Bone Anatomy and Biomechanics

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Questions and Answers

Which of the following is NOT a systemic influence on bone structure and function?

  • Nutritional intake
  • Bone Geometry (correct)
  • Pharmacological agents
  • Endocrine factors

What is the primary function of collagen in the organic extracellular matrix of bone?

  • Providing tensile strength (correct)
  • Facilitating cell communication
  • Providing flexibility
  • Mineralizing the bone matrix

Which of the following best describes the role of osteoclasts in bone?

  • Trapping themselves in the bone matrix
  • Building new bone matrix
  • Transporting substances within the bone
  • Resorbing bone (correct)

What is the main function of hydroxyapatite crystals in bone?

<p>Mechanical Strength (D)</p> Signup and view all the answers

What is the definition of 'stress' in the context of bone biomechanics?

<p>The amount of force per unit area within a structure (D)</p> Signup and view all the answers

According to Wolff's Law, how does bone adapt to strain?

<p>It remodels to align with the magnitude and direction of strain. (C)</p> Signup and view all the answers

What is required to simply maintain bone mass, according to the Mechanostat Theory?

<p>A Minimum Effective Strain (MES) (B)</p> Signup and view all the answers

What is the term for bone formation along periosteal and endosteal surfaces?

<p>Modeling (B)</p> Signup and view all the answers

During bone resorption, what happens to the porosity and stiffness of the bone?

<p>Porosity increases, stiffness decreases (A)</p> Signup and view all the answers

What potential issue can arise from cyclic loading during the resorption phase of bone remodeling?

<p>Bucked shins or dorsal cortical fracture (C)</p> Signup and view all the answers

Which of the following is a component of the 'Bucked Shins Complex'?

<p>Periosteal new bone formation (D)</p> Signup and view all the answers

What is the potential outcome of repetitive loading on bone?

<p>Microdamage (B)</p> Signup and view all the answers

According to the information provided, what measure is associated with preventing catastrophic fractures?

<p>Appropriately resting the body (C)</p> Signup and view all the answers

Which type of bone has high resistance to stress and low resistance to strain?

<p>Compact (Cortical) Bone (C)</p> Signup and view all the answers

Which of the following is NOT a function of bone?

<p>Nutrient Storage (B)</p> Signup and view all the answers

Which type of bone cell is trapped in the bone matrix and facilitates communication within the bone?

<p>Osteocytes (C)</p> Signup and view all the answers

What does 'Strain' refer to in bone biomechanics?

<p>The localized change in dimension of the bone (C)</p> Signup and view all the answers

What is the approximate percentage of bone's wet weight attributed to the organic extracellular matrix?

<p>21% (C)</p> Signup and view all the answers

Which action primarily describes the function of osteoblasts?

<p>Forming new bone tissue (B)</p> Signup and view all the answers

Which component of bone provides flexibility and resilience?

<p>Proteoglycans (PGs) (D)</p> Signup and view all the answers

If bone adapts to its mechanical environment, what can cause it to become abnormal?

<p>Abnormal loading (B)</p> Signup and view all the answers

Which is a factor that prompts a resultant osteogenic effect in bone?

<p>Strain magnitude (B)</p> Signup and view all the answers

How does bone strength and stiffness relate to the direction of load?

<p>Greatest in the direction where loads are most commonly expressed (C)</p> Signup and view all the answers

Which statement explains bone adaptation to exercise?

<p>Bone changes shape and strength in response to the magnitude and direction of strain. (B)</p> Signup and view all the answers

What is the significance of HISA in the context of bone changes and prevention in racehorses?

<p>HISA aims to ensure integrity and safety in horseracing. (D)</p> Signup and view all the answers

When bone is loaded, what temporary change occurs?

<p>It temporarily changes its shape (B)</p> Signup and view all the answers

What happens to cellular responsiveness with repeated mechanical stimulation?

<p>There is almost no discernible osteogenic benefit established beyond ~100 loading cycles (D)</p> Signup and view all the answers

Which type of bone changes have been extensively studied in Thoroughbred racehorses?

<p>Cortical bone changes (D)</p> Signup and view all the answers

What is the function of the inner osteogenic layer of the periosteum?

<p>Adaptive response (D)</p> Signup and view all the answers

What is the term of localized change in dimension that occurs within a structure as it responds to externally applied loads??

<p>Strain (A)</p> Signup and view all the answers

Which statement accurately depicts apposition in bone remodeling?

<p>Porosity decreases as new bone is laid down (D)</p> Signup and view all the answers

What is the result of microdamage often healing through modeling and remodeling?

<p>Microdamage often heals through modeling and remodeling but it can accumulate (A)</p> Signup and view all the answers

Which organization, as mentioned in the content, has the goal of ensuring integrity and safety or horseracing??

<p>HISA (D)</p> Signup and view all the answers

How is stress defined in bone biomechanics?

<p>Force per unit area. (D)</p> Signup and view all the answers

In the context of bone remodeling what is the primary purpose of osteocytes?

<p>Transport and communications within the bone (A)</p> Signup and view all the answers

What is an important characteristic about long bones?

<p>Load predictability likes long bones that are slightly curved (A)</p> Signup and view all the answers

What key factor determines whether strain is resorptive, regenerative, or formative in bone according to the mechanostat theory?

<p>The magnitude (A)</p> Signup and view all the answers

Which action must be undertaken to prevent catastrophic fracture?

<p>Appropriately resting the body (D)</p> Signup and view all the answers

There is almost no discernible osteogenic benefit established when what threshold is reached?

<p>Beyond ~100 loading cycles (D)</p> Signup and view all the answers

Besides the magnitude of strain what are some other factors within the same environment that prompt a resultant osteogenic effect?

<p>Strain magnitude, Strain rate, Strain frequency, Strain distribution, Number of loading cycles, Rest-recovery periods (C)</p> Signup and view all the answers

How many days did Control 1 need before taking a layup?

<p>170 days (C)</p> Signup and view all the answers

Which component of bone provides the greatest amount of tensile strength?

<p>Collagen (B)</p> Signup and view all the answers

Which of the following describes the primary function of the outer fibrous layer of the periosteum?

<p>Supportive function. (D)</p> Signup and view all the answers

Which statement best describes the relationship between bone loading and deformation?

<p>Loading causes deformation, which is described by Stress = Strain. (B)</p> Signup and view all the answers

According to Wolff's Law, what determines the changes in bone shape and strength?

<p>The magnitude and direction of strain. (D)</p> Signup and view all the answers

According to the Mechanostat Theory, what happens when strain magnitude is too low?

<p>Bone is resorbed. (D)</p> Signup and view all the answers

Which of the following is most accurate regarding cellular responsiveness and repeated stimulation, as explained by the Mechanostat Theory?

<p>Cellular responsiveness decreases after a small number of loading cycles. (B)</p> Signup and view all the answers

What is a potential consequence of cyclic loading during the resorption phase of bone remodeling?

<p>Dorsal cortical fracture or bucked shins. (A)</p> Signup and view all the answers

What strategic approach is most effective in preventing catastrophic fractures in racehorses?

<p>Detecting trauma before it becomes clinical. (B)</p> Signup and view all the answers

Which bone type exhibits high resistance to stress and low resistance to strain?

<p>Compact (cortical) bone (B)</p> Signup and view all the answers

Assuming consistent environmental parameters besides the degree or extent of strain, which factor does NOT have a resultant osteogenic effect in bone?

<p>Bone Geometry (B)</p> Signup and view all the answers

In longitudinal bone growth via endochondral ossification, which zone of the physis is located closest to the epiphysis?

<p>Reserve zone (C)</p> Signup and view all the answers

Which zone of the physis is most susceptible to a fracture resulting from an overload?

<p>Hypertrophic zone (A)</p> Signup and view all the answers

What is the primary role of the zone of provisional calcification in the physis?

<p>Scaffolding for vascular invasion (A)</p> Signup and view all the answers

According to the Salter-Harris classification, which type of physeal fracture involves both the physis and the adjacent metaphysis?

<p>Type II (B)</p> Signup and view all the answers

Which of the following characterizes a Salter-Harris type V fracture?

<p>Crushing injury to the physis (B)</p> Signup and view all the answers

What is the likely consequence of interrupting the blood supply to the epiphysis in the physis?

<p>Permanent cessation of growth (C)</p> Signup and view all the answers

Retained cartilaginous cores in the distal ulnar physis result in what orthopedic condition?

<p>Carpal valgus deformity (D)</p> Signup and view all the answers

In foals, what term describes a lateral (outward) deviation of the limb distal to the point of deformity?

<p>Valgus (D)</p> Signup and view all the answers

Why is it critical to assess the condition of cuboidal bones in foals with angular limb deformities (ALD) within the first 24 hours of birth?

<p>To prevent crushing due to incomplete ossification (B)</p> Signup and view all the answers

A foal presents with a moderate carpal valgus deformity of 15 degrees. What intervention is MOST appropriate based on the information provided?

<p>Conservative management and possible surgical intervention. (D)</p> Signup and view all the answers

What is the primary distinction between bone modeling and remodeling, based on the lecture?

<p>Modeling is the formation of new bone without prior resorption, whereas remodeling involves resorption followed by new bone formation. (B)</p> Signup and view all the answers

Which of the following best describes the function of osteocytes within bone tissue?

<p>To sense mechanical loads and signal for bone remodeling or modeling. (C)</p> Signup and view all the answers

What is the primary function of the periosteum's germinal layer in bone?

<p>To serve as a source of osteoblasts for new bone formation during modeling. (C)</p> Signup and view all the answers

Why are long bones typically hollow cylinders rather than solid structures?

<p>Hollow cylinders maximize strength while minimizing bone mass. (A)</p> Signup and view all the answers

According to the lecture, what is the significance of bone's viscoelastic property?

<p>It implies that bone's response to stress depends on the rate at which the stress is applied. (B)</p> Signup and view all the answers

In the context of bone biomechanics, what does 'stress' specifically refer to?

<p>The force distributed over a unit area of bone. (C)</p> Signup and view all the answers

What is the 'plastic region' on a bone's stress-strain curve indicative of?

<p>The area where bone undergoes permanent deformation. (A)</p> Signup and view all the answers

According to the Mechanostat Theory, what is the effect of extremely low magnitude strain on bone?

<p>It primarily leads to bone resorption. (B)</p> Signup and view all the answers

Why might a slightly curved bone be more advantageous than a perfectly cylindrical bone in living organisms?

<p>Curved bones are better adapted to withstand predictable, directional loads. (D)</p> Signup and view all the answers

What is the consequence of repetitive loading during the bone resorption phase of remodeling, as mentioned in the lecture?

<p>Increased risk of microdamage accumulation and potential fatigue fractures. (D)</p> Signup and view all the answers

What is the practical implication of the finding that bone cell responsiveness to mechanical stimulation diminishes after a limited number of loading cycles per day?

<p>Short bursts of activity may be more osteogenically effective than extended workouts. (D)</p> Signup and view all the answers

Why is early race training, initiated in late teens to early two-year-old horses, considered important for skeletal development despite concerns about young horses racing?

<p>To capitalize on the period of high bone plasticity to shape bones optimally for high-speed exercise. (A)</p> Signup and view all the answers

What distinguishes cortical bone from cancellous bone in terms of structure and function?

<p>Cortical bone is dense and rigid, providing strength and resistance to bending, while cancellous bone is porous and facilitates energy distribution and strain accommodation. (C)</p> Signup and view all the answers

What is the role of the mineral component, primarily calcium and phosphate, in bone?

<p>To impart structural rigidity and compressive strength to bone. (C)</p> Signup and view all the answers

What is the primary component of the organic matrix of bone, and what property does it primarily contribute?

<p>Collagen fibers; tensile strength. (C)</p> Signup and view all the answers

What scenario exemplifies 'abnormal loading' on bone, potentially leading to injury, as described in the lecture?

<p>A horse experiencing a sudden side impact or twisting force on its limb. (D)</p> Signup and view all the answers

According to the lecture, what is a key factor in preventing catastrophic fractures in racehorses, in addition to controlled training regimens?

<p>Ensuring bone adaptation through appropriate loading and avoiding excessive fatigue. (C)</p> Signup and view all the answers

What is the primary goal of the Horse Racing Integrity and Safety Authority (HISA) mentioned in the lecture?

<p>To ensure the ethical treatment of racehorses and reduce injuries through regulations. (B)</p> Signup and view all the answers

What is the relationship between stress and strain, as described in the lecture regarding bone biomechanics?

<p>Stress is the applied force, and strain is the resulting deformation of bone. (B)</p> Signup and view all the answers

What is meant by 'maladaptive bone modeling and remodeling' in the context of racehorse training?

<p>Bone adaptation that is insufficient or detrimental, increasing the risk of injury. (A)</p> Signup and view all the answers

Considering the stress-strain relationship of bone, what does the 'area under the curve' represent?

<p>The total energy absorbed by the bone up to a specific point of deformation. (B)</p> Signup and view all the answers

What is the potential outcome of excessive density in subchondral bone at the ends of long bones, as mentioned in the lecture?

<p>Increased brittleness and susceptibility to cracking and cartilage damage. (D)</p> Signup and view all the answers

Which type of bone is described as being 'sponge-like' or 'trabecular' and is found in areas like the metaphyses of long bones?

<p>Cancellous bone (B)</p> Signup and view all the answers

What best describes the initial response of osteocytes to mechanical loading, according to the Mechanostat Theory?

<p>Rapid and significant response promoting osteogenesis. (A)</p> Signup and view all the answers

What percentage of bone's wet weight is approximately attributed to the organic extracellular matrix?

<p>21% (C)</p> Signup and view all the answers

Which of the following is NOT mentioned as a systemic influence on bone structure and function in the lecture?

<p>Ambient temperature (C)</p> Signup and view all the answers

What is the primary role of osteoclasts in bone remodeling?

<p>To resorb and remove existing bone tissue during the remodeling process. (A)</p> Signup and view all the answers

What is the term for bone formation occurring on the outer and inner surfaces of existing bone, contributing to changes in bone shape and size?

<p>Apposition (C)</p> Signup and view all the answers

In what type of environment are astronauts likely to experience bone adaptation that is considered 'bad' or detrimental, according to the lecture?

<p>Microgravity environments due to reduced mechanical loading. (D)</p> Signup and view all the answers

What is the most efficient structural shape for supporting weight and load for a given mass of material, although less evolutionarily 'constructible' than a cylinder, as mentioned in the lecture?

<p>I-beam (D)</p> Signup and view all the answers

What observation from the lecture suggests that tendons may play a role in vibration absorption in horse legs?

<p>Tendons wrap around bones in the horse's leg. (B)</p> Signup and view all the answers

According to the Mechanostat Theory and the lecture, what frequency and magnitude of loading is considered most 'safe' and beneficial for bone?

<p>High frequency, low magnitude loads. (B)</p> Signup and view all the answers

What is a potential consequence of excessively dense cortical bone, such as that seen in racehorses adapted to high-speed training?

<p>Reduced 'bendiness' and increased susceptibility to microcracks and fractures. (A)</p> Signup and view all the answers

What broad effect does the environment have on the skeleton?

<p>It influences the skeleton's remodeling, which can have lasting repercussions, both good and bad. (C)</p> Signup and view all the answers

Why do horses need an ambulation system capable of rapid acceleration?

<p>To escape from predators, given their large digestive system. (A)</p> Signup and view all the answers

Which factor does NOT directly modulate the systemic and macro/microstructural influences on bone?

<p>Endocrine Status. (D)</p> Signup and view all the answers

From a load-bearing perspective, what is a key advantage of long bones being hollow cylinders?

<p>They reduce mass while maintaining strength and support. (A)</p> Signup and view all the answers

Why might a slightly curved bone be more advantageous than a perfectly cylindrical one for most mammals?

<p>It adapts to specific, repetitive tasks, enhancing load absorption. (D)</p> Signup and view all the answers

Which bone type is best suited for impact distribution (changing shape), versus strictly load-bearing?

<p>Cancellous bone. (C)</p> Signup and view all the answers

What is the role of the germinal layer within the periosteum?

<p>To provide for new bone formation during modeling. (A)</p> Signup and view all the answers

How are osteocytes interconnected, and why is this significant?

<p>They have long tendrils that connect, enabling them to work together in response to mechanical forces. (C)</p> Signup and view all the answers

What is the key distinction between bone modeling and remodeling?

<p>Modeling involves laying down new bone without prior resorption, while remodeling involves both resorption and formation. (A)</p> Signup and view all the answers

What is the primary function of the mineral component in bone?

<p>Gives bone its structural strength due to calcium and phosphate crystals. (B)</p> Signup and view all the answers

What happens when bone is loaded in an unusual direction?

<p>It may sustain damage because it is not adapted to accept that type of energy input. (C)</p> Signup and view all the answers

Why are bone strength and stiffness greatest in the direction of most common loads?

<p>Because modeling and remodeling adapt the bone to best withstand those specific forces. (B)</p> Signup and view all the answers

What term describes the temporary stretch or change in shape that results from applying a force to bone?

<p>Strain. (D)</p> Signup and view all the answers

Which statement best describes viscoelasticity in biological tissues like bone or tendon?

<p>They resist additional load initially but then stretch, with the amount of stretch depending on the rate of stress. (B)</p> Signup and view all the answers

What role do tendons near bones play in load-bearing?

<p>They absorb vibrations that are transmitted through the bone when loaded. (C)</p> Signup and view all the answers

What does the area under a bone's stress-strain curve represent?

<p>The amount of energy the bone stores. (A)</p> Signup and view all the answers

In the context of bone remodeling, what does 'stress' refer to?

<p>The force exerted over a unit area. (D)</p> Signup and view all the answers

How does bone initially respond to stress?

<p>By changing shape elastically, returning to its original form when unloaded. (D)</p> Signup and view all the answers

What is the ultimate consequence of bone reaching the 'plastic region' on the stress-strain curve?

<p>The bone undergoes microscopic damage and does not return to its original shape. (C)</p> Signup and view all the answers

According to Wolff's Law, how does bone primarily adapt to applied forces?

<p>It remodels to better withstand those forces. (A)</p> Signup and view all the answers

According to the mechanostat theory, which type of loading is considered most safe and beneficial for bone?

<p>High frequency, low magnitude loads. (B)</p> Signup and view all the answers

After how many loading cycles per day does the benefit to bone from additional loading diminish significantly?

<p>20-40 (C)</p> Signup and view all the answers

What is a potential negative consequence of repetitive overstimulation?

<p>Fatigue fractures of the bones. (B)</p> Signup and view all the answers

Besides the magnitude of strain that triggers an osteogenic effect in bone, which factor is MOST important?

<p>The number of loading cycles. (C)</p> Signup and view all the answers

Why, specifically, have researchers extensively studied training outcomes in racehorses?

<p>Because catastrophic breakdowns are very common. (A)</p> Signup and view all the answers

What is the significance of the earlier research done in turkeys, regarding bone adaptation?

<p>It established a model for understanding bone adaptation influenced by mechanical loading. (D)</p> Signup and view all the answers

What maladaptive change can occur with rigorous race training leading to a thickened cortex in horses?

<p>Microcracks can develop due to reduced bendiness, potentially leading to catastrophic fractures. (C)</p> Signup and view all the answers

What is 'maladaptive bone disease'?

<p>When bone adaptation is unsuccessful due to factors like the animal's age, the number of loads in a set period, or its nutritional status. (B)</p> Signup and view all the answers

What is the clinical relevance of maladaptive bone remodeling at the subchondral level?

<p>Excessive bone density can result, causing cracking and cartilage damage. (D)</p> Signup and view all the answers

What is unique about bone's reparative capability (after an injury)?

<p>Bone tissue can completely replace itself after an injury with completely replacement of all cells and tissues. (C)</p> Signup and view all the answers

What is the purpose of the Horse Racing Integrity and Safety Authority (HISA)?

<p>To control the industry by limiting drugs, controlling exercise, and other things designed to reduce bone damage. (C)</p> Signup and view all the answers

When considering the strain effects on bone, how do the magnitude and rate/frequency of loading cycles relate to resultant bone effects?

<p>These all have a resultant effect on the bone and it's ability to strengthen or weaken. (B)</p> Signup and view all the answers

If the extensor tendons of a horse's front leg primarily function to absorb vibrations, what is the most likely consequence of damaging them?

<p>Increased stress concentrations causing microscopic cracking to the bone. (D)</p> Signup and view all the answers

You have a bone sample from two horses with varying levels of bone density. Horse A has a bone density of 4, horse B has a bone density of 6. Which bone has higher resistance to strain assuming all other bone attributes are equal?

<p>Bone B. (D)</p> Signup and view all the answers

A veterinarian is advising a racehorse trainer on a training regimen. Knowing that bone cell responsiveness diminishes with repeated mechanical stimulation, what would be the MOST strategic recommendation?

<p>Incorporate short bouts/episodes of bone loading into work out, with rest periods. (D)</p> Signup and view all the answers

What is the MAIN reason that young racehorses are trained in their late teens to early two-year-old year despite concerns about young horses racing?

<p>To optimize bone adaptation to high-speed exercise during their most responsive period. (B)</p> Signup and view all the answers

Given what you know, what can you infer about bone adaptation (particularly bone mineral density) in a group of astronauts who spend extended periods in space?

<p>Their bones respond poorly to adaptation, and a long recovery period is needed. (A)</p> Signup and view all the answers

What is the best analogy for osteocytes?

<p>A unified entity such as ants or flocks of birds. (D)</p> Signup and view all the answers

Wolff's law in bone remodeling says the bone adapts to better handle force. How does this happen at a cellular level?

<p>The amount of force is experienced by the osteocytes and the other small cells in the matrix and prompts a response. (C)</p> Signup and view all the answers

What is the most efficient structural shape for supporting weight and load for a given mass of material?

<p>I beam. (C)</p> Signup and view all the answers

What is the primary reason that an animal like a horse needs an ambulation system capable of rapid acceleration?

<p>To escape from predators (B)</p> Signup and view all the answers

Flashcards

Bone Anatomy

The comprehensive study of bone anatomy and its components.

Bone Biomechanics

The study of how mechanical forces affect bone behavior.

Load (Stress) & Deformation (Strain)

The force applied to a bone, leading to deformation.

Systemic Bone Influences

Endocrine, nutritional, pharmacological, and stochastic effects on bone.

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Macrostructural Level

Bone mass and geometry comprises this level.

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Microstructural Level

Cells, organic extracellular matrix, and inorganic portion.

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Compact (Cortical) Bone

Shafts of long bones; offer high resistance to stress.

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Cancellous (Trabecular) Bone

Ends of long bones; have low resistance to stress.

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Osteoblasts

Cells responsible for forming new bone matrix.

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Osteoclasts

Cells that resorb or break down bone tissue.

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Osteocytes

Bone cells trapped in bone matrix; transport and communicate within the bone.

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Tensile Strength

95% type 1 collagen provides...

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Proteoglycans (PGs)

Provide flexibility and resilience in bone.

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Inorganic Portion

Calcium, phosphate, and hydroxyapatite crystals in bone.

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Stress

Amount of force per unit area that develops on a plane surface in response to an external load.

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Strain

Localized change in dimension within a structure responding to loads.

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Strain Environment Aspects

Magnitude, rate, and frequency of stress.

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Wolff's Law

Bone changes shape and strength in response to strain.

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Minimum Effective Strain (MES)

Balance between resorption and formation to maintain bone mass.

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Modeling

Bone formation along periosteal and endosteal surfaces.

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Remodeling

Formed bone is replaced by process of resorption.

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"Bucked Shins"

New bone on dorsal cortex.

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Microtrauma

Damage can culminate in this level.

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Cancellous

Adaptive changes occur in these type of bone

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Subchondral

Can result from intense remodeling.

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Repetitive Loading

Loading leading to injury.

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HISA

The Horseracing Integrity & Safety Authority.

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Rest.

Helps resting the body.

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Physeal Fractures

Injuries to the growth plate in immature animals

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Longitudinal Bone Growth

Endochondral ossification creates longitudinal bone growth.

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Four Zones of the Physis

Reserve, Proliferating, Hypertrophic, and Zone of Provisional Calcification

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Fracture Zone

Through the hypertrophic zone

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Salter-Harris Classification

Classification system used to grade fractures of the growth plate

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Fixation Device Effects on Physis

Bone plates/screws prevent growth; smooth pins allow sliding. Remove pins post-healing.

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Retained Cartilaginous Cores

Delayed ossification of distal ulnar physis, causing a shortened ulna (+carpal valgus)

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Angular Limb Deviation (ALD)

Deviation from normal limb axis in foals; can be valgus or varus.

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Valgus

Lateral deviation distal to the deformity's point

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Varus

Medial deviation distal to the deformity's point

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Bone Modeling and Remodeling

The ability of bone to adapt its structure to best suit its environment, influenced by factors like gravity and physical activity.

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Long Bone Structure

Hollow cylinders with a circular cross-section, optimizing strength while minimizing weight.

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Bone Modeling (Strict Definition)

New bone formation without prior resorption, typically performed by osteoblasts.

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Bone Remodeling

Bone resorption followed by new bone formation, involving both osteoclasts and osteoblasts.

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Osteocyte Processes

These connect osteocytes, allowing them to communicate and coordinate bone remodeling in response to mechanical forces.

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Organic Matrix (Osteoid)

Collagen fibers deposited by osteoblasts that provide a framework for mineral deposition.

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Mineral Component of Bone

Calcium and phosphate crystals embedded within the collagen matrix that provide bone's rigidity and strength.

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Bone Adaptation

Bone strength and stiffness align with the direction of the most common loads.

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Elastic Behavior of Bone

Bone's ability to change shape under load, returning to its original form once unloaded.

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Plastic Region of Bone

The point where bone deforms permanently after loading.

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Mechanostat Theory Summary

Bones remodel to adapt to forces; high frequency, low magnitude loads are safest.

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Bone's Reparative Capability

The ability of bone to repair itself completely perfectly even after injury.

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Maladaptive Bone Disease

A condition where bone remodeling is not successful due to factors like age, load frequency, or nutrition.

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Viscoelasticity

Tendency of biological tissues to resist an immediate load and then stretch.

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Study Notes

  • Modeling and remodeling of bone is important for ambulation, adaptation to environments, and has lasting repercussions.
  • The ability to remodel the skeleton allows it to best suit the environment whether on Earth or in space.
  • Upon returning from space, astronauts' bones are poorly adapted to Earth's environment, requiring time to readjust.

Lecture Overview

  • Review of relevant bone structure related to remodeling and modeling.
  • Discussion of biomechanics causing modeling and remodeling.
  • Review of stress and strain concepts, particularly how strain influences bone remodeling.
  • Overview of strategies to prevent bone injury by influencing bone modeling and remodeling.

Bone Function (Horse Example)

  • Bones enable rapid acceleration of a large mass over distance
  • Horses have a large digestive component with the need to be athletic to escape predators.
  • The horse and rider can be seen as a ball of energy composed of:
    • Gravitational energy based on height above the ground.
    • Kinetic energy based on speed and mass.
    • Elastic energy stored in tendons and ligaments upon landing.
  • Limb bones are primarily responsible for adapting the animal to its environment.

Structure and Function of Bone (Modeling/Remodeling Perspective)

  • Systemic factors include endocrine, nutritional, pharmacological, and stochastic influences.
  • Macrostructural factors include bone mass and geometry.
  • Microstructural factors include cells, matrix, and the inorganic crystalline portion of bone.
  • All the above factors are modulated by animal activity through muscle activity, loading, and gravity.
  • Bones are hollow cylinders, an efficient structure in terms of material use to support the animal.
  • Long bones in mammals are hollow to reduce mass and largely circular for strength.
  • Bones are slightly curved and offset to best support loads
  • Bone curves and offsets adapt to the tasks
  • I-beam structures that are made of bone are efficient in supporting weight and load compared to cylinders, but cylinders are easier to construct
  • Cortical Bone:
    • Dense bone on x-rays, forms exterior of the cylinder.
    • Rigid; effectively supports loads without significant shape change.
  • Cancellous Bone:
    • Trabecular or sponge-like bone found in metaphyses.
    • Less capable of supporting load but better at supporting distribution or strain.
    • Supports distribution or strain/change in shape at the ends of bones.
  • The germinal layer inside the periosteum gives rise to new bone for modeling The sock that envelops long bones
  • Osteoblasts lay down new bone.
  • Osteoclasts resorb old bone.
  • Osteocytes:
    • Embedded in bone with long arms that connect to each other.
    • Respond to mechanical force and change the local environment to activate osteoblasts or osteoclasts.
  • Modeling is laying down new bone without a preceding resorptive phase (strictly osteoblasts).
  • Remodeling involves resorption of existing bone and reshaping it with new bone (osteoblasts and osteoclasts).
  • Osteoclasts resorb bone
  • Osteocytes message to switch on bone formation or bone resorption.
  • Osteoclasts are multinucleate with a curtain around the edges, releasing hydrochloric acid to resorb bone.
  • Collagen fibers laid down by osteoblasts in a randomized pattern initially and then remold to align with the most frequent type of load.
  • The mineral component provides structural strength via calcium and phosphate crystals embedding within collagen fibers.
  • Different bone types exist depending on age, activity level, etc

Normal and Abnormal Bone Remodeling

  • Horse skeletons are typically loaded in a standardized fashion, allowing them to jump safely
  • Unusual loads, like side swipes, can lead to contusions, microcracks, or macro fractures.
  • Bone strength and stiffness are greatest in the direction where loads are most commonly expressed.
  • High-energy impact cause uncontrolled energy release
  • Abnormal loading can damage bone, leading to stress fractures.
  • Adaptation of bone for the load's it's receiving is necessary
  • When bone has not adapted it is more susceptible to damage

Stress and Strain

  • Tendons stretch safely up to about 4% of their original length
  • Biological structures (bone, tendon, ligament) are viscoelastic resisting initial loads then stretching
  • Bone changes shape under load with micro strain (thousandths of a percent).
  • Tendons wrap around bone and absorb vibrations
  • Bone absorbs energy, distributes/stores it, and returns it as it goes back to it's original shape.
  • In the plastic deformation region, the bone bends but does not return back to it's shape and microscopic damage occurs.
  • Energy stored in bone is also realised when popping the bone
  • When a bone fractures the amount of energy absorption is the bones surface area.
  • Stress is the force over a unit area.
  • Strain is the change in shape in a particular dimension divided by the original distance.
  • Strain Metrics:
    • Magnitude of strain.
    • Rate of strain.
    • Frequency of strain.
    • Distribution of strain.
    • The number of loading cycles.
    • Rest recovery periods.

Wolff's Law

  • Bone remodels to better adapt to applied force, influenced by osteocytes and small cells in the matrix.

Mechanostat Theory

  • Osteocytes respond readily to loading but become fatigued over time.
  • Mechanical stimulation promotes osteogenesis
  • Loading between 20 and 40 cycles per day gives maximum response; additional cycling does not further benefit the skeleton.
  • Additional cycling beyond 40 can cause issues
  • Bone can replace itself after an injury with a completely new, perfect structure.
  • Bone can return to its original mechanical quality.

Bone Adaptation in Racehorses

  • Cannon bone research has shown that Thoroughbred horses require appropriate timing of exercise to ensure proper bone maintenance
  • Racehorses are most responsive until three years old; humans up to 30 years old.
  • Starting race training in late teens/early two-year-old year is important
  • Later race-training leads to more injuries

Bone Modeling vs Remodeling

  • Modeling is bone formation on top of existing surfaces (periosteum, endosteum, growth plate).
  • Remodeling is when formed bone is resorbed and replaced (osteoclasts and osteoblasts involved).
  • Thick bone = super dense, and has less bendiness
  • Running around a racetrack needs bendiness from the bone
  • Maladaptive bone modeling and remodeling is where adaptation wasn't successful (age of the animal, the number of loads it had in a set period of time or its nutritional status)
  • Too much load on dense bones leads to cracks
  • Subchondral bone can become too dense and crack easily.

Injury Prevention

  • The Horseracing Integrity & Safety Authority (HISA) works to control the industry and reduce bone damage.
  • Federally mandated authority to control the racing industry to reduce bone damage
  • HISA limiting drugs which can be given, when they can be given, how much exercise the animal can have
  • Veterinarians can be sued for illegal drug practices.

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