Brain Blood Supply: Arteries and Regions
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Questions and Answers

The lenticulostriate arteries, after passing through the space where the lenticular nucleus was, enter which structure?

  • Internal capsule (correct)
  • Middle cerebral artery
  • Insula
  • Vertebrobasilar system

The middle cerebral artery is a branch of the vertebrobasilar system.

False (B)

The vertebrobasilar system supplies blood to the brainstem, parts of the cerebrum, and the spinal _____

cord

Which artery is NOT a direct branch of the vertebral artery?

<p>Anterior Inferior Cerebellar Artery (C)</p> Signup and view all the answers

Which arteries does the internal carotid artery divide into?

<p>Middle and anterior cerebral arteries (A)</p> Signup and view all the answers

The basilar artery bifurcates into the posterior ________ arteries.

<p>cerebral</p> Signup and view all the answers

The vertebral arteries join to form the basilar artery before giving rise to the posterior inferior cerebellar artery.

<p>True (A)</p> Signup and view all the answers

The vertebral-basilar system supplies which major regions of the brain?

<p>brainstem, diencephalon, inferior and posterior parts of the cerebral hemispheres</p> Signup and view all the answers

Match the following arteries with their origin:

<p>Anterior spinal artery = Vertebral artery Superior cerebellar artery = Basilar artery Posterior cerebral artery = Basilar artery Posterior inferior cerebellar artery = Vertebral artery</p> Signup and view all the answers

Which of the following arteries supplies the labyrinth?

<p>Labyrinthine artery (C)</p> Signup and view all the answers

The basilar artery bifurcates into the ________ cerebral arteries.

<p>posterior</p> Signup and view all the answers

Which of the following arteries primarily contribute to the brain's blood supply?

<p>Internal carotid and vertebral arteries (D)</p> Signup and view all the answers

Match each artery with its major branch:

<p>Vertebral artery = Posterior inferior cerebellar artery Basilar artery = Posterior communicating artery Internal carotid artery = Middle cerebral artery</p> Signup and view all the answers

The posterior cerebral artery is a branch of the vertebral artery.

<p>False (B)</p> Signup and view all the answers

Cerebral blood vessels dilate in response to increased blood pressure to maintain constant blood flow.

<p>False (B)</p> Signup and view all the answers

What is the purpose of autoregulation in the context of cerebral blood flow?

<p>maintain constant flow</p> Signup and view all the answers

If the posterior cerebral artery on one side originates from the internal carotid artery instead of the basilar artery, this is considered:

<p>A relatively common variant. (C)</p> Signup and view all the answers

The Circle of Willis is typically symmetrical in all individuals.

<p>False (B)</p> Signup and view all the answers

The circle of Willis allows for distribution of contrast medium to the contralateral side during a unilateral injection due to its ______ nature.

<p>arterial</p> Signup and view all the answers

Match the neuroimaging technique with its primary function:

<p>Positron Emission Tomography (PET) = Maps increased glucose consumption in the brain Functional Magnetic Resonance Imaging (fMRI) = Demonstrates activity in the auditory and visual cortex Angiography = Visualizes cerebral arteries using contrast medium</p> Signup and view all the answers

Name two arteries that arise from the basilar artery before its bifurcation.

<p>anterior inferior cerebellar, superior cerebellar</p> Signup and view all the answers

What stimulates collaborative local responses of neurons, astrocytes, and cerebral vessels?

<p>Increased neural activity (B)</p> Signup and view all the answers

Positron emission tomography (PET) scanning uses 18F-fluorodeoxyglucose to map decreased glucose consumption in specific brain areas during tasks.

<p>False (B)</p> Signup and view all the answers

Name two neuroimaging techniques used to study brain activity or blood flow.

<p>PET, fMRI</p> Signup and view all the answers

What percentage of the body's total oxygen supply does the brain consume?

<p>25% (A)</p> Signup and view all the answers

Gray matter requires more blood supply than white matter due to the higher metabolic needs of neuronal cell bodies.

<p>True (A)</p> Signup and view all the answers

Within what distance must a capillary be from any neuron in the cortex?

<p>100 μm</p> Signup and view all the answers

The internal carotid artery provides approximately ______ of the brain's blood supply.

<p>80%</p> Signup and view all the answers

Match the arteries with the brain regions they primarily supply:

<p>Anterior Cerebral Artery = Medial parts of frontal and parietal lobes Middle Cerebral Artery = Basal nuclei and internal capsule Anterior Choroidal Artery = Optic tract, choroid plexus, hippocampus</p> Signup and view all the answers

Which of the following would most likely occur after 20 seconds of ischemia?

<p>Electrical activity ceases (A)</p> Signup and view all the answers

The vertebral artery supplies 80% of the brain's blood flow.

<p>False (B)</p> Signup and view all the answers

Name one structure that the anterior choroidal artery supplies.

<p>hippocampus</p> Signup and view all the answers

Which brain region is activated by both white noise and spoken words, as indicated by increased blood flow in fMRI scans?

<p>Superior Temporal Gyrus (C)</p> Signup and view all the answers

Functional MRI data of a subject watching a reversing checkerboard only activates the occipital cortex.

<p>False (B)</p> Signup and view all the answers

What technique is used to map blood flow after intravenous injection of H215O?

<p>PET Scan</p> Signup and view all the answers

Moving visual stimuli activate an area on the lateral surface of the occipital lobe, near its junction with the ______ lobe.

<p>temporal</p> Signup and view all the answers

What type of MRI scan is used to reconstruct the surface of the subject's brain for coregistration with PET data?

<p>T1-weighted MRI (A)</p> Signup and view all the answers

Match the stimulus with the primary brain region it activates (according to the text):

<p>White Noise = Superior Temporal Gyrus Spoken Words = Superior Temporal Gyrus Reversing Checkerboard = Occipital Cortex and Lateral Geniculate Nucleus Moving Visual Stimuli = Lateral Occipital Lobe (near temporal junction)</p> Signup and view all the answers

Why is coregistration of PET and MRI data important when studying brain activity?

<p>To overlay functional data (PET) onto anatomical data (MRI). (A)</p> Signup and view all the answers

The calcarine sulcus is the principal thalamic nucleus relaying visual information.

<p>False (B)</p> Signup and view all the answers

Which of the following accurately describes the relationship between ventricular spaces, subarachnoid spaces, and the brain's extracellular spaces?

<p>The ventricular and subarachnoid spaces are in free communication, and both communicate with the brain's extracellular spaces. (A)</p> Signup and view all the answers

Circumventricular organs are characterized by a fully intact blood-brain barrier, similar to most brain regions, but located near ventricles.

<p>False (B)</p> Signup and view all the answers

Which circumventricular organ is primarily involved in detecting toxins in the bloodstream and initiating the vomiting reflex?

<p>Area postrema (C)</p> Signup and view all the answers

The pineal gland secretes __________, which plays a role in regulating circadian rhythms.

<p>melatonin</p> Signup and view all the answers

Which of the following best describes the role of the vascular organ of the lamina terminalis?

<p>Control of fluid balance and potential involvement in neuroendocrine functions. (D)</p> Signup and view all the answers

Match the following blood drainage systems with their corresponding descriptions:

<p>Superficial veins = Drain the outer surface of the brain and primarily empty into the superior sagittal sinus. Deep veins = Include the basal vein and internal cerebral vein; drain deeper brain structures. Dural sinuses = Venous channels located between the dura mater layers; collect blood from the brain and empty into the internal jugular vein.</p> Signup and view all the answers

Explain why the median eminence is crucial for neuroendocrine function. What structural characteristic allows it to perform this function?

<p>The median eminence lacks a blood-brain barrier, enabling hypothalamic hormones to directly enter the bloodstream for regulating pituitary function.</p> Signup and view all the answers

A researcher is studying the effects of a neurotoxin that can easily cross the blood-brain barrier. Which area would be MOST vulnerable to direct exposure and subsequent damage?

<p>The area postrema (D)</p> Signup and view all the answers

Flashcards

Brain Weight Proportion

The brain constitutes about 2% of total body weight.

Brain's Share of Cardiac Output

The brain uses around 15% of cardiac output.

Brain Oxygen Consumption

The brain consumes 25% of the body’s oxygen.

Ischemia: Time to Unconsciousness

Loss of consciousness occurs after 10 seconds of ischemia.

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Ischemia: Brain Electrical Activity Stops

Electrical activity in the brain ceases after 20 seconds of ischemia.

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Anterior Choroidal Artery (AChA) Function

Supplies optic tract, choroid plexus, internal capsule, thalamus, hippocampus, and cerebral peduncle.

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Anterior Cerebral Artery (ACA) Function

Supplies medial parts & partly dorsolateral surface of frontal and parietal lobes.

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Middle Cerebral Artery (MCA) Function

Supplies basal nuclei & internal capsule.

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Brain's Blood Supply

Primary arteries supplying the brain.

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Circle of Willis

Connects the internal carotid and vertebral arteries, providing collateral circulation in the brain.

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Cerebral Arteries

Anterior, middle, and posterior cerebral arteries.

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Autoregulation (Brain)

The brain maintains constant blood flow despite changes in blood pressure.

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Collaborative Local Response

Neurons, astrocytes, and cerebral vessels work together to increase blood flow to active brain regions.

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Positron Emission Tomography (PET)

A medical imaging technique that detects changes in blood flow by measuring glucose metabolism.

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Functional Magnetic Resonance Imaging (fMRI)

Imaging technique that detects changes in blood flow by measuring oxygen levels.

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PET Scan Use

Used to map increased glucose consumption in specific brain areas during tasks

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Internal Carotid Artery

Divides into middle and anterior cerebral arteries, after giving rise to posterior communicating and anterior choroidal arteries.

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Middle and Anterior Cerebral Arteries

Supplies anterior and lateral parts of the cerebrum.

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Basilar Artery

Formed by joined vertebral arteries; it supplies the brainstem, diencephalon, and posterior cerebrum.

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Anterior Inferior and Superior Cerebellar Arteries

Provide blood supply to different regions of the brainstem.

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Posterior Cerebral Arteries

Branches from the basilar artery and supplies the posterior portions of the cerebral hemispheres.

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Posterior Communicating Artery

Connects the internal carotid and posterior cerebral arteries.

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Lenticulostriate Arteries

Small arteries crossing from the lenticular nucleus space to the internal capsule.

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Vertebrobasilar System

Artery that supplies the brainstem, parts of the cerebrum, and spinal cord.

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Vertebral Artery Branches

Gives rise to anterior & posterior spinal arteries, and posterior inferior cerebellar artery (PICA).

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Basilar Artery Branches

Gives rise to anterior inferior cerebellar, labyrinthine, pontine, and superior cerebellar arteries; then bifurcates into posterior cerebral arteries.

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Posterior Inferior Cerebellar Artery (PICA)

Supplies the cerebellum's back and bottom.

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Anterior Inferior Cerebellar Artery (AICA)

Feeds the cerebellum's front and bottom.

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Superior Cerebellar Artery

Nourishes the cerebellum above.

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Posterior Cerebral Artery

Artery that supplies the inferior surface of the brain.

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Functional MRI (fMRI)

A neuroimaging technique that measures brain activity by detecting changes associated with blood flow.

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Superior Temporal Gyrus activation

These areas show increased activity when processing auditory stimuli like white noise and spoken words.

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Spoken Words

Compared to white noise, they activate a more extensive area of the superior temporal gyrus.

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Occipital Cortex

A brain area that processes visual information.

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Lateral Geniculate Nucleus (LGN)

Located in the thalamus; relays visual information to the occipital cortex.

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Calcarine Sulcus

A brain area activated by moving visual stimuli.

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Coregistration (PET and MRI)

Combining data from different imaging modalities to provide a more complete picture.

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Communicating Brain Spaces

Spaces in the brain that freely connect, allowing communication between ventricular, subarachnoid, and extracellular areas.

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Circumventricular Organs

Specialized areas in the brain lacking a normal blood-brain barrier, allowing direct monitoring of blood content.

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Subfornical Organ (SFO)

Located in the third ventricle, it's involved in controlling fluid balance and drinking behavior. An example of a circumventricular organ.

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Vascular Organ of the Lamina Terminalis (VOLT)

Embedded in the lamina terminalis, participates in fluid balance control and neuroendocrine functions. Another example of a circumventricular organ.

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Pineal Gland

Releases melatonin to regulate circadian rhythms and seasonal reproductive cycles.

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Area Postrema

Monitors blood for toxins and triggers vomiting. Located in the caudal end of the fourth ventricle.

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Superficial Veins of brain

Drain blood from the brain's surface.

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Deep Veins of Brain

Drain blood from the brain's deeper structures, such as basal ganglia.

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Study Notes

Brain Blood Supply

  • Brain represents 2% of total body weight.
  • It consumes 15% of cardiac output.
  • Brain utilizes 25% of the body's oxygen.
  • Ischemia leads to loss of consciousness in 10 seconds.
  • Ischemia causes electrical activity to cease in 20 seconds.
  • Capillaries are located no more than ≤100 µm from any neuron in the cortex.

Internal Carotid Artery

  • Supplies 80% of brain's blood
  • Branches: ophthalmic a., anterior choroidal a., posterior communicating a.
  • Bifurcates into middle and anterior cerebral arteries.

Vertebral Artery

  • Supplies 20% of brains blood
  • Supplies anterior and posterior spinal arteries, and posterior inferior cerebellar artery

Anterior Choroidal Artery (AChA)

  • Supplies optic tract, choroid plexus, internal capsule, thalamus, hippocampus, and cerebral peduncle.

Anterior Cerebral Artery

  • Supplies anterior communicating artery.
  • Perfuses the frontal and parietal lobes.
  • Specifically, it supplies medial parts and partly dorsolateral surface
  • Encompasses A1 & A2 segments
  • Continues as a. pericallosa

Middle Cerebral Artery

  • Includes medial and lateral lenticulostriate arteries that supply basal nuclei & internal capsule.
  • Includes Insular branches
  • Supplies the insula and lateral surface of the hemisphere

Vertebrobasilar System

  • This system provides blood to the brainstem.
  • It also supplies parts of the cerebrum and spinal cord.

Basilar Artery

  • Anterior Inferior Cerebellar, Labyrinthine, Pontine; Superior Cerebellar Arteries; Posterior Cerebral Arteries
  • Arterial Supply to the Spinal Cord:

Anterior and Posterior Spinal Arteries

  • Anterior spinal artery supllies 2/3 of the spinal cord.
  • Posterior spinal artery supplies 1/3 of the spinal cord.

Control of Cerebral Blood Flow

  • The total flow rate remains constant despite regional changes.
  • Autoregulation: Cerebral blood vessels maintain consistent flow.
  • Vessels constrict when blood pressure increases and relax when it decreases.
  • Collaborative local response: Neurons, astrocytes, and cerebral vessels collaborate to respond to neural activity.

Deep Cerebral Veins

  • Thalamostriate v.
  • Choroidal v.
  • Internal cerebral v.
  • Great cerebral v.
  • Straight sinus

Subependymal Region

  • This drains venous blood into the inferior sagittal sinus superiorly or into the great cerebral vein of Galen inferiorly.
  • Both the superior and inferior drain into the straight sinus.

Superficial Veins

  • Superior cerebral v.
  • Superficial middle v.
  • Superior and inferior anastomotic v.

Dural Venous Sinuses

  • Superior sagittal, Inferior sagittal, Straight, Occipital; Confluence of sinuses, Transverse (right and left), Sigmoid (right and left), Cavernous (paired), Intercavernous, Sphenoparietal (paired), Superior petrosal (paired), Inferior petrosal (paired), Basilar

Ventricles

  • Lateral
  • Third
  • Fourth
  • Interventricular foramen
  • Cerebral aqueduct
  • Lateral recess
  • Lateral aperture
  • Median aperture

Cerebrospinal Fluid

  • Volume is approximately 150 ml in general.
  • Volume In ventricles is about 25 ml (range is 10-50 ml).
  • Volume in III & IV ventricles together is about 2 ml.

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Explore the intricate network of arteries providing blood to the brain. Key arteries include lenticulostriate, middle cerebral, vertebral, and basilar arteries. Understand their origins, branches, supplied regions, and their roles in brain function.

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