers

Phase 3, also known as the ______, is identified by the efflux of potassium ions.

<p>rapid repolarization</p> Signup and view all the answers

Because the vagus nerve is associated with ______ responses, a problem would result with the heart slowing down too much.

<p>parasympathetic</p> Signup and view all the answers

Flashcards

Heart Muscle Characteristics

Heart muscle is stimulated by nerves/self-excitable and has a long refractory period.

Automaticity

The heart's ability to initiate its own electrical impulses.

Sinoatrial (SA) node

Generates impulses about 75 times per minute.

Atrioventricular (AV) node

Delays the impulse approximately 0.1 second.

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Bundle branches

Carry the impulse toward the apex of the heart.

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Purkinje fibers

Carry the impulse to the heart apex and ventricular walls.

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Autorhythmic cells

Initiate action potentials; have unstable resting potentials.

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Pacemaker potentials

Unstable resting potentials in autorhythmic cells.

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Autorhythmic Action Potential

Uses calcium influx for rising phase.

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Cardiac AP Phase 0

Rapid depolarization due to sodium influx.

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Cardiac AP Phase 1

Brief repolarization due to potassium efflux.

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Cardiac AP Phase 2

Plateau sustained by calcium influx and potassium efflux.

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Cardiac AP Phase 3

Rapid repolarization due to potassium efflux.

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Cardiac AP Phase 4

Resting membrane potential.

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Intracellular Action Potential

Time course superimposed on ECG.

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Action Potential Depolarization

Depolarization coincides with QRS.

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Action Potential Repolarization

Repolarization coincides with the T wave.

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Heart Stimulation

Mediated by sympathetic cardioacceleratory center.

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Heart Inhibition

Mediated by parasympathetic cardioinhibitory center.

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Cardiac Action Potentials

The nervous system cannot elicit cardiac action potentials; this can only happen via the SA node.

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Resting Potential

The state of a cardiac cell when it is not stimulated; inside is negative relative to outside.

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Study Notes

  • Cardiac physiology covers the cardiac action potential.

Cardiac Muscle Contraction

  • Heart muscle is stimulated by nerves, and is self-excitable, known as automaticity.
  • Cardiac muscle contracts as a unit.
  • It has a long absolute refractory period of 250 ms.
  • Cardiac muscle contraction is similar to skeletal muscle contraction.

Heart Physiology: Sequence of Excitation

  • The sinoatrial (SA) node generates impulses about 75 times per minute.
  • The atrioventricular (AV) node delays the impulse approximately 0.1 second.
  • Impulses pass from the atria to the ventricles via the bundle of His.
  • The bundle of His splits into two pathways in the interventricular septum, which are the bundle branches.
  • Bundle branches carry the impulse toward the apex of the heart.
  • Purkinje fibers carry the impulse to the heart apex and ventricular walls.

Heart Physiology: Intrinsic Conduction System

  • Autorhythmic cells initiate action potentials.
  • They have unstable resting potentials called pacemaker potentials.
  • Calcium influx, rather than sodium, is used for the rising phase of the action potential in autorhythmic cells.

Phases of the Cardiac Action Potential

  • Phase 0 is depolarization.
  • Phase 1 is the early repolarization phase.
  • Phase 2 is the plateau phase.
  • Phase 3 is the rapid repolarization phase.

ECG and Action Potential

  • The intracellular action potential's time course has been superimposed on the electrocardiogram (ECG).
  • The depolarization phase of the action potential coincides with the QRS complex on the ECG.
  • Repolarization of the action potential coincides with the T wave on the ECG.

Autonomic Control

  • Typically, about 75-80 action potentials are generated per minute.
  • This can be regulated externally:
  • The heart is stimulated by the sympathetic cardioacceleratory center.
  • The heart is inhibited by the parasympathetic cardioinhibitory center.
  • The nervous system is unable to elicit cardiac action potentials, only the sinoatrial node can.

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