Questions and Answers
What is the brand name of brexpiprazole?
Rexulti
What conditions is Rexulti (brexpiprazole) prescribed for?
Schizophrenia (ages 13 to 17 and in adults), treatment-resistant depression (adjunct)
What is the pharmacological class of brexpiprazole?
Dopamine partial agonist
What is the usual dosage of Rexulti for schizophrenia in ages 13 to 17 and adults?
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What are some important considerations regarding Rexulti (brexpiprazole) when breastfeeding?
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Which of the following drugs are partial agonists of D2? (Select all that apply)
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Study Notes
Drug Overview
- Brexpiprazole is marketed under the brand name Rexulti.
- Prescribed for schizophrenia in patients aged 13 to 17 and adults, and as an adjunct treatment for treatment-resistant depression.
Pharmacological Classification
- Classified as a dopamine partial agonist.
- Also recognized as a dopamine-serotonin partial agonist and a stabilizer.
- Categorized as an atypical antipsychotic, and sometimes deemed a second-generation antipsychotic.
- Possesses potential mood stabilizing properties.
Dosage Information
- Recommended dosage for schizophrenia: 2-4 mg taken once daily for individuals aged 13 and older.
- Suggested starting dosage for depression: 2 mg taken once daily.
Important Considerations
- Approved as an adjunctive treatment for depression, often in combination with SSRIs or SNRIs.
- Contraindicated in breastfeeding; either discontinue the drug or opt for bottle feeding.
- Notable side effects include akathisia and restlessness, both of which are dose-dependent, along with potential anxiety.
Other Relevant Drugs
- Three drugs exhibiting partial agonism at D2 receptors include Abilify, Rexulti, and Vraylar.
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Description
This quiz covers the important aspects of Brexpiprazole, including its pharmacological classification, recommended dosages for schizophrenia and depression, and key considerations for its use. Test your knowledge on this atypical antipsychotic, its mechanisms, and its side effects.
