Cancer Drug Regimens: Induction, Consolidation, and Maintenance Therapy

Play an AI-generated podcast conversation about this lesson

Which class of cell cycle specific inhibitors specifically targets the M phase of the cell cycle?

Vinca alkaloids (correct)

Antimetabolites

Topoisomerase I inhibitors

Folate antagonists

Which cytotoxic drug class is effective for both low and high growth fraction malignancies?

Cell cycle non-specific agents (correct)

Cell cycle specific agents

Antimetabolites

Topoisomerase II inhibitors

Which adverse effect is commonly associated with the use of cytotoxic drugs?

Reduced gastrointestinal toxicity

Improved hair growth

Myelosuppression (correct)

Increased wound healing

Which class of cytotoxic drugs specifically targets the G1-S phase of the cell cycle?

Topoisomerase II inhibitors Signup and view all the answers

What is the purpose of combining different classes of cytotoxic drugs in a chemotherapy regimen?

To target specific phases of the cell cycle Signup and view all the answers

Which class of cytotoxic drugs is considered a cell cycle non-specific agent?

Alkylating agents Signup and view all the answers

What is the key hypothesis regarding the effectiveness of repeated courses of cancer treatment?

Each course of therapy eliminates a constant fraction of the remaining tumour cells, which reduces the number of tumour cells to a level the immune system can eradicate. Signup and view all the answers

What is the relationship between tumour size and the effectiveness of cancer treatment?

The smaller the tumour, the more effective the cancer treatment will be. Signup and view all the answers

What is the purpose of systemic anticancer treatment?

All of the above are purposes of systemic anticancer treatment. Signup and view all the answers

How do cytotoxic drugs used in cancer treatment affect the cell cycle?

Cytotoxic drugs are cell cycle-specific, targeting cells in specific phases of the cell cycle. Signup and view all the answers

What is the purpose of surgical removal of a tumour in the context of cancer treatment?

Surgical removal of a tumour supports the subsequent use of chemotherapy and other systemic treatments. Signup and view all the answers

Which of the following is a key advantage of catching cancer early?

Early detection leads to a higher likelihood of successful surgical removal of the tumour. Signup and view all the answers

What is the purpose of induction therapy in cancer treatment?

To produce a rapid reduction in tumor cell burden and symptomatic improvement Signup and view all the answers

Why are cancer treatments administered as intermittent courses rather than continuous therapy?

To allow the bone marrow and other normal host cells to recover between treatment courses and reduce toxicity Signup and view all the answers

Which of the following statements about cytotoxic therapy is correct?

For rapid-growing tumors, a given dose of cytotoxic drug destroys a constant fraction of malignant cells Signup and view all the answers

What is the main challenge in cancer chemotherapy related to the different compartments of tumor cells?

The existence of compartment B, which contains cells that are not very sensitive to cytotoxic drugs and can re-enter compartment A after chemotherapy Signup and view all the answers

What is the purpose of consolidation therapy in cancer treatment?

To complete and extend the remission Signup and view all the answers

Which statement best describes the role of maintenance therapy in cancer treatment?

To sustain the remission as long as possible Signup and view all the answers