Podcast
Questions and Answers
Which of the following genes is associated with the highest lifetime risk of ovarian cancer among the moderate penetrance genes mentioned?
Which of the following genes is associated with the highest lifetime risk of ovarian cancer among the moderate penetrance genes mentioned?
- RAD51C
- ATM
- RAD51D (correct)
- BRIP1
At what approximate age range is the risk of ovarian cancer highest for individuals with mutations in the BRIP1 and RAD51D genes?
At what approximate age range is the risk of ovarian cancer highest for individuals with mutations in the BRIP1 and RAD51D genes?
- 45-59 years (correct)
- 70-79 years
- 60-69 years
- 35-39 years
Based on the information provided, which of the following statements is true regarding the management of ovarian cancer risk for women with moderate penetrance gene mutations?
Based on the information provided, which of the following statements is true regarding the management of ovarian cancer risk for women with moderate penetrance gene mutations?
- Both b and c (correct)
- Recommendations should be tailored based on family history and other risk factors.
- RRSO is not indicated for women with an average risk of ovarian cancer.
- Risk-reducing salpingo-oophorectomy (RRSO) is routinely recommended for all women with moderate penetrance gene mutations.
According to the information provided, what is the approximate lifetime risk of ovarian cancer for individuals with a mutation in the ATM gene?
According to the information provided, what is the approximate lifetime risk of ovarian cancer for individuals with a mutation in the ATM gene?
Which of the following risk thresholds is generally used in the UK for considering risk-reducing surgery (RRSO) for ovarian cancer?
Which of the following risk thresholds is generally used in the UK for considering risk-reducing surgery (RRSO) for ovarian cancer?
Based on the information provided, which of the following statements is true regarding the risk of ovarian cancer for women with one affected first-degree relative?
Based on the information provided, which of the following statements is true regarding the risk of ovarian cancer for women with one affected first-degree relative?
Which of the following statements about BRCA1/2 mutation carriers is correct based on the provided information?
Which of the following statements about BRCA1/2 mutation carriers is correct based on the provided information?
According to the information provided, what is the estimated risk of male breast cancer for BRCA1 mutation carriers by age 70?
According to the information provided, what is the estimated risk of male breast cancer for BRCA1 mutation carriers by age 70?
Which of the following statements about the management of pancreatic cancer risk in BRCA1/2 mutation carriers is correct?
Which of the following statements about the management of pancreatic cancer risk in BRCA1/2 mutation carriers is correct?
Which of the following genes, in addition to BRCA1/2, should be considered when evaluating inherited risk of breast and ovarian cancer?
Which of the following genes, in addition to BRCA1/2, should be considered when evaluating inherited risk of breast and ovarian cancer?
Based on the provided information, which of the following statements about prostate cancer screening for BRCA2 mutation carriers is correct?
Based on the provided information, which of the following statements about prostate cancer screening for BRCA2 mutation carriers is correct?
According to the information provided, which of the following statements about the management of melanoma risk in BRCA1/2 mutation carriers is correct?
According to the information provided, which of the following statements about the management of melanoma risk in BRCA1/2 mutation carriers is correct?
What is the estimated lifetime risk of breast cancer for individuals with a pathogenic variant in the BARD1 gene?
What is the estimated lifetime risk of breast cancer for individuals with a pathogenic variant in the BARD1 gene?
Which of the following genes is associated with the highest lifetime risk of ovarian cancer among the moderate-penetrance genes mentioned in the text?
Which of the following genes is associated with the highest lifetime risk of ovarian cancer among the moderate-penetrance genes mentioned in the text?
According to the UK consensus guidelines, what is the recommended screening strategy for women with a pathogenic variant in a moderate-penetrance breast cancer gene?
According to the UK consensus guidelines, what is the recommended screening strategy for women with a pathogenic variant in a moderate-penetrance breast cancer gene?
According to the information provided, what is the approximate percentage of ovarian cancer patients who have a germline mutation?
According to the information provided, what is the approximate percentage of ovarian cancer patients who have a germline mutation?
According to the UK consensus recommendations, which of the following genes should be considered when evaluating inherited risk of breast and ovarian cancer, in addition to BRCA1/2?
According to the UK consensus recommendations, which of the following genes should be considered when evaluating inherited risk of breast and ovarian cancer, in addition to BRCA1/2?