BofA Securities Q&A on Pluvicto® Supply and Market Expansion
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Questions and Answers

What is the annualized revenue for Pluvicto® mentioned in the text?

Over USD 700 million

According to Vasant Narasimhan, has the initial estimate of the VISION population underestimated the potential of this population?

Yes

What is the key challenge in meeting the demand for the medicine mentioned in the text?

Expanding capacity to meet the much larger interested population than initially expected

What is the opportunity for Pluvicto® in the PSMAfore study?

<p>To move first into the pre-taxane setting, expanding the patient pool from 27,000 to 42,000 patients.</p> Signup and view all the answers

What are the specific illnesses mentioned in the text that the company is focusing on?

<p>PNH, C3G, aHUS, IC-MPGN</p> Signup and view all the answers

What program does the company have for iptacopan, and in what conditions is it being evaluated?

<p>The company has a program for iptacopan evaluated in geographic atrophy and related retinal diseases.</p> Signup and view all the answers

What is the expected expansion with the PSMAddition study?

<p>Further expansion into the hormonesensitive setting.</p> Signup and view all the answers

How many facilities does the company believe they would need to be able to provide Pluvicto® in the US market to reach the potential basin population across the 3 indications mentioned?

<p>About 500 facilities</p> Signup and view all the answers

What is the company's plan for Pluvicto® in the future?

<p>To evaluate further expansion into the biochemical recurrence setting or the localized prostate cancer setting.</p> Signup and view all the answers

What is the goal of generating a broad set of data for Pluvicto®?

<p>To support its use in as many prostate cancer patients as possible.</p> Signup and view all the answers
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