Cancer Drug Regimens: Induction, Consolidation, and Maintenance Therapy
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Questions and Answers

Which class of cell cycle specific inhibitors specifically targets the M phase of the cell cycle?

  • Vinca alkaloids (correct)
  • Antimetabolites
  • Topoisomerase I inhibitors
  • Folate antagonists

Which cytotoxic drug class is effective for both low and high growth fraction malignancies?

  • Cell cycle non-specific agents (correct)
  • Cell cycle specific agents
  • Antimetabolites
  • Topoisomerase II inhibitors

Which adverse effect is commonly associated with the use of cytotoxic drugs?

  • Reduced gastrointestinal toxicity
  • Improved hair growth
  • Myelosuppression (correct)
  • Increased wound healing

Which class of cytotoxic drugs specifically targets the G1-S phase of the cell cycle?

<p>Topoisomerase II inhibitors (A)</p> Signup and view all the answers

What is the purpose of combining different classes of cytotoxic drugs in a chemotherapy regimen?

<p>To target specific phases of the cell cycle (C)</p> Signup and view all the answers

Which class of cytotoxic drugs is considered a cell cycle non-specific agent?

<p>Alkylating agents (C)</p> Signup and view all the answers

What is the key hypothesis regarding the effectiveness of repeated courses of cancer treatment?

<p>Each course of therapy eliminates a constant fraction of the remaining tumour cells, which reduces the number of tumour cells to a level the immune system can eradicate. (C)</p> Signup and view all the answers

What is the relationship between tumour size and the effectiveness of cancer treatment?

<p>The smaller the tumour, the more effective the cancer treatment will be. (C)</p> Signup and view all the answers

What is the purpose of systemic anticancer treatment?

<p>All of the above are purposes of systemic anticancer treatment. (D)</p> Signup and view all the answers

How do cytotoxic drugs used in cancer treatment affect the cell cycle?

<p>Cytotoxic drugs are cell cycle-specific, targeting cells in specific phases of the cell cycle. (A)</p> Signup and view all the answers

What is the purpose of surgical removal of a tumour in the context of cancer treatment?

<p>Surgical removal of a tumour supports the subsequent use of chemotherapy and other systemic treatments. (B)</p> Signup and view all the answers

Which of the following is a key advantage of catching cancer early?

<p>Early detection leads to a higher likelihood of successful surgical removal of the tumour. (B)</p> Signup and view all the answers

What is the purpose of induction therapy in cancer treatment?

<p>To produce a rapid reduction in tumor cell burden and symptomatic improvement (C)</p> Signup and view all the answers

Why are cancer treatments administered as intermittent courses rather than continuous therapy?

<p>To allow the bone marrow and other normal host cells to recover between treatment courses and reduce toxicity (D)</p> Signup and view all the answers

Which of the following statements about cytotoxic therapy is correct?

<p>For rapid-growing tumors, a given dose of cytotoxic drug destroys a constant fraction of malignant cells (D)</p> Signup and view all the answers

What is the main challenge in cancer chemotherapy related to the different compartments of tumor cells?

<p>The existence of compartment B, which contains cells that are not very sensitive to cytotoxic drugs and can re-enter compartment A after chemotherapy (C)</p> Signup and view all the answers

What is the purpose of consolidation therapy in cancer treatment?

<p>To complete and extend the remission (C)</p> Signup and view all the answers

Which statement best describes the role of maintenance therapy in cancer treatment?

<p>To sustain the remission as long as possible (B)</p> Signup and view all the answers

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