Questions and Answers
What is the brand name of capsaicin?
What are the common FDA indications for capsaicin?
Pain
What drug class does capsaicin belong to?
Topical analgesic
What is the mechanism of action (MOA) of capsaicin?
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Renal dosing adjustment is required for capsaicin.
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What are the available dosage forms of capsaicin?
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What is the recommended dosing for adults and children over 12 years of age for capsaicin?
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What are the common adverse drug reactions (ADRs) of capsaicin?
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What are the serious adverse drug reactions (ADRs) of capsaicin?
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What monitoring parameters should be observed when using capsaicin?
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What are the counseling points for applying capsaicin?
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There are known drug interactions with capsaicin.
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What are the contraindications for capsaicin?
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Study Notes
Capsaicin Overview
- Brand Name: Capsaicin-P
- Drug Class: Categorized as a topical analgesic, providing localized pain relief.
Indications and Usage
- Common FDA Indications: Primarily indicated for pain management.
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Dosing Instructions:
- For adults and children over 12 years: Apply 1 patch or thin layer to the affected area 3-4 times per day for up to 7 days.
- A patch can stay in place for up to 8 hours.
- Best results observed after 2-4 weeks of continuous use; efficacy decreases if used less than 3 times daily.
Mechanism of Action
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MOA (Mechanism of Action):
- Acts as an agonist for the TRPV1 receptor located in nociceptive nerve fibers.
- TRPV1 activation leads to depolarization, action potential initiation, and pain signal transmission to the spinal cord.
- Ultimately causes desensitization and reduction in pain signal initiation.
Dosage Forms
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Available Dosage Forms:
- Topical patch
- Topical cream
- Topical gel
- Topical lotion
Side Effects and Monitoring
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Common ADRs (Adverse Drug Reactions):
- Local erythema and pain, dry skin, pruritus (itching), burning sensation in the treated area.
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Serious ADRs:
- Severe rash and hypersensitivity reactions possible.
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Monitoring Parameters:
- Look for decreased pain.
- Mild stinging or burning may occur, typically resolving in 2-3 days.
- Seek medical attention if no improvement is noted after 10 days, or if severe skin irritation or rash develops.
Counseling and Precautions
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Counseling Points:
- Wash and dry the application area before use.
- Apply a thin layer or patch, may use gloves during application.
- Avoid contact with broken or irritated skin; do not expose the area to heat or direct sunlight.
- Avoid bandaging and refrain from bathing, showering, or swimming for 30 minutes post-application.
- Remove patch an hour before bathing, showering, or swimming.
Additional Considerations
- Renal Dosing Adjustment: Not required.
- Drug Interactions: No significant interactions found.
- Contraindications: Use is contraindicated in individuals with hypersensitivity to capsaicin.
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Description
Test your knowledge about capsaicin with these flashcards focusing on its brand names, FDA indications, drug class, and mechanism of action. Understand how capsaicin interacts with the TRPV1 receptor and its use in pain management.
