Bone Composition and Remodeling Quiz

Play an AI-generated podcast conversation about this lesson

What is the inorganic mineral phase of bone composed of?

Calcium, phosphate, and hydroxyl ions (correct)

Calcium and phosphate

Phosphorus and hydroxyl ions

Calcium and collagen

What cells are responsible for resorbing old bone in the process of bone remodeling?

Osteocytes

Osteoblasts

Osteoclasts (correct)

Chondrocytes

What is the purpose of bone-seeking radiopharmaceuticals like technetium-labeled diphosphonates?

To image the skeleton (correct)

To treat bone fractures

To promote bone turnover

To stimulate osteoblast activity

Which part of the skeleton is composed of the skull, spine, and shoulder girdle?

Axial skeleton Signup and view all the answers

What factor can lead to decreased skeletal activity in bone scans?

Impairment of renal function Signup and view all the answers

Which imaging technique is used to improve lesion detection in large joints and the spine?

SPECT imaging Signup and view all the answers

How do bone-seeking radiopharmaceuticals primarily accumulate in bone?

By absorption onto the bone surface Signup and view all the answers

What is the main advantage of Fluorine-18 sodium fluoride over technetium-99m diphosphonate for bone scanning?

Higher extraction efficiency Signup and view all the answers

What can cause increased soft-tissue activity in planar bone scans?

Injection site extravasation Signup and view all the answers

Where is increased activity commonly observed in older patients with arthritis during bone scans?

Shoulders Signup and view all the answers

What is a common clinical application for bone scanning according to the text?

Evaluating prosthetic joint infections Signup and view all the answers

Which imaging technique has shown higher sensitivity and specificity compared to conventional bone imaging with 99mTc-diphosphonate?

18F-NaF PET/CT Signup and view all the answers

What is the appearance of osteoid osteoma on bone scans according to the text?

Intense activity at the site of the vascular nidus Signup and view all the answers

Which type of tumor can result in soft-tissue activity on bone scans?

Mucin-producing tumors Signup and view all the answers

What is the role of bone scans in detecting fibrous cortical defects according to the text?

Have normal or near-normal intensity Signup and view all the answers

What imaging technique is particularly useful for identifying hidden hip and knee fractures or when the site of pain is localized?

MRI Signup and view all the answers

Which phase of a bone scan follows the acute phase and shows more localized and intense activity lasting 2 to 3 months?

Subacute phase Signup and view all the answers

What is typically seen on bone scans in cases of shin splints?

Normal blood flow and pool Signup and view all the answers

What radiographic signs initially indicate osteomyelitis?

Loss of soft tissue fascial margins Signup and view all the answers

Which imaging technique offers high effectiveness and spatial resolution for detecting early bone involvement in inflammatory diseases, but may not be suitable for patients with infected metallic prostheses?

MRI Signup and view all the answers

What can cause a false-negative bone scan in the early stages of osteomyelitis?

Disrupted blood supply to the bone Signup and view all the answers

Which condition is characterized by increased activity in all phases on a bone scan?

Septic arthritis Signup and view all the answers

What is a distinct appearance on bone scans for hypertrophic pulmonary osteoarthropathy?

Periosteal reaction along the cortex of long bones Signup and view all the answers

What is a common characteristic of avascular necrosis on bone scans?

Absent or decreased activity in the affected area Signup and view all the answers

What type of activity may indicate complex regional pain syndrome (CRPS) on a bone scan?

Asymmetric periarticular activity Signup and view all the answers

Which imaging technique is commonly used alongside 111In-WBC imaging to differentiate normal marrow from leukocyte accumulation in cases of suspected infected joint replacements?

99mTc-sulfur colloid scans Signup and view all the answers

At what age should screening for osteoporosis begin for women?

65 Signup and view all the answers

What is the most widely used method for accurately determining Bone Mineral Density (BMD)?

DEXA Signup and view all the answers

Which tool provides a 10-year risk of hip and global fractures and is commonly used to assess fracture risk?

WHO fracture risk assessment tool (FRAX) Signup and view all the answers

What do T-scores compare a patient's Bone Mineral Density (BMD) to?

Mean BMD of a young adult population Signup and view all the answers

What is the half-life of Strontium-89 (89Sr) chloride?

50.5 days Signup and view all the answers

How is Strontium-89 (89Sr) primarily excreted from the body?

Through feces Signup and view all the answers

What leukocyte count is considered a contraindication for the use of Strontium-89 therapy?

Below 2400/μL Signup and view all the answers

What is the range of the soft-tissue for Samarium-153 lexidronam?

0.6 mm Signup and view all the answers

What is the primary elimination route of Radium-223 (223Ra) after injection?

Fecal excretion Signup and view all the answers

What is the recommended dose of Samarium-153 lexidronam?

1.0 mCi/kg Signup and view all the answers

What is the typical dose range for Strontium-89 chloride therapy?

$40$ to $60$ μCi/kg Signup and view all the answers

What percentage of patients typically experience pain relief with Samarium-153 lexidronam therapy?

~35% Signup and view all the answers

What distinguishes the range of alpha-particles from beta-emitters in tissue?

< 100 μm Signup and view all the answers

What distinguishes Radium-223 (223Ra) from beta-emitters regarding elimination pathways?

Fecal excretion only Signup and view all the answers