Cardiac Physiology and Action Potential

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Questions and Answers

What is represented in phase 3 of the action potential?

  • Unstable resting membrane potential
  • Repolarization (correct)
  • Depolarization
  • Stable resting membrane potential

Phase 0 of the action potential involves fast Na+ entry.

True (A)

What causes phase 3 of the action potential?

K+ efflux

Phase 4 represents the ______ membrane potential.

<p>resting</p> Signup and view all the answers

Match the following phases with their characteristics:

<p>Phase 0 = Fast Na+ entry Phase 3 = K+ efflux Phase 4 = Resting membrane potential Phase 2 = Slow Ca+2 entry</p> Signup and view all the answers

What represents phase 4 of the action potential?

<p>Stable resting membrane potential (A)</p> Signup and view all the answers

Phase 0 of the action potential is characterized by depolarization.

<p>True (A)</p> Signup and view all the answers

What ion entry primarily causes phase 0 of the action potential?

<p>Na+</p> Signup and view all the answers

Phase 4 is caused by _______ efflux.

<p>K+</p> Signup and view all the answers

Match the action potential phases with their characteristics:

<p>Phase 0 = Rapid depolarization due to Na+ influx Phase 4 = Stable resting membrane potential Phase 3 = Repolarization due to K+ efflux Phase 1 = Initial repolarization</p> Signup and view all the answers

What is the phase of depolarization in an action potential commonly referred to as?

<p>Phase 0 (B)</p> Signup and view all the answers

Resting membrane potential is also known as 'unresting membrane potential'.

<p>False (B)</p> Signup and view all the answers

What occurs during the depolarization phase of an action potential?

<p>Sodium channels open, allowing Na+ ions to enter the cell.</p> Signup and view all the answers

During phase 0 of an action potential, the membrane undergoes __________.

<p>depolarization</p> Signup and view all the answers

Match the following action potential phases with their descriptions:

<p>Phase 0 = Rapid depolarization due to sodium influx Phase 1 = Initial repolarization Phase 2 = Plateau phase Phase 3 = Rapid repolarization due to potassium efflux</p> Signup and view all the answers

Flashcards

Phase 3 of Action Potential

Repolarization phase, caused by potassium efflux (K+ leaving the cell).

Phase 0 of Action Potential

Rapid depolarization phase, primarily due to the fast influx of sodium ions (Na+).

Phase 4 of Action Potential

Resting membrane potential; a stable, polarized state.

Resting Membrane Potential

The electrical potential difference across the cell membrane when it is not actively firing an action potential.

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Repolarization

Return of the cell to resting membrane potential following depolarization.

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Cardiac Output

The amount of blood pumped by the heart per minute.

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Heart Muscle Type

Heart muscle is a specialized type of tissue called a syncytium.

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Blood Flow Order

Blood flows from the right atrium, to the right ventricle, lungs, left atrium, left ventricle, and then to the rest of the body.

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Cardiac Action Potential Phases

The phases of a cardiac action potential are typically described in terms of their membrane potential.

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Resting Membrane Potential (RMP)

The stable, negative electrical potential across the cell membrane when the neuron is not actively transmitting a signal.

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What causes Phase 0?

The rapid influx of sodium ions (Na+) into the cell through voltage-gated sodium channels, driven by the electrochemical gradient.

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Study Notes

Cardiac Physiology

  • Normal Heart Rate: 70/min
  • Heart Rate During Exercise: 120-150/min
  • Cardiac Output: 5 L/min
  • Heart Muscle: Syncytium
  • Blood Flow Order: Right atria, right ventricle, lungs, left atria, left ventricle, rest of the body

Action Potential

  • SA Node: Initiates the heartbeat. This is the pace-maker
  • Phase 0 (depolarization): Caused by rapid Na+ entry
  • Phase 4 (resting membrane potential): Unstable
  • Phase 3 (repolarization): K+ efflux
  • Phase 2 (plateau): Caused by slow Ca++ entry

ECG Waves

  • P-wave: Atrial depolarization
  • QRS complex: Ventricular depolarization
  • T-wave: Ventricular repolarization

Factors Affecting Cardiac Output

  • Stroke volume: Determined by preload, afterload, and contractility
  • Preload: Blood volume in ventricles before contraction
  • Afterload: Resistance to ejection of blood from ventricles
  • Contractility: Force of ventricular contraction
  • Blood volume: Influences preload
  • Venous return: Influences preload
  • Blood viscosity: Affects TPR (total peripheral resistance)

Contractility Factors

  • Length of blood vessels
  • Viscosity of blood
  • Diameter of lumen
  • Cardiac output
  • Blood volume

Factors Affecting Blood Pressure

  • Cardiac output
  • Blood volume
  • Viscosity

Respiratory Physiology

  • Traps Microorganisms: Mucus, cilia, and hair

  • Keeps Trachea Open: Cilia, Cartilage rings

  • Alveoli Structure: Single layer, moist, surrounded by capillaries

  • Surfactant: Decreases surface tension, preventing collapse

  • External Respiration: Gas exchange between air and blood

  • Internal Respiration: Gas exchange between blood and tissues

  • Cellular Respiration: Uses oxygen and food to produce ATP

  • Inhalation: Diaphragm and muscles contract

  • Exhalation: Diaphragm and muscles relax

  • Tidal Volume (Males): 0.5-1.5L

  • Tidal Volume (Females): 400 mL

  • Lung Capacity: Includes inspiratory reserve volume, expiratory reserve volume, tidal volume and residual volume

  • Oxygen Transport: Primarily by hemoglobin

  • Carbon Dioxide Transport: Primarily in the form of bicarbonate ion

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