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Questions and Answers
What is the role of calnexin in the assembly of MHC class I molecules?
What is the role of calnexin in the assembly of MHC class I molecules?
- It binds to the fully folded MHC class I α chain
- It binds to the β2-microglobulin
- It forms a bridge between MHC class I molecules and TAP
- It retains the MHC class I molecule in a partly folded state (correct)
What happens when β2-microglobulin binds to the α chain?
What happens when β2-microglobulin binds to the α chain?
- The MHC class I α:β2-microglobulin heterodimer stays in a partly folded state
- The MHC class I α:β2-microglobulin heterodimer binds to calnexin
- The MHC class I α:β2-microglobulin heterodimer dissociates from calnexin and binds to the MHC class I peptide-loading complex (correct)
- The MHC class I α:β2-microglobulin heterodimer binds to tapasin
What is the function of tapasin in the MHC class I peptide-loading complex?
What is the function of tapasin in the MHC class I peptide-loading complex?
- It binds to the β2-microglobulin
- It retains MHC class I in a partly folded state
- It binds to the fully folded MHC class I α chain
- It forms a bridge between MHC class I molecules and TAP (correct)
Which protein is similar to calnexin and probably also has a general chaperone function?
Which protein is similar to calnexin and probably also has a general chaperone function?
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What proteins does calnexin associate with in addition to MHC class I?
What proteins does calnexin associate with in addition to MHC class I?
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