Podcast
Questions and Answers
Which of the following is NOT a systemic influence on bone structure and function?
Which of the following is NOT a systemic influence on bone structure and function?
- Nutritional intake
- Bone Geometry (correct)
- Pharmacological agents
- Endocrine factors
What is the primary function of collagen in the organic extracellular matrix of bone?
What is the primary function of collagen in the organic extracellular matrix of bone?
- Providing tensile strength (correct)
- Facilitating cell communication
- Providing flexibility
- Mineralizing the bone matrix
Which of the following best describes the role of osteoclasts in bone?
Which of the following best describes the role of osteoclasts in bone?
- Trapping themselves in the bone matrix
- Building new bone matrix
- Transporting substances within the bone
- Resorbing bone (correct)
What is the main function of hydroxyapatite crystals in bone?
What is the main function of hydroxyapatite crystals in bone?
What is the definition of 'stress' in the context of bone biomechanics?
What is the definition of 'stress' in the context of bone biomechanics?
According to Wolff's Law, how does bone adapt to strain?
According to Wolff's Law, how does bone adapt to strain?
What is required to simply maintain bone mass, according to the Mechanostat Theory?
What is required to simply maintain bone mass, according to the Mechanostat Theory?
What is the term for bone formation along periosteal and endosteal surfaces?
What is the term for bone formation along periosteal and endosteal surfaces?
During bone resorption, what happens to the porosity and stiffness of the bone?
During bone resorption, what happens to the porosity and stiffness of the bone?
What potential issue can arise from cyclic loading during the resorption phase of bone remodeling?
What potential issue can arise from cyclic loading during the resorption phase of bone remodeling?
Which of the following is a component of the 'Bucked Shins Complex'?
Which of the following is a component of the 'Bucked Shins Complex'?
What is the potential outcome of repetitive loading on bone?
What is the potential outcome of repetitive loading on bone?
According to the information provided, what measure is associated with preventing catastrophic fractures?
According to the information provided, what measure is associated with preventing catastrophic fractures?
Which type of bone has high resistance to stress and low resistance to strain?
Which type of bone has high resistance to stress and low resistance to strain?
Which of the following is NOT a function of bone?
Which of the following is NOT a function of bone?
Which type of bone cell is trapped in the bone matrix and facilitates communication within the bone?
Which type of bone cell is trapped in the bone matrix and facilitates communication within the bone?
What does 'Strain' refer to in bone biomechanics?
What does 'Strain' refer to in bone biomechanics?
What is the approximate percentage of bone's wet weight attributed to the organic extracellular matrix?
What is the approximate percentage of bone's wet weight attributed to the organic extracellular matrix?
Which action primarily describes the function of osteoblasts?
Which action primarily describes the function of osteoblasts?
Which component of bone provides flexibility and resilience?
Which component of bone provides flexibility and resilience?
If bone adapts to its mechanical environment, what can cause it to become abnormal?
If bone adapts to its mechanical environment, what can cause it to become abnormal?
Which is a factor that prompts a resultant osteogenic effect in bone?
Which is a factor that prompts a resultant osteogenic effect in bone?
How does bone strength and stiffness relate to the direction of load?
How does bone strength and stiffness relate to the direction of load?
Which statement explains bone adaptation to exercise?
Which statement explains bone adaptation to exercise?
What is the significance of HISA in the context of bone changes and prevention in racehorses?
What is the significance of HISA in the context of bone changes and prevention in racehorses?
When bone is loaded, what temporary change occurs?
When bone is loaded, what temporary change occurs?
What happens to cellular responsiveness with repeated mechanical stimulation?
What happens to cellular responsiveness with repeated mechanical stimulation?
Which type of bone changes have been extensively studied in Thoroughbred racehorses?
Which type of bone changes have been extensively studied in Thoroughbred racehorses?
What is the function of the inner osteogenic layer of the periosteum?
What is the function of the inner osteogenic layer of the periosteum?
What is the term of localized change in dimension that occurs within a structure as it responds to externally applied loads??
What is the term of localized change in dimension that occurs within a structure as it responds to externally applied loads??
Which statement accurately depicts apposition in bone remodeling?
Which statement accurately depicts apposition in bone remodeling?
What is the result of microdamage often healing through modeling and remodeling?
What is the result of microdamage often healing through modeling and remodeling?
Which organization, as mentioned in the content, has the goal of ensuring integrity and safety or horseracing??
Which organization, as mentioned in the content, has the goal of ensuring integrity and safety or horseracing??
How is stress defined in bone biomechanics?
How is stress defined in bone biomechanics?
In the context of bone remodeling what is the primary purpose of osteocytes?
In the context of bone remodeling what is the primary purpose of osteocytes?
What is an important characteristic about long bones?
What is an important characteristic about long bones?
What key factor determines whether strain is resorptive, regenerative, or formative in bone according to the mechanostat theory?
What key factor determines whether strain is resorptive, regenerative, or formative in bone according to the mechanostat theory?
Which action must be undertaken to prevent catastrophic fracture?
Which action must be undertaken to prevent catastrophic fracture?
There is almost no discernible osteogenic benefit established when what threshold is reached?
There is almost no discernible osteogenic benefit established when what threshold is reached?
Besides the magnitude of strain what are some other factors within the same environment that prompt a resultant osteogenic effect?
Besides the magnitude of strain what are some other factors within the same environment that prompt a resultant osteogenic effect?
How many days did Control 1 need before taking a layup?
How many days did Control 1 need before taking a layup?
Which component of bone provides the greatest amount of tensile strength?
Which component of bone provides the greatest amount of tensile strength?
Which of the following describes the primary function of the outer fibrous layer of the periosteum?
Which of the following describes the primary function of the outer fibrous layer of the periosteum?
Which statement best describes the relationship between bone loading and deformation?
Which statement best describes the relationship between bone loading and deformation?
According to Wolff's Law, what determines the changes in bone shape and strength?
According to Wolff's Law, what determines the changes in bone shape and strength?
According to the Mechanostat Theory, what happens when strain magnitude is too low?
According to the Mechanostat Theory, what happens when strain magnitude is too low?
Which of the following is most accurate regarding cellular responsiveness and repeated stimulation, as explained by the Mechanostat Theory?
Which of the following is most accurate regarding cellular responsiveness and repeated stimulation, as explained by the Mechanostat Theory?
What is a potential consequence of cyclic loading during the resorption phase of bone remodeling?
What is a potential consequence of cyclic loading during the resorption phase of bone remodeling?
What strategic approach is most effective in preventing catastrophic fractures in racehorses?
What strategic approach is most effective in preventing catastrophic fractures in racehorses?
Which bone type exhibits high resistance to stress and low resistance to strain?
Which bone type exhibits high resistance to stress and low resistance to strain?
Assuming consistent environmental parameters besides the degree or extent of strain, which factor does NOT have a resultant osteogenic effect in bone?
Assuming consistent environmental parameters besides the degree or extent of strain, which factor does NOT have a resultant osteogenic effect in bone?
In longitudinal bone growth via endochondral ossification, which zone of the physis is located closest to the epiphysis?
In longitudinal bone growth via endochondral ossification, which zone of the physis is located closest to the epiphysis?
Which zone of the physis is most susceptible to a fracture resulting from an overload?
Which zone of the physis is most susceptible to a fracture resulting from an overload?
What is the primary role of the zone of provisional calcification in the physis?
What is the primary role of the zone of provisional calcification in the physis?
According to the Salter-Harris classification, which type of physeal fracture involves both the physis and the adjacent metaphysis?
According to the Salter-Harris classification, which type of physeal fracture involves both the physis and the adjacent metaphysis?
Which of the following characterizes a Salter-Harris type V fracture?
Which of the following characterizes a Salter-Harris type V fracture?
What is the likely consequence of interrupting the blood supply to the epiphysis in the physis?
What is the likely consequence of interrupting the blood supply to the epiphysis in the physis?
Retained cartilaginous cores in the distal ulnar physis result in what orthopedic condition?
Retained cartilaginous cores in the distal ulnar physis result in what orthopedic condition?
In foals, what term describes a lateral (outward) deviation of the limb distal to the point of deformity?
In foals, what term describes a lateral (outward) deviation of the limb distal to the point of deformity?
Why is it critical to assess the condition of cuboidal bones in foals with angular limb deformities (ALD) within the first 24 hours of birth?
Why is it critical to assess the condition of cuboidal bones in foals with angular limb deformities (ALD) within the first 24 hours of birth?
A foal presents with a moderate carpal valgus deformity of 15 degrees. What intervention is MOST appropriate based on the information provided?
A foal presents with a moderate carpal valgus deformity of 15 degrees. What intervention is MOST appropriate based on the information provided?
What is the primary distinction between bone modeling and remodeling, based on the lecture?
What is the primary distinction between bone modeling and remodeling, based on the lecture?
Which of the following best describes the function of osteocytes within bone tissue?
Which of the following best describes the function of osteocytes within bone tissue?
What is the primary function of the periosteum's germinal layer in bone?
What is the primary function of the periosteum's germinal layer in bone?
Why are long bones typically hollow cylinders rather than solid structures?
Why are long bones typically hollow cylinders rather than solid structures?
According to the lecture, what is the significance of bone's viscoelastic property?
According to the lecture, what is the significance of bone's viscoelastic property?
In the context of bone biomechanics, what does 'stress' specifically refer to?
In the context of bone biomechanics, what does 'stress' specifically refer to?
What is the 'plastic region' on a bone's stress-strain curve indicative of?
What is the 'plastic region' on a bone's stress-strain curve indicative of?
According to the Mechanostat Theory, what is the effect of extremely low magnitude strain on bone?
According to the Mechanostat Theory, what is the effect of extremely low magnitude strain on bone?
Why might a slightly curved bone be more advantageous than a perfectly cylindrical bone in living organisms?
Why might a slightly curved bone be more advantageous than a perfectly cylindrical bone in living organisms?
What is the consequence of repetitive loading during the bone resorption phase of remodeling, as mentioned in the lecture?
What is the consequence of repetitive loading during the bone resorption phase of remodeling, as mentioned in the lecture?
What is the practical implication of the finding that bone cell responsiveness to mechanical stimulation diminishes after a limited number of loading cycles per day?
What is the practical implication of the finding that bone cell responsiveness to mechanical stimulation diminishes after a limited number of loading cycles per day?
Why is early race training, initiated in late teens to early two-year-old horses, considered important for skeletal development despite concerns about young horses racing?
Why is early race training, initiated in late teens to early two-year-old horses, considered important for skeletal development despite concerns about young horses racing?
What distinguishes cortical bone from cancellous bone in terms of structure and function?
What distinguishes cortical bone from cancellous bone in terms of structure and function?
What is the role of the mineral component, primarily calcium and phosphate, in bone?
What is the role of the mineral component, primarily calcium and phosphate, in bone?
What is the primary component of the organic matrix of bone, and what property does it primarily contribute?
What is the primary component of the organic matrix of bone, and what property does it primarily contribute?
What scenario exemplifies 'abnormal loading' on bone, potentially leading to injury, as described in the lecture?
What scenario exemplifies 'abnormal loading' on bone, potentially leading to injury, as described in the lecture?
According to the lecture, what is a key factor in preventing catastrophic fractures in racehorses, in addition to controlled training regimens?
According to the lecture, what is a key factor in preventing catastrophic fractures in racehorses, in addition to controlled training regimens?
What is the primary goal of the Horse Racing Integrity and Safety Authority (HISA) mentioned in the lecture?
What is the primary goal of the Horse Racing Integrity and Safety Authority (HISA) mentioned in the lecture?
What is the relationship between stress and strain, as described in the lecture regarding bone biomechanics?
What is the relationship between stress and strain, as described in the lecture regarding bone biomechanics?
What is meant by 'maladaptive bone modeling and remodeling' in the context of racehorse training?
What is meant by 'maladaptive bone modeling and remodeling' in the context of racehorse training?
Considering the stress-strain relationship of bone, what does the 'area under the curve' represent?
Considering the stress-strain relationship of bone, what does the 'area under the curve' represent?
What is the potential outcome of excessive density in subchondral bone at the ends of long bones, as mentioned in the lecture?
What is the potential outcome of excessive density in subchondral bone at the ends of long bones, as mentioned in the lecture?
Which type of bone is described as being 'sponge-like' or 'trabecular' and is found in areas like the metaphyses of long bones?
Which type of bone is described as being 'sponge-like' or 'trabecular' and is found in areas like the metaphyses of long bones?
What best describes the initial response of osteocytes to mechanical loading, according to the Mechanostat Theory?
What best describes the initial response of osteocytes to mechanical loading, according to the Mechanostat Theory?
What percentage of bone's wet weight is approximately attributed to the organic extracellular matrix?
What percentage of bone's wet weight is approximately attributed to the organic extracellular matrix?
Which of the following is NOT mentioned as a systemic influence on bone structure and function in the lecture?
Which of the following is NOT mentioned as a systemic influence on bone structure and function in the lecture?
What is the primary role of osteoclasts in bone remodeling?
What is the primary role of osteoclasts in bone remodeling?
What is the term for bone formation occurring on the outer and inner surfaces of existing bone, contributing to changes in bone shape and size?
What is the term for bone formation occurring on the outer and inner surfaces of existing bone, contributing to changes in bone shape and size?
In what type of environment are astronauts likely to experience bone adaptation that is considered 'bad' or detrimental, according to the lecture?
In what type of environment are astronauts likely to experience bone adaptation that is considered 'bad' or detrimental, according to the lecture?
What is the most efficient structural shape for supporting weight and load for a given mass of material, although less evolutionarily 'constructible' than a cylinder, as mentioned in the lecture?
What is the most efficient structural shape for supporting weight and load for a given mass of material, although less evolutionarily 'constructible' than a cylinder, as mentioned in the lecture?
What observation from the lecture suggests that tendons may play a role in vibration absorption in horse legs?
What observation from the lecture suggests that tendons may play a role in vibration absorption in horse legs?
According to the Mechanostat Theory and the lecture, what frequency and magnitude of loading is considered most 'safe' and beneficial for bone?
According to the Mechanostat Theory and the lecture, what frequency and magnitude of loading is considered most 'safe' and beneficial for bone?
What is a potential consequence of excessively dense cortical bone, such as that seen in racehorses adapted to high-speed training?
What is a potential consequence of excessively dense cortical bone, such as that seen in racehorses adapted to high-speed training?
What broad effect does the environment have on the skeleton?
What broad effect does the environment have on the skeleton?
Why do horses need an ambulation system capable of rapid acceleration?
Why do horses need an ambulation system capable of rapid acceleration?
Which factor does NOT directly modulate the systemic and macro/microstructural influences on bone?
Which factor does NOT directly modulate the systemic and macro/microstructural influences on bone?
From a load-bearing perspective, what is a key advantage of long bones being hollow cylinders?
From a load-bearing perspective, what is a key advantage of long bones being hollow cylinders?
Why might a slightly curved bone be more advantageous than a perfectly cylindrical one for most mammals?
Why might a slightly curved bone be more advantageous than a perfectly cylindrical one for most mammals?
Which bone type is best suited for impact distribution (changing shape), versus strictly load-bearing?
Which bone type is best suited for impact distribution (changing shape), versus strictly load-bearing?
What is the role of the germinal layer within the periosteum?
What is the role of the germinal layer within the periosteum?
How are osteocytes interconnected, and why is this significant?
How are osteocytes interconnected, and why is this significant?
What is the key distinction between bone modeling and remodeling?
What is the key distinction between bone modeling and remodeling?
What is the primary function of the mineral component in bone?
What is the primary function of the mineral component in bone?
What happens when bone is loaded in an unusual direction?
What happens when bone is loaded in an unusual direction?
Why are bone strength and stiffness greatest in the direction of most common loads?
Why are bone strength and stiffness greatest in the direction of most common loads?
What term describes the temporary stretch or change in shape that results from applying a force to bone?
What term describes the temporary stretch or change in shape that results from applying a force to bone?
Which statement best describes viscoelasticity in biological tissues like bone or tendon?
Which statement best describes viscoelasticity in biological tissues like bone or tendon?
What role do tendons near bones play in load-bearing?
What role do tendons near bones play in load-bearing?
What does the area under a bone's stress-strain curve represent?
What does the area under a bone's stress-strain curve represent?
In the context of bone remodeling, what does 'stress' refer to?
In the context of bone remodeling, what does 'stress' refer to?
How does bone initially respond to stress?
How does bone initially respond to stress?
What is the ultimate consequence of bone reaching the 'plastic region' on the stress-strain curve?
What is the ultimate consequence of bone reaching the 'plastic region' on the stress-strain curve?
According to Wolff's Law, how does bone primarily adapt to applied forces?
According to Wolff's Law, how does bone primarily adapt to applied forces?
According to the mechanostat theory, which type of loading is considered most safe and beneficial for bone?
According to the mechanostat theory, which type of loading is considered most safe and beneficial for bone?
After how many loading cycles per day does the benefit to bone from additional loading diminish significantly?
After how many loading cycles per day does the benefit to bone from additional loading diminish significantly?
What is a potential negative consequence of repetitive overstimulation?
What is a potential negative consequence of repetitive overstimulation?
Besides the magnitude of strain that triggers an osteogenic effect in bone, which factor is MOST important?
Besides the magnitude of strain that triggers an osteogenic effect in bone, which factor is MOST important?
Why, specifically, have researchers extensively studied training outcomes in racehorses?
Why, specifically, have researchers extensively studied training outcomes in racehorses?
What is the significance of the earlier research done in turkeys, regarding bone adaptation?
What is the significance of the earlier research done in turkeys, regarding bone adaptation?
What maladaptive change can occur with rigorous race training leading to a thickened cortex in horses?
What maladaptive change can occur with rigorous race training leading to a thickened cortex in horses?
What is 'maladaptive bone disease'?
What is 'maladaptive bone disease'?
What is the clinical relevance of maladaptive bone remodeling at the subchondral level?
What is the clinical relevance of maladaptive bone remodeling at the subchondral level?
What is unique about bone's reparative capability (after an injury)?
What is unique about bone's reparative capability (after an injury)?
What is the purpose of the Horse Racing Integrity and Safety Authority (HISA)?
What is the purpose of the Horse Racing Integrity and Safety Authority (HISA)?
When considering the strain effects on bone, how do the magnitude and rate/frequency of loading cycles relate to resultant bone effects?
When considering the strain effects on bone, how do the magnitude and rate/frequency of loading cycles relate to resultant bone effects?
If the extensor tendons of a horse's front leg primarily function to absorb vibrations, what is the most likely consequence of damaging them?
If the extensor tendons of a horse's front leg primarily function to absorb vibrations, what is the most likely consequence of damaging them?
You have a bone sample from two horses with varying levels of bone density. Horse A has a bone density of 4, horse B has a bone density of 6. Which bone has higher resistance to strain assuming all other bone attributes are equal?
You have a bone sample from two horses with varying levels of bone density. Horse A has a bone density of 4, horse B has a bone density of 6. Which bone has higher resistance to strain assuming all other bone attributes are equal?
A veterinarian is advising a racehorse trainer on a training regimen. Knowing that bone cell responsiveness diminishes with repeated mechanical stimulation, what would be the MOST strategic recommendation?
A veterinarian is advising a racehorse trainer on a training regimen. Knowing that bone cell responsiveness diminishes with repeated mechanical stimulation, what would be the MOST strategic recommendation?
What is the MAIN reason that young racehorses are trained in their late teens to early two-year-old year despite concerns about young horses racing?
What is the MAIN reason that young racehorses are trained in their late teens to early two-year-old year despite concerns about young horses racing?
Given what you know, what can you infer about bone adaptation (particularly bone mineral density) in a group of astronauts who spend extended periods in space?
Given what you know, what can you infer about bone adaptation (particularly bone mineral density) in a group of astronauts who spend extended periods in space?
What is the best analogy for osteocytes?
What is the best analogy for osteocytes?
Wolff's law in bone remodeling says the bone adapts to better handle force. How does this happen at a cellular level?
Wolff's law in bone remodeling says the bone adapts to better handle force. How does this happen at a cellular level?
What is the most efficient structural shape for supporting weight and load for a given mass of material?
What is the most efficient structural shape for supporting weight and load for a given mass of material?
What is the primary reason that an animal like a horse needs an ambulation system capable of rapid acceleration?
What is the primary reason that an animal like a horse needs an ambulation system capable of rapid acceleration?
Flashcards
Bone Anatomy
Bone Anatomy
The comprehensive study of bone anatomy and its components.
Bone Biomechanics
Bone Biomechanics
The study of how mechanical forces affect bone behavior.
Load (Stress) & Deformation (Strain)
Load (Stress) & Deformation (Strain)
The force applied to a bone, leading to deformation.
Systemic Bone Influences
Systemic Bone Influences
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Macrostructural Level
Macrostructural Level
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Microstructural Level
Microstructural Level
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Compact (Cortical) Bone
Compact (Cortical) Bone
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Cancellous (Trabecular) Bone
Cancellous (Trabecular) Bone
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Osteoblasts
Osteoblasts
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Osteoclasts
Osteoclasts
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Osteocytes
Osteocytes
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Tensile Strength
Tensile Strength
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Proteoglycans (PGs)
Proteoglycans (PGs)
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Inorganic Portion
Inorganic Portion
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Stress
Stress
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Strain
Strain
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Strain Environment Aspects
Strain Environment Aspects
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Wolff's Law
Wolff's Law
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Minimum Effective Strain (MES)
Minimum Effective Strain (MES)
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Modeling
Modeling
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Remodeling
Remodeling
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"Bucked Shins"
"Bucked Shins"
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Microtrauma
Microtrauma
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Cancellous
Cancellous
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Subchondral
Subchondral
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Repetitive Loading
Repetitive Loading
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HISA
HISA
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Rest.
Rest.
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Physeal Fractures
Physeal Fractures
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Longitudinal Bone Growth
Longitudinal Bone Growth
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Four Zones of the Physis
Four Zones of the Physis
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Fracture Zone
Fracture Zone
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Salter-Harris Classification
Salter-Harris Classification
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Fixation Device Effects on Physis
Fixation Device Effects on Physis
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Retained Cartilaginous Cores
Retained Cartilaginous Cores
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Angular Limb Deviation (ALD)
Angular Limb Deviation (ALD)
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Valgus
Valgus
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Varus
Varus
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Bone Modeling and Remodeling
Bone Modeling and Remodeling
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Long Bone Structure
Long Bone Structure
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Bone Modeling (Strict Definition)
Bone Modeling (Strict Definition)
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Bone Remodeling
Bone Remodeling
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Osteocyte Processes
Osteocyte Processes
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Organic Matrix (Osteoid)
Organic Matrix (Osteoid)
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Mineral Component of Bone
Mineral Component of Bone
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Bone Adaptation
Bone Adaptation
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Elastic Behavior of Bone
Elastic Behavior of Bone
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Plastic Region of Bone
Plastic Region of Bone
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Mechanostat Theory Summary
Mechanostat Theory Summary
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Bone's Reparative Capability
Bone's Reparative Capability
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Maladaptive Bone Disease
Maladaptive Bone Disease
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Viscoelasticity
Viscoelasticity
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Study Notes
- Modeling and remodeling of bone is important for ambulation, adaptation to environments, and has lasting repercussions.
- The ability to remodel the skeleton allows it to best suit the environment whether on Earth or in space.
- Upon returning from space, astronauts' bones are poorly adapted to Earth's environment, requiring time to readjust.
Lecture Overview
- Review of relevant bone structure related to remodeling and modeling.
- Discussion of biomechanics causing modeling and remodeling.
- Review of stress and strain concepts, particularly how strain influences bone remodeling.
- Overview of strategies to prevent bone injury by influencing bone modeling and remodeling.
Bone Function (Horse Example)
- Bones enable rapid acceleration of a large mass over distance
- Horses have a large digestive component with the need to be athletic to escape predators.
- The horse and rider can be seen as a ball of energy composed of:
- Gravitational energy based on height above the ground.
- Kinetic energy based on speed and mass.
- Elastic energy stored in tendons and ligaments upon landing.
- Limb bones are primarily responsible for adapting the animal to its environment.
Structure and Function of Bone (Modeling/Remodeling Perspective)
- Systemic factors include endocrine, nutritional, pharmacological, and stochastic influences.
- Macrostructural factors include bone mass and geometry.
- Microstructural factors include cells, matrix, and the inorganic crystalline portion of bone.
- All the above factors are modulated by animal activity through muscle activity, loading, and gravity.
- Bones are hollow cylinders, an efficient structure in terms of material use to support the animal.
- Long bones in mammals are hollow to reduce mass and largely circular for strength.
- Bones are slightly curved and offset to best support loads
- Bone curves and offsets adapt to the tasks
- I-beam structures that are made of bone are efficient in supporting weight and load compared to cylinders, but cylinders are easier to construct
- Cortical Bone:
- Dense bone on x-rays, forms exterior of the cylinder.
- Rigid; effectively supports loads without significant shape change.
- Cancellous Bone:
- Trabecular or sponge-like bone found in metaphyses.
- Less capable of supporting load but better at supporting distribution or strain.
- Supports distribution or strain/change in shape at the ends of bones.
- The germinal layer inside the periosteum gives rise to new bone for modeling The sock that envelops long bones
- Osteoblasts lay down new bone.
- Osteoclasts resorb old bone.
- Osteocytes:
- Embedded in bone with long arms that connect to each other.
- Respond to mechanical force and change the local environment to activate osteoblasts or osteoclasts.
- Modeling is laying down new bone without a preceding resorptive phase (strictly osteoblasts).
- Remodeling involves resorption of existing bone and reshaping it with new bone (osteoblasts and osteoclasts).
- Osteoclasts resorb bone
- Osteocytes message to switch on bone formation or bone resorption.
- Osteoclasts are multinucleate with a curtain around the edges, releasing hydrochloric acid to resorb bone.
- Collagen fibers laid down by osteoblasts in a randomized pattern initially and then remold to align with the most frequent type of load.
- The mineral component provides structural strength via calcium and phosphate crystals embedding within collagen fibers.
- Different bone types exist depending on age, activity level, etc
Normal and Abnormal Bone Remodeling
- Horse skeletons are typically loaded in a standardized fashion, allowing them to jump safely
- Unusual loads, like side swipes, can lead to contusions, microcracks, or macro fractures.
- Bone strength and stiffness are greatest in the direction where loads are most commonly expressed.
- High-energy impact cause uncontrolled energy release
- Abnormal loading can damage bone, leading to stress fractures.
- Adaptation of bone for the load's it's receiving is necessary
- When bone has not adapted it is more susceptible to damage
Stress and Strain
- Tendons stretch safely up to about 4% of their original length
- Biological structures (bone, tendon, ligament) are viscoelastic resisting initial loads then stretching
- Bone changes shape under load with micro strain (thousandths of a percent).
- Tendons wrap around bone and absorb vibrations
- Bone absorbs energy, distributes/stores it, and returns it as it goes back to it's original shape.
- In the plastic deformation region, the bone bends but does not return back to it's shape and microscopic damage occurs.
- Energy stored in bone is also realised when popping the bone
- When a bone fractures the amount of energy absorption is the bones surface area.
- Stress is the force over a unit area.
- Strain is the change in shape in a particular dimension divided by the original distance.
- Strain Metrics:
- Magnitude of strain.
- Rate of strain.
- Frequency of strain.
- Distribution of strain.
- The number of loading cycles.
- Rest recovery periods.
Wolff's Law
- Bone remodels to better adapt to applied force, influenced by osteocytes and small cells in the matrix.
Mechanostat Theory
- Osteocytes respond readily to loading but become fatigued over time.
- Mechanical stimulation promotes osteogenesis
- Loading between 20 and 40 cycles per day gives maximum response; additional cycling does not further benefit the skeleton.
- Additional cycling beyond 40 can cause issues
- Bone can replace itself after an injury with a completely new, perfect structure.
- Bone can return to its original mechanical quality.
Bone Adaptation in Racehorses
- Cannon bone research has shown that Thoroughbred horses require appropriate timing of exercise to ensure proper bone maintenance
- Racehorses are most responsive until three years old; humans up to 30 years old.
- Starting race training in late teens/early two-year-old year is important
- Later race-training leads to more injuries
Bone Modeling vs Remodeling
- Modeling is bone formation on top of existing surfaces (periosteum, endosteum, growth plate).
- Remodeling is when formed bone is resorbed and replaced (osteoclasts and osteoblasts involved).
- Thick bone = super dense, and has less bendiness
- Running around a racetrack needs bendiness from the bone
- Maladaptive bone modeling and remodeling is where adaptation wasn't successful (age of the animal, the number of loads it had in a set period of time or its nutritional status)
- Too much load on dense bones leads to cracks
- Subchondral bone can become too dense and crack easily.
Injury Prevention
- The Horseracing Integrity & Safety Authority (HISA) works to control the industry and reduce bone damage.
- Federally mandated authority to control the racing industry to reduce bone damage
- HISA limiting drugs which can be given, when they can be given, how much exercise the animal can have
- Veterinarians can be sued for illegal drug practices.
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