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Questions and Answers
What are the three major waves seen on an electrocardiogram (ECG)?
What are the three major waves seen on an electrocardiogram (ECG)?
What does the P wave on an ECG represent?
What does the P wave on an ECG represent?
What does the QRS complex on an ECG represent?
What does the QRS complex on an ECG represent?
Which of the following is NOT a benefit of using an ECG?
Which of the following is NOT a benefit of using an ECG?
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What is the normal range for heart rate, as measured by an ECG?
What is the normal range for heart rate, as measured by an ECG?
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Which of the following is TRUE regarding the role of the parasympathetic nervous system on the heart?
Which of the following is TRUE regarding the role of the parasympathetic nervous system on the heart?
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What is the function of the sympathetic nervous system on the heart?
What is the function of the sympathetic nervous system on the heart?
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What is the primary reason that heart cells contract?
What is the primary reason that heart cells contract?
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What is the effect of action potentials on heart muscle cells?
What is the effect of action potentials on heart muscle cells?
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Which of the following is NOT a method for studying cardiac excitability?
Which of the following is NOT a method for studying cardiac excitability?
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What is the key connection between cardiac excitability and the study of the heart?
What is the key connection between cardiac excitability and the study of the heart?
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What is the primary function of the SA node in the heart?
What is the primary function of the SA node in the heart?
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Which structure routes electrical signals and delays their transmission?
Which structure routes electrical signals and delays their transmission?
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What is the heart rate of the AV node under normal conditions?
What is the heart rate of the AV node under normal conditions?
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What neurotransmitter is released by the vagus nerve to lower heart rate?
What neurotransmitter is released by the vagus nerve to lower heart rate?
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Under what condition can the Purkinje fibers act as a pacemaker?
Under what condition can the Purkinje fibers act as a pacemaker?
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Why are there no gap junctions between atrial and ventricular myocytes?
Why are there no gap junctions between atrial and ventricular myocytes?
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What is the effect of atropine on heart rate?
What is the effect of atropine on heart rate?
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Which nerve activity primarily influences the resting heart rate?
Which nerve activity primarily influences the resting heart rate?
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What primarily causes the rapid depolarization phase in non-pacemaker cardiac muscle cells?
What primarily causes the rapid depolarization phase in non-pacemaker cardiac muscle cells?
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Which ions are involved in both the pacemaker potential and action potential of cardiac pacemaker cells?
Which ions are involved in both the pacemaker potential and action potential of cardiac pacemaker cells?
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What role do gap junctions play in cardiac conduction?
What role do gap junctions play in cardiac conduction?
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What phase of the action potential does Ca2+ influx primarily prolong in non-pacemaker cardiac cells?
What phase of the action potential does Ca2+ influx primarily prolong in non-pacemaker cardiac cells?
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What is a characteristic feature of the SA node in heart physiology?
What is a characteristic feature of the SA node in heart physiology?
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During which phase do Na+ channels primarily contribute to the cardiac pacemaker potential?
During which phase do Na+ channels primarily contribute to the cardiac pacemaker potential?
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What happens to the conduction of electrical activity as it passes through the AV node?
What happens to the conduction of electrical activity as it passes through the AV node?
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What initiates the electrical activity in the heart?
What initiates the electrical activity in the heart?
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What is the primary neurotransmitter released by sympathetic nerves to increase heart rate?
What is the primary neurotransmitter released by sympathetic nerves to increase heart rate?
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What effect does sympathetic activity have on cAMP in the SA node?
What effect does sympathetic activity have on cAMP in the SA node?
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What happens to the membrane potential during sympathetic stimulation of the SA node?
What happens to the membrane potential during sympathetic stimulation of the SA node?
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Which type of channels are increased in activity due to sympathetic stimulation?
Which type of channels are increased in activity due to sympathetic stimulation?
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What is the effect of vagus nerve activation on the heart rate?
What is the effect of vagus nerve activation on the heart rate?
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Which statement accurately describes the effect of increasing cAMP concentration in autorhythmic cells?
Which statement accurately describes the effect of increasing cAMP concentration in autorhythmic cells?
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What characterizes the membrane potential of autorhythmic cells?
What characterizes the membrane potential of autorhythmic cells?
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What is the role of catecholamines like epinephrine in heart rate modulation?
What is the role of catecholamines like epinephrine in heart rate modulation?
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What is the primary role of the funny current channels (If) in cardiac autorhythmic cells?
What is the primary role of the funny current channels (If) in cardiac autorhythmic cells?
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What is the primary function of the calcium channels (Ca2+) in cardiac autorhythmic cells?
What is the primary function of the calcium channels (Ca2+) in cardiac autorhythmic cells?
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What is the role of potassium channels (K+) in cardiac autorhythmic cells?
What is the role of potassium channels (K+) in cardiac autorhythmic cells?
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Why is the resting membrane potential of autorhythmic cells described as unstable?
Why is the resting membrane potential of autorhythmic cells described as unstable?
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Which of the following statements accurately describes the relationship between the action potential and the pacemaker potential in autorhythmic cells?
Which of the following statements accurately describes the relationship between the action potential and the pacemaker potential in autorhythmic cells?
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What is the primary difference between non-pacemaker cells (myocytes) and pacemaker cells (autorhythmic cells) in the heart?
What is the primary difference between non-pacemaker cells (myocytes) and pacemaker cells (autorhythmic cells) in the heart?
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Which of the following statements accurately describes the role of calcium ions (Ca2+) in cardiac action potentials?
Which of the following statements accurately describes the role of calcium ions (Ca2+) in cardiac action potentials?
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Where are pacemaker cells primarily located in the heart?
Where are pacemaker cells primarily located in the heart?
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Flashcards
Cardiac Excitability
Cardiac Excitability
The ability of heart cells to respond to stimuli and generate action potentials.
Heart Contraction
Heart Contraction
The process by which heart cells shorten and generate force to pump blood.
Action Potential
Action Potential
A rapid change in electrical charge across a cell membrane that leads to contraction.
Electrocardiogram (ECG)
Electrocardiogram (ECG)
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Heart Rate
Heart Rate
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Na+ Role in Cardiac Action Potentials
Na+ Role in Cardiac Action Potentials
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Pacemaker Potential
Pacemaker Potential
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Ca2+ Role in Cardiac Action Potentials
Ca2+ Role in Cardiac Action Potentials
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Ca2+ in Pacemaker Cells
Ca2+ in Pacemaker Cells
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Autorhythmic Cells
Autorhythmic Cells
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SA Node Importance
SA Node Importance
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Gap Junctions Function
Gap Junctions Function
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AV Node Role
AV Node Role
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SA Node
SA Node
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AV Node
AV Node
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Purkinje Fibers
Purkinje Fibers
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Heart Rate Regulation
Heart Rate Regulation
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Vagal Tone
Vagal Tone
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ACh (Acetylcholine) role
ACh (Acetylcholine) role
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Muscarinic Receptors (M2R)
Muscarinic Receptors (M2R)
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Gap Junctions
Gap Junctions
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Sympathetic Activation
Sympathetic Activation
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Norepinephrine (NE)
Norepinephrine (NE)
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Beta-Adrenergic Receptors (bARs)
Beta-Adrenergic Receptors (bARs)
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cAMP
cAMP
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Heart Rate Modulation
Heart Rate Modulation
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Vagus Nerves
Vagus Nerves
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Parasympathetic Fibers
Parasympathetic Fibers
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Sympathetic Fibers
Sympathetic Fibers
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SA Node Function
SA Node Function
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P Wave in ECG
P Wave in ECG
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QRS Complex in ECG
QRS Complex in ECG
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T Wave in ECG
T Wave in ECG
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ECG Analysis Questions
ECG Analysis Questions
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Type 1 Action Potentials
Type 1 Action Potentials
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Type 2 Action Potentials
Type 2 Action Potentials
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Funny Current Channels (If)
Funny Current Channels (If)
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Threshold
Threshold
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Membrane Potential Changes
Membrane Potential Changes
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Atrial and Ventricular Myocytes
Atrial and Ventricular Myocytes
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Sinoatrial and Atrioventricular Nodes
Sinoatrial and Atrioventricular Nodes
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Study Notes
Cardiac Excitability: Heart Rate and ECG
- Cardiac cells contract due to specific electrical signals.
- Understanding these signals helps study the heart's function and identify potential issues.
- Two main types of cardiac action potentials exist: non-pacemaker (myocyte) cells and pacemaker cells (autorhythmic).
Two Types of Cardiac Action Potentials
Type 1: Non-Pacemaker Cells (Myocytes)
- Characterized as "fast response" action potentials; rapid depolarization upon receiving a signal.
- Contractile cells need signals to contract.
- Make up most of the atrial and ventricular muscle walls.
Type 2: Pacemaker (Autorhythmic) Cells
- Unstable resting potential leads to spontaneous triggering.
- Non-contractile cells; "generals" providing signals that other cells follow.
- Found in the sinoatrial (SA) and atrioventricular (AV) nodes.
Action Potentials in Cardiac Autorhythmic Cells
- Funny current channels (If) allow both potassium (K+) and sodium (Na+) to influence the unstable resting potential.
- The pacemaker potential gradually becomes less negative until it reaches threshold, triggering an action potential.
- Ion movements are crucial during pacemaker and action potentials.
Role of Na+ and Ca2+
Role of Na+
- Rapid depolarization phase in cardiac muscle (non-pacemaker cells) due to sodium (Na+) channel opening.
- Gradual depolarization in pacemaker cells results in net sodium (Na+) influx.
Role of Ca2+
- Calcium (Ca2+) influx prolongs the duration of action potentials in cardiac muscle (non-pacemaker cells), creating a plateau phase.
- In pacemaker cells, calcium (Ca2+) is important in initial depolarization.
Electrical Conduction to Myocardial Cells
- Autorhythmic signals spread quickly to adjacent contractile cells via gap junctions.
- Electrical activity originates in the SA node and spreads through the heart.
All Cells of the Intrinsic Conduction System
- All intrinsic conduction cells can produce spontaneous action potentials, i.e., are autorhythmic.
- Structures include the SA node, AV node, bundle of His, bundle branches, and Purkinje fibers.
Nodes (Control Points)
- SA node: sets heart rate at roughly 70 bpm.
- AV node: routes electrical signals and delays their transmission.
Conductive Fibres
- Conductive fibres are often sheathed and separated from myocyte connections, except for specialized contact regions of atria and ventricles.
- Atrial and ventricular myocyte syncytia are separated by inert fibrous tissue; no gap junctions exist.
Heart Rate is Controlled by Both Sympathetic and Parasympathetic Nerves
- Parasympathetic activity slows heart rate; vagus nerve stimulates SA node.
- Sympathetic activity speeds heart rate; norepinephrine (NE) binds to beta-adrenergic receptors (BARs) on SA node cells.
Heart Rate Regulation - SA Node Action Potential Firing Rate
- Regulated by both sympathetic and parasympathetic fibers.
- Acetylcholine (Ach) binds to muscarinic receptors, lowering heart rate.
- Norepinephrine (NE) binds to beta-adrenergic receptors, raising heart rate.
- Various receptors and channels are involved at the cellular level.
Control of Heart Rate
- To increase heart rate (beyond intrinsic rate), sympathetic nerves need activation.
- Catecholamines released by the adrenal gland can also stimulate heart rate.
Modulation of Heart Rate by the Autonomic Nervous System
- Sympathetic stimulation causes pacemaker potentials to reach threshold quickly.
- Parasympathetic stimulation causes pacemaker potentials to reach threshold more slowly.
Review Question – Autorhythmic Cells
- Statement "c": The membrane potential is unstable, drifting between -90mV and -55 mV, is true.
Control of Heart Rate vs. Contraction Strength
- Vagus nerve activity (parasympathetic) influences heart rate, but not contraction force.
- Sympathetic fibers increase heart rate and contraction force.
ECG (Electrocardiogram): Normal Waves
- Three major waves: P wave, QRS complex, and T wave.
Electrical Activity – Overview
- The ECG tracing correlates with electrical events in the heart.
- Each wave represents specific electrical events in the heart.
Electrical Events of the Cardiac Cycle
- P wave: atrial depolarization.
- PQ or PR segment: AV nodal and A-V bundle conduction.
- QRS complex: ventricular depolarization.
- ST segment: ventricular depolarization.
- T wave: ventricular repolarization.
Comparison of ECG and Myocardial Action Potential
- ECG reflects summed electrical activity across the whole heart.
- Myocardial action potentials are recorded intracellularly.
Tips for ECG Analysis
- Analyze rate, rhythm, and wave forms.
- Verify that QRS appears with each P wave.
- Check both P-R and P-R timings.
ECG: Normal and Abnormal Electrocardiograms
- Various abnormal patterns represent different heart conditions.
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Description
Test your knowledge on the ECG waves and their significance in cardiac physiology. This quiz covers the P wave, QRS complex, heart rate norms, and the roles of the sympathetic and parasympathetic nervous systems. Assess your understanding of cardiac excitability and the various methods used to study it.