Cardiac Muscle Contraction Factors
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Questions and Answers

What is the role of ATP in muscular contraction and relaxation?

  • ATP binds to troponin C to initiate muscle contraction.
  • ATP breaks down to supply energy for muscular contraction and relaxation. (correct)
  • ATP inhibits the binding of myosin to actin filaments.
  • ATP is responsible for the release of calcium ions from the sarcoplasmic reticulum.
  • Which step involves the sliding of thin filaments over thick filaments in muscular contraction?

  • Step 6: Shortening obtained by disconnection and reconnection of myosin heads. (correct)
  • Step 1: Generation of action potential in myelinated motor nerve.
  • Step 3: Release of calcium ions from the sarcoplasmic reticulum.
  • Step 8: Reuptake of calcium by the sarcoplasmic reticulum to stop muscle interaction.
  • During muscular relaxation, what leads to the cessation of myosin and actin interaction?

  • Increase in troponin C levels in the muscles.
  • Reuptake of calcium by the sarcoplasmic reticulum. (correct)
  • Active release of ATP by the sarcoplasmic reticulum.
  • Binding of calcium to troponin C.
  • Which process uncovers the binding sites of myosin on actin filaments during muscular contraction?

    <p>Release of calcium ions from lateral sacs of the sarcoplasmic reticulum.</p> Signup and view all the answers

    Which structure is responsible for spreading action potential to the depth of myofibrils?

    <p>T-tubular system</p> Signup and view all the answers

    In which step is more shortening obtained by disconnection, cocking, reconnection, and swiveling of myosin heads on actin filaments?

    <p>Step 5: Sliding of thin filaments over thick filaments.</p> Signup and view all the answers

    What is the role of the sympathetic nervous system in cardiac muscle contraction?

    <p>Activates β1-adrenoceptors</p> Signup and view all the answers

    How does physiological stimulation via sympathetic nerves affect the rate of relaxation in cardiac muscle?

    <p>Accelerates Ca++ re-entry into the SR</p> Signup and view all the answers

    Which protein undergoes phosphorylation due to the activation of β1-adrenoceptors?

    <p>Phospholamban</p> Signup and view all the answers

    How do drugs like milrinone and caffeine affect cAMP levels?

    <p>Inhibit phosphodiesterases</p> Signup and view all the answers

    What effect does increasing intracellular [Ca++] have on cardiac muscle contraction?

    <p>Increases force of contraction</p> Signup and view all the answers

    How does phosphorylation of phospholamban influence Ca++ levels in the sarcoplasmic reticulum?

    <p>Increases Ca++ retention in the SR</p> Signup and view all the answers

    Where does the majority of the Ca++ used to trigger contraction of cardiac muscle come from?

    <p>Sarcoplasmic reticulum (SR)</p> Signup and view all the answers

    In which type of muscle does the source of Ca++ for the contractile mechanism differ from cardiac muscle?

    <p>Skeletal muscle</p> Signup and view all the answers

    What triggers an initial increase in intracellular calcium ion [Ca++i] concentration in cardiac muscle cells?

    <p>Inward flow of calcium from extracellular fluid</p> Signup and view all the answers

    What role do L-type calcium channels play in cardiac muscle contraction?

    <p>Mediate inward flow of extracellular calcium</p> Signup and view all the answers

    Which component helps spread electrical excitation rapidly into cardiac muscle cells?

    <p>T tubules</p> Signup and view all the answers

    What type of muscle uses only sarcoplasmic reticulum (SR) stores of Ca++ for contraction?

    <p>Skeletal muscle</p> Signup and view all the answers

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