Cancer Biology: Small Molecule Inhibitors
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Questions and Answers

How do small molecule inhibitors exert their anti-cancer effects?

  • a) By directly killing cancer cells through necrosis.
  • b) By inducing mutations in cancer-related genes.
  • c) By targeting specific molecules or pathways essential for cancer cell survival and proliferation. (correct)
  • d) By enhancing DNA repair mechanisms in cancer cells.

    • What is the primary goal of personalized cancer therapy?

  • a) To target cancer cells indiscriminately.
  • b) To identify specific molecular alterations in individual tumors and tailor treatment accordingly. (correct)
  • c) To administer the same treatment to all cancer patients.
  • d) To prevent cancer recurrence in healthy individuals.

    • What is the potential benefit of combining small molecule inhibitors with immunotherapy in cancer treatment?

  • a) Decreased toxicity.
  • b) Increased risk of drug resistance.
  • c) Enhanced anti-tumor immune response. (correct)
  • d) Inhibition of DNA repair mechanisms.

    • What is the primary advantage of small molecule inhibitors over traditional chemotherapy drugs?

    <p>a) Greater specificity for cancer cells.</p> Signup and view all the answers

    Which of the following is a limitation of small molecule inhibitors in cancer therapy?

    <p>b) Resistance mechanisms that can develop over time.</p> Signup and view all the answers

    Which of the following is a well-known small molecule inhibitor targeting the BCR-ABL fusion protein in chronic myeloid leukemia (CML)?

    <p>b) Imatinib.</p> Signup and view all the answers

    What is the primary mechanism of resistance to small molecule inhibitors targeting the epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC)?

    <p>d) Acquisition of secondary mutations in the EGFR kinase domain.</p> Signup and view all the answers

    How do small molecule inhibitors targeting angiogenesis inhibit tumor growth?

    <p>c) By inhibiting vascular endothelial growth factor (VEGF) signaling.</p> Signup and view all the answers

    describe the action of tyrosine kinase inhibitors

    <p>tyrosine kinase inhibitors work by binding to the active site of tyrosine kinases preventing the binding of ATP which prevents enzymatic activity which blocks pathways involved in cell growth, proliferation and survival by disrupting downstream oncogenic signalling cascades</p> Signup and view all the answers

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