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Questions and Answers
What is the purpose of the prothrombin time (PT) test?
What is the purpose of the prothrombin time (PT) test?
Which factor is especially monitored using the prothrombin time (PT) test?
Which factor is especially monitored using the prothrombin time (PT) test?
What is the activated partial thromboplastin time a measure of?
What is the activated partial thromboplastin time a measure of?
Which test is used as a means for measuring the effect of anticoagulant therapy?
Which test is used as a means for measuring the effect of anticoagulant therapy?
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Which factor initiates the activation of factor VII in the prothrombin time (PT) test?
Which factor initiates the activation of factor VII in the prothrombin time (PT) test?
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What converts fibrinogen into fibrin in the prothrombin time (PT) test?
What converts fibrinogen into fibrin in the prothrombin time (PT) test?
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What is the purpose of the tourniquet test (Rumple Leede method) in relation to capillary fragility?
What is the purpose of the tourniquet test (Rumple Leede method) in relation to capillary fragility?
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In a patient undergoing the tourniquet test, what would '4+' petechiae indicate?
In a patient undergoing the tourniquet test, what would '4+' petechiae indicate?
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What is the significance of petechiae formation during the tourniquet test?
What is the significance of petechiae formation during the tourniquet test?
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How is capillary fragility assessed using the Rumple Leede method?
How is capillary fragility assessed using the Rumple Leede method?
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What does a positive tourniquet test indicate in terms of capillary fragility?
What does a positive tourniquet test indicate in terms of capillary fragility?
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What is the relationship between platelet count and capillary fragility based on the tourniquet test?
What is the relationship between platelet count and capillary fragility based on the tourniquet test?
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What is the purpose of examining the forearm, hands, and fingers for petechiae after performing the blood pressure cuff test?
What is the purpose of examining the forearm, hands, and fingers for petechiae after performing the blood pressure cuff test?
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Which condition is associated with a normal clot retraction time according to the Macfarlane Method?
Which condition is associated with a normal clot retraction time according to the Macfarlane Method?
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In which condition will a small clot with increased red cell fallout be observed?
In which condition will a small clot with increased red cell fallout be observed?
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What is the significance of a small and ragged clot appearance in clot retraction testing?
What is the significance of a small and ragged clot appearance in clot retraction testing?
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Which condition can lead to a limited degree of clot retraction due to a high red cell count within the clot?
Which condition can lead to a limited degree of clot retraction due to a high red cell count within the clot?
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In the Macfarlane Method, what is necessary for normal clot retraction to occur?
In the Macfarlane Method, what is necessary for normal clot retraction to occur?
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Study Notes
Prothrombin Time (PT) Test
- The prothrombin time (PT) test is used to monitor the extrinsic and common coagulation pathways.
- The PT test especially monitors the factor VII.
- Factor VII is initiated by tissue thromboplastin in the PT test.
- Thrombin converts fibrinogen into fibrin in the PT test.
Activated Partial Thromboplastin Time (aPTT)
- The aPTT is a measure of the intrinsic and common coagulation pathways.
Anticoagulant Therapy
- The PT test is used to measure the effect of anticoagulant therapy.
Tourniquet Test (Rumple Leede Method)
- The tourniquet test is used to assess capillary fragility.
- The test involves inflating a blood pressure cuff to midway between the systolic and diastolic pressures for 5-10 minutes.
- The number of petechiae (small hemorrhages) that appear on the forearm indicates capillary fragility.
- '4+' petechiae indicate severe capillary fragility.
- Petechiae formation during the tourniquet test indicates increased capillary fragility.
- A positive tourniquet test indicates increased capillary fragility.
- There is an inverse relationship between platelet count and capillary fragility based on the tourniquet test.
Blood Pressure Cuff Test
- The purpose of examining the forearm, hands, and fingers for petechiae after the blood pressure cuff test is to assess capillary fragility.
Clot Retraction Test (Macfarlane Method)
- A normal clot retraction time is associated with a condition like idiopathic thrombocytopenic purpura.
- A small clot with increased red cell fallout is observed in conditions like thrombocytopenia.
- A small and ragged clot appearance indicates a defect in platelet function.
- A high red cell count within the clot can lead to a limited degree of clot retraction.
- Normal clot retraction requires platelet aggregation, thromboxane A2, and a stable clot structure.
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Description
Learn how to perform the capillary fragility test using the Tourniquet Test (Rumple Leede Method) for assessing platelet function and correlating it with bleeding tendencies. Follow step-by-step instructions to measure capillary fragility.
