S10 Easy - Glycolysis

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Questions and Answers

Where is the active site of glucose-6-phosphatase enzyme located?

  • Golgi apparatus
  • ER lumen (correct)
  • Mitochondria
  • Cytosol

Fast-twitch muscle fibers use aerobic glycolysis for metabolism.

False (B)

What is the last source of material for gluconeogenesis?

muscle protein (after glycogen and fat)

Lactate is transferred by _______________________ cells.

<p>red blood</p> Signup and view all the answers

Match the sources of lactate with their descriptions:

<p>Fast-twitch muscle fiber = Uses anaerobic glycolysis for metabolism Red blood cells = Transfers lactate</p> Signup and view all the answers

What is the purpose of gluconeogenesis?

<p>Synthesize glucose from non-carbohydrate sources (D)</p> Signup and view all the answers

Cori Cycle involves the synthesis of glucose from lactate.

<p>True (A)</p> Signup and view all the answers

An important function of glucose-6-phosphatase enzyme is to regulate _______________________ levels.

<p>blood sugar</p> Signup and view all the answers

What is the end result of carbohydrate digestion?

<p>Monosaccharides (A)</p> Signup and view all the answers

Glycolysis is an anabolic pathway.

<p>False (B)</p> Signup and view all the answers

What is the standard free energy change associated with the complete oxidation of glucose to CO2 and H2O?

<p>-2,840 kJ/mol</p> Signup and view all the answers

Glycolysis is a series of __________ enzyme-catalyzed reactions.

<p>ten</p> Signup and view all the answers

Match the following metabolic pathways with their respective functions:

<p>Glycolysis = Breakdown of glucose into pyruvate Gluconeogenesis = Synthesis of glucose from non-carbohydrate sources</p> Signup and view all the answers

What is the fate of non-digestible carbohydrates, such as cellulose?

<p>They are not absorbed and end up in feces (C)</p> Signup and view all the answers

What type of reaction occurs during the breakdown of glycogen?

<p>Phosphorolysis (D)</p> Signup and view all the answers

The breakdown of glycogen releases glucose-1-phosphate.

<p>True (A)</p> Signup and view all the answers

What is the function of glycogen phosphorylase in the breakdown of glycogen?

<p>catalyzes the phosphorolytic breakdown of glycogen</p> Signup and view all the answers

Glycogen is a type of _______________ storing glucose molecules.

<p>homopolymer</p> Signup and view all the answers

What is the result of the phosphorolytic breakdown of glycogen?

<p>Glycogen molecule is shortened by one glucose residue (B)</p> Signup and view all the answers

Glycogen phosphorylase is an enzyme that catalyzes the hydrolytic breakdown of glycogen.

<p>False (B)</p> Signup and view all the answers

What is the significance of the nonreducing end of a glycogen molecule?

<p>it is the site of phosphorolytic breakdown</p> Signup and view all the answers

Match the following enzyme with its function:

<p>Glycogen phosphorylase = Catalyzes the phosphorolytic breakdown of glycogen</p> Signup and view all the answers

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Study Notes

Breakdown of Glycogen to Supply Glucose

  • Glycogen is a homopolymer of glucose stored in the liver and muscles
  • Glycogen phosphorylase catalyzes the breakdown of glycogen into glucose 1-phosphate through a phosphorolysis reaction
  • The reaction involves the attack of inorganic phosphate on the terminal glucosyl residue at the non-reducing end of a glycogen molecule
  • Glucose 1-phosphate is released, and the glycogen molecule is shortened by one glucose residue

Regulation of Glycolysis and Gluconeogenesis

  • The pathway of glycolysis and gluconeogenesis is regulated to maintain blood sugar levels within an acceptable range
  • The Cori Cycle plays a key role in this regulation by synthesizing glucose from lactate
  • Lactate is sourced from fast-twitch muscle fibers and red blood cells
  • Gluconeogenesis from amino acids involves protein mobilization, with muscle protein being the last source of material for gluconeogenesis

Digestion of Carbohydrates

  • Carbohydrates must be broken down into monosaccharides to be absorbed through the intestine wall and into the bloodstream
  • Monosaccharides are transported into cells by passive diffusion through transmembrane proteins
  • Non-digestible carbohydrates, such as cellulose, are not absorbed and end up in feces

Major Pathways of Glucose Utilization

  • Glycolysis, gluconeogenesis, and the pentose phosphate pathway are major pathways of glucose utilization
  • Glycolysis and catabolism involve the breakdown of glucose, while gluconeogenesis and anabolism involve the synthesis of glucose
  • Glycolysis yields ATP, NADH, and pyruvate as products

What is Glycolysis?

  • Glycolysis is a series of ten enzyme-catalyzed reactions that degrade glucose into pyruvate
  • Glucose is the major fuel of most organisms and is rich in potential energy
  • The complete oxidation of glucose to CO2 and H2O proceeds with a standard free energy change of -2,840 kJ/mol

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