Thoracic Anesthesia
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Questions and Answers

A patient with a tumor located in the anterior mediastinum is scheduled for surgery. What is the primary anesthetic concern regarding this tumor's location?

  • Compression of the trachea, potentially complicating intubation and positive pressure ventilation. (correct)
  • Increased risk of hemorrhage during surgical manipulation.
  • Development of a tension pneumothorax due to tumor invasion of the pleural space.
  • Potential for esophageal compression leading to dysphagia postoperatively.

During a mediastinoscopy, which anatomical structures are at greatest risk of injury, leading to significant complications?

  • Great vessels (aorta, vena cava) and pleura, predisposing to hemorrhage and pneumothorax. (correct)
  • Pulmonary veins and phrenic nerve, resulting in pulmonary edema and diaphragmatic paralysis.
  • Azygos vein, esophagus, and vagus nerve, leading to bleeding, dysphagia, and vocal cord paralysis.
  • Trachea and recurrent laryngeal nerve, causing airway obstruction and hoarseness.

The right mainstem bronchus has a larger diameter and a 25-degree angle of take-off from the trachea, whereas the left mainstem bronchus has a smaller diameter and a 45-degree angle of take-off. During intubation with a standard ETT, why is there is a risk of mainstem intubation?

  • The cuff of the ETT is able to fully expand in the right bronchus, preventing dislodgement.
  • The larger diameter of the right bronchus facilitates easier entry compared to the left.
  • The anatomical differences between the bronchi do not influence the risk of mainstem intubation; depth is the primary factor.
  • The smaller more vertical angle of the right bronchus compared to the left encourages advancement of the ETT into the right mainstem (correct)

What is the most critical factor in optimizing survival rates for patients diagnosed with lung cancer?

<p>Early detection or cancer in resectable location. (B)</p> Signup and view all the answers

A patient presents with a lung tumor and is subsequently diagnosed with Small Cell Lung Cancer (SCLC). Which of the following characteristics is LEAST likely to be associated with this type of lung cancer?

<p>Typically responding well to surgical intervention as the primary treatment. (B)</p> Signup and view all the answers

A patient is diagnosed with Large Cell Lung Cancer. Which of the following characteristics is most consistent with this diagnosis?

<p>Presentation as a large, cavitating tumor in the periphery of the lung. (A)</p> Signup and view all the answers

A patient presents with a lung tumor located at the apex of the lung, invading the brachial plexus and causing shoulder pain. Which type of lung cancer is most likely associated with this presentation?

<p>Adenocarcinoma, specifically a Pancoast tumor. (D)</p> Signup and view all the answers

Which of the following scenarios best illustrates the typical progression and characteristics of squamous cell carcinoma of the lung?

<p>A slow-growing central tumor causing bronchial obstruction, hypercalcemia, and late metastasis, with a strong smoking history. (D)</p> Signup and view all the answers

A patient with a history of heavy smoking is diagnosed with a centrally located lung tumor obstructing the mainstem bronchus. Which of the following complications is LEAST likely to be directly caused by the tumor's location and characteristics?

<p>Lambert-Eaton myasthenic syndrome. (D)</p> Signup and view all the answers

A patient is found to have a firm, marble-like tumor in the periphery of their lung, composed of normal tissue elements. Which of the following is the most likely diagnosis?

<p>Hamartoma consisting of normal lung tissue. (C)</p> Signup and view all the answers

Which paraneoplastic syndrome is frequently observed in Small Cell Lung Cancer (SCLC) due to release of ADH from tumor?

<p>Syndrome of Inappropriate Antidiuretic Hormone (SIADH) secretion, causing euvolemic hypo-osmolar hyponatremia. (A)</p> Signup and view all the answers

A patient with small cell lung cancer presents with euvolemic hypo-osmolar hyponatremia. Which paraneoplastic syndrome is most likely the cause?

<p>Syndrome of Inappropriate Antidiuretic Hormone (SIADH) (B)</p> Signup and view all the answers

A patient with a history of squamous cell carcinoma develops hypercalcemia. Which mechanism is the most likely cause of this electrolyte imbalance?

<p>Ectopic production of parathyroid hormone-like substance by the tumor. (D)</p> Signup and view all the answers

A patient presents with miosis, ptosis, and anhidrosis on the right side of their face, along with shoulder pain. Imaging reveals a mass in the apex of the right lung. Which condition is most likely causing these signs and symptoms?

<p>Horner Syndrome (A)</p> Signup and view all the answers

Which of the following anesthetic considerations is most critical for a patient diagnosed with Lambert-Eaton Myasthenic Syndrome (LEMS) secondary to lung cancer? select 2

<p>Sensitivity to non-depolarizing neuromuscular blocking agents (A), Decreased presynaptic ACh so muscle weakness improves with repeated effort (C)</p> Signup and view all the answers

What is the primary physiological consequence of chronic hypoxemia in COPD patients that leads to right ventricular dysfunction?

<p>Increased pulmonary artery pressure causing increased right ventricular afterload. (B)</p> Signup and view all the answers

A patient with lung cancer develops Superior Vena Cava (SVC) syndrome. Which of the following clinical signs would be observed?

<p>Edematous head and neck (A), Swelling of upper arms and torso (B), Cyanotic appearance of skin (C), Appearance of collateralized chest wall veins (D)</p> Signup and view all the answers

A patient with severe COPD is scheduled for a lung resection. Preoperative assessment reveals a significantly reduced FEV1. Which additional measurement would be MOST important in predicting postoperative respiratory complications?

<p>Predicted postoperative FEV1 (ppoFEV1). (D)</p> Signup and view all the answers

A patient with a history of COPD is scheduled for a surgical procedure. Which of the following intraoperative ventilator strategies should be used with caution? select 3

<p>No N2O due to risk of rupture of bullae (A), PPV due to risk of rupture of bullae (C), Overdistention of lungs due to risk of air trapping reducing compliance and cardiac output (D)</p> Signup and view all the answers

Which of the following signs or symptoms is associated with lung cancer?

<p>Productive Sputum (A), Dyspnea (B), Hemoptysis (C), Weight loss (D), Dysphagia (@), Hoarseness (@)</p> Signup and view all the answers

Which of the following best describes the utility of the 'reversibility test' in the context of FEV1 measurement for COPD patients?

<p>To determine the degree of fixed airway obstruction versus reversible bronchospasm. (A)</p> Signup and view all the answers

What is the rationale behind avoiding nitrous oxide (N2O) in patients with significant bullous emphysema undergoing mechanical ventilation?

<p>N2O diffuses into air-filled spaces more rapidly than nitrogen exits, potentially enlarging pulmonary bullae. (B)</p> Signup and view all the answers

Which of the following paraneoplastic syndromes is associated with ectopic release of ACTH, leading to symptoms such as moon face, buffalo hump, and hypokalemia?

<p>Cushing Syndrome (A)</p> Signup and view all the answers

A patient with a carcinoid tumor experiences intraoperative hemodynamic instability and coronary artery spasm. Which of the following substances is most likely implicated in this crisis?

<p>Serotonin (C)</p> Signup and view all the answers

A patient presents with migratory thrombophlebitis. Which of the following conditions is most likely associated with this finding?

<p>Trousseau Syndrome (D)</p> Signup and view all the answers

A patient is scheduled to undergo a major oncologic resection. Preoperative evaluation reveals usage of bleomycin and mitomycin. What specific perioperative concern should be anticipated in this patient?

<p>Increased risk of acute respiratory distress syndrome (ARDS) and pulmonary fibrosis due to pulmonary toxicity (A)</p> Signup and view all the answers

During a left-sided thoracoscopy with one-lung ventilation, the arterial oxygen saturation suddenly drops to 85%. Initial troubleshooting steps, including assessment of DLT position, have been unsuccessful. What is the MOST appropriate next step in managing this acute hypoxemia?

<p>Apply continuous positive airway pressure (CPAP) to the non-dependent lung. (D)</p> Signup and view all the answers

In a patient undergoing one-lung ventilation for a left lower lobectomy, you observe a progressive increase in the peak inspiratory pressure of the ventilated lung. Auscultation reveals decreased breath sounds on the right side. What is the MOST likely cause of this change?

<p>Migration of the double-lumen tube into the right mainstem bronchus. (B)</p> Signup and view all the answers

What is the underlying mechanism by which chronic hypoxemia leads to right ventricular dysfunction in COPD patients?

<p>Pulmonary vasoconstriction and remodeling in response to hypoxemia, increasing pulmonary artery pressure. (D)</p> Signup and view all the answers

Which statement accurately relates FEV1 results to the potential benefits of bronchodilator therapy in COPD patients?

<p>The 'reversibility test' is utilized to gauge if a bronchodilator meaningfully improves airflow obstruction, thus guiding long-term therapy decisions and symptomatic improvement. (A)</p> Signup and view all the answers

A patient presents with a constellation of symptoms including proximal muscle weakness that improves with repeated exertion. Diagnostic workup reveals the presence of an underlying lung malignancy. Which specific paraneoplastic syndrome is most likely contributing to this patient's presentation?

<p>Lambert-Eaton Myasthenic Syndrome (LEMS) (B)</p> Signup and view all the answers

A patient with COPD is scheduled for lung resection. Preoperative evaluation reveals treatment with cisplastin. What specific perioperative concern should be anticipated?

<p>Increased risk of nephrotoxicity (B)</p> Signup and view all the answers

A 68-year-old male with a 50 pack-year smoking history is diagnosed with squamous cell carcinoma of the lung. Given the typical pathophysiology of this cancer type, which of the following complications is most likely to arise directly from the tumor's location and growth pattern?

<p>Superior vena cava syndrome due to compression of mediastinal structures (D)</p> Signup and view all the answers

A patient is diagnosed with a peripheral lung lesion and undergoes a biopsy revealing adenocarcinoma. Further molecular testing identifies a mutation associated with increased growth factor signaling. Which of the following subsequent clinical courses is most anticipated, given the characteristics of adenocarcinoma? select 2

<p>Paraneoplastic syndromes involving growth hormone and corticotropin (Cushing's) (A), Rapid progression with early distant metastasis, commonly to the brain and bones (D)</p> Signup and view all the answers

What is the underlying mechanism to why patients with carcinoid syndrome can have intraoperative hemodynamic instability?

<p>Histamine, serotonin and prostaglandin release (B)</p> Signup and view all the answers

What is the purpose of a mediastinoscopy?

<p>To diagnose and stage lung cancer (A)</p> Signup and view all the answers

What complications are commonly associated with mediastinoscopy? (Select all that apply)

<p>Hemorrhage (A), Pneumothorax (B)</p> Signup and view all the answers

Which type of non-small cell carcinoma is considered the most aggressive?

<p>Large cell carcinoma (C)</p> Signup and view all the answers

Match the lung cancer to its appropriate description:

<p>Adenocarcinoma = Fast growing, early mets, peripheral lesions that are associated with Pancoast tumors and Cushing syndrome Small cell lung cancer = Fast growing, early mets, central lesion Large cell lung cancer = Fast growing, early mets, peripheral lesions that are LARGE and cavitating Squamous cell lung cancer = Slow growing, late mets, LARGE central lesions with a strong link to smoking and hypercalcemia</p> Signup and view all the answers

What type of tumor is typically a large space-occupying lesion that can be benign or malignant and is associated with mesothelioma?

<p>Pleural tumor (A)</p> Signup and view all the answers

Which type of tumors are typically benign and noted to cause pneumonia distal to the tumor?

<p>Bronchial adenomas (A)</p> Signup and view all the answers

What are the signs and symptoms of Horner's syndrome? (Select all that apply)

<p>Miosis (B), Anhidrosis (C), Ptosis (A)</p> Signup and view all the answers

Why is Horner syndrome associated with lung cancer?

<p>It is caused by mass effect from a tumor compressing the stellate ganglion. (A)</p> Signup and view all the answers

What are the signs and symptoms of Pancoast syndrome? (Select all that apply)

<p>Ipsilateral shoulder and arm pain (A), Paresthesias (B), Horner's syndrome (D), Paresis and atrophy of the thenar muscles of the hand due involvement of lower nerve roots of branchial plexus (C)</p> Signup and view all the answers

What is the cause of Pancoast syndrome?

<p>Bronchiogenic carcinoma in the apex of the lung (A)</p> Signup and view all the answers

What are the two most common paraneoplastic syndromes associated with lung cancer?

<p>Hypercalcemia (A), SIADH (B)</p> Signup and view all the answers

What is Trousseau syndrome?

<p>Migratory thrombophlebitis with small recurrent thrombus formation in atypical veins (B)</p> Signup and view all the answers

What chemotherapy medication is associated with cardiac toxicity?

<p>Doxorubicin (A)</p> Signup and view all the answers

What are the three pillars that serve as predictors of postoperative pulmonary complications for patients undergoing pulmonary surgery?

<p>Lung parenchymal function (gas exchange via DLCO) (A), Cardiopulmonary reserve (via VO2 max) (C), Respiratory mechanics (airflow via FEV1) (B)</p> Signup and view all the answers

What is FEV1?

<p>The maximum amount of air that can be forcefully expired in 1 second - influenced by gender, height, and weight (A)</p> Signup and view all the answers

Which pulmonary function test (PFT) helps determine obstructive vs restrictive disease?

<p>FEV1/FVC Ratio (B)</p> Signup and view all the answers

What is the most valid single test for post-thoracotomy respiratory complications?

<p>PPO FEV1 (Predicted Postoperative FEV1 ) (A)</p> Signup and view all the answers

Which PPO FEV1 is associated with increased risk of post-thoracotomy respiratory complications?

<p>&lt;40% (C)</p> Signup and view all the answers

Which preoperative FEV1 is associated with a high risk of post-thoracotomy respiratory complications?

<p>&lt;30% (A)</p> Signup and view all the answers

Predicted post-op DLCO < 40% → Increased complications Predicted Postoperative FEV1 (ppoFEV1) <40% → Increased complications

<p>True (A)</p> Signup and view all the answers

What test correlates with the total functional surface of the alveolar-capillary interface?

<p>DLCO (B)</p> Signup and view all the answers

Which lung function test can be adversely affected by preoperative chemotherapy?

<p>DLCO (Diffusing Capacity for Carbon Monoxide) (C)</p> Signup and view all the answers

Inability to climb 1 flight of stairs is indicative of a VO2 max of less than ___ ml/kg/min and is associated with an ____ risk of postoperative complications.

<p>&lt;10, increased (A)</p> Signup and view all the answers

What is VO2 max?

<p>The maximum amount of oxygen the body can utilize during maximum exertion (A)</p> Signup and view all the answers

Which of the following are associated with an increased risk of postoperative complications? (Select all that apply)

<p>DLCO &lt; 40% predicted (A), VO2 Max &lt; 10 ml/kg/min (B), Advanced age (C), Poor general health status (D), COPD (@), BMI &gt; 30 kg/m² (@), Predicted post-op FEV1 &lt; 40% (@)</p> Signup and view all the answers

Flashcards

Lung Lobes

The right lung has 3 and the left lung has 2, due to space for the heart.

Carina

The point where the trachea divides into the left and right main bronchi, located at the T4-T5 level.

Mainstem Intubation Risk

Right mainstem bronchus has a wider diameter and a 25-degree angle, increasing the risk of unintentional intubation.

Average ETT Depth

Around 21 cm in women, 23 cm in men, and 1.5 cm below the glottic opening.

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Mediastinoscopy Complications

Hemorrhage and pneumothorax.

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Non-Small Cell Lung Cancer (NSCLC)

Includes adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Often associated with early metastasis

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Small Cell Lung Cancer (SCLC)

Fast-growing lung cancer, early metastases, usually central lesions, neuroendocrine origin, and managed medically.

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Large Cell Lung Cancer

Faster-growing NSCLC, early metastasis, usually peripheral, presents as large, cavitating tumor.

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Adenocarcinoma (Lung)

Fast-growing NSCLC, early metastases, usually peripheral lesions, most common type of lung cancer.

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Squamous Cell Lung Cancer

Slower-growing NSCLC, late metastases, usually central lesions, strong link to smoking.

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Hamartomas (Lung)

Tumors located in the lung periphery, consist of normal tissue.

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Bronchial Adenomas

Tumors that arise from mucous glands and ducts, often obstruct the bronchial lumen.

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Carcinoid Tumors (Lung)

Neuroendocrine tumors that release hormones.

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Postoperative O2 Management

Administer supplemental O2 to maintain PaO2 > 60-65 mmHg to address potential decreases in FRC postoperatively.

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RV Dysfunction in COPD Cause

RV dysfunction in COPD is often due to chronic hypoxemia, leading to increased pulmonary artery pressure.

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Cor Pulmonale

Cor pulmonale is right-sided heart failure caused by pulmonary hypertension, common in COPD.

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4 M's of Preoperative Assessment

Mass effect, metabolic effects, metastases, and medications affecting respiratory function and surgical outcomes.

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Pulmonary Toxic Medications

Bleomycin and mitomycin.

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FEV1

Maximum air forcefully exhaled in 1 second. Affected by height, weight, and gender.

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FEV1 Reversibility Test

Used to see if bronchodilators improve lung function.

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FVC

Maximum air forcibly exhaled after full inhalation.

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Carcinoid Syndrome Hormones

Hormones that can cause intraoperative hemodynamic crisis and coronary artery spasm. Treat with octreotide or somatostatin.

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SVC Syndrome

Edematous head and neck, swelling of upper arms/torso, collateralized chest wall veins, and cyanotic skin due to obstructed blood flow through the superior vena cava.

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Pancoast Syndrome

Bronchiogenic carcinoma in the lung apex causing ipsilateral shoulder/arm pain, paresthesias, muscle atrophy, and Horner's syndrome.

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Paraneoplastic Syndromes

Symptoms caused by organ/tissue damage remote from the primary tumor, such as hypercalcemia or SIADH.

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Hypercalcemia (Lung Cancer)

Release of parathyroid hormone-like substance from tumor; symptoms include polyuria, polydipsia, confusion. Common in squamous cell carcinoma.

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SIADH (Lung Cancer)

Release of ADH from tumor, causing euvolemic hypo-osmolar hyponatremia. Most common in small cell lung cancer.

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Lambert-Eaton Syndrome

Antibodies inhibit voltage-gated calcium channels, causing decreased acetylcholine release and proximal muscle weakness. Sensitivity to NDMRs.

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Cushing Syndrome (Lung Cancer)

Ectopic release of ACTH leading to moon face, buffalo hump, hypertension, metabolic alkalosis and hypokalemia.

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COPD

Characterized by impaired expiratory flow and commonly elevated PaCO2. Common to see bullae, so risk for rupture with PPV.

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Migratory Thrombophlebitis (Trousseau Syndrome)

Small recurrent thrombus formation in atypical veins.

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Mediastinoscopy

Surgical technique used to diagnose and stage lung cancer by examining mediastinal lymph nodes.

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Anterior Mediastinal Tumor Concern

Compression of the trachea, causing difficulty passing the endotracheal tube and with positive pressure ventilation.

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Smoking and Lung Cancer

Smoking-related lung cancers.

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Lung Cancer Mortality

Higher mortality rate, but early detection and surgical removal improves chances of survival.

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Mediastinum contents

Located within the mediastinum including the heart, esophagus, trachea, bronchi, and great vessels.

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Overinflated Lungs (COPD)

Lung collapse due to over-inflated alveoli, can cause increased dead space.

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Resectability

Determined by tumor staging. Affects treatment and prognosis.

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Operability

Determined by the extent of the planned procedure and the patient's physiological status.

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Respiratory Mechanical Function

How well the lungs move air. Assessed with pulmonary function testing.

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Lung Parenchymal Function

How well the lungs exchange gases (O2 and CO2).

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Cardiopulmonary Interaction

Assesses the interaction between the respiratory and cardiovascular systems.

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RV/TLC Ratio

Ratio of residual volume to total lung capacity. Indicates air trapping.

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Lung Cancer Early S/S

Cough, productive sputum, hemoptysis, wheezing, dyspnea, weight loss, fever, pleuritic chest pain, hoarseness

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Horner Syndrome Triad

Miosis (constricted pupil), ptosis (drooping eyelid), and anhidrosis (lack of sweating).

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SVC Syndrome Signs

Edematous head and neck, swelling of upper arms/torso, collateralized chest wall veins, and cyanotic skin.

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Pancoast Syndrome Symptoms

Ipsilateral shoulder and arm pain, paresthesias, muscle atrophy, often with Horner's syndrome due to apical lung tumor involvement.

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Hypercalcemia Symptoms

Polyuria, polydipsia, confusion, vomiting, and abdominal cramping.

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SIADH Lab Finding

Low serum Na+ (dilutional hyponatremia).

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LEMS Muscle Strength

Strength increases with repeated effort.

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LEMS & Anesthesia

Sensitivity to NDNMBAs.

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Cushing Syndrome Symptoms

Moon face, buffalo hump, peripheral edema, hypertension, metabolic alkalosis, and hypokalemia.

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COPD Types

Emphysema, peripheral airway disease & chronic bronchitis.

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