Cancer Systemic Therapy and Treatment Assessment

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Questions and Answers

What is the primary mechanism of action for alkylating agents in chemotherapy?

  • Promotion of microtubule assembly and stability
  • Inhibition of DNA topoisomerases
  • Interference with microtubule assembly
  • Alkylation of RNA and proteins (correct)

Which class of drugs in chemotherapy is known for its mechanism of intercalation between DNA base pairs?

  • Plant alkaloids
  • Antimetabolites
  • Topoisomerase inhibitors
  • Antibiotics (correct)

What is the primary mechanism of action for topoisomerase I inhibitors in chemotherapy?

  • Alkylation and cross-linking of DNA
  • Promotion of microtubule assembly and stability
  • Interference with microtubule assembly
  • Inhibition of DNA topoisomerases (correct)

Which phase of the cell cycle do taxanes primarily affect?

<p>M phase (D)</p> Signup and view all the answers

Which type of cancer shows a high level of chemosensitivity to chemotherapy?

<p>Hodgkin’s disease (A)</p> Signup and view all the answers

Which neoplasm is among the main therapeutic modalities for chemotherapy?

<p>Choriocarcinoma (D)</p> Signup and view all the answers

What is the primary mechanism of action for plant alkaloids, specifically Vinca alkaloids, in chemotherapy?

<p>Blockage of microtubule polymerization (A)</p> Signup and view all the answers

In which phase of the cell cycle do antimetabolites primarily interfere?

<p>S phase (A)</p> Signup and view all the answers

Which type of cancer is among the low level of chemosensitivity to chemotherapy?

<p>Pancreatic cancer (B)</p> Signup and view all the answers

In which neoplasm can primary chemotherapy allow for less mutilating surgery?

<p>Anal carcinoma (B)</p> Signup and view all the answers

Which class of drugs in chemotherapy is known for its mechanism of action involving DNA intercalation, inhibition of DNA topoisomerases, and free radical formation?

<p>Antibiotics (D)</p> Signup and view all the answers

Which neoplasm is among the main therapeutic modalities for chemotherapy?

<p>Hodgkin’s lymphoma (D)</p> Signup and view all the answers

What is the primary mechanism of action for anthracyclines in chemotherapy?

<p>Intercalation between DNA base pairs and free radical formation (C)</p> Signup and view all the answers

In which phase of the cell cycle do antimetabolites primarily interfere?

<p>S phase (D)</p> Signup and view all the answers

What is the primary mechanism of action for alkylating agents in chemotherapy?

<p>Chemical interaction with DNA by forming covalent bonds with nucleic acid (A)</p> Signup and view all the answers

Which type of cancer shows a high level of chemosensitivity to chemotherapy?

<p>Non-Hodkin’s lymphoma (D)</p> Signup and view all the answers

What is the primary mechanism of action for plant alkaloids, specifically Taxanes, in chemotherapy?

<p>Promotion of microtubule assembly and stability (A)</p> Signup and view all the answers

Which class of drugs in chemotherapy is known for its mechanism of action involving interference with the action of topoisomerase enzymes?

<p>Antimetabolites (A)</p> Signup and view all the answers

In which neoplasm can primary chemotherapy allow for less mutilating surgery?

<p>Breast cancer (C)</p> Signup and view all the answers

What is the primary mechanism of action for nitrogen mustards in chemotherapy?

<p>$cross-linking$ of DNA (A)</p> Signup and view all the answers

Which type of cancer shows a low level of chemosensitivity to chemotherapy?

<p>$NSCLC$ (Non-Small Cell Lung Cancer) (B)</p> Signup and view all the answers

What is the primary mechanism of action for topoisomerase I inhibitors in chemotherapy?

<p>Interference with topoisomerase enzymes that control changes in DNA (C)</p> Signup and view all the answers

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