CARD15 Gene and Crohn's Disease Relationship
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Questions and Answers

What is the most commonly applied definition of disease recurrence in the context of recurrent CD activity?

  • The variability in the severity of symptoms
  • The occurrence of radiologic and endoscopic tests
  • The need for reoperation
  • The development of symptoms related to recurrent CD activity (correct)

    • What is generally accepted as defining clinical recurrence in the context of recurrent CD activity?

  • CDAI greater than 150 (correct)
  • Variability in severity of symptoms
  • Onset of insidious symptoms
  • Reported crude recurrence rates

    • What is the clearest end point as a definition of recurrence in the context of recurrent CD activity?

  • Radiologic and endoscopic tests
  • Reported cumulative recurrence rates
  • The need for reoperation (correct)
  • Severe variability in symptoms

    • What percentage of patients experience symptomatic recurrence at 5 years in the context of recurrent CD activity?

    <p>60%</p> Signup and view all the answers

    At what time frame can clinical recurrence occur in between 75% and 95% of cases in the context of recurrent CD activity?

    <p>20 years</p> Signup and view all the answers

    What is the predominant characteristic of the stricturing pattern of Crohn's disease?

    <p>Partial or complete intestinal obstruction</p> Signup and view all the answers

    Which type of pattern is characterized by the development of sinus tracts, fistulae, and abscesses?

    <p>Perforating pattern</p> Signup and view all the answers

    What is the most likely outcome for strictures resulting from the stricturing pattern of Crohn's disease?

    <p>Surgical intervention required</p> Signup and view all the answers

    What is a notable characteristic of the perforating pattern of Crohn's disease?

    <p>Development of sinus tracts and fistulae</p> Signup and view all the answers

    What tends to be the determining factor for clinical presentation and therapeutic options in Crohn's disease?

    <p>Predominant disease pattern</p> Signup and view all the answers

    What is the characteristic feature of the remission phase of Crohn's disease?

    <p>Healing of the inflamed tissue</p> Signup and view all the answers

    Which histopathologic feature is typically seen in the active phase of Crohn's disease?

    <p>Transmural inflammation</p> Signup and view all the answers

    What is a characteristic microscopic feature of Crohn's disease that is demonstrated in only 50% of resected specimens?

    <p>Noncaseating granuloma</p> Signup and view all the answers

    Which factor has been associated with the development and exacerbation of Crohn's disease?

    <p>Smoking</p> Signup and view all the answers

    Which infectious agent has NOT been consistently associated with Crohn's disease according to the text?

    <p>Measles virus</p> Signup and view all the answers

    What is the characteristic feature of the inflammatory pattern of Crohn's disease?

    <p>Adynamic segment of intestine and luminal narrowing</p> Signup and view all the answers

    Which symptom is most commonly associated with the obstructive pattern of Crohn's disease?

    <p>Presence of a palpable mass in the right lower quadrant</p> Signup and view all the answers

    Which imaging study is considered the best means for assessing the small bowel for Crohn's disease?

    <p>Small bowel follow­through or enteroclysis</p> Signup and view all the answers

    What is the primary manifestation that can be identified in the early stages of Crohn's disease?

    <p>Mucosal granulations with ulceration and nodularity</p> Signup and view all the answers

    Which symptom is more likely to respond to medical therapy in Crohn's disease?

    <p>Mucosal granulations with ulceration and nodularity</p> Signup and view all the answers

    Which of the following best describes the distribution of Crohn's disease (CD) within families?

    <p>It shows no specific pattern of inheritance within families</p> Signup and view all the answers

    What is the current understanding of the etiology of Crohn's disease (CD)?

    <p>It is a result of an unknown pathologic trigger inducing an overreaction in an otherwise normal immune system</p> Signup and view all the answers

    What has been demonstrated in both Crohn's disease (CD) patients and their symptom-free first-degree relatives?

    <p>A specific primary defect in the systemic immune system</p> Signup and view all the answers

    What is the role of the CARD15/NOD2 gene in relation to Crohn's disease (CD)?

    <p>It has been linked to susceptibility to CD</p> Signup and view all the answers

    What is the relationship between genetic predisposition and environmental triggers in the manifestation of Crohn's disease (CD)?

    <p>Genetic predisposition may play a role, whereas environmental triggers may start the pathologic sequence leading to CD</p> Signup and view all the answers

    What is the genetic relationship of CARD15/NOD2 to Crohn's disease (CD)?

    <p>Complex and poorly understood</p> Signup and view all the answers

    What characteristic histopathologic lesion is found in Crohn's disease specimens?

    <p>Noncaseating granulomas</p> Signup and view all the answers

    Which infectious agent has been isolated from resected Crohn's disease specimens?

    <p>Mycobacterium paratuberculosis</p> Signup and view all the answers

    What has been associated with the development of Crohn's disease?

    <p>Smoking</p> Signup and view all the answers

    What role does diet modification play in Crohn's disease development according to the text?

    <p>Can ameliorate the symptoms but not identified as a cause</p> Signup and view all the answers

    What is the most commonly affected location by Crohn disease?

    <p>Terminal ileum</p> Signup and view all the answers

    What percentage of all patients with Crohn disease have more than one intestinal segment affected simultaneously?

    <p>One-fifth</p> Signup and view all the answers

    Which regions have the highest incidence of Crohn disease?

    <p>United States, Canada, and Europe</p> Signup and view all the answers

    What is the current estimated incidence of Crohn disease in the United States?

    <p>4 new cases per year for every 100,000 persons</p> Signup and view all the answers

    In which age range is the peak age for contracting Crohn disease?

    <p>15-25 years</p> Signup and view all the answers

    Which part of the gastrointestinal system is least commonly affected by Crohn disease?

    <p>Mouth</p> Signup and view all the answers

    Where is Crohn disease much less common?

    <p>Asia, South America, and Japan</p> Signup and view all the answers

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