Cancer Biology Quiz
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Questions and Answers

What suffix is used to denote a benign neoplasm?

  • -itis
  • -oma (correct)
  • -sarcoma
  • -carcinoma
  • Which of the following is an example of a benign mesenchymal neoplasm?

  • Carcinoma
  • Melanoma
  • Fibrosarcoma
  • Osteoma (correct)
  • What type of malignant neoplasm arises from mesenchymal tissues?

  • Adenoma
  • Fibroma
  • Carcinoma
  • Sarcoma (correct)
  • Which characteristic is NOT typically associated with malignant cells?

    <p>Uniform nuclear size (A)</p> Signup and view all the answers

    Which of the following neoplasms is incorrectly classified as malignant?

    <p>Dermatofibroma (A)</p> Signup and view all the answers

    What term describes the variation in size and shape of nuclei from cell to cell in cancer cells?

    <p>Anisokaryosis (A)</p> Signup and view all the answers

    What is the term for dedifferentiation of normal cells during tumorigenesis?

    <p>Anaplasia (A)</p> Signup and view all the answers

    Which of the following best describes abnormal mitotic figures?

    <p>Abnormalities in cell division (A)</p> Signup and view all the answers

    What is the definition of a neoplasm?

    <p>An abnormal mass of tissue with unregulated growth (C)</p> Signup and view all the answers

    What are oncogenes?

    <p>Mutated genes that cause uncontrolled cell growth (D)</p> Signup and view all the answers

    What is a proto-oncogene?

    <p>A gene that regulates normal cell growth and can mutate into an oncogene (B)</p> Signup and view all the answers

    Which factor underlies the persistence of tumors?

    <p>Autonomous genetic alterations in tumor cells (C)</p> Signup and view all the answers

    Which statements describes carcinogenesis?

    <p>Environmental agents can cause genetic damage leading to cancer (C)</p> Signup and view all the answers

    What is the primary cause of oncogenes formation?

    <p>Mutations in proto-oncogenes (A)</p> Signup and view all the answers

    What does 'nonlethal genetic damage' signify in cancer development?

    <p>Mutations that can lead to malignant transformations over time (C)</p> Signup and view all the answers

    Which of the following is NOT a factor in the development of oncogenes?

    <p>Normal cellular division processes (D)</p> Signup and view all the answers

    What type of tumors are formed by the clonal expansion of a single precursor cell?

    <p>Monoclonal tumors (B)</p> Signup and view all the answers

    Which class of genes primarily inhibits cell growth?

    <p>Tumor suppressor genes (D)</p> Signup and view all the answers

    Which term describes a tumor that does not invade surrounding tissues or metastasize?

    <p>Benign tumor (B)</p> Signup and view all the answers

    What is the characteristic behavior of malignant tumors?

    <p>They can spread to distant sites. (B)</p> Signup and view all the answers

    Which of the following is NOT a target gene class related to tumor formation?

    <p>Genes involved in blood clotting (A)</p> Signup and view all the answers

    What is the key process in carcinogenesis?

    <p>Multistep genetic damage (D)</p> Signup and view all the answers

    Which of the following statements about benign tumors is true?

    <p>They can cause serious disease despite being localized. (C)</p> Signup and view all the answers

    What term is used to describe malignant tumors collectively?

    <p>Cancers (C)</p> Signup and view all the answers

    What type of immune response is primarily produced by T cells?

    <p>Cell-mediated immune response (D)</p> Signup and view all the answers

    Which cells play a significant protective role against virus-associated neoplasms?

    <p>Cytotoxic T lymphocytes (A)</p> Signup and view all the answers

    Which of the following statements about antibodies in tumor immunity is true?

    <p>They are ineffective against spontaneous tumors. (D)</p> Signup and view all the answers

    What concept was coined by Lewis Thomas and Macfarlane Burnet regarding tumor immunity?

    <p>Immune surveillance (A)</p> Signup and view all the answers

    Natural killer (NK) cells are known for their ability to do what?

    <p>Act as the first line of defense against tumors (C)</p> Signup and view all the answers

    What is the primary mechanism of anti-tumor immunity in vivo?

    <p>Cell-mediated immunity (B)</p> Signup and view all the answers

    What role do activated macrophages play in tumor immunity?

    <p>They exhibit cytotoxicity against tumor cells. (B)</p> Signup and view all the answers

    How do tumor cells typically avoid detection by the immune system?

    <p>By developing mechanisms to escape immune recognition (D)</p> Signup and view all the answers

    What is defined as the transfer of malignant cells from one site to another not directly connected with it?

    <p>Metastasis (B)</p> Signup and view all the answers

    Which characteristic is typically associated with benign neoplasms in terms of differentiation?

    <p>Well differentiated (A)</p> Signup and view all the answers

    How do malignant neoplasms generally grow compared to benign neoplasms?

    <p>They grow rapidly and at an erratic pace (B)</p> Signup and view all the answers

    Which of the following is a step in the mechanism of tumor invasion?

    <p>Embolization (C)</p> Signup and view all the answers

    Which of the following neoplasms is unlikely to metastasize?

    <p>Basal cell carcinoma (B)</p> Signup and view all the answers

    What describes the state of malignant cells that lack differentiation?

    <p>Anaplastic (A)</p> Signup and view all the answers

    What is the general trend in the growth rate of malignant neoplasms compared to benign neoplasms?

    <p>Malignant neoplasms grow more rapidly (C)</p> Signup and view all the answers

    Which characteristic of malignant neoplasms distinguishes them from benign neoplasms in terms of local invasion?

    <p>Infiltrate and destroy surrounding tissue (B)</p> Signup and view all the answers

    What distinguishes cachexia from starvation in terms of weight loss?

    <p>Equal loss of fat and lean muscle (A)</p> Signup and view all the answers

    What is the primary role of the innate immune system?

    <p>To act rapidly against pathogens (D)</p> Signup and view all the answers

    Which of the following components is NOT part of the innate immune system?

    <p>B lymphocytes (D)</p> Signup and view all the answers

    What is the main characteristic of the adaptive immune system?

    <p>It develops memory against specific pathogens (B)</p> Signup and view all the answers

    The components of the immune system work together to identify and eliminate foreign invaders by recognizing what?

    <p>Self and non-self (A)</p> Signup and view all the answers

    Which type of immunity is characterized by being present from birth?

    <p>Innate immunity (B)</p> Signup and view all the answers

    Which cells are primarily responsible for the adaptive immune response?

    <p>T and B lymphocytes (C)</p> Signup and view all the answers

    What happens when a pathogen breaches the innate defenses?

    <p>The adaptive immune system becomes activated (D)</p> Signup and view all the answers

    Flashcards

    Neoplasm

    An abnormal tissue mass that grows uncontrollably, independent of normal tissue growth signals.

    Oncogenes

    Mutated genes that promote excessive cell growth, leading to cancer.

    Proto-oncogenes

    Normal genes responsible for cell growth and division.

    Carcinogenesis

    The process of cancer development.

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    Genetic Damage

    Mutations that can lead to uncontrolled cell growth and cancer.

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    Environmental Agents

    Substances like chemicals, radiation, or infectious agents that can cause genetic damage.

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    Tumor

    A mass of tissue that can be cancerous or non-cancerous.

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    Autonomous Growth

    Growth independent of normal signals like hormones, that regulates the growth of cells in a normal body.

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    Tumor Formation

    Tumors arise from the uncontrolled growth and division of a single, damaged cell.

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    Benign Tumor

    A non-cancerous tumor that stays localized and rarely spreads.

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    Malignant Tumor

    A cancerous tumor that can invade surrounding tissues and spread to other parts of the body (metastasize).

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    Cancer

    An umbrella term for malignant tumors.

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    Monoclonal Tumor

    A tumor that arises from a single progenitor cell.

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    Multiclonal Tumor

    A tumor that arises from multiple progenitor cells.

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    Benign neoplasm suffix

    The suffix '-oma' indicates a benign tumor.

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    Mesenchymal tumor naming

    Benign tumors originating from connective tissues like muscle, bone, fat, and cartilage are named based on the tissue type with '-oma' added.

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    Epithelial tumor naming

    Benign tumors from glandular epithelium are called 'adenomas', breast tumors are 'fibroadenomas', and smooth muscle tumors are 'leiomyomas'.

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    Sarcoma

    A malignant tumor originating from mesenchymal tissues.

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    Carcinoma

    A malignant tumor originating from epithelial cells, derived from any of the three germ layers.

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    Nucleo-cytoplasmic ratio

    The ratio of the size of the nucleus to the size of the cytoplasm in a cell. It's increased in malignant cells.

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    Nuclear Hyperchromasia

    Increased density of the chromatin in the nucleus of a cell, often observed in malignant cells.

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    Anisokaryosis

    Variation in the size and shape of nuclei from cell to cell, a characteristic of cancer cells.

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    Metastasis

    The spread of cancer cells from their original site to other parts of the body.

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    What is the most reliable indicator of malignancy?

    Metastasis is the most reliable sign of malignancy.

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    Anaplasia

    The loss of differentiation in cells, making them more primitive and abnormal. This is often seen in malignant tumors.

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    Differentiation in tumors

    The degree to which cancer cells resemble the normal cells of their origin. Well-differentiated tumors are closer to normal cells.

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    Rate of growth in tumors

    Benign tumors typically grow slowly, while malignant tumors tend to grow rapidly and sometimes erratically.

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    Local invasion

    The ability of a tumor to spread into surrounding tissues, which is more common in malignant tumors.

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    Carcinoma in-situ

    A group of abnormal cells confined to the original location where they formed, without invading surrounding tissue.

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    How do malignant cells invade the basement membrane?

    Malignant cells release enzymes like collagenase type IV and other proteases that break down the basement membrane, allowing invasion.

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    Cachexia

    A complex syndrome characterized by severe weight loss, muscle wasting, and loss of appetite, often associated with chronic diseases like cancer.

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    Tumor Burden

    The size and extent of a tumor, reflecting the amount of cancerous tissue present in the body.

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    Immunology

    The study of the body's immune system, encompassing the molecules, cells, organs, and systems involved in defending against pathogens.

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    Immunity

    The ability of the body to resist infection and disease, protecting against harmful microorganisms.

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    Non-Specific Immunity

    The innate immune system, present at birth, providing a first line of defense against pathogens with general mechanisms.

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    Specific Immunity

    The adaptive immune system, developing over time, providing a targeted and specific defense against pathogens with memory.

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    Adaptive Immune System

    The acquired immune system that develops over time and specifically targets pathogens, relying on T and B lymphocytes.

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    Innate Immune System

    The natural immune system that provides the first line of defense, acting immediately and non-specifically.

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    Immune Surveillance

    The body's natural defense mechanism that identifies and eliminates emerging cancer cells.

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    Cell-mediated Immunity

    The primary anti-tumor mechanism where immune cells directly attack and destroy cancer cells.

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    Cytotoxic T Lymphocytes (CTLs)

    A type of immune cell that directly kills cancer cells, especially those infected by viruses.

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    Natural Killer (NK) Cells

    Immune cells that can kill cancer cells without prior sensitization, acting as the first line of defense.

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    Macrophages

    Immune cells that engulf and destroy cancer cells, often activated by other immune cells like T cells and NK cells.

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    Monoclonal Antibodies

    Highly specific antibodies produced in the lab that can target cancer cells for destruction.

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    Immune Escape

    Strategies used by tumor cells to avoid detection and destruction by the immune system.

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    Tumour Immunity

    The body's ability to recognize and respond to cancer cells.

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