Breastfeeding and Mammary Glands Quiz
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Questions and Answers

During which stage of development do breasts develop lobules and alveoli?

  • Puberty
  • Menstrual cycle (correct)
  • Birth
  • Pregnancy
  • What contributes to the growth of the breast at puberty?

  • Growth of lactiferous ducts
  • Initiation of lobules
  • Deposition of fat
  • All of the above (correct)
  • Which of the following is NOT a reason a woman might be hesitant to breastfeed?

  • She's confident in her ability to breastfeed (correct)
  • She's concerned about measuring baby's intake
  • She feels it's too embarrassing
  • She's worried about the baby not latching on
  • What is the primary function of the mammary gland?

    <p>To produce milk (D)</p> Signup and view all the answers

    What hormonal change triggers breast development during pregnancy?

    <p>Increased estrogen levels (D)</p> Signup and view all the answers

    What is the primary reason for breastfeeding, as stated in the content?

    <p>Provides all needed nutrients, no need for supplemental vitamins. (B)</p> Signup and view all the answers

    What is the aim of the International Code of Marketing of Breast-milk Substitutes?

    <p>To promote breastfeeding as the ideal method of infant nutrition. (D)</p> Signup and view all the answers

    Which of these is NOT a benefit of breastfeeding for the infant, as stated in the content?

    <p>Ensures the infant is always at the correct temperature. (C)</p> Signup and view all the answers

    According to the content, what are some of the potential long-term benefits of breastfeeding that are still under research?

    <p>Influence on the infant's microbiome and epigenetics. (D)</p> Signup and view all the answers

    Which of the following is a reason mentioned in the content for choosing formula feeding over breastfeeding?

    <p>Formula feeding is more affordable in developing countries where safe water is scarce. (E)</p> Signup and view all the answers

    Which of the following is NOT a source of longer chain fatty acids in breast milk?

    <p>Ketone bodies (C)</p> Signup and view all the answers

    What is the role of lactalbumin in lactose synthesis?

    <p>It modifies the substrate specificity of galactosyltransferase. (A)</p> Signup and view all the answers

    Which of the following is NOT a function of lactose in breast milk?

    <p>Increasing the allergenicity of breast milk. (B)</p> Signup and view all the answers

    What is the primary source of amino acids for protein synthesis in breast milk?

    <p>Dietary intake (B)</p> Signup and view all the answers

    What is the function of β-D-galactosyltransferase in lactose synthesis?

    <p>It transfers galactose from UDP-galactose to glucose. (B)</p> Signup and view all the answers

    What is the mechanism by which milk fat globules are released into the alveolus?

    <p>They are released by a process of budding and pinching off. (C)</p> Signup and view all the answers

    Which of the following proteins is NOT typically found in breast milk?

    <p>Insulin (A)</p> Signup and view all the answers

    How is the glycerol backbone for triglyceride synthesis in breast milk obtained?

    <p>Synthesized from blood glucose. (D)</p> Signup and view all the answers

    Which hormone is responsible for milk ejection?

    <p>Oxytocin (B)</p> Signup and view all the answers

    Which of the following statements accurately describes the relationship between prolactin and progesterone during pregnancy?

    <p>Progesterone inhibits prolactin's action (B)</p> Signup and view all the answers

    What is the primary function of the myoepithelial cells in breast tissue?

    <p>Contract to expel milk from alveoli (A)</p> Signup and view all the answers

    How does suckling influence prolactin levels?

    <p>Suckling stimulates prolactin release (D)</p> Signup and view all the answers

    What is the significance of the "Milk Ejection Reflex" in relation to breastfeeding?

    <p>It describes how the milk is actually released from the breast (B)</p> Signup and view all the answers

    What distinguishes fore milk from hind milk composition?

    <p>Fore milk is lower in fat, while hind milk is higher in fat (B)</p> Signup and view all the answers

    Why is lactation considered an unreliable contraceptive method?

    <p>Lactation can have unpredictable effects on menstrual cycles (D)</p> Signup and view all the answers

    Which of the following hormones contributes to general breast development and enlargement during pregnancy?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the primary function of alpha-lactalbumin in breast milk synthesis?

    <p>It regulates the production of lactose (D)</p> Signup and view all the answers

    Which of the following is NOT a component found in breast milk?

    <p>Hemoglobin (B)</p> Signup and view all the answers

    How does the fat content of breast milk affect the infant's feeding behavior?

    <p>Higher fat content helps induce satiation in the infant (A)</p> Signup and view all the answers

    What is the primary distinction between colostrum and mature milk?

    <p>Colostrum is higher in protein and lower in fat, while mature milk has more fat and fewer proteins (A)</p> Signup and view all the answers

    How does the hormonal balance of a breastfeeding mother influence the composition of her breast milk?

    <p>Hormonal fluctuations can lead to variations in breast milk components (C)</p> Signup and view all the answers

    Why is it important that alveolar epithelial cells are able to synthesize milk components?

    <p>They are the only cells capable of producing milk (B)</p> Signup and view all the answers

    What is the primary energy source for breast milk?

    <p>Fat (D)</p> Signup and view all the answers

    What is the primary difference between human and bovine milk composition?

    <p>Bovine milk is richer in minerals and proteins compared to human milk (B)</p> Signup and view all the answers

    What is the primary component of milk that helps protect infants from bacterial infections?

    <p>Antibodies (D)</p> Signup and view all the answers

    Which of the following components in milk is responsible for sequestering iron, making it unavailable to harmful bacteria?

    <p>Lactoferrin (A)</p> Signup and view all the answers

    What is the primary reason why untreated cow's milk is not recommended for infants under the age of 12 months?

    <p>It lacks essential nutrients that are crucial for infant growth. (A)</p> Signup and view all the answers

    What is the main objective of the International Code on Marketing of Breast-milk Substitutes?

    <p>To promote and protect breastfeeding by restricting the marketing of formula milk. (A)</p> Signup and view all the answers

    Which of the following is NOT a component of the WHO's recommendations for infant feeding?

    <p>Introducing formula milk as a primary source of nutrition from birth. (D)</p> Signup and view all the answers

    What is the main reason why infant formula is considered nutritionally inferior to breast milk?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the primary reason why infant formula is modified to resemble human milk?

    <p>To provide a more balanced nutritional profile for infants. (C)</p> Signup and view all the answers

    What is the primary function of lysozyme in breast milk?

    <p>To protect infants from bacterial infections by attacking bacterial cell walls. (B)</p> Signup and view all the answers

    Which of these factors contributes to a more effective weight loss for breastfeeding mothers compared to formula feeding mothers?

    <p>The physical act of breastfeeding itself burning additional calories. (D)</p> Signup and view all the answers

    A breastfeeding mother's milk composition can be influenced by a number of factors. Which of these factors is LEAST likely to directly influence the milk's composition?

    <p>The mother's genetic predisposition for milk production. (D)</p> Signup and view all the answers

    While breastfeeding is considered the ideal feeding method, certain circumstances can lead to the use of formula feeding. Identify the reason MOST likely to prompt a decision for formula feeding.

    <p>A mother's inability to produce sufficient milk for her infant. (A)</p> Signup and view all the answers

    What is the primary reason why untreated cow's milk is NOT recommended for infants under 12 months?

    <p>Inadequate levels of essential nutrients needed for infant development. (A)</p> Signup and view all the answers

    The International Code on Marketing of Breast-milk Substitutes aims to promote breastfeeding. Which of the following is NOT a direct objective of this code?

    <p>Promoting the use of breast milk substitutes as a viable alternative to breastfeeding. (B)</p> Signup and view all the answers

    Which of the following accurately describes the relationship between prolactin and progesterone during pregnancy?

    <p>Progesterone inhibits prolactin release, preventing milk production until after birth. (B)</p> Signup and view all the answers

    Which of the following statements is TRUE regarding the hormonal control of milk 'letdown'?

    <p>The release of oxytocin is triggered by a nervous signal from the hypothalamus to the posterior pituitary. (C)</p> Signup and view all the answers

    Which of the following accurately describes the composition of colostrum?

    <p>Colostrum has a lower fat content than mature milk and a greater amount of antibodies, providing immune protection to the newborn. (B)</p> Signup and view all the answers

    Which of the following BEST explains the difference between fore milk and hind milk?

    <p>Fore milk is thinner and lower in fat, providing hydration for the infant, while hind milk is richer in fat, providing energy and promoting satiation. (B)</p> Signup and view all the answers

    Which of the following is TRUE about the relationship between prolactin and fertility during lactation?

    <p>Prolactin inhibits the release of GnRH, suppressing ovulation and reducing fertility. (C)</p> Signup and view all the answers

    Which of the following hormones, besides prolactin and oxytocin, plays a role in breast development and milk production?

    <p>Cortisol, as it regulates stress response and plays a role in overall breast development. (D)</p> Signup and view all the answers

    Which of the following accurately describes the role of alpha-lactalbumin in milk production?

    <p>Alpha-lactalbumin is a protein involved in the synthesis of lactose, a primary sugar in breast milk. (A)</p> Signup and view all the answers

    Which of the following accurately portrays the process of milk fat globule release into the alveolus?

    <p>Milk fat globules are packaged into vesicles within the alveolar epithelial cells and then released by exocytosis. (C)</p> Signup and view all the answers

    Which of the following is most likely to contribute to the diurnal changes in breast milk composition?

    <p>All of the above factors contribute to diurnal changes in breast milk. (D)</p> Signup and view all the answers

    Which of the following is TRUE regarding the relationship between breastfeeding and menstruation?

    <p>Conception can occur before menstruation returns, making it a poor indicator of fertility. (D)</p> Signup and view all the answers

    Which of the following explains why untreated cow's milk is not recommended for infants under 12 months?

    <p>Cow's milk lacks essential nutrients like iron and fatty acids needed for infant growth. (B)</p> Signup and view all the answers

    Why is infant formula considered nutritionally inferior to breast milk?

    <p>Formula milk lacks the complex and unique antibodies and immune factors found in breast milk. (B)</p> Signup and view all the answers

    What type of fatty acids are primarily synthesized in the mammary gland from blood glucose and ketone bodies?

    <p>Short and medium-chain fatty acids (A)</p> Signup and view all the answers

    What component of milk is predominantly formed in the Golgi apparatus before being exocytosed into the alveolus?

    <p>Lactose (B)</p> Signup and view all the answers

    Which protein modifies the substrate specificity of galactosyltransferase in lactose synthesis?

    <p>Lactalbumin (D)</p> Signup and view all the answers

    What is the primary structural characteristic of casein proteins in breast milk?

    <p>Forms micelles with calcium (B)</p> Signup and view all the answers

    Which process in milk fat globule formation involves the membrane closing behind the globule?

    <p>Exocytosis (D)</p> Signup and view all the answers

    What role does UDP-Galactose play in lactose synthesis?

    <p>It activates glucose for conversion to galactose (A)</p> Signup and view all the answers

    Which milk protein is associated with the transport of iron and may influence the absorption of minerals?

    <p>Lactoferrin (D)</p> Signup and view all the answers

    From which sources are longer chain fatty acids in breast milk primarily derived?

    <p>Diet and adipose tissue (B)</p> Signup and view all the answers

    What is the primary immunological benefit of lactoferrin found in breast milk?

    <p>Sequesters iron, making it unavailable to pathogens (D)</p> Signup and view all the answers

    Which of the following steps is involved in the processing of cow's milk for infant formula?

    <p>Partial or total replacement of dairy fat with vegetable or marine fats (C)</p> Signup and view all the answers

    According to WHO recommendations, what is the recommended duration for exclusive breastfeeding?

    <p>Six months (B)</p> Signup and view all the answers

    What role do leukocytes, specifically macrophages, primarily serve in breast milk?

    <p>Providing passive immunity to the infant (B)</p> Signup and view all the answers

    What is a key reason why the International Code on Marketing of Breast-milk Substitutes was created?

    <p>To protect and promote breastfeeding practices (D)</p> Signup and view all the answers

    What is the primary nutritional disadvantage of infant formula compared to breast milk?

    <p>Inability to provide passive immunity (D)</p> Signup and view all the answers

    Which component of breast milk is primarily responsible for promoting beneficial bacteria?

    <p>Lactose (D)</p> Signup and view all the answers

    What is the main reason untreated cow's milk is not recommended for infants under 12 months?

    <p>It may cause anemia due to high protein content (D)</p> Signup and view all the answers

    Which of the following is NOT a potential reason for a woman to feel hesitant about breastfeeding?

    <p>She is overly concerned that she can't measure the baby's intake (C)</p> Signup and view all the answers

    Which of the following is NOT a contributing factor to breast development during puberty?

    <p>Formation of alveoli (D)</p> Signup and view all the answers

    Which statement accurately describes the role of estrogen and progesterone in breast development?

    <p>During puberty, estrogen promotes duct branching, but progesterone primarily contributes to lobules and alveoli development during pregnancy. (B)</p> Signup and view all the answers

    The content indicates that the breast reaches its full functional capacity for milk production once a woman is fully developed. What is the primary reason for this?

    <p>The full development of lobules and alveoli, which are essential for milk production, is complete by the time a woman reaches full maturity. (C)</p> Signup and view all the answers

    Why might it be difficult to determine a woman's capacity for breastfeeding based solely on the size or appearance of her breasts?

    <p>The size of the ducts and lobules, responsible for milk production, can vary significantly regardless of breast size. (C)</p> Signup and view all the answers

    Flashcards

    Key Hormones in Milk Production

    Hormones like prolactin and oxytocin control milk synthesis and release.

    Lactose Biosynthesis

    Lactose is synthesized in the mammary gland from glucose and galactose.

    Composition of Human vs Bovine Milk

    Human milk has more antibodies; bovine milk has more protein.

    WHO Breastfeeding Recommendations

    Exclusive breastfeeding for the first 6 months is recommended by WHO.

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    Benefits of Breastfeeding

    Breastfeeding provides immunity, optimal nutrition, and enhances bonding.

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    Breastfeeding aversion

    A feeling of repulsion or lack of interest in breastfeeding.

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    Mammary gland

    An exocrine gland responsible for milk production.

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    Breast development stages

    The process of breast growth influenced by hormones during life stages.

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    Role of estrogens

    Hormones that promote breast development and lobule growth.

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    Milk production readiness

    Breasts cannot produce milk until pregnancy hormones are present.

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    Short and medium chain FA

    Fatty acids synthesized in breast from blood glucose and ketone bodies.

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    Long chain FA

    Fatty acids derived from chylomicrons, VLDL, and free fatty acids in the bloodstream.

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    Triglyceride synthesis

    Glycerol backbone for triglycerides is made from blood glucose.

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    Milk fats production

    Milk fats are synthesized in the ER and enter alveolus as membrane-bound globules.

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    Lactose

    A disaccharide made of galactose and glucose, synthesized from blood glucose.

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    Lactose Synthase

    Enzyme complex that synthesizes lactose, composed of protein A and B.

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    Casein vs. Whey

    Casein is low solubility protein; whey remains soluble after milk clots.

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    Lactose functions

    Lactose provides energy, promotes gut bacteria growth, and mineral absorption.

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    Passive Immunity from Milk

    Milk provides antibodies that protect infants during immune development.

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    IgA Antibodies

    IgA antibodies in milk protect infants from pathogens.

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    Role of Lactoferrin

    Lactoferrin binds iron, making it unavailable to harmful bacteria.

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    Importance of Leukocytes

    Milk contains high levels of leukocytes, mainly macrophages, for immune support.

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    Infant Formula Composition

    Infant formula alters proteins and adds ingredients for infant nutrition.

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    Risks of Untreated Cow Milk

    Untreated cow's milk is not recommended for infants under 12 months.

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    International Code on Breastfeeding

    A WHO framework promoting breastfeeding and regulating infant feeding marketing.

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    WHO Feeding Recommendation

    Infants should be exclusively breastfed for the first 6 months for optimal health.

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    Hypertrophy in Pregnancy

    Dilation of the alveolar lumen and growth of duct-lobule-alveolus during pregnancy.

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    Prolactin Function

    A peptide hormone that stimulates lactation and is produced in the anterior pituitary.

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    Hormonal Regulation During Pregnancy

    Prolactin levels rise during pregnancy but are inhibited by progesterone from the placenta.

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    Milk Production Trigger

    Suckling sends nervous signals that promote prolactin release for milk production.

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    Oxytocin Function

    A nonapeptide hormone from the posterior pituitary that causes milk ejection.

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    Milk Ejection Reflex

    The process by which oxytocin causes myoepithelial cells to contract and expel milk.

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    Reduced Fertility During Lactation

    Lactation delays ovulation and menstruation due to elevated prolactin levels.

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    Milk Composition

    Milk contains fats, proteins, and lactose, with variations in human and bovine milk.

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    Colostrum Characteristics

    The first milk produced post-birth, rich in nutrients and antibodies, less fat.

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    Fore Milk vs. Hind Milk

    Fore milk is lower in fat, while hind milk, produced later, is higher in fat.

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    Mature Milk Production

    Produced after the transitional phase, containing lower IgA and higher volume.

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    Role of Lipids in Milk

    Lipids provide about 50% of the energy content in milk, including fats and vitamins.

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    Hormones Affecting Milk

    Prolactin and oxytocin promote milk synthesis and ejection, respectively.

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    Pregnancy & Breast Cancer

    Less-differentiated breast cells during pregnancy are at higher risk for cancer, but pregnancy offers some protection.

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    Hormonal Sources in Lactation

    Prolactin from the anterior pituitary and oxytocin from the posterior pituitary regulate lactation.

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    Nutritional Factors in Breastfeeding

    Breast milk contains all necessary nutrients for infant growth and development.

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    Immunity Factors in Breastfeeding

    Breast milk provides antibodies that reduce infection rates in infants.

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    Breastfeeding Benefits for Mothers

    Breastfeeding supports maternal health by increasing antibody levels and aiding postpartum weight loss.

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    Breastfeeding vs. Formula Feeding

    Breastfeeding provides tailored nutrition, while formula feeding lacks some natural benefits.

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    WHO Breastfeeding Aim

    The WHO aims for exclusive breastfeeding during the first 6 months for infant health.

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    Mammary gland development

    Breasts begin with few alveoli at birth, develop structure during puberty.

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    Breast size increase

    Breast size increases due to fat deposition and connective tissue growth from hormones.

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    Milk production ability

    Breasts cannot produce milk until pregnancy hormones are present.

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    Latching difficulties

    Problems in getting the baby to securely attach to the breast for feeding.

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    Fatty Acid Sources in Breast

    Short and medium chain fatty acids are synthesized in the breast from blood glucose and ketone bodies.

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    Long Chain Fatty Acids

    Longer chain fatty acids are sourced from chylomicrons, VLDL, and free fatty acids in the bloodstream.

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    IgA Antibodies in Milk

    IgA antibodies protect infants from infections and are found in high levels in milk.

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    Triglyceride Formation

    The glycerol backbone for triglycerides is made from blood glucose.

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    Lactoferrin Function

    Lactoferrin sequesters iron, making it less available to bacteria, thus reducing infections.

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    Lactose Structure

    Lactose is a disaccharide made of galactose linked to glucose with a β-1,4 linkage.

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    Lactose Synthase Components

    Lactose synthase consists of two proteins: β-D-galactosyltransferase and lactalbumin.

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    Leukocytes in Milk

    Milk contains a high number of leukocytes, mainly macrophages, which help fight infections.

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    Infant Formula Processing

    Infant formula modifies cow's milk to better match human milk and adds essential nutrients.

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    Casein Function

    Casein proteins have low solubility and form complexes with calcium.

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    Whey Characteristics

    Whey proteins remain in solution after milk is clotted.

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    Lactose Benefits

    Lactose provides energy, supports good gut bacteria, and enhances mineral absorption.

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    WHO Infant Feeding Recommendation

    The WHO advises exclusive breastfeeding for the first 6 months for optimal infant health.

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    Breast Tissue Differentiation

    Final differentiation of breast tissue cells occurs at the end of pregnancy.

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    Pregnancy and Cancer Risk

    Less differentiated breast cells during pregnancy may be more cancerous; pregnancy offers some cancer protection.

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    Prolactin Overview

    Prolactin is a peptide hormone from the anterior pituitary, key for milk synthesis.

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    Role of Progesterone

    Progesterone from the placenta opposes the action of prolactin during pregnancy.

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    Oxytocin Role

    Oxytocin is released by the posterior pituitary and triggers milk ejection during feeding.

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    Effects of Suckling

    Suckling stimulates prolactin release and milk production; intensity affects yield.

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    Lactation and Fertility

    Lactation can suppress normal menstrual cycles and ovulation, affecting fertility.

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    Mature Milk Composition

    Mature milk after 2–3 weeks has low IgA and high volume for infant nourishment.

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    Lipids in Milk

    Lipids make up about 50% of milk's energy, including essential fats and vitamins.

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    Milk Composition Variability

    Milk composition can change based on maternal diet, hormonal levels, and feeding times.

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    Breast Development Hormones

    Progesterone and estrogens facilitate breast tissue development during pregnancy.

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    Nutritional Value of Milk

    Breast milk provides complete nutrition, including proteins, fats, and antibodies for infants.

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    Study Notes

    Mammary Gland and Lactation

    • Module: Endocrine
    • Class: MedYear 1, semester 2
    • Date: February 7, 2024
    • Lecturer: Paul O'Farrell

    Learning Objectives

    • Identify the hormones involved in milk synthesis and release
    • Outline lactose biosynthesis in lactating mammary glands
    • Compare and contrast human and bovine milk composition
    • State current WHO recommendations for infant breastfeeding
    • Outline the aim of the International Code of Marketing of Breast-milk Substitutes

    Why Breastfeed?

    • Meets baby's nutritional needs, eliminating the need for supplemental vitamins.
    • Provides nutritional factors for optimal growth and development.
    • Contains immunity factors, reducing infection rates.
    • Protects against allergies.
    • Supports normal jaw, tooth, and speech development.
    • Always available at the correct temperature and amount, even for multiples.
    • Enhances bonding.
    • Associated with milder baby stools compared to formula-fed infants.
    • Promotes maternal postpartum weight loss.
    • Improves maternal health by increasing maternal circulating antibodies.
    • Important in developing countries due to potential lack of safe water for formula.
    • Ongoing research explores the impact on microbiome and epigenetics.

    Why Formula Feed?

    • Breastfeeding may be perceived as repulsive or embarrassing.
    • Breastfeeding may be seen as too complex or restrictive.
    • Mothers may experience difficulty in latching.
    • Reluctance to breastfeeding due to lifestyle or nervousness.
    • Concern about not adequately measuring baby's intake.
    • Underlying medical conditions such as reflux or dietary requirements.
    • Inability for the baby to gain weight.
    • Other issues.

    The Breast (Mammary Gland Anatomy)

    • An exocrine gland
    • Diagram showing lobule, alveoli, myoepithelial cells, milk-secreting epithelial cells, lactiferous ducts, nipple, areola, and pectoralis major. (anatomy)

    Breast Development

    • At birth, the breast mainly has lactiferous ducts and few alveoli.
    • Estrogens and progesterone stimulate further duct growth, branching, and lobule development during puberty.
    • Cyclic hormonal changes during the menstrual cycle affect breast size and tissue growth.
    • Breast competence for milk production begins during pregnancy.
    • Hypertrophy of duct-lobule-alveolus system takes place during early pregnancy.
    • Alveolar epithelial cells develop ability to secrete milk during pregnancy, especially in mid-pregnancy.

    Clinical Note: Pregnancy and Breast Cancer

    • Final breast tissue cell differentiation occurs at the end of pregnancy.
    • Less differentiated cells have a higher cancer risk.
    • Pregnancy offers protection against breast cancer.
    • Later primigravida (first-time pregnant women) shows less protection.

    Hormonal Control of Milk Production - Prolactin

    • Anterior pituitary hormone.
    • Promotes lactation, steadily increasing during pregnancy (10-20 times pre-pregnancy levels).
    • Progesterone from the placenta counteracts prolactin's effects.
    • Progesterone levels decrease postpartum, allowing milk production.
    • Suckling stimulates prolactin release.
    • Milk production is proportional to stimulation duration and intensity.
    • Twins typically stimulate more milk production.
    • (includes graph detailing prolactin levels, mature milk, transitional milk, colostrum)

    Hormonal Control of Milk "Letdown" - Oxytocin

    • Posterior pituitary hormone.
    • Produced within alveoli but needing ejection.
    • Suckling triggers nervous signals to the hypothalamus promoting oxytocin release.
    • Oxytocin travels to the breast.
    • Myoepithelial cells contract, releasing milk from alveoli.
    • Suckling on one breast triggers milk flow in the other.
    • Emotional response (e.g., fondling, hearing cries) releases oxytocin and promotes milk release.
    • (includes graph detailing pathway)

    Fertility Reduced During Lactation

    • Menstruation and ovulation return slower in lactating women.
    • Conception can occur without an intervening menstruation.
    • Elevated prolactin suppresses GnRH release, affecting FSH and LH, leading to no cycle.
    • Breastfeeding is unreliable as a contraceptive method (Irish twins).

    Hormones: Summary Table

    • Table listing hormones, their source(s), and function in milk production. (includes prolactin, oxytocin, progesterone, estrogens, hGH, cortisol, parathyroid hormone and insulin)

    Milk Composition

    • Table comparing human and cow's milk constituent percentages (Water, Fat, Lactose, Casein, Lactalbumin, Other Proteins, Ash).
    • Details on how fat contributes to caloric value (50% in humans), protein content (human milk has a higher protein content).
    • Higher lactose content and higher ash levels in human milk compared to cow's milk.

    Compositional Changes During Lactation

    • Colostrum is early breast milk (yellowish, sticky); high protein, lower fat, and higher nutrient levels, including vitamins.
    • Transitional milk is produced after colostrum, also characterized by lower fat content and higher protein content than mature milk.
    • Mature milk is produced after approximately 2-3 weeks and contains lower IgA, lactoferrin, and cell levels.
    • Fore milk: low fat content, early in a feeding session.
    • Hind milk: higher fat content, later in a feeding session; aids satiation.
    • Diurnal changes in milk composition due to maternal diet and hormonal changes.

    Synthesis of Milk - Lactose

    • Lactose is milk sugar (a disaccharide), composed of galactose and glucose.
    • Synthesized from blood glucose; galactose is created and activated through a UTP-coupling process.
    • UDP-Galactose is combined with another glucose by lactose synthase.

    Lactose Synthase

    • Composed of two proteins: beta-D-galactosyltransferase (Protein A) and lactalbumin (Protein B).
    • Beta-D-galactosyltransferase is a crucial enzyme for sugar chain formation in various tissues.
    • Lactalbumin modifies galactosyltransferase and functions only in the lactating mammary gland.
    • Lactose is produced within Golgi, passes to alveolar lumen via exocytosis process.
    • Functions include energy source for Lactobacillus bifidus population, colonisation of the gut by good bacteria, and mineral absorption (especially calcium.)

    Immunological Properties of Milk

    • Supplies passive immunity by supporting infant immune system development.
    • Contains antibodies (mostly IgA) protected from digestion by a secretory component.
    • Contains lactoferrin (iron sequestering element), lysozyme (bacteria-attacking enzyme) and lactose (facilitates beneficial bacteria growth).
    • Leukocytes (especially macrophages) also provide protective mechanisms (10⁴-10⁵/mL milk).

    Infant Formula

    • Based on cow's milk but processed for better protein balance closer to human milk.
    • Contains added essential ingredients and/or partial or total fat replacement using vegetable or marine fats.
    • Nutritionally inferior to breast milk but higher quality than unprocessed cow's milk to other substitutes.
    • Not recommended under the age of 12 months, untreated cow's milk.

    International Code on Marketing of Breast-milk Substitutes

    • Adopted by WHO member countries in 2002
    • Aims to promote and protect breastfeeding.
    • Aims to limit marketing practices of artificial feeding products.
    • Aims to give health workers the responsibility to encourage and promote breastfeeding.

    WHO Infant Feeding Recommendations

    • Breastfeeding is an ideal food for healthy infant growth and development. It is an integral part of reproductive health.
    • Exclusive breastfeeding is recommended for the first six months of life to optimize health and development.
    • Complementary foods should be introduced to meet evolving nutritional needs up to the age of two years.
    • ( Includes recommendations for exclusive breastfeeding levels globally - likely 35% worldwide average).

    Other Points

    • Vegans, and those with dietary restrictions, require careful consideration.
    • Diabetic mothers need special care due to glucose demands for milk production.
    • The American Academy of Pediatrics recommends 400IU vitamin D/day supplementation for breastfed infants.
    • Infants have low vitamin K reserves. Some mothers have low vit K milk levels due to medication. Supplementing is recommended prophylactically (for example, in haemolytic disease). Vitamin K supplements for babies are also available in an injectable form.

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    Mammary Gland Bio Function PDF

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    Test your knowledge on breastfeeding, mammary gland development, and related hormonal changes. This quiz covers essential functions, benefits, and considerations regarding breastfeeding and formula feeding. Ideal for students and professionals in health and nutrition fields.

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