Cancer and Tumor Grading in the Brain

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Questions and Answers

What is the primary characteristic of primary brain tumors?

  • They originate from tissues outside the brain.
  • They are always malignant and invasive.
  • They tend to spread to other parts of the body.
  • They begin in the brain and tend to stay in the brain. (correct)

Which factor is commonly linked to the development of brain tumors?

  • Consuming high amounts of water.
  • Genetic predisposition and hereditary factors. (correct)
  • Excessive physical activity.
  • Frequent use of smartphones.

Which symptom is NOT commonly associated with brain tumors?

  • Unusual headaches.
  • Seizures.
  • Visual changes such as blurred vision.
  • Increased physical endurance. (correct)

What percentage of admissions in brain tumor rehabilitation studies are typically associated with Glioblastoma?

<p>30% (C)</p> Signup and view all the answers

Which environmental factor has been implicated in the etiology of brain tumors?

<p>Pesticides and chemicals. (D)</p> Signup and view all the answers

What is a significant side effect of chemotherapy that can impact rehabilitation?

<p>Nausea and vomiting (D)</p> Signup and view all the answers

Which medication can be used to help manage nausea during chemotherapy?

<p>Ondansetron (C)</p> Signup and view all the answers

What is a common risk associated with chemotherapy that involves blood cell counts?

<p>Neutropenia (A)</p> Signup and view all the answers

Which of the following is a potential long-term side effect of radiation therapy?

<p>Cognitive decline (D)</p> Signup and view all the answers

What percentage range represents the incidence of postoperative deep vein thrombosis (DVT) in patients with high-grade gliomas?

<p>3%–60% (D)</p> Signup and view all the answers

Which of the following can occur as a side effect of radiation therapy?

<p>Local alopecia (D)</p> Signup and view all the answers

What complication can arise from surgery in patients with brain tumors regarding blood clots?

<p>Deep vein thrombosis (C)</p> Signup and view all the answers

What can corticosteroids help alleviate during radiation therapy?

<p>Nausea and vomiting (C)</p> Signup and view all the answers

What is the primary concern for patients undergoing surgery for brain tumors regarding their functional status?

<p>All of the above (D)</p> Signup and view all the answers

Why is chemotherapy not commonly used for benign brain tumors?

<p>It is ineffective for benign tumors. (B)</p> Signup and view all the answers

What are common side effects of radiation therapy for brain tumor patients?

<p>Hair loss and fatigue (A)</p> Signup and view all the answers

What complication should be monitored in brain tumor patients post-surgery?

<p>Deep vein thrombosis (DVT) (D)</p> Signup and view all the answers

What is a major concern for caregivers of brain tumor patients?

<p>Safety and caregiving responsibilities (B)</p> Signup and view all the answers

What factors are considered to ideally select a candidate for brain tumor surgery?

<p>Patient age, functional status, and accessibility of lesions (A)</p> Signup and view all the answers

Which tumor grade indicates the fastest growth and highest aggressiveness?

<p>Grade IV (B)</p> Signup and view all the answers

How can care of the caregiver be impacted in families dealing with brain tumors?

<p>It takes a secondary or tertiary place. (B)</p> Signup and view all the answers

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Study Notes

Brain Tumors Overview

  • Originates from abnormal cells in the brain or central spine canal, leading to growth that forms a mass.
  • Tumors are classified as primary (originating in the brain) or metastatic (spreading from other body sites).
  • Always malignant when metastasized.

Tumor Grading (WHO System)

  • Grade I: Least malignant, slow growth.
  • Grade II: Slow growing, potential for spread and recurrence.
  • Grade III: Faster growth, higher malignancy, often recurring.
  • Grade IV: Most aggressive, fastest growing; may consist of various cell grades.

Common Primary Brain Tumors

  • Meningioma
  • Gliomas:
    • Low Grade Astrocytoma
    • Malignant Astrocytoma
    • Glioblastoma
    • Oligodendroglioma
  • Medulloblastoma

Family Impact of Brain Tumors

  • Shift in traditional family roles and dynamics.
  • Possibility of single parenting within two-parent households.
  • Loss of existing relationships and changes in caregiving responsibilities.
  • Emotional fears related to seizures, behavioral changes, future uncertainties, and caregiver neglect.

Treatment and Rehabilitation Implications

  • Surgery:

    • Primary treatment for most patients; improves survival and quality of life.
    • Ideal candidates: surgically accessible tumors, good functional status, younger patients, well-controlled primary tumors.
  • Chemotherapy:

    • Not typically effective for benign or metastatic tumors.
    • Increasing use in primary malignant tumors; side effects include nausea and thrombocytopenia.
  • Radiation Therapy:

    • Uses high-energy beams to damage tumor cells; administered on an outpatient basis.
    • Side effects: skin issues, fatigue, cognitive decline, and potential long-term memory impairment.
    • Corticosteroids may alleviate symptoms during treatment.
  • Deep Vein Thrombosis (DVT):

    • Patients with brain tumors are at risk for thromboembolic events, with DVT incidence ranging from 3%-60% post-surgery, affected by prophylaxis used.

Epidemiology

  • Incidence of brain tumors: 8-25 per 100,000 individuals.
  • Second leading cause of cancer-related death.
  • Among rehabilitation admissions for brain tumors, approximately:
    • 30% are Glioblastoma
    • 25% are metastatic tumors (most commonly from lung and breast cancers)
    • 20% are meningiomas.

Common Symptoms of Brain Tumors

  • Unusual headaches.
  • Seizures.
  • Changes in memory, personality, or behavior.
  • Difficulty processing information.
  • Visual disturbances (blurred or double vision).
  • Changes in motor control.

Etiology Factors

  • Genetic predispositions and hereditary factors.
  • Viral infections, particularly Epstein-Barr linked to primary brain lymphoma.
  • Environmental exposures (e.g., pesticides, chemicals).

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