17 Questions
Which of the following genes is associated with the highest lifetime risk of ovarian cancer among the moderate penetrance genes mentioned?
RAD51D
At what approximate age range is the risk of ovarian cancer highest for individuals with mutations in the BRIP1 and RAD51D genes?
45-59 years
Based on the information provided, which of the following statements is true regarding the management of ovarian cancer risk for women with moderate penetrance gene mutations?
Both b and c
According to the information provided, what is the approximate lifetime risk of ovarian cancer for individuals with a mutation in the ATM gene?
3%
Which of the following risk thresholds is generally used in the UK for considering risk-reducing surgery (RRSO) for ovarian cancer?
5%
Based on the information provided, which of the following statements is true regarding the risk of ovarian cancer for women with one affected first-degree relative?
The risk is approximately 3%.
Which of the following statements about BRCA1/2 mutation carriers is correct based on the provided information?
Prophylactic mastectomy at age 25 and prophylactic oophorectomy at age 40 maximize survival probability.
According to the information provided, what is the estimated risk of male breast cancer for BRCA1 mutation carriers by age 70?
~7%
Which of the following statements about the management of pancreatic cancer risk in BRCA1/2 mutation carriers is correct?
There is no proven screening approach for pancreatic cancer in BRCA1/2 mutation carriers.
Which of the following genes, in addition to BRCA1/2, should be considered when evaluating inherited risk of breast and ovarian cancer?
PALB2 and ATM
Based on the provided information, which of the following statements about prostate cancer screening for BRCA2 mutation carriers is correct?
Prostate cancer screening with PSA and DRE is recommended starting at age 40-45.
According to the information provided, which of the following statements about the management of melanoma risk in BRCA1/2 mutation carriers is correct?
Dermatology skin screening and exposure reduction are recommended.
What is the estimated lifetime risk of breast cancer for individuals with a pathogenic variant in the BARD1 gene?
Approximately 30%
Which of the following genes is associated with the highest lifetime risk of ovarian cancer among the moderate-penetrance genes mentioned in the text?
BRIP1
According to the UK consensus guidelines, what is the recommended screening strategy for women with a pathogenic variant in a moderate-penetrance breast cancer gene?
Annual mammography and MRI screening from age 30
According to the information provided, what is the approximate percentage of ovarian cancer patients who have a germline mutation?
15-20%
According to the UK consensus recommendations, which of the following genes should be considered when evaluating inherited risk of breast and ovarian cancer, in addition to BRCA1/2?
All of the above
Test your knowledge on the survival advantage of prophylactic mastectomy in BRCA1/2 mutation carriers based on data modeling. Explore the effectiveness of different cancer risk reduction strategies including prophylactic mastectomy and screening methods like mammography and MRI.
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