Breast Cancer Overview and Risk Factors
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Questions and Answers

What is the most common non-skin malignancy in women?

  • Endometrial Cancer
  • Cervical Cancer
  • Breast Cancer (correct)
  • Ovarian Cancer

Women who have full-term pregnancies at age 20 or younger have a higher chance of developing breast cancer.

False (B)

Alcohol consumption is a major risk factor for breast cancer.

False (B)

What is the most common type of breast cancer?

<p>Invasive ductal carcinoma (B)</p> Signup and view all the answers

What does DCIS stand for?

<p>Ductal carcinoma in situ</p> Signup and view all the answers

LCIS is a true form of cancer.

<p>False (B)</p> Signup and view all the answers

Which of the following is not a major prognostic factor for breast cancer?

<p>Caffeine consumption (C)</p> Signup and view all the answers

Which of the following is considered an aggressive form of breast cancer?

<p>Inflammatory carcinoma (D)</p> Signup and view all the answers

A lumpectomy is a suitable treatment for large tumors.

<p>False (B)</p> Signup and view all the answers

What is the most common histological subtype of cervical cancer?

<p>Squamous cell carcinoma (B)</p> Signup and view all the answers

Cervical adenocarcinoma originates in granular cells in the cervix.

<p>True (A)</p> Signup and view all the answers

Which of the following is a major risk factor for cervical cancer?

<p>All of the above (D)</p> Signup and view all the answers

Oral contraceptive pills increase the risk of cervical cancer.

<p>False (B)</p> Signup and view all the answers

What is the most effective way to prevent cervical cancer?

<p>All of the above (D)</p> Signup and view all the answers

A cervical biopsy is always performed after a Pap smear.

<p>False (B)</p> Signup and view all the answers

Loop electrosurgical excision procedure (LEEP) is only a diagnostic procedure.

<p>False (B)</p> Signup and view all the answers

Endometrial cancer is more common in women younger than 40 years old.

<p>False (B)</p> Signup and view all the answers

What is the primary reason for the increased risk of endometrial cancer after menopause?

<p>Increased estrogen levels (D)</p> Signup and view all the answers

Obesity is a risk factor for endometrial cancer.

<p>True (A)</p> Signup and view all the answers

What is the most common treatment for early invasive endometrial cancer?

<p>Cone biopsy (C)</p> Signup and view all the answers

Leiomyosarcoma is a common malignant neoplasm.

<p>False (B)</p> Signup and view all the answers

What is the most common site of origin for leiomyosarcoma?

<p>Uterus (B)</p> Signup and view all the answers

Which of the following is not a typical symptom of leiomyosarcoma?

<p>Skin rash (C)</p> Signup and view all the answers

Leiomyosarcoma is more likely to metastasize than other types of uterine cancer.

<p>True (A)</p> Signup and view all the answers

A radical prostatectomy is a curative treatment for prostate cancer.

<p>True (A)</p> Signup and view all the answers

What is the normal PSA level for a 65-year-old man?

<p>4.5 ng/ml</p> Signup and view all the answers

Cryotherapy is a common treatment for prostate cancer.

<p>False (B)</p> Signup and view all the answers

Hormonal therapy for prostate cancer targets the growth of cancerous cells by blocking the effects of hormones.

<p>True (A)</p> Signup and view all the answers

What is the precursor lesion for bowenoid papulosis?

<p>Carcinoma in situ (B)</p> Signup and view all the answers

Circumcision is a risk factor for penile cancer.

<p>False (B)</p> Signup and view all the answers

Esophageal cancer is more common in people who smoke cigarettes.

<p>True (A)</p> Signup and view all the answers

Achalasia is a condition that increases the risk of esophageal cancer.

<p>True (A)</p> Signup and view all the answers

Eating hot beverages can increase the risk of esophageal cancer.

<p>True (A)</p> Signup and view all the answers

Nutritional deficiencies are associated with an increased risk of esophageal cancer.

<p>True (A)</p> Signup and view all the answers

Plummer-Vinson syndrome is associated with squamous cell carcinoma of the esophagus.

<p>True (A)</p> Signup and view all the answers

The most common symptom of esophageal cancer is chest pain.

<p>False (B)</p> Signup and view all the answers

What is the most common cause of adenocarcinoma of the stomach?

<p>Chronic Helicobacter pylori infection (A)</p> Signup and view all the answers

The risk of stomach cancer is lower in people who consume leafy green vegetables and citrus fruits.

<p>True (A)</p> Signup and view all the answers

Stomach cancer is more common in men.

<p>True (A)</p> Signup and view all the answers

A fecal occult blood test is used to detect cancer cells in the stool.

<p>False (B)</p> Signup and view all the answers

What is the most common type of treatment for esophageal cancer?

<p>All of the above (D)</p> Signup and view all the answers

Gastrointestinal stromal tumors (GISTs) are more common in the stomach than in the small intestine.

<p>True (A)</p> Signup and view all the answers

What is the most common sign of a GIST in the stomach?

<p>All of the above (D)</p> Signup and view all the answers

Hepatocellular carcinoma (HCC) is more common in women than in men.

<p>False (B)</p> Signup and view all the answers

What is the leading risk factor for developing HCC?

<p>Cirrhosis (C)</p> Signup and view all the answers

HCC is more common in developed countries than in developing countries.

<p>False (B)</p> Signup and view all the answers

Which of the following is NOT a risk factor for breast cancer?

<p>Full-term pregnancy at age 20 or younger (A)</p> Signup and view all the answers

What is the most common type of invasive breast cancer?

<p>Invasive ductal carcinoma (A)</p> Signup and view all the answers

Which of the following is a significant risk factor for esophageal cancer?

<p>Frequent consumption of very hot beverages (B)</p> Signup and view all the answers

The most common type of gastric cancer is adenocarcinoma.

<p>True (A)</p> Signup and view all the answers

Which of the following is NOT a common symptom of adenocarcinoma of the stomach?

<p>Chest pain (A)</p> Signup and view all the answers

Hepatocellular carcinoma is more prevalent in developed countries.

<p>False (B)</p> Signup and view all the answers

What is the primary treatment for early stages of esophageal cancer?

<p>Surgery</p> Signup and view all the answers

Which of the following is a common risk factor for endometrial cancer?

<p>Unopposed estrogen (A)</p> Signup and view all the answers

What is the most common treatment for invasive endometrial cancer?

<p>Hysterectomy (D)</p> Signup and view all the answers

What is the name of the test that is used to measure the concentration of prostate-specific antigen (PSA) in the blood?

<p>PSA test</p> Signup and view all the answers

The most common form of penile cancer is bowenoid papulosis.

<p>False (B)</p> Signup and view all the answers

What is the name of the precursor lesion to invasive penile cancer?

<p>Bowenoid papulosis</p> Signup and view all the answers

Name a commonly used drug in palliative treatment of esophageal cancer.

<p>Cisplatin</p> Signup and view all the answers

What is the name of the condition that is characterized by a thickening of the esophagus and difficulty swallowing, often associated with iron deficiency anemia?

<p>Plummer-Vinson syndrome</p> Signup and view all the answers

Which of the following is a significant risk factor for developing cervical cancer?

<p>All of the above (D)</p> Signup and view all the answers

The majority of invasive cervical cancers are caused by HPV, specifically types 16 and 18.

<p>True (A)</p> Signup and view all the answers

Which of the following is NOT a diagnostic test used for cervical cancer?

<p>Colonoscopy (B)</p> Signup and view all the answers

Which of the following is considered a precancerous lesion of the cervix?

<p>Cervical intraepithelial neoplasia (CIN) (A)</p> Signup and view all the answers

Most cases of cervical cancer are diagnosed in early stages.

<p>False (B)</p> Signup and view all the answers

The most effective way to prevent cervical cancer is vaccination against HPV.

<p>True (A)</p> Signup and view all the answers

What is the primary treatment for early stages of invasive cervical cancer?

<p>Cone biopsy</p> Signup and view all the answers

Which of the following is a common treatment for early stage endometrial cancer?

<p>Hysterectomy (A)</p> Signup and view all the answers

Leiomyosarcoma is a type of cancer that originates only in the uterus.

<p>False (B)</p> Signup and view all the answers

The 5-year survival rate for leiomyosarcoma is high.

<p>False (B)</p> Signup and view all the answers

What type of imaging study is commonly used to detect metastatic osteoblastic carcinoma?

<p>Magnetic Resonance Imaging (MRI)</p> Signup and view all the answers

Which of the following is NOT a risk factor for developing prostate cancer?

<p>High intake of lycopene-rich foods (B)</p> Signup and view all the answers

What is the name of the surgical procedure used to remove the entire prostate gland?

<p>Radical prostatectomy</p> Signup and view all the answers

What is the name of the minimally invasive procedure that uses freezing temperatures to destroy cancerous tissue in the prostate?

<p>Cryotherapy</p> Signup and view all the answers

Hormonal therapy is used to treat prostate cancer by blocking the production of testosterone.

<p>True (A)</p> Signup and view all the answers

The most common type of ovarian cancer is a borderline tumor.

<p>False (B)</p> Signup and view all the answers

What is the name of the rare and aggressive type of cancer that develops in the placenta?

<p>Choriocarcinoma</p> Signup and view all the answers

Gastrointestinal stromal tumor (GIST) is more common in the stomach than in other parts of the gastrointestinal tract.

<p>True (A)</p> Signup and view all the answers

Hepatocellular carcinoma is more prevalent in men than in women.

<p>True (A)</p> Signup and view all the answers

Which of the following is NOT a common symptom of hepatocellular carcinoma?

<p>Headache (A)</p> Signup and view all the answers

The primary treatment for hepatocellular carcinoma is liver transplantation.

<p>True (A)</p> Signup and view all the answers

Which of the following is NOT a risk factor for developing hepatocellular carcinoma?

<p>High intake of dietary fiber (D)</p> Signup and view all the answers

Flashcards

Breast Cancer

Most common non-skin malignancy in women.

Carcinoma in situ (DCIS)

Abnormal cells in breast lining, but haven't spread.

Lobular carcinoma in situ (LCIS)

Cancer cells in breast lobules, hasn't spread.

Invasive ductal carcinoma

Breast cancer that has spread into surrounding tissues, in milk ducts.

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Invasive lobular carcinoma

Breast cancer that spreads from lobules, hard to detect.

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Medullary carcinoma

Breast cancer type with distinctive microscopic appearance; less aggressive.

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Mucinous (colloid) carcinoma

Breast cancer w/ cancer cells in mucin; slow-growing.

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Tubular carcinoma

Breast cancer resembling tubes in microscope, usually has a good prognosis.

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Invasive papillary carcinoma

Finger-like cancer cells; relatively rare.

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Metaplastic carcinoma

Rare and uncommon breast cancer; poor prognosis.

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Distant metastases

Spread of cancer beyond breast, to other organs.

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Lymph node metastases

Cancer spread to lymph nodes; systemic.

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Tumor size

Indicates cancer stage, extent of surgery, and type of treatment needed.

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Locally advanced disease

Cancer spread to nearby tissues, not distant organs; requires aggressive treatment.

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Inflammatory carcinoma

Aggressive breast cancer; breasts swollen and red.

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Mammography

Breast X-ray for cancer detection.

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Ultrasound

Uses soundwaves to create images of breast.

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MRI

Detailed breast imaging using magnetic fields.

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Biopsy

Removal of tissue sample for microscopic analysis.

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Lumpectomy

Removal of breast lump; breast-conserving surgery.

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Partial/Segmental Mastectomy

Removal of larger breast section, saving breast tissue; possible one quadrant.

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Total Mastectomy

Removal of entire breast, but not lymph nodes; used for high recurrence risk.

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Modified Radical Mastectomy

Removal of entire breast and some axillary lymph nodes; less invasive than radical mastectomy.

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Cellular Aberration

A change in cells that often includes alterations in shape, size, structure, and function. It can occur due to different factors, and is commonly associated with abnormal growth and development.

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Cyclins

Proteins that act like timers or switches controlling the progression of the cell cycle. They're important for ensuring the cycle proceeds in the correct order.

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Cyclin-dependent kinases (CDK)

Enzymes that work with cyclins to regulate the cell cycle. They are essential for cell growth and division.

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Proto-oncogenes

Normal genes involved in early development. Their activity is usually not needed after embryonic life. They are not abnormal genes but can become oncogenes if mutated.

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Tumor suppressor genes

Genes that normally slow down cell division, repair DNA mistakes, and tell cells when to die (apoptosis). They act like 'brakes' for cell growth.

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Cancer

A disease process that begins with an abnormal cell transformed by mutations in the cellular DNA. This cell forms a clone and proliferates abnormally, ignoring growth-regulating signals.

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Hyperplasia

An abnormal increase in the number of cells in a tissue or organ. It's not always cancerous, but can be a precursor to cancer.

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Metaplasia

A reversible change where one type of cell transforms into a different type of cell. This can be a response to environmental stress but may also be linked to cancer.

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Dysplasia

Cells begin to look and behave abnormally, but haven't yet become malignant. It's a pre-cancerous condition.

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Anaplasia

Cells become highly abnormal, losing their mature characteristics, often seen in aggressive cancers.

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Neoplasia

New growth, or tumor, can be either benign or malignant. It's uncontrolled cell growth that doesn't follow normal physiological demands.

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Benign Tumor

Not cancerous, a stable abnormal growth that is usually treatable and not life-threatening.

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Malignant Tumor

Cancerous, cells are invasive and tend to metastasize. They are often uncontrollable and resistant to therapy, spreading rapidly.

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Invasion

A cancerous tumor's growth into surrounding host tissues, indicating its invasive nature.

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Metastasis

The dissemination or spread of malignant cells to distant sites in the body. It is often the primary cause of death in cancer patients.

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Hypertrophy

An increase in the size of individual cells, leading to an increase in the size of the entire organ or tissue.

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Atrophy

A decrease in the size of an organ due to a reduction in cell size and number.

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Necrosis

Cell death

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Apoptosis

Programmed cell death, a natural process where cells die in a controlled way.

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Differentiation

The specialized form and function that cells or tissues develop, particularly during embryonic development.

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Carcinogenesis

The process by which a normal cell transforms into a cancer cell. It involves multiple stages and mutations.

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Carcinogen

A substance or agent that can damage cell DNA and potentially cause cancer. Carcinogens can be chemical, physical, or biological.

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Endogenous risk factors

Factors for developing cancer that are not modifiable or changeable, such as genetics, age, and sex.

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Exogenous risk factors

Factors for developing cancer that are modifiable or changeable, such as lifestyle, diet, and exposure to carcinogens.

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Tumor marker

A substance found in tumor tissue, blood, or other body fluids. They can help diagnose and monitor cancer.

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Genetic tumor marker

Mutations or alterations in genes found in tumors or body tissues that can be used to diagnose, predict treatment response, and monitor cancer progression.

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Tumor Staging

A system used to categorize the extent of cancer spread, including tumor size, lymph node involvement, and distant metastasis. Staging helps determine the best treatment options and predict the outcome.

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Tumor Grading

A system used to assess the aggressiveness of cancer cells based on their microscopic appearance. Grades influence treatments and prognosis.

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Angiogenesis

The growth of new blood vessels into a tumor, allowing it to access more nutrients and oxygen, facilitating its growth and spread.

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Immunotherapy

Treatment that utilizes the body's immune system to target and destroy cancer cells.

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Photodynamic therapy

A cancer treatment involving a light-sensitive drug and laser light to destroy cancer cells.

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Study Notes

Carcinoma of the Breast

  • Most common non-skin malignancy in women
  • Gender and genetics are major risk factors
  • Incidence increases throughout a woman's life, peaking at 75-80 years
  • Early menarche (before 11 years old) and late menopause increase risk
  • Full-term pregnancy under 20, or over 35 at first birth, reduces risk
  • Hormonal changes during pregnancy and breastfeeding offer some protection against breast cancer
  • Other risk factors include first-degree relatives with breast cancer, atypical hyperplasia, ethnicity, and estrogen exposure
  • Breast density and radiation exposure are also risk factors
  • Estrogen exposure, notably from hormone therapy or early menarche, is a significant risk factor
  • Caffeine has a protective effect on breast tissue
  • Alcohol consumption increases the risk of breast cancer
  • Obesity increases estrogen levels, thus increasing risk
  • Exercise and breastfeeding lower the risk of breast cancer

Forms of Breast Cancer

  • Carcinoma in situ (DCIS): Non-invasive, abnormal cells within milk ducts
  • Lobular carcinoma in situ (LCIS): Abnormal cells in the lobules, not considered cancer itself but indicates a higher risk
  • Invasive ductal carcinoma: Most common type, invades surrounding tissues.
  • Invasive lobular carcinoma: Often doesn't form a distinct lump, making detection challenging
  • Medullary carcinoma: distinct, less aggressive under a microscope.
  • Mucinous (colloid) carcinoma: Cancer cells are embedded in a slimy substance called mucin. Slow-growing, with a better prognosis. 
  • Tubular carcinoma: Tube-like appearance under a microscope, tending to have a good prognosis
  • Invasive papillary carcinoma: Finger-like shape, typically has a good prognosis
  • Metaplastic carcinoma: Rare and less common, with a worse prognosis

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Description

Explore the critical information regarding carcinoma of the breast, the most common non-skin malignancy in women. This quiz covers risk factors such as genetics, lifestyle, and hormonal influences, as well as the various forms of breast cancer. Understand how these factors impact incidence and prevention strategies.

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