5 Questions
What is the role of calnexin in the assembly of MHC class I molecules?
It retains the MHC class I molecule in a partly folded state
What happens when β2-microglobulin binds to the α chain?
The MHC class I α:β2-microglobulin heterodimer dissociates from calnexin and binds to the MHC class I peptide-loading complex
What is the function of tapasin in the MHC class I peptide-loading complex?
It forms a bridge between MHC class I molecules and TAP
Which protein is similar to calnexin and probably also has a general chaperone function?
Calreticulin
What proteins does calnexin associate with in addition to MHC class I?
T-cell receptors, immunoglobulins, and MHC class II molecules
Test your knowledge on the role of calnexin in the assembly of immunological molecules like MHC class I α chains, T-cell receptors, and immunoglobulins.
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