Bordetella Pertussis Characteristics and Whooping Cough Details
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Questions and Answers

What is the main route of entry for Bordetella pertussis into the human body?

Inhalation

What is the function of Pertussis toxin (PT)?

ADP-ribosylates GTP-binding protein (Gi)

How does filamentous hemagglutinin (FHA) contribute to Bordetella pertussis virulence?

Allows adherence to ciliated epithelial cells

What is the significance of the RGD loops in Pertactin (Prn)?

<p>Binds integrin on host cells</p> Signup and view all the answers

How does Bordetella pertussis damage neurons during infection?

<p>By toxins such as Adenylate cyclase toxin and Pertussis toxin</p> Signup and view all the answers

What is the action of Adenylate cyclase toxin (ACT / CyaA) on target cells?

<p>Increases cAMP levels and forms a pore in cell membranes</p> Signup and view all the answers

How does the acellular pertussis vaccine differ from the heat-killed vaccine?

<p>Acellular vaccine contains purified components without endotoxins</p> Signup and view all the answers

What are the characteristics of Bordetella pertussis in terms of size and shape?

<p>Small Gram-negative coccobacilli</p> Signup and view all the answers

What are the two types of fimbriae present in Bordetella pertussis?

<p>Fim2 and Fim3</p> Signup and view all the answers

What is the main stage of whooping cough characterized by fits of rapid coughing and the 'whooping' sound?

<p>Paroxysmal stage</p> Signup and view all the answers

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