Podcast
Questions and Answers
What is the role of ATP in muscular contraction and relaxation?
What is the role of ATP in muscular contraction and relaxation?
Which step involves the sliding of thin filaments over thick filaments in muscular contraction?
Which step involves the sliding of thin filaments over thick filaments in muscular contraction?
During muscular relaxation, what leads to the cessation of myosin and actin interaction?
During muscular relaxation, what leads to the cessation of myosin and actin interaction?
Which process uncovers the binding sites of myosin on actin filaments during muscular contraction?
Which process uncovers the binding sites of myosin on actin filaments during muscular contraction?
Signup and view all the answers
Which structure is responsible for spreading action potential to the depth of myofibrils?
Which structure is responsible for spreading action potential to the depth of myofibrils?
Signup and view all the answers
In which step is more shortening obtained by disconnection, cocking, reconnection, and swiveling of myosin heads on actin filaments?
In which step is more shortening obtained by disconnection, cocking, reconnection, and swiveling of myosin heads on actin filaments?
Signup and view all the answers
What is the role of the sympathetic nervous system in cardiac muscle contraction?
What is the role of the sympathetic nervous system in cardiac muscle contraction?
Signup and view all the answers
How does physiological stimulation via sympathetic nerves affect the rate of relaxation in cardiac muscle?
How does physiological stimulation via sympathetic nerves affect the rate of relaxation in cardiac muscle?
Signup and view all the answers
Which protein undergoes phosphorylation due to the activation of β1-adrenoceptors?
Which protein undergoes phosphorylation due to the activation of β1-adrenoceptors?
Signup and view all the answers
How do drugs like milrinone and caffeine affect cAMP levels?
How do drugs like milrinone and caffeine affect cAMP levels?
Signup and view all the answers
What effect does increasing intracellular [Ca++] have on cardiac muscle contraction?
What effect does increasing intracellular [Ca++] have on cardiac muscle contraction?
Signup and view all the answers
How does phosphorylation of phospholamban influence Ca++ levels in the sarcoplasmic reticulum?
How does phosphorylation of phospholamban influence Ca++ levels in the sarcoplasmic reticulum?
Signup and view all the answers
Where does the majority of the Ca++ used to trigger contraction of cardiac muscle come from?
Where does the majority of the Ca++ used to trigger contraction of cardiac muscle come from?
Signup and view all the answers
In which type of muscle does the source of Ca++ for the contractile mechanism differ from cardiac muscle?
In which type of muscle does the source of Ca++ for the contractile mechanism differ from cardiac muscle?
Signup and view all the answers
What triggers an initial increase in intracellular calcium ion [Ca++i] concentration in cardiac muscle cells?
What triggers an initial increase in intracellular calcium ion [Ca++i] concentration in cardiac muscle cells?
Signup and view all the answers
What role do L-type calcium channels play in cardiac muscle contraction?
What role do L-type calcium channels play in cardiac muscle contraction?
Signup and view all the answers
Which component helps spread electrical excitation rapidly into cardiac muscle cells?
Which component helps spread electrical excitation rapidly into cardiac muscle cells?
Signup and view all the answers
What type of muscle uses only sarcoplasmic reticulum (SR) stores of Ca++ for contraction?
What type of muscle uses only sarcoplasmic reticulum (SR) stores of Ca++ for contraction?
Signup and view all the answers