CARD15 Gene and Crohn's Disease Relationship

What is the most commonly applied definition of disease recurrence in the context of recurrent CD activity?

What is generally accepted as defining clinical recurrence in the context of recurrent CD activity?

What is the clearest end point as a definition of recurrence in the context of recurrent CD activity?

What percentage of patients experience symptomatic recurrence at 5 years in the context of recurrent CD activity?

At what time frame can clinical recurrence occur in between 75% and 95% of cases in the context of recurrent CD activity?

What is the predominant characteristic of the stricturing pattern of Crohn's disease?

Which type of pattern is characterized by the development of sinus tracts, fistulae, and abscesses?

What is the most likely outcome for strictures resulting from the stricturing pattern of Crohn's disease?

What is a notable characteristic of the perforating pattern of Crohn's disease?

What tends to be the determining factor for clinical presentation and therapeutic options in Crohn's disease?

What is the characteristic feature of the remission phase of Crohn's disease?

Which histopathologic feature is typically seen in the active phase of Crohn's disease?

What is a characteristic microscopic feature of Crohn's disease that is demonstrated in only 50% of resected specimens?

Which factor has been associated with the development and exacerbation of Crohn's disease?

Which infectious agent has NOT been consistently associated with Crohn's disease according to the text?

What is the characteristic feature of the inflammatory pattern of Crohn's disease?

Which symptom is most commonly associated with the obstructive pattern of Crohn's disease?

Which imaging study is considered the best means for assessing the small bowel for Crohn's disease?

What is the primary manifestation that can be identified in the early stages of Crohn's disease?

Which symptom is more likely to respond to medical therapy in Crohn's disease?

Which of the following best describes the distribution of Crohn's disease (CD) within families?

What is the current understanding of the etiology of Crohn's disease (CD)?

What has been demonstrated in both Crohn's disease (CD) patients and their symptom-free first-degree relatives?

What is the role of the CARD15/NOD2 gene in relation to Crohn's disease (CD)?

What is the relationship between genetic predisposition and environmental triggers in the manifestation of Crohn's disease (CD)?

What is the genetic relationship of CARD15/NOD2 to Crohn's disease (CD)?

What characteristic histopathologic lesion is found in Crohn's disease specimens?

Which infectious agent has been isolated from resected Crohn's disease specimens?

What has been associated with the development of Crohn's disease?

What role does diet modification play in Crohn's disease development according to the text?

What is the most commonly affected location by Crohn disease?

What percentage of all patients with Crohn disease have more than one intestinal segment affected simultaneously?

Which regions have the highest incidence of Crohn disease?

What is the current estimated incidence of Crohn disease in the United States?

In which age range is the peak age for contracting Crohn disease?

Which part of the gastrointestinal system is least commonly affected by Crohn disease?

Where is Crohn disease much less common?