Cancer Overview and History

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Questions and Answers

Based on the provided data, which cancer type has the highest number of estimated cases?

  • Lung cancer
  • Breast cancer
  • Skin (basal and squamous cell) (correct)
  • Prostate cancer

Which cancer type has the highest estimated death rate relative to its number of estimated cases?

  • Colon
  • Lung cancer (correct)
  • Prostate cancer
  • Breast cancer

If the number of cancer survivors is calculated by subtracting the number of estimated deaths from the number of estimated cases, approximately what percentage of patients diagnosed with prostate cancer survive?

  • 40%
  • 87.5% (correct)
  • 12.5%
  • 96%

According to the data, which cancer type is considered to be the least common?

<p>Skin (melanoma) (C)</p> Signup and view all the answers

What is the ratio of estimated deaths to estimated cases for skin cancer (melanoma)?

<p>2 to 3 (B)</p> Signup and view all the answers

What is the primary effect of a mutagen on DNA?

<p>It causes mutations in DNA. (B)</p> Signup and view all the answers

How many gene mutations are typically needed to transform a healthy cell into a cancerous cell?

<p>A few gene mutations. (D)</p> Signup and view all the answers

What is the role of oncogenes in cell division?

<p>They act as an accelerator to start cell division. (C)</p> Signup and view all the answers

What is the function of tumor-suppressor genes?

<p>To slow down or stop cell division. (A)</p> Signup and view all the answers

What happens when tumor-suppressor genes are damaged?

<p>Cell growth becomes erratic, potentially leading to cancer. (D)</p> Signup and view all the answers

What are the two broad categories of genes that control cell division, according to the content?

<p>Oncogenes and tumor-suppressor genes. (C)</p> Signup and view all the answers

Based on the provided content, what is the relationship between radiation and cancer?

<p>There is a clear link between radiation and cancer. (A)</p> Signup and view all the answers

What is a characteristic of cancer-causing genes?

<p>They regulate the speed of cell growth and division. (D)</p> Signup and view all the answers

What is the primary reason it's difficult to compare cancer rates from the past to present?

<p>Cancer diagnosis and understanding were limited in the past. (D)</p> Signup and view all the answers

What suggests that cancer existed in ancient times according to the text?

<p>Mummified remains showing bone lesions. (B)</p> Signup and view all the answers

Why is cancer not considered contagious?

<p>It arises from faulty genes within an individual's own cells. (C)</p> Signup and view all the answers

What does the term 'malignant' mean in the context of tumors?

<p>The tumor cells can spread to other parts of the body. (B)</p> Signup and view all the answers

What did Hippocrates observe about malignant tumors that led to the term 'carcinoma'?

<p>That they had swollen blood vessels. (D)</p> Signup and view all the answers

What is a tumor?

<p>A cluster of cells not part of the body's original plan. (B)</p> Signup and view all the answers

What is the primary function of cell division in the human body?

<p>To facilitate growth, repair, and replacement of cells. (A)</p> Signup and view all the answers

A tumor that is determined to be benign is characterized by:

<p>Its cells being contained in one area. (D)</p> Signup and view all the answers

The oldest known description of cancer was found on an Egyptian pappyri, and referred to:

<p>tumors of the breast (A)</p> Signup and view all the answers

Which statement best describes the role of genes in healthy cell division?

<p>They limit or control the cell's ability to divide to maintain homeostasis. (B)</p> Signup and view all the answers

What causes cells to undergo programmed cell death?

<p>The need for replacement by newer cells. (B)</p> Signup and view all the answers

What is the result of damage in genes responsible for cell division?

<p>The cells are no longer restrained and divide uncontrollably, causing cancer. (D)</p> Signup and view all the answers

What environmental factors may contribute to higher rates of cancer?

<p>Pesticide runoff and pollution in urban areas. (B)</p> Signup and view all the answers

What is a characteristic of red blood cells mentioned in the text?

<p>They do not make copies of themselves. (A)</p> Signup and view all the answers

What is the relationship between DNA, genes and cell division?

<p>Genes are segments of DNA that provide instructions for healthy cell division. (D)</p> Signup and view all the answers

What do 'environmental factors' refer to in the context of cancer development?

<p>External influences such as pollution and pesticides that may contribute to cancer. (C)</p> Signup and view all the answers

Flashcards

What is a tumor?

A group of cells that grow abnormally and are not part of the body's original plan.

What is the oldest known description of cancer?

The oldest known description of cancer was found on an Egyptian papyri written between 3000-2000 BC. This writing referred to tumors of the breast.

Is cancer contagious?

Cancer is not contagious because it does not involve the transmission of pathogens. Cancer is caused by a faulty gene in your own cells.

What is the difference between malignant and benign tumors?

A malignant tumor is a growth that spreads to other parts of the body, while a benign tumor is contained to one area and does not spread.

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Who is credited with recognizing the difference between benign and malignant tumors?

The ancient Greek philosopher Hippocrates is credited with recognizing the difference between benign and malignant tumors.

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What is the origin of the term 'carcinoma'?

Hippocrates noticed that blood vessels swell around malignant tumors. He compared this to crab claws and named the disease 'karkinos', which translates to 'carcinoma'.

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Benign Tumor

Tumors can be classified based on the behavior of the cells. Benign tumors are non-cancerous, slow-growing, and do not spread.

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Malignant Tumor

Malignant tumors are cancerous, invasive, spread to other parts of the body, and can cause death.

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Why did Hippocrates call it 'cancer'?

Hippocrates was an ancient Greek physician who lived in the 5th century BC. He described tumors as resembling a crab due to their tendrils, which he believed gripped onto surrounding tissue.

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What is Cancer?

The term 'cancer' is used to describe a disease where cells grow and divide uncontrollably, forming malignant tumors that invade surrounding tissues and can spread to other parts of the body.

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What causes cancer?

Cancer arises from damage to genes that control cell division. These damaged genes allow cells to divide unchecked, leading to the formation of tumors.

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Why do cells divide?

Cells divide for normal biological processes like growth, repair, and replacement.

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What is programmed cell death?

Cells have a programmed cell death mechanism. Old cells need to be replaced by new ones.

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Environmental factors and cancer

Environmental factors, such as pollution and pesticides, have been linked to increased cancer rates in certain areas.

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What are mutagens?

Substances that can damage DNA, leading to genetic mutations.

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What are oncogenes?

Genes that regulate and stimulate cell division, acting as an accelerator for cell growth.

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What are tumor-suppressor genes?

Genes that control and suppress cell division, acting as brakes to regulate growth.

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Which cancer type is most common?

The cancer type with the highest number of estimated cases.

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What is cell division?

The process of a cell dividing into two identical daughter cells.

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Which cancer type is least common?

The cancer type with the lowest number of estimated cases.

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Why do cells need to divide?

  1. Growth and development: for an organism to grow, more cells are needed.
  2. Repair and replacement: damaged or worn-out cells need to be replaced.
  3. Reproduction: some organisms reproduce by cell division.
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How to Calculate Survival Rate

Survival rate is the percentage of individuals who survive a particular cancer. It can be calculated by dividing the number of survivors by the total number of estimated cases and multiplying by 100%.

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What is a mutation?

A change in the sequence of DNA caused by damage or errors during replication.

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Which cancer type seems to be least treatable?

The cancer type with the biggest difference between estimated cases and estimated deaths.

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Which cancer type seems to be most treatable?

The cancer type with the smallest difference between estimated cases and estimated deaths.

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Study Notes

Cancer Overview

  • Cancer is a serious, complex disease affecting humans throughout history
  • Cancer incidence rates are difficult to compare historically due to differing diagnoses
  • Cancer is not contagious; it results from faulty genes within cells
  • Tumors are clusters of cells; malignant tumors spread to other body parts, benign tumors remain contained
  • Hippocrates recognized distinction between benign and malignant cancers, coining the term karkinos (crab), translating to carcinoma

History of Cancer

  • Ancient Egyptians and Peruvians documented breast and bone tumors
  • Cancer was not well understood for centuries, making historical incidence difficult to measure
  • Hippocrates, the Greek philosopher, recognized different types of tumors, noticing swollen blood vessels around malignant ones
  • The term "carcinoma" derives from Hippocrates' observation of crab-like tumor growth

What is Cancer?

  • Cells divide for growth, repair and replacement
  • Cellular reproduction is regulated by genes
  • Cancer originates from damaged genes that affect cellular division control
  • Damaged genes can lead to uncontrolled cell growth, resulting in tumors

Causes of Cancer

  • Environmental factors may be linked to higher cancer rates in certain areas, such as polluted urban environments
  • Pollutants and radiation act as mutagens, substances damaging DNA
  • Cancer-causing alterations can be introduced through few gene mutations in cells
  • Two types of genes regulate cell division include oncogenes and tumor suppressor genes
  • Oncogenes act like an accelerator, promoting cell division while tumour suppressors act as brakes, slowing cell division

Types of Cancer

  • Cancer can affect many organs and can present in various forms (basal/squamous cell skin cancer, breast cancer, lung cancer, prostate cancer, colon cancer)
  • Specific cancers vary in treatable outcomes

Important Figures

  • Hippocrates - Ancient Greek philosopher who identified the differences in tumors and recognized the importance of blood vessel swelling around malignant tumors

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