6 Questions
What are the structural changes to ageing skin?
Loss of rete ridges, thinner epidermis, smoother epidermal/dermis barrier, less adherence
Increased expression of matrix metalloproteases (MMP) does what?
Degrade Collagen/Elastin
What does this induce?
Apoptosis
What does UV light/smoking affect?
DNA stability, mutations, promotor cellular malignant transformations
How does UV light/smoking affect DNA stability?
Accumulation of ROS, and p53 inability to remove them
What is the inflammation of the skin caused by?
Interleukins, immunosuppression and MMP
Test your knowledge on the structural changes in ageing skin and the impact of increased expression of matrix metalloproteases (MMP). Explore the effects of UV light, smoking, and inflammation on skin health, as well as their influence on DNA stability.
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