Questions and Answers
What is the purpose of distinguishing between a false positive and a true positive?
To avoid unnecessary referrals for invasive coronary angiography
What is a false positive TMT result?
An ischemic response and no obstructive coronary artery disease
What was used to evaluate the performance of the model based on predictive factors?
The area under the ROC curve
Study Notes
- False positive results are common in treadmill exercise ECG testing for obstructive coronary artery disease screening.
- It is important to distinguish between a false positive and a true positive to avoid unnecessary referrals for invasive coronary angiography.
- The study analyzed a cohort of patients referred for ICA for stable coronary artery disease diagnosis.
- Traditional and nontraditional coronary artery disease risk factors were assessed.
- Modified Framingham risk score, symptoms, pre-test probability of OCAD, left ventricular ejection fraction and ICA results were also evaluated.
- A FP TMT result was defined as an ischemic response and no OCAD.
- The predictors of a FP result were determined through statistical tests and multivariate analysis.
- The discriminatory power of a model based on predictive factors was assessed.
- The study was conducted in a single tertiary-care center from 2006-2011.
- The area under the ROC curve was used to evaluate the model's performance.
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