Guyton and Hall Physiology Chapter 59 - The Limbic System and the Hypothalamus

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Questions and Answers

What is the primary function of the brain stem in relation to the cerebrum?

  • To continuously transmit nerve signals that activate the cerebrum. (correct)
  • To serve as the primary storage site for long-term memories.
  • To inhibit all signals to the cerebrum.
  • To regulate specific hormone production within the cerebrum.

Why might damage to the brain stem at the junction between the mesencephalon and cerebrum result in a permanent coma?

  • It causes uncontrolled hormone release, disrupting brain function.
  • It disrupts the activation of the cerebrum by brain stem signals. (correct)
  • It directly damages memory storage areas.
  • It prevents nerve signals from reaching the muscles, causing paralysis.

What are the two ways in which nerve signals in the brain stem activate the cerebrum?

  • By initiating motor reflexes and managing respiratory functions.
  • By directly stimulating neuronal activity and activating hormonal systems. (correct)
  • By producing specific enzymes and regulating sleep cycles.
  • By constricting blood vessels and controlling sensory input.

What is the primary role of the bulboreticular facilitory area in controlling brain activity?

<p>Serving as the central driving component for the brain's activity level. (C)</p> Signup and view all the answers

The reticular excitatory area sends signals upward. Where do most of these signals go first?

<p>To the thalamus. (A)</p> Signup and view all the answers

What is the function of acetylcholine released by the nerve endings of large neuronal cell bodies in the brain stem reticular area?

<p>Exciting the cerebrum for a few milliseconds. (B)</p> Signup and view all the answers

What is the function of the second type of excitatory signal originating from small neurons in the brain stem reticular excitatory area?

<p>To build up the background excitability level of the brain over longer periods. (A)</p> Signup and view all the answers

How do peripheral sensory signals impact the activity of the reticular excitatory area and the brain?

<p>Sensory signals, especially pain, increase activity, creating alertness. (B)</p> Signup and view all the answers

What happens to neuronal activity in the brain if all sensory signals entering the brain stem from the periphery are eliminated?

<p>The brain transitions instantly to a state of greatly reduced activity, approaching a permanent comatose state. (C)</p> Signup and view all the answers

What positive feedback mechanism contributes to maintaining or enhancing cerebral cortex excitation?

<p>Signals from the cortex activate the brain stem excitatory area, which in turn sends more excitatory signals back to the cortex. (C)</p> Signup and view all the answers

What is the primary role of the thalamus in controlling activity in the cerebral cortex, and how does it achieve this?

<p>The thalamus acts as a relay station, distributing signals to specific cortical regions and engaging in reverberation with the cortex. (D)</p> Signup and view all the answers

Where is the reticular inhibitory area located, and how does it function to decrease activity in the superior portions of the brain?

<p>Located medially and ventrally in the medulla, it excites serotonergic neurons that inhibit the reticular facilitory area. (C)</p> Signup and view all the answers

How do neurohormonal systems differ from direct nerve signal transmissions in controlling brain activity?

<p>Neurohormonal systems provide longer periods of control by secreting neurotransmitters that persist for minutes or hours. (D)</p> Signup and view all the answers

In what ways do the norepinephrine, dopamine, and serotonin systems affect brain excitability?

<p>Norepinephrine usually excites, serotonin usually inhibits, and dopamine has varied effects depending on the brain area. (B)</p> Signup and view all the answers

Which neurotransmitter system is most associated with the regulation of sleep, and how does it achieve this?

<p>The serotonin system; an essential inhibitory role. (D)</p> Signup and view all the answers

What is the main role of the gigantocellular neurons of the reticular excitatory area, and which neurotransmitter do they utilize?

<p>Acutely awake and excite the nervous system using acetylcholine. (A)</p> Signup and view all the answers

What does the term 'limbic system' refer to, and how has its definition evolved over time?

<p>Originally describing border structures around the basal cerebrum, it has expanded to include neuronal circuitry controlling emotional behavior and motivational drives. (C)</p> Signup and view all the answers

In addition to behavioral control, what broader set of functions does the hypothalamus, as part of the limbic system, control?

<p>Many vegetative functions of the body, such as temperature, osmolarity, eating and drinking drives, and body weight. (A)</p> Signup and view all the answers

Which area is regarded as one of the central elements of the limbic system and what structural features are associated with it?

<p>Hypothalamus; interconnected complex of basal brain elements, including septum, paraolfactory area, and portions of the basal ganglia. (D)</p> Signup and view all the answers

What is the functional role of the limbic cortex in relation to the neocortex and the lower limbic structures?

<p>Acting as a two-way communication and association linkage between the neocortex and the lower limbic structure. (A)</p> Signup and view all the answers

Where do the hypothalamus and its allied structures send output signals and to what systems are they primarily directed?

<p>Brain stem and autonomic nervous system, higher areas of the diencephalon and cerebrum, and the pituitary glands. (A)</p> Signup and view all the answers

Despite its small size, what percentage of the brain mass does the hypothalamus represent, and what is its significance in controlling bodily functions?

<p>1%; controls vegetative endocrine functions. (D)</p> Signup and view all the answers

What roles does the hypothalamus play in regulating the cardiovascular system?

<p>Causing many neurogenic effects on the cardiovascular system, including changes in arterial pressure and heart rate. (D)</p> Signup and view all the answers

Which area of the hypothalamus is primarily involved in the regulation of body temperature, and how does it achieve this?

<p>The preoptic area; increases activity of temperature-sensitive neurons when the blood temperature increases. (C)</p> Signup and view all the answers

How does the hypothalamus regulate body water content, and what specific regions are involved in these processes?

<p>The thirst center in the lateral hypothalamus creates the sensation of thirst, and the supraoptic nuclei control the excretion of water into the urine. (B)</p> Signup and view all the answers

How does stimulation of the paraventricular nuclei affect uterine contractility and milk ejection from the breasts?

<p>Stimulates increased uterine contractility and lactation and releases oxytocin. (D)</p> Signup and view all the answers

Stimulation of which area of the hypothalamus leads to the sensations of extreme hunger, voracious appetite, and an intense desire to search for food?

<p>The lateral hypothalamic area. (A)</p> Signup and view all the answers

What roles do the suprachiasmatic nucleus (SCN) play in circadian rhythms, and what happens when lesions occur?

<p>The SCN serves as a 'master clock' that organizes sleep, is innervated by the retina to entrain activities to day-night cycles, and loss of disruption causes many physiological and behavioral disturbances. (B)</p> Signup and view all the answers

How do environmental changes, such as light-dark cycles, affect the circadian rhythms regulated by the SCN (Suprachiasmatic nucleus)?

<p>Altered or 'entrained' through specialized retinal ganglion cells and retinohypothalamic tract. (D)</p> Signup and view all the answers

What is the effect of lateral hypothalamic stimulation when assessing behavioral outcomes in animals?

<p>Causes thirst and eating while increasing rage and fighting. (A)</p> Signup and view all the answers

How do lesions in the lateral hypothalamus typically affect an animal's behavior, and what are the likely outcomes?

<p>Lethal starvation. (D)</p> Signup and view all the answers

What is the primary function of reward and punishment centers in the limbic system?

<p>Influence and control all bodily activities, drives, aversions, and motivations. (C)</p> Signup and view all the answers

What effect do tranquilizers, such as chlorpromazine, have on the reward and punishment centers within the brain?

<p>Inhibit both centers, decreasing the affective reactivity of the animal. (C)</p> Signup and view all the answers

What is the role of reward and punishment in learning and memory, specifically in the context of habituation and reinforcement?

<p>Create selection criteria to determine what will be retained by building strong memory traces or habituation. (D)</p> Signup and view all the answers

What is anterograde amnesia, and how does it manifest after bilateral removal of the hippocampi?

<p>The inability to form new memories based verbal symbolism. (B)</p> Signup and view all the answers

How do bilateral ablations of the amygdala lead to Klüver-Bucy syndrome, and which behaviors are characteristic of this condition?

<p>Excite intense sex drive. (C)</p> Signup and view all the answers

What is the likely outcome of severing the brain stem above the entry point of the fifth cranial nerves (trigeminal)?

<p>The brain maintains normal activity levels due to intact sensory signals from facial regions. (D)</p> Signup and view all the answers

How does the reciprocal signaling between the cerebral cortex and the brain stem's excitatory area contribute to overall brain function?

<p>It allows for sustained or enhanced cortical activity, supporting wakefulness and cognitive processes. (B)</p> Signup and view all the answers

What is the functional consequence of stimulating a specific point within the thalamus?

<p>Activation of a specific, corresponding region of the cerebral cortex. (C)</p> Signup and view all the answers

How does the reticular inhibitory area in the medulla decrease activity in the superior portions of the brain?

<p>By exciting serotonergic neurons that secrete inhibitory neurohormones. (D)</p> Signup and view all the answers

What distinguishes the influence of neurohormonal systems on brain activity from that of direct nerve signal transmissions?

<p>Neurohormonal systems provide sustained control over minutes to hours, while nerve signals offer immediate activation or inhibition. (B)</p> Signup and view all the answers

How does norepinephrine generally affect brain activity, and where does the norepinephrine system spread?

<p>It excites brain activity and spreads to virtually every area of the brain. (D)</p> Signup and view all the answers

What is the primary role of the raphe nuclei, and which substance do they secrete to achieve this?

<p>To suppress pain and help cause sleep by secreting serotonin. (A)</p> Signup and view all the answers

How do the gigantocellular neurons of the reticular excitatory area affect the nervous system, and which neurotransmitter do they utilize?

<p>They excite both the spinal cord and higher brain centers using acetylcholine. (D)</p> Signup and view all the answers

What broader physiological functions, beyond emotional behavior and motivational drives, are associated with the limbic system?

<p>Control of internal conditions, such as body temperature, osmolarity, and drives to eat and drink. (B)</p> Signup and view all the answers

How does the limbic cortex function as a link between the neocortex and other limbic structures?

<p>By providing a two-way communication and association pathway between the neocortex and lower limbic structures. (C)</p> Signup and view all the answers

How does stimulation of different areas within the hypothalamus affect cardiovascular regulation?

<p>Stimulation can cause a range of neurogenic effects, including changes in arterial pressure and heart rate, depending on the specific area stimulated. (D)</p> Signup and view all the answers

How does body water regulation occur via the hypothalamus, and what are the critical areas involved?

<p>By creating the sensation of thirst via the lateral hypothalamus and controlling renal water excretion via the supraoptic nuclei. (C)</p> Signup and view all the answers

How does the hypothalamus regulate uterine contractility and milk ejection from the breasts?

<p>By secreting oxytocin from the paraventricular nuclei, which increases uterine contractility and causes contraction of myoepithelial cells in the breasts. (D)</p> Signup and view all the answers

How do lesions in the lateral hypothalamus typically affect an animal's behavior concerning hunger and thirst?

<p>They lead to decreased drinking and eating, often resulting in lethal starvation and extreme passivity. (C)</p> Signup and view all the answers

How does SCN coordinate circadian rhythms by receiving and transmitting information?

<p>By receiving direct innervation from the retina and projecting to various brain centers to coordinate feeding, sleep, and hormonal rhythms. (A)</p> Signup and view all the answers

How does the SCN utilize genetic mechanisms to maintain circadian rhythms?

<p>Through transcriptional activators and “clock genes” that regulate protein synthesis in a 24-hour pattern. (A)</p> Signup and view all the answers

What role do reward and punishment centers play in learning and memory?

<p>They selectively reinforce and retain sensations that are rewarding or punishing while facilitating habituation to indifferent stimuli. (A)</p> Signup and view all the answers

In the context of reward and punishment centers, what is the effect of administering tranquilizers, such as chlorpromazine?

<p>It inhibits both reward and punishment centers, reducing the affective reactivity of the animal. (C)</p> Signup and view all the answers

Why is the hippocampus believed to be critical in decision-making, especially regarding sensory inputs?

<p>It originated as part of the olfactory cortex and likely evolved to assess the importance of sensory signals for survival and memory consolidation. (C)</p> Signup and view all the answers

What is the proposed method by which the hippocampus facilitates the conversion of short-term memories into long-term memories?

<p>By causing the mind to actively rehearse new information, leading to permanent storage. (A)</p> Signup and view all the answers

How does bilateral ablation of the amygdala lead to Klüver-Bucy syndrome?

<p>By causing tameness, extreme curiosity, rapid forgetting, hypersexuality, and a tendency to place objects in the mouth. (D)</p> Signup and view all the answers

What are the effects of stimulating the punishment centers within the limbic system?

<p>Inhibition of the reward/pleasure centers combined with expression of fear reactions. (D)</p> Signup and view all the answers

Which brain region is most closely associated with the conversion of sensory stimuli into long-term memories?

<p>Hippocampus. (B)</p> Signup and view all the answers

What is the main symptom shown in patients with resections in the amygdalae?

<p>Klüver-Bucy disorder. (D)</p> Signup and view all the answers

Under normal circumstances, what maintains the rage phenomenon?

<p>Inhibitory signals via the ventromedial hypothalmus or regions of the anterior limbic cortex. (A)</p> Signup and view all the answers

In relation to the body's biological clock, which components of the activation complex are the initial instigators?

<p>CLOCK and BMAL1. (C)</p> Signup and view all the answers

How do lesions in the ventromedial areas of the hypothalamus affect drinking an eating versus lesions in the lateral area of the hypothalmus?

<p>Bilateral lesions cause excessive drinking and eating versus Bilateral damage leads to zero drinking and eating. (D)</p> Signup and view all the answers

For the four neurohormonal systems (dopamine, norepinepherine, serotonin, acetylcholine) in the brain, which is excitatory and directly correlated to wakefulness/excited nervous system?

<p>Acetylcholine (D)</p> Signup and view all the answers

Multiple transmitters function to help regulate areas of the brain, which of the following neurotransmitters is directly related to pain suppression?

<p>Serotonin (A)</p> Signup and view all the answers

Name 2 parts that are part of the limbic systems:

<p>Olfactory Bulb and Cingulate Gyrus. (A)</p> Signup and view all the answers

Name one main effect of damaging the Septum area.

<p>Can become vicious and much more subject to fits of rage. (D)</p> Signup and view all the answers

What is the main characteristic of damaging that Mammillary body?

<p>Feeding Reflexes. (B)</p> Signup and view all the answers

The anterior part of the thalamus is most directly associated to which processes?

<p>Oxytocin release and Water conservation. (B)</p> Signup and view all the answers

Where are the axons for the SCN projected and what is the reasoning for the projection?

<p>Hypothalamus and organs/tissues that function to alter hormonal and sleep changes. (A)</p> Signup and view all the answers

Which regions within the rat brain activate the four (norepinephrine, dopamine, serotonin, and acetylcholine) neurohormonal systems?

<p>Locus ceruleus, substantia nigra, raphe nuclei, and reticular excitatory area. (D)</p> Signup and view all the answers

What is the result of stimulating central brain components such as the periventricular nuclei?

<p>Induce fear and cause punishment (D)</p> Signup and view all the answers

What is the expected outcome of broadly stimulating the reticular formation?

<p>Generalized increase in cerebral cortical activity. (A)</p> Signup and view all the answers

How would the selective destruction of acetylcholine-secreting neurons in the brainstem reticular area impact brain function?

<p>Reduced short-term excitatory post-synaptic potentials in the cerebrum. (A)</p> Signup and view all the answers

What effect do slowly conducting fibers from the intralaminar nuclei of the thalamus have on the cerebral cortex?

<p>Progressively building, longer-term increase in excitability. (A)</p> Signup and view all the answers

If one were to experimentally eliminate all sensory input to the reticular excitatory area, how would function of the cerebral cortex change?

<p>Excitatory activity in the cortex would diminish significantly. (A)</p> Signup and view all the answers

How does transection of the brainstem below the entry point of the fifth cranial nerve affect coma development?

<p>It prevents the development of a permanent coma. (D)</p> Signup and view all the answers

What is the functional significance of the reciprocal connections between the cerebral cortex and the brain stem's excitatory area?

<p>They help maintain or enhance cortical excitation through positive feedback. (C)</p> Signup and view all the answers

Which outcome would you expect from stimulating a specific point within the thalamus?

<p>Activation of a specific, small region of the cortex. (B)</p> Signup and view all the answers

How does the reticular inhibitory area in the medulla influence activity in the brain?

<p>By exciting serotonergic neurons, which then inhibit activity in upper brain regions. (D)</p> Signup and view all the answers

How do direct nerve signals and neurohormonal systems from the lower brain areas compare in their control over brain activity?

<p>Direct signals provide brief activation, while neurohormones offer longer periods of control. (A)</p> Signup and view all the answers

What are the effects of the norepinephrine system on brain excitability?

<p>It typically excites most brain areas. (A)</p> Signup and view all the answers

How would one characterize the function of the raphe nuclei in controlling brain activity?

<p>They inhibit the brain by secreting serotonin. (C)</p> Signup and view all the answers

The gigantocellular neurons of the reticular excitatory area utilize what neurotransmitter and what results from its activation?

<p>Acetylcholine, resulting in acute wakefulness. (D)</p> Signup and view all the answers

What role does the limbic cortex play in the broader context of brain function?

<p>It links the neocortex with other limbic structures. (C)</p> Signup and view all the answers

What is the general effect of stimulating the lateral hypothalamus?

<p>Elevated arterial pressure and heart rate. (D)</p> Signup and view all the answers

How does the hypothalamus facilitate the conservation of body water by the kidneys?

<p>Stimulating the supraoptic nuclei to secrete vasopressin. (B)</p> Signup and view all the answers

In an experimental animal, what is the impact of bilateral lesions in the lateral hypothalamus on drinking and eating behavior?

<p>Decreased drinking and eating, potentially leading to starvation. (D)</p> Signup and view all the answers

How does the suprachiasmatic nucleus (SCN) coordinate circadian rhythms?

<p>By receiving direct light signals and transmitting via nervous and hormonal signals. (B)</p> Signup and view all the answers

What is the effect of electrically stimulating the periventricular nuclei?

<p>Induction of fear and punishment reactions. (D)</p> Signup and view all the answers

How do hypothalamic lesions of the ventromedial areas affect an animal's behavior?

<p>Excessive eating, weight gain, and heightened aggression. (B)</p> Signup and view all the answers

If a person receives a sensory experience that is neither rewarding nor punishing, what is the likely outcome regarding memory of that experience?

<p>The sensory experience will cause the individual to become habituated to the experience. (C)</p> Signup and view all the answers

According to available studies, which of the limbic structures, when electrically stimulated, can completely inhibit responses in the reward centers?

<p>Punishment Centers (C)</p> Signup and view all the answers

How do lesions in the anterior cingulate gyri and subcallosal gyri affect an animal's behavior, particularly concerning rage?

<p>They release the rage centers from prefrontal inhibitory control. (A)</p> Signup and view all the answers

What is a key function attributed to the hippocampus in the context of learning and memory?

<p>Filtering and translating short-term memories into long-term memories. (B)</p> Signup and view all the answers

After bilateral removal of the hippocampi, what specific memory deficit is most prominent?

<p>Inability to form new long-term declarative memories. (A)</p> Signup and view all the answers

What is the theorized role of the amygdala in relation to the limbic system and sensory information?

<p>It serves as a &quot;window&quot; through which the limbic system assesses a person's surroundings. (C)</p> Signup and view all the answers

What are some of the common effects of stimulating the amygdala?

<p>Effects similar to those caused by direct stimulation of the hypothalamus. (A)</p> Signup and view all the answers

Bilateral ablation of the anterior temporal cortex, including the amygdala results in:

<p>Klüver-Bucy syndrome. (D)</p> Signup and view all the answers

Ablation of which cerebral region typically leads to increased motor restlessness and insomnia?

<p>Posterior orbital frontal cortex. (A)</p> Signup and view all the answers

In the context of the limbic system, what is the primary effect of administering tranquilizers like chlorpromazine?

<p>Inhibition of reward and punishment centers. (C)</p> Signup and view all the answers

The limbic system is primarily involved in motor control rather than behavioral and motivational mechanisms.

<p>False (B)</p> Signup and view all the answers

Severe compression of the brain stem at the juncture between the pons and medulla always results in a permanent state of coma.

<p>False (B)</p> Signup and view all the answers

Nerve signals activate the cerebrum by only stimulating a background level of neuronal activity.

<p>False (B)</p> Signup and view all the answers

The bulboreticular facilitory area solely transmits signals downward to maintain tone in the antigravity muscles.

<p>False (B)</p> Signup and view all the answers

Signals from the brain stem reticular area excite the cerebrum through the release of the neurotransmitter serotonin.

<p>False (B)</p> Signup and view all the answers

Increased sensory signals from the periphery decrease activity in the reticular excitatory area, leading to reduced brain activity.

<p>False (B)</p> Signup and view all the answers

The statement sleep enhances cerebral cortex activity is true.

<p>False (B)</p> Signup and view all the answers

Stimulation of a specific point in the thalamus activates its own specific small region of the cerebellum.

<p>False (B)</p> Signup and view all the answers

The reticular inhibitory area in the medulla increases activity in the superior portions of the brain.

<p>False (B)</p> Signup and view all the answers

The serotonin system is directed mainly into the basal ganglial regions of the brain.

<p>False (B)</p> Signup and view all the answers

Norepinephrine generally inhibits the brain to decreased activity.

<p>False (B)</p> Signup and view all the answers

The locus ceruleus is located at the juncture between the pons and cerebellum.

<p>False (B)</p> Signup and view all the answers

The substantia nigra neurons send nerve endings mainly to the cerebellum

<p>False (B)</p> Signup and view all the answers

The hypothalamus is not part of the limbic system.

<p>False (B)</p> Signup and view all the answers

Stimulation of the ventromedial nucleus in the hypothalamus can cause extreme hunger.

<p>False (B)</p> Signup and view all the answers

The anterior pituitary gland receives its blood supply directly from the general circulation.

<p>False (B)</p> Signup and view all the answers

The suprachiasmatic nucleus synchronizes with environmental light-dark cycles but is unable to maintain its function in the absence of external cues.

<p>False (B)</p> Signup and view all the answers

Stimulation of the lateral hypothalamus typically leads to satiety, decreased eating, and tranquility.

<p>False (B)</p> Signup and view all the answers

Stimulation of the punishment centers can frequently enhance the reward and pleasure centers.

<p>False (B)</p> Signup and view all the answers

The hippocampus transmits signals that seem to prevent the mind from rehearsing new information, inhibiting long-term memory consolidation.

<p>False (B)</p> Signup and view all the answers

Match the neurohormone with its general function in the brain:

<p>Norepinephrine = Excitatory; increases brain activity Serotonin = Inhibitory; helps cause normal sleep Dopamine = Inhibitory in basal ganglia; possibly excitatory elsewhere Acetylcholine = Excitatory; leads to an acutely awake and excited nervous system</p> Signup and view all the answers

Match the area of the hypothalamus with its primary function:

<p>Lateral hypothalamus = Thirst and hunger Ventromedial nuclei = Satiety Preoptic area = Body temperature regulation Supraoptic nuclei = Control of renal excretion of water</p> Signup and view all the answers

Match the limbic structure with its associated function:

<p>Hippocampus = Consolidation of long-term memories Amygdala = Behavioral awareness and emotional responses Limbic cortex = Cerebral association area for control of behavior Hypothalamus = Vegetative and endocrine functions, emotional behavior</p> Signup and view all the answers

Match the effects of electrical stimulation with the corresponding area of the hypothalamus:

<p>Lateral hypothalamus = Increased activity, rage, and fighting Ventromedial nucleus = Satiety and tranquility Periventricular nuclei = Fear and punishment reactions Anterior hypothalamus = Sexual drive</p> Signup and view all the answers

Match the effects of lesions with the corresponding area of the hypothalamus:

<p>Lateral hypothalamus = Decreased drinking and eating, passivity Ventromedial areas = Excessive drinking and eating, hyperactivity, rage Anterior hypothalamus = Disruptions in body temperature regulation Supraoptic nucleus = Problems with osmoregulation</p> Signup and view all the answers

Match the brain area with its role in the reward or punishment system:

<p>Medial forebrain bundle = Major reward centers Central gray area = Punishment and escape tendencies Septum = Secondary reward center Amygdala = Secondary reward/punishment center</p> Signup and view all the answers

Match the component of the circadian rhythm system with its function:

<p>Suprachiasmatic nucleus (SCN) = Master clock Retinohypothalamic tract = Entrains circadian activity to day-night cycles PER and CRY genes = Establish circadian pattern Melanopsin = Photosensitive pigment</p> Signup and view all the answers

Relate the description to the correct term:

<p>Klüver-Bucy syndrome = Loss of fear, extreme curiosity, rapid forgetting, oral tendencies, and inappropriate sexual behavior Anterograde Amnesia = Inability to form new memories after the event that caused amnesia Rage Pattern = Defense posture, hissing, and savage attack after the slightest provocation Vegetative Functions = Control of internal conditions of the body</p> Signup and view all the answers

Match the function to the subcortical nuclei.

<p>Amygdala = Receives neuronal signals from all portions of the limbic cortex, as well as from the neocortex of the temporal, parietal, and occipital lobes Hypothalamus = Has two-way communicating pathways with all levels of the limbic system Raphe nuclei = Many of the neurons in these nuclei secrete serotonin. Locus ceruleus = Nerve fibers from this area spread throughout the brain, and they secrete norepinephrine.</p> Signup and view all the answers

Match what system activates:

<p>Dopamin system = The basal ganglial regions Norepinephrine system = Virtually every area of the brain Serotonin system = The midline structures Reticular activating system = General awareness</p> Signup and view all the answers

Flashcards

Limbic System

Basal brain regions loosely termed the limbic system that play a key role in motivational drives, learning, and feelings of pleasure and punishment.

Reticular Excitatory Area

An area in the brain stem that sends continuous excitatory signals to the cerebrum, maintaining brain activity.

Reticular Inhibitory Area

Area located medially in the medulla of the brain stem that inhibits activity in the Reticular Excitatory Area.

Norepinephrine System

Neurohormonal system in the brain that generally excites the brain, increasing activity.

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Dopamine System

Neurohormonal system that acts as an inhibitory transmitter in the basal ganglia and possibly excitatory in other regions of the brain.

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Serotonin System

Neurohormonal system that plays an essential inhibitory role, helping to cause normal sleep.

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Locus Ceruleus

The locus ceruleus is a small area located bilaterally where nerve fibers spread and secrete the neurotransmitter norepinephrine. It generally excites the brain to increase activity.

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Substantia Nigra

The substantia nigra is where neurons send nerve endings that secrete dopamine to the caudate nucleus and the putamen of the cerebrum.

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Raphe Nuclei

Several thin nuclei located in the midline of the pons and medulla where neurons secrete serotonin. They send fibers to the diencephalon and spinal cord.

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Gigantocellular Neurons

Neurons in the reticular excitatory area of the pons and mesencephalon that secrete acetylcholine. Their fibers divide into two branches, one passing upward and the other downward into the spinal cord.

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Hypothalamus

Functions include Cardiovascular Regulation, Body Temperature Regulation, Body Water Regulation, Regulation of Uterine Contractility, and Milk Ejection.

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Preoptic Area

Area of the hypothalamus concerned with regulation of body temperature. Increased blood temperature in this area increases neuron activity.

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Thirst Center

Area of the hypothalamus that regulates body water by creating the sensation of thirst.

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Supraoptic Nuclei

Nuclei in the hypothalamus, where stimulated neurons project downward into the posterior pituitary gland

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Paraventricular Nuclei

Nucleus of the hypothalamus that contains neurons that secrete the hormone oxytocin.

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Lateral Hypothalamic Area

Area of the hypothalamus where stimulation causes extreme hunger and an intense desire to search for food.

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Satiety Center

A center located in the ventromedial nuclei that opposes the desire for food. Stimulation of this area inhibits hunger.

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Arcuate Nucleus

Nucleus that contains different types of neurons that, when stimulated, either increase or decrease appetite.

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Suprachiasmatic Nucleus

Nucleus of the hypothalamus that serves as the "master clock" for many physiological, mental, and behavioral activities.

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CLOCK and BMAL1

(CLOCK) and Brain and Muscle Arnt-Like 1 (BMAL1) are transcriptional activators that bind to each other and initiate transcription of clock genes

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Reward and Punishment

Areas mainly concerned with the affective nature of sensory sensations. Sensations can be pleasant or unpleasant.

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Hippocampus

Elongated portion of the cerebral cortex that folds inward to form the ventral surface of much of the inside of the lateral ventricle

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Amygdala

Complex of multiple small nuclei located immediately beneath the cerebral cortex of the medial anterior pole of each temporal lobe

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Anterograde Amnesia

Condition where a person cannot even learn the names of people with whom they come in contact every day.

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Limbic Cortex

Ring of cerebral cortex that surrounds the subcortical limbic structures

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Klüver-Bucy Syndrome

Syndrome that changes normal behavior in an animal, who become not afraid of anything, forget rapidly, tendency to place everything in its mouth

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Brain Stem Excitatory Signals

A general system for controlling the activity level of the brain, which sends facilitory signals downward to the spinal cord. Damage can lead to coma.

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Cortical Feedback Signals

A positive feedback mechanism where signals from the cerebral cortex enhance activity in the brain stem excitatory area, maintaining or increasing cortical excitation.

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Neurohormonal Control

Secretory cells that release excitatory or inhibitory neurotransmitter hormonal agents into the brain, providing long-term control over brain activity.

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Subcortical Structures

Structures including the septum, paraolfactory area, portions of the basal ganglia, hippocampus, and amygdala. It is located in the middle of all these structures is the extremely small hypothalamus

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Medial Forebrain Bundle

The medial forebrain bundle extends from the septal and orbitofrontal regions of the cerebral cortex downward through the middle of the hypothalamus to the brain stem reticular formation.

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Association Linkage

Areas where signals are transmitted to specific brain areas.

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Anterior Cingulate Gyri

Areas where destruction releases the rage centers of the septum that causes the animal to become vicious and more subject to fits of rage than normally.

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Thalamocortical reverberation

System where signals regularly reverberate between the thalamus and the cerebral cortex.

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Bulboreticular Facilitory Area

Area in the brain stem crucial for maintaining muscle tone and spinal reflexes, also sending activating signals upward.

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Peripheral Sensory Signals

Sensory information activates the brain by stimulating the reticular excitatory area, increasing alertness

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State of Coma

A state of greatly reduced brain activity, approaching a permanent loss of consciousness

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Brain Stem Activation

The activation of neurohormonal systems that release specific facilitory or inhibitory neurotransmitters into selected areas of the brain.

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Thalamic Distribution

A state where signals are transmitted to specific brain areas through electrical stimulation that activates specific regions of the Thalamus.

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Brain Stem Centers

Multiple centers in the brain stem that secrete different transmitter substances.

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Medial Forebrain communication

A bundle which extends from the septal that carriers fibers in both directions, forming a trunk line communication system.

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Vegetative Control

Centers that control signals that are sent through the thalamus as a functional unit.

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Body Temperature.

An area where the medial preoptic activity increases, causing temperature sensitive neurons.

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Daily Rhythm.

The suprachiasmatic nucleus directs daily cycles of our physiology and behavior that set our lives in motion.

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Anterior Temporal Cortex.

When the anterior temporal cortex is removed it causes the Klüver-Bucy syndrome. The animal develops both consummatory behavior.

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Causes of Stimulation.

Located in the medulla it can cause several neurogenic effects on the cardiovascular system, which includes arterial pressure or the heart rate

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Posterior Orbital Frontal Cortex

Bilateral removal of the posterior portion causes the animal to develop insomnia associated with intense motor restlessness. The animal will be unable to sit still and will move continuously.

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Hippocampus Signal.

The hippocampus sends signals that make the mind rehearse over and over the new information until permanent storage takes place.

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Study Notes

  • Control of behavior involves the entire nervous system
  • Wakefulness and sleep cycles are crucial behavioral patterns

Overview

  • Mechanisms controlling brain activity levels are examined
  • Motivational drives, especially their influence on learning, pleasure, and punishment are explored
  • The basal brain regions, collectively known as the limbic system, primarily perform these functions
  • Limbic means 'border'

Activating-Driving Systems of the Brain

  • Continuous nerve signal transmission into the cerebrum from the lower brain is essential
  • Severe brain stem compression can cause lasting coma
  • Pineal tumour can cause unremitting coma

Activating the Cerebrum

  • Nerve signals activate it by:
    • Directly stimulating neuronal activity
    • Activating neurohormonal systems via neurotransmitters

Control by Excitatory Signals from the Brain Stem

  • The level of brain activity is regulated by the reticular excitatory area in the pons and mesencephalon
  • The central driving component is in the reticular substance of the pons and mesencephalon
  • This area also called the bulboreticular facilitory area
  • The same area that transmits signals to maintain antigravity muscle tone also sends signals upwards
  • Signals travel to the thalamus, exciting neurons which then transmit to the cerebral cortex, and subcortical areas

Thalamic Signal Types

  • Rapidly transmitted action potentials excite the cerebrum briefly
    • Originate from large neuronal cell bodies in the brain stem reticular area
    • Release acetylcholine, an excitatory agent
    • Acetylcholine lasts for only a few milliseconds before destruction

Second Type of Excitatory

  • Originate from small neurons in the brain stem reticular excitatory area
  • Pass to the thalamus, synapsing in intralaminar and reticular nuclei
  • Fibers distribute throughout the cerebral cortex
  • This system controls the longer-term background excitability of the brain

Excitation by Peripheral Sensory Signals

  • Peripheral sensory signals determine the activity level of the reticular excitatory area
  • Pain signals increase activity which strongly excites the brain
  • Severing the brain stem above the fifth cerebral nerves reduces sensory signals and brain activity
  • The fifth cerebral nerves are the highest nerves entering the brain that transmit significant numbers of somatosensory signals

Feedback Signals from the Cerebral Cortex

  • Excitatory signals pass to the cortex and return to the brain stem excitatory area perpetuating cerebral excitation
  • A positive feedback mechanism sustains and enhances brain activity, leading to wakefulness

Function of Thalamus

  • The thalamus connects almost every area of the cerebral cortex to a specific point
  • Electrical stimulation of a thalamic point activates a specific cortical region
  • Signals regularly reverberate between the thalamus and cortex, which may establish long-term memories
  • It is not clear whether the thalamus calls forth memories or activates processes, but it does have the appropriate neuronal networks

Reticular Inhibitory Area

  • An inhibitory area in the medulla can inhibit the reticular facilitory area which decreasing activity in the brain
  • It excites serotonergic neurons that secrete serotonin

Neurohormonal Control

  • Excitatory or inhibitory neurotransmitter hormonal agents are secreted into the brain
  • Neurohormones provide extended control over minutes or hours, not instantaneous activation
  • A norepinephrine system is generally excitatory
  • A serotonin system is generally inhibitory
  • Dopamine being excitatory sometimes
  • These systems affect excitability differently in various brain parts

Systems in the Human Brain

  • Brain stem areas activate four systems, the same as in rats, with the addition of the acetylcholine system with specific functions
  • The locus ceruleus and norepinephrine generally excites the brain, plays a role in REM sleep
  • The substantia nigra and dopamine system neurons project to the caudate nucleus and putamen
  • Dopamine acts as a transmitter basal ganglia, possibly excitatory in areas.
  • Destruction of dopaminergic neurons causes Parkinson's
  • Raphe nuclei and the serotonin system, project to the diencephalon, cortex, and spinal cord, suppresses pain
  • The acetylcholine from the gigantocellular neurons functions as an excitatory neurotransmitter

Other Neurotransmitters

  • Enkephalins
  • Gamma-aminobutyric acid
  • Glutamate
  • Vasopressin
  • Adrenocorticotropic hormone
  • a-Melanocyte stimulating hormone
  • Neuropeptide-Y
  • Epinephrine
  • Histamine
  • Endorphins
  • Angiotensin II
  • Neurotensin
  • Each system helps controlling brain function

Limbic System Function

  • The limbic system includes the neuronal circuitry controlling emotional behavior and motivation
  • The hypothalamus and related structures, control internal conditions (e.g., temperature, fluid balance, hunger) in addition to behavior

Functional Anatomy

  • The limbic system is an interconnected collection of basal brain elements
  • The hypothalamus is central
  • Subcortical structures like the septum, specific thalamic nuclei, parts of the basal ganglia, hippocampus, and amygdala surround it
  • The limbic cortex, which encircles the subcortical zones, includes the orbitofrontal area, subcallosal gyrus, cingulate gyrus, and parahippocampal gyrus
  • The cortex acts as a link between the neocortex and structures

Hypothalamus

  • Despite its size of roughly 4 grams, the hypothalamus communicates with the limbic system
  • It sends output signals to the brain stem, diencephalon, cerebrum, and pituitary gland

Centers

  • Stimulating different hypothalamic areas causes a range of vegetative functions
  • Posterior and lateral stimulation raises arterial pressure and heart rate
  • Preoptic area stimulation lowers heart rate and arterial pressure

Body Temp

  • The hypothalamus regulates body temperature
  • It can also create the sensation of thirst
  • And regulates water excretion via antidiuretic hormone

Uterine

  • Oxytocin from the paraventricular nuclei increases uterine contractility and milk ejection
  • Lateral hypothalamus stimulation causes hunger, whereas ventromedial nuclei stimulation induces satiety
  • Mammillary bodies control feeding reflexes

Hypothalamic Control of Hormones

  • Hypothalamic stimulation causes the anterior pituitary to secrete hormones
  • Specific releasing and inhibitory hormones traverse from hypothalamic nuclei via blood for function

Suprachiasmatic Nucleus

  • The suprachiasmatic nucleus governs circadian rhythms
  • The neurons follow a circadian pattern
  • Lesions disrupt sleep-wake cycles
  • SCN clock information sends through action potentials with effects
  • Temperature variations
  • Hormonal changes
  • Sleep-wake cycle
  • Light entrains oscillations by intrinsically photosensitive retinal ganglion cells that contains melanopsin

Stimulation Effects

  • Lateral hypothalamus stimulation can cause thirst, eating, increase activity, rage, and fighting
  • Ventromedial nucleus stimulation induces satiety and tranquility
  • Periventricular nuclei stimulation leads to fear and punishment reactions Sexual drive starts from areas, especially anterior and posterior

Lesion Effects

  • Lesions have opposite effects
  • Lateral hypothalamus lesions decrease drinking and eating
  • Ventromedial area lesions trigger excessive eating, drinking, hyperactivity, and rage
  • Limbic system lesions cause similar effect

Limbic System

  • Several structures concern sensory sensations
  • These affective qualities are reinforcement
  • Electrically stimulating please while terror
  • The degrees of stimulation affect animal

Reward Centers Important

  • Centers locate with medial forebrain bundle, especially lateral and ventromedial nucleus of the hypothalamus
  • Reward centers are lower than one of hypothalamus
  • Strong stimuli result rage

Punishment Centers

  • Most areas locate with the central gray are the surround aqueduct of Sylvius
  • Lesions can inhibit center demonstrate pain

Punishment Centers Associations

  • The punishment centers causes rage, defense and posture
  • Factors cause attack as a part of behavior

Reward Importance

  • Everything is based on both
  • Affective reactivity of animals is based on reward

Learning Important

  • Experience needs two ways. Record to remember

Hippocampus Functions

  • This is cortex which folds forward from ventral surface of lateral ventricle
  • Contains sensory information
  • Functions during sexual and rage
  • It distributes outgoing signals to the thalamus, hypothalamus, and limbic system

Amygdala

  • The amygdala is called a "window" for how the limbic system sees a person's place in the world
  • The Basolateral nuclei portion of the amygdala has important roles in behavioral activities

Cerebral Cortex

  • The cerebral cortex functions as a transitional zone for control of behavior
  • The limbic cortex in effect functions as a cerebral association area for control of behavior

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