Cannabis Use and Schizophrenia Risks
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Cannabis Use and Schizophrenia Risks

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Questions and Answers

What technique did Laruelle et al. utilize to estimate dopamine release in individuals with schizophrenia?

  • Single Photon Emission Computed Tomography
  • Functional MRI
  • A device similar to a PET scanner (correct)
  • Magnetic Resonance Imaging

    • What was the significant finding of Laruelle et al. regarding dopamine release in individuals with schizophrenia after amphetamine injection?

  • Dopamine release was similar to that of control subjects.
  • Dopamine release showed no relation to positive symptoms.
  • Dopamine release was higher compared to control subjects. (correct)
  • Dopamine release was significantly lower than in control subjects.

    • Which of the following is NOT an indirect index used to measure dopaminergic activity according to the content?

  • Dopamine release
  • Dopamine degradation (correct)
  • Number of dopamine receptors
  • Dopamine synthesis

    • What relation was observed between dopamine release and positive symptoms in individuals with schizophrenia?

    <p>Higher dopamine release correlates with more severe positive symptoms.</p> Signup and view all the answers

    Why is measuring dopamine levels directly in humans not possible?

    <p>Dopamine levels can fluctuate excessively in real-time.</p> Signup and view all the answers

    What is the adjusted odds ratio for daily use of 'skunk-like' cannabis in relation to psychotic disorders?

    <p>5.4</p> Signup and view all the answers

    Which of the following risk factors is associated with the highest risk for developing schizophrenia?

    <p>Having a first-degree relative with schizophrenia</p> Signup and view all the answers

    Which risk factor is considered an intermediate factor for psychotic disorders?

    <p>Being raised in an urban area</p> Signup and view all the answers

    What is the odds ratio for cannabis use as a risk factor for schizophrenia?

    <p>2.10–2.93</p> Signup and view all the answers

    According to the comparison, which risk factors are linked to conception and the perinatal period?

    <p>Prenatal stress and obstetrical complications</p> Signup and view all the answers

    Which type of cannabis has been linked to the highest risk of psychotic disorders according to the study?

    <p>High-potency cannabis</p> Signup and view all the answers

    What is the relative risk of being an offspring of an immigrant from selected countries in relation to developing schizophrenia?

    <p>4.5</p> Signup and view all the answers

    Which of the following reflects a low-risk factor for schizophrenia?

    <p>Having a father older than 45</p> Signup and view all the answers

    Which variant of the COMT gene is associated with a higher risk of developing schizophrenia in individuals who used cannabis during adolescence?

    <p>Val variant</p> Signup and view all the answers

    What type of research design did Caspi et al. (2005) utilize to demonstrate the effects of cannabis use and genetic factors on adult psychosis?

    <p>Longitudinal study</p> Signup and view all the answers

    According to Estrada et al. (2011), how is the timing of cannabis use related to the onset of schizophrenia-spectrum disorders?

    <p>Earlier use correlates with an earlier onset of disorder</p> Signup and view all the answers

    What does the research suggest regarding the effects of cannabis use on individuals with different COMT genotypes?

    <p>Val/Val genotype carriers show an earlier age at onset of disorders</p> Signup and view all the answers

    What is one hypothesis suggested by Estrada regarding the effects of cannabis on young patients?

    <p>The stage of brain development at exposure influences outcomes</p> Signup and view all the answers

    What did the results of the studies by Caspi et al. and Estrada et al. primarily focus on?

    <p>Gene-environment interactions impacting schizophrenia risk</p> Signup and view all the answers

    Which of the following outcomes is suggested to correlate with the COMT Val158Met genotype according to research?

    <p>Age at onset of schizophrenia spectrum disorders</p> Signup and view all the answers

    What implication does the research suggest about cannabis sensitivity during adolescence?

    <p>Cannabis may have more significant effects due to brain development</p> Signup and view all the answers

    Which of the following drugs is known to stimulate the synthesis of dopamine?

    <p>L-DOPA</p> Signup and view all the answers

    What increases as a result of chlorpromazine administration according to Carlsson & Lindqvist's findings?

    <p>Dopamine metabolites</p> Signup and view all the answers

    What does the dopamine hypothesis suggest is the cause of positive symptoms in schizophrenia?

    <p>Overactivity of dopaminergic synapses</p> Signup and view all the answers

    What was the main conclusion regarding potent anti-schizophrenic drugs and their action?

    <p>They selectively bind to D2 receptors.</p> Signup and view all the answers

    What did Snyder demonstrate about the binding of drugs to D2 receptors?

    <p>It correlates with their efficacy as anti-schizophrenic agents.</p> Signup and view all the answers

    Which of the following statements best describes chlorpromazine's mechanism of action?

    <p>It acts as a receptor blocker at dopamine synapses.</p> Signup and view all the answers

    What was a significant gap in the early version of the dopamine hypothesis?

    <p>Ignores the role of neurodevelopmental deficits.</p> Signup and view all the answers

    What is a common feature of ineffective agents in relation to dopamine receptors?

    <p>They show low affinity for dopamine receptors.</p> Signup and view all the answers

    What is the primary cause of positive symptoms of schizophrenia according to the dopamine hypothesis?

    <p>Excess of dopamine in the mesolimbic pathway</p> Signup and view all the answers

    What compound was discovered by Henri Laborit that initially showed anti-anxiety effects?

    <p>Promethazine</p> Signup and view all the answers

    Which of the following statements is true about chlorpromazine?

    <p>It is frequently associated with mild motor side effects resembling Parkinson’s disease</p> Signup and view all the answers

    What was a key finding of Ehringer and Hornykiewicz in 1960 regarding Parkinson's disease?

    <p>There was a significant reduction of dopamine in the striatum</p> Signup and view all the answers

    What effect do dopamine agonists have on the positive symptoms of schizophrenia?

    <p>They exacerbate the symptoms</p> Signup and view all the answers

    What type of symptoms did chlorpromazine primarily reduce in patients with schizophrenia?

    <p>Positive symptoms</p> Signup and view all the answers

    What is a limitation of the dopamine hypothesis regarding schizophrenia?

    <p>The exact reasons for the excess dopamine activity are unknown</p> Signup and view all the answers

    Reserpine was discovered to be effective as an anti-schizophrenic agent from which plant?

    <p>Snakeroot</p> Signup and view all the answers

    Study Notes

    Cannabis Use and Schizophrenia

    • Cannabis use during adolescence is associated with an increased risk of developing schizophrenic-type disorders for individuals with the Val variant of the COMT gene.
    • Individuals with the Met variant of the COMT gene are not affected by cannabis use.
    • The earlier someone first used cannabis, the earlier the age of onset of schizophrenia-spectrum disorder.
    • The COMT Val158Met genotype modulates the association between cannabis use and the age at onset of schizophrenia-spectrum disorders.
    • Val/Val genotype carriers have an earlier age at onset of disorder than Met carriers.

    Risk Factors for Schizophrenia

    • Highest Risk Factors
      • Having a first-degree relative with schizophrenia (mother, father, sibling).
      • Being the offspring of an immigrant from selected countries.
    • Intermediate Risk Factors
      • Having antibodies to Toxoplasma gondii.
      • Being an immigrant from selected countries.
      • Being raised in an urban area.
      • Being a cannabis user.
      • Having minor physical anomalies.
      • A father over 55 years old.
    • Low Risk Factors
      • Head injuries in early childhood.
      • Obstetrical complications.
      • Having a father 45 or older.
      • Specific common genetic polymorphisms.
      • Birth seasonality.
      • Maternal exposure to influenza.
      • Extreme prenatal stress.

    Dopamine Hypothesis of Schizophrenia

    • The dopamine hypothesis explains positive symptoms of schizophrenia as being caused by an excess of dopamine in the mesolimbic pathway.
    • Chlorpromazine, an effective anti-psychotic agent, was discovered to block dopamine receptors.
    • Drugs like cocaine, amphetamine, methylphenidate (block reuptake of DA) and L-DOPA (stimulates synthesis of DA) reproduce positive symptoms of schizophrenia.
    • Anti-psychotic drugs alleviate these positive symptoms.
    • Chlorpromazine increases the level of dopamine metabolites and therefore reduces the amount of dopamine available at the synapses.
    • The potency of drugs like haloperidol as anti-schizophrenic agents is directly related to their affinity to D2 receptors.
    • The dopamine hypothesis has evolved to incorporate genetic and neurodevelopmental factors.

    Evidence of Abnormalities in DA Transmission

    • Dopamine levels cannot be measured directly in humans.
    • There is evidence of increased dopamine release in the striatum of individuals with schizophrenia.
    • Amphetamine causes greater dopamine release in the striatum of those with schizophrenia versus controls.
    • Individuals with greater amounts of dopamine release experience greater increases in positive symptoms.

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    Lecture 12 Schizophrenia PS403 PDF

    Description

    This quiz explores the complex relationship between cannabis use and the onset of schizophrenia, particularly focusing on the role of the COMT gene variants. It discusses how genetic factors and early cannabis exposure correlate with schizophrenia risk, alongside various environmental factors that may contribute to this disorder.

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