Podcast
Questions and Answers
What is the main effect of fatty acids and ketone bodies on pyruvate dehydrogenase activity?
What is the main effect of fatty acids and ketone bodies on pyruvate dehydrogenase activity?
- Have no impact on pyruvate dehydrogenase activity
- Activate the conversion of pyruvate to acetyl CoA
- Increase the activity of pyruvate dehydrogenase
- Inhibit the activity of pyruvate dehydrogenase (correct)
In the context of Randle's Cycle, what happens to glucose uptake in muscle when fatty acid oxidation is intense?
In the context of Randle's Cycle, what happens to glucose uptake in muscle when fatty acid oxidation is intense?
- Halts completely
- Decreases (correct)
- Increases
- Remains constant
How is the rate of carbohydrate (pyruvate and lactate) oxidation by the heart related to plasma free fatty acid concentration?
How is the rate of carbohydrate (pyruvate and lactate) oxidation by the heart related to plasma free fatty acid concentration?
- Directly proportional
- Only affects lactate oxidation
- Inversely proportional (correct)
- Has no relation
What effect do high rates of fatty acid oxidation have on the uptake and oxidation of glucose and lactate?
What effect do high rates of fatty acid oxidation have on the uptake and oxidation of glucose and lactate?
Which enzyme phosphorylates pyruvate dehydrogenase, leading to a decrease in its activity?
Which enzyme phosphorylates pyruvate dehydrogenase, leading to a decrease in its activity?
What is the main function of Randle's cycle in cardiac metabolism?
What is the main function of Randle's cycle in cardiac metabolism?
How does insulin affect carbohydrate metabolism in the heart?
How does insulin affect carbohydrate metabolism in the heart?
Which of the following best describes the role of insulin in fatty acid metabolism in the heart?
Which of the following best describes the role of insulin in fatty acid metabolism in the heart?
How do partial FFA oxidation inhibitors impact cardiac metabolism?
How do partial FFA oxidation inhibitors impact cardiac metabolism?
What effect does glucose uptake in cardiac muscles have on heart function?
What effect does glucose uptake in cardiac muscles have on heart function?
How does insulin affect glycogen storage?
How does insulin affect glycogen storage?
What is the effect of high insulin levels, such as after a meal, on fatty acid uptake and oxidation by the heart?
What is the effect of high insulin levels, such as after a meal, on fatty acid uptake and oxidation by the heart?
How does insulin lower circulating free fatty acid levels?
How does insulin lower circulating free fatty acid levels?
What effect does insulin have on glucose and lactate uptake and oxidation in the heart?
What effect does insulin have on glucose and lactate uptake and oxidation in the heart?
What is the impact of insulin on the release of fatty acid inhibition on PDH?
What is the impact of insulin on the release of fatty acid inhibition on PDH?
Which fuel source provides the majority of energy to the heart under basal aerobic conditions?
Which fuel source provides the majority of energy to the heart under basal aerobic conditions?
What happens to fatty acid oxidation in the heart when plasma free fatty acid concentrations are high?
What happens to fatty acid oxidation in the heart when plasma free fatty acid concentrations are high?
Which of the following is NOT a primary source of carbohydrate fuel for the myocardium?
Which of the following is NOT a primary source of carbohydrate fuel for the myocardium?
Where is glucose uptake in cardiac muscles regulated by?
Where is glucose uptake in cardiac muscles regulated by?
Which isoform of the glucose transporter family is predominant in the myocardium?
Which isoform of the glucose transporter family is predominant in the myocardium?
What effect does an increase in acetyl CoA/CoA and NADH/NAD ratios have on PDH kinase activity?
What effect does an increase in acetyl CoA/CoA and NADH/NAD ratios have on PDH kinase activity?
How does high rates of fatty acid oxidation impact pyruvate oxidation?
How does high rates of fatty acid oxidation impact pyruvate oxidation?
Which group of anti-anginal drugs shifts cardiomyocyte metabolism toward carbohydrate utilization?
Which group of anti-anginal drugs shifts cardiomyocyte metabolism toward carbohydrate utilization?
How does insulin indirectly increase glucose uptake in cardiac muscles?
How does insulin indirectly increase glucose uptake in cardiac muscles?
What effect does insulin have on hexokinase enzyme activity in cardiac muscles?
What effect does insulin have on hexokinase enzyme activity in cardiac muscles?
Flashcards are hidden until you start studying
