Calnexin in Immunological Assembly

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Questions and Answers

What is the role of calnexin in the assembly of MHC class I molecules?

  • It binds to the fully folded MHC class I α chain
  • It binds to the β2-microglobulin
  • It forms a bridge between MHC class I molecules and TAP
  • It retains the MHC class I molecule in a partly folded state (correct)

What happens when β2-microglobulin binds to the α chain?

  • The MHC class I α:β2-microglobulin heterodimer stays in a partly folded state
  • The MHC class I α:β2-microglobulin heterodimer binds to calnexin
  • The MHC class I α:β2-microglobulin heterodimer dissociates from calnexin and binds to the MHC class I peptide-loading complex (correct)
  • The MHC class I α:β2-microglobulin heterodimer binds to tapasin

What is the function of tapasin in the MHC class I peptide-loading complex?

  • It binds to the β2-microglobulin
  • It retains MHC class I in a partly folded state
  • It binds to the fully folded MHC class I α chain
  • It forms a bridge between MHC class I molecules and TAP (correct)

Which protein is similar to calnexin and probably also has a general chaperone function?

<p>Calreticulin (C)</p> Signup and view all the answers

What proteins does calnexin associate with in addition to MHC class I?

<p>T-cell receptors, immunoglobulins, and MHC class II molecules (C)</p> Signup and view all the answers

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