Body Fluid Compartments and Third Spacing
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Explain the different body fluid compartments.

-Intracellular fluid is the fluid contained within cells, comprising about two-thirds of total body water. It contains solutes like electrolytes and glucose. -Extracellular fluid is the fluid outside of cells, making up about one-third of total body water. -ECF is further divided into:

  1. Interstitial fluid - the fluid between cells and surrounding them, but not inside blood vessels.
  2. Intravascular fluid - the fluid inside blood vessels, also called blood plasma.
  3. Transcellular fluids - fluids contained in epithelial-lined cavities like cerebrospinal, synovial, pleural, and peritoneal fluids. -The distribution and composition of these fluid compartments is carefully regulated to maintain proper cellular function, transport nutrients, remove wastes, and provide the optimal internal environment.

Explain third spacing.

Third spacing refers to the abnormal shift of fluid from the intravascular space into the interstitial space or body cavities. This can occur in certain medical conditions like ascites, pleural effusions, intestinal obstructions, and severe burns. Although the total body fluid remains the same, the fluid becomes trapped or 'third spaced' outside of the vascular system. This leads to a relative decrease in intravascular volume, which can result in hypovolemic shock if severe enough. Clinically, third spacing presents as edema or fluid accumulation in areas like the abdomen or extremities.

What is the normal range for sodium (Na+)?

  • 135-145 mEq/L (correct)
  • 140-150 mEq/L
  • 150-160 mEq/L
  • 120-130 mEq/L

Name three signs and symptoms of hyponatremia.

<p>Extreme thirst, confusion, muscle twitches, seizures</p> Signup and view all the answers

What is the normal range for calcium?

<p>8.5-10.2 mg/dL (A)</p> Signup and view all the answers

What are the abnormal signs and symptoms of Hypercalcemia?

<p>Nausea, vomiting, confusion, kidney stones</p> Signup and view all the answers

What is the normal range for bicarbonate (HCO3-)?

<p>22-28 mEq/L (B)</p> Signup and view all the answers

What are the impacts of low bicarbonate levels?

<p>Metabolic acidosis - nausea, fatigue, Kussmaul respirations</p> Signup and view all the answers

What are the abnormal signs and symptoms of Hyperalbuminemia?

<p>Dehydration, rarely symptomatic</p> Signup and view all the answers

What are isotonic solutions?

<p>Isotonic solutions have the same osmotic pressure as blood plasma and cells. They cause no fluid shift between compartments. Examples are 0.9% normal saline, LR, D5W</p> Signup and view all the answers

When would a doctor order hypertonic, isotonic, and hypotonic solutions as treatments?

<p>-Isotonic solutions like 0.9% normal saline are used to replace fluid losses and maintain intravascular volume without disrupting the fluid balance between compartments.</p> <p>-Hypertonic solutions like 3% saline are used to treat severe hyponatremia (low sodium levels) by raising the sodium concentration in the extracellular fluid and pulling water out of cells. However, they must be administered cautiously to avoid complications.</p> <p>-Hypotonic solutions like 0.45% saline are used to treat hypernatremia (high sodium levels) by diluting the extracellular fluid and allowing water to move into cells. They may also be used for fluid replacement in patients with elevated sodium levels.</p> Signup and view all the answers

What are crystalloids?

<p>Crystalloids are aqueous solutions of electrolytes or other water-soluble molecules. They are used to replace fluid losses, maintain fluid balance, and deliver medications. Examples include normal saline, Ringer's lactate, and dextrose solutions. Crystalloids are given for fluid resuscitation in conditions like dehydration, hypovolemia, and shock.</p> Signup and view all the answers

Explain: Colloid - albumin - hyper-oncotic - expands the plasma volume by about four times its volume.

<p>This statement means that when albumin, which is a colloid solution, is administered intravenously, it has a higher oncotic (osmotic) pressure than blood plasma. This hyper-oncotic property causes fluid from the interstitial spaces to be pulled into the vascular space, effectively expanding the plasma volume by approximately 4 times the volume of albumin infused. Albumin is used to expand intravascular volume in conditions like hypovolemic shock or burns when plasma volume replacement is needed.</p> Signup and view all the answers

Explain how albumin can increase blood pressure, potentially cause pulmonary edema, and increase urination.

<p>Albumin can increase blood pressure by expanding the plasma volume when administered intravenously. The increased blood volume leads to increased venous return to the heart, increasing cardiac output and blood pressure.</p> <p>-Albumin administration can potentially cause pulmonary edema if too much fluid enters the pulmonary vasculature, increasing hydrostatic pressure and leading to fluid leakage into the lung interstitium and alveoli.</p> <p>-Albumin draws fluid from the interstitial spaces into the vascular space due to its oncotic properties. This fluid shift can increase renal perfusion and glomerular filtration rate, resulting in increased urination as the kidneys excrete the excess fluid.</p> Signup and view all the answers

List five signs and symptoms of fluid volume deficit.

<ul> <li>Thirst and dry mucous membranes</li> <li>Decreased skin turgor and dry skin</li> <li>Sunken eyeballs</li> <li>Orthostatic hypotension (dizziness upon standing)</li> <li>Oliguria (decreased urine output)</li> </ul> Signup and view all the answers

List five signs and symptoms of fluid volume excess.

<ul> <li>Weight gain</li> <li>Edema (swelling) in the legs, feet, hands</li> <li>Distended neck veins</li> <li>Shortness of breath</li> <li>Crackles or wheezing in the lungs</li> </ul> Signup and view all the answers

Define edema.

<p>Edema is the accumulation of excessive fluid in the interstitial spaces between cells or body tissues.</p> Signup and view all the answers

List five types of edema.

<p>-Localized edema - Swelling confined to a specific area, often due to injury, inflammation or obstruction. -Generalized edema - Widespread swelling throughout the body, often seen in conditions like heart, liver or kidney disease. (called anasarca) -Pitting edema - Edema that leaves an indentation or pit after pressing on the swollen area with a finger. -Non-pitting edema - Firm swelling that does not indent with pressure, seen in conditions like lymphedema. -Peripheral edema - Swelling in the extremities like legs, ankles and feet due to fluid accumulation.</p> Signup and view all the answers

Explain how hormones regulate fluid intake.

<p>-Hormones regulate fluid intake through various mechanisms:</p> <ul> <li>ADH stored in posterior pituitary gland, release in response to changes in blood osmolarity -Aldosterone released by adrenal cortex, great NA conserver -RAA system to combat hypovolemia</li> </ul> Signup and view all the answers

What is the role of antidiuretic hormone (ADH) in fluid regulation?

<ul> <li>Antidiuretic hormone (ADH) stored in and released from the posterior pituitary gland in response to changes in blood osmolarity. ADH increases water reabsorption by the kidneys.</li> </ul> Signup and view all the answers

What is the role of aldosterone, in the body?

<ul> <li>Aldosterone released by the adrenal cortex acts as a potent sodium conserver, causing the kidneys to reabsorb more sodium and water.</li> </ul> Signup and view all the answers

Explain how the renin-angiotensin-aldosterone (RAA) system combats hypovolemia and low blood pressure.

<ul> <li>The renin-angiotensin-aldosterone (RAA) system combats hypovolemia and low blood pressure by increasing sodium and water retention through angiotensin II and aldosterone effects.</li> </ul> Signup and view all the answers

What is the role of atrial natriuretic peptide (ANP) in fluid balance?

<p>Atrial natriuretic peptide (ANP) released by the heart. ANP promotes excretion of sodium and water by the kidneys, helping to reduce blood volume and blood pressure.</p> Signup and view all the answers

Explain which organs release the hormonal regulators (and how they work in the body).

<p>-Hypothalamus - Produces antidiuretic hormone (ADH) which is stored and released from the posterior pituitary gland. ADH increases water reabsorption by the kidneys.</p> <p>-Kidneys - Specialized cells in the kidneys release renin, which initiates the renin-angiotensin-aldosterone system (RAAS). Renin converts angiotensinogen to angiotensin I, which is further converted to angiotensin II. Angiotensin II stimulates aldosterone release.</p> <p>-Adrenal Cortex - Releases aldosterone in response to angiotensin II. Aldosterone causes the kidneys to reabsorb more sodium and water, increasing blood volume.</p> <p>-Heart Atria - Releases atrial natriuretic peptide (ANP) which counters RAAS by promoting excretion of sodium and water by the kidneys, reducing blood volume.</p> <p>-The integration of these hormones from different organs allows for precise regulation of body fluid levels and blood pressure homeostasis.</p> Signup and view all the answers

List five fluid and electrolyte diagnostic tests and briefly describe what they measure.

<p>-Serum electrolyte tests - Measure sodium, potassium, chloride, bicarbonate levels. Compare to normal ranges to detect imbalances. -Serum hematocrit measures the percentage of red blood cells and can indicate dehydration or overhydration. -Hemoglobin is a protein in red blood cells that carries oxygen. Low levels suggest anemia or fluid imbalance. -BUN (blood urea nitrogen) is a waste product filtered by the kidneys. Elevated levels indicate dehydration or kidney dysfunction. -Creatinine is another waste product eliminated by the kidneys. Rising levels signal impaired kidney function.</p> Signup and view all the answers

Name five medications that can cause electrolyte disturbances.

<p>-Diuretics can cause metabolic alkalosis and hypokalemia (low potassium) or hyperkalemia (high potassium) depending on the type of diuretic. -Steroids like prednisone can lead to metabolic alkalosis. -Potassium supplements may cause gastrointestinal upset, ulcers, or diarrhea if taken in excess. -Respiratory depressants that decrease respiratory rate and depth can result in respiratory acidosis. -Antibiotics: nephrotoxicity, and certain antibiotics like vancomycin can cause hyperkalemia, while others like zosyn (piperacillin/tazobactam) may lead to hypernatremia.</p> Signup and view all the answers

The generic medication name for Lasix is ______.

<p>furosemide</p> Signup and view all the answers

What electrolyte imbalance are patients taking furosemide at risk for?

<p>Hypokalemia (B)</p> Signup and view all the answers

Prednisone is a type of ______ medication.

<p>steroid</p> Signup and view all the answers

Identify 3 important actions a nurse should take related to a patient taking Prednisone.

<p>Monitor weight, blood glucose, and potassium levels. Administer potassium supplements if ordered, and teach the patient to report swelling.</p> Signup and view all the answers

Tums contains the active ingredient ______.

<p>calcium carbonate</p> Signup and view all the answers

What are the signs and symptoms a nurse should watch for in a patient taking calcium carbonate?

<p>Monitor bowel movements, encourage fluids, and check calcium levels. Also, teach the patient to take with food/milk to minimize constipation. Report nausea, vomiting, or loss of appetite.</p> Signup and view all the answers

Kayexalate's (sodium polystyrene sulfonate) action works by binding ______ in the intestines for elimination.

<p>potassium</p> Signup and view all the answers

For what signs and symptoms should a nurse look for in a patient taking Kayexalate?

<p>Monitor potassium levels and bowel movements, encourage fluids, and teach the patient to take with plenty of water/fluids. Also, report severe constipation, abdominal pain</p> Signup and view all the answers

List five assessments a nurse can take related to abnormal electrolyte laboratory values.

<ul> <li>Respiratory</li> <li>Circulatory</li> <li>Integumentary -Monitor Intake and Output -Monitor daily weight</li> </ul> Signup and view all the answers

List the signs and symptoms of Acidosis.

<p>Headache, lethargy, confusion, coma, Kussmaul respirations (rapid, deep breathing), Anorexia, nausea, vomiting, diarrhea, abdominal discomfort, Dysrhythmias, hypotension, Muscle weakness, cramping, Fatigue, restlessness</p> Signup and view all the answers

What is the pH in a compensated arterial blood gas reading for both alkalosis and acidosis?

<p>Normal (B)</p> Signup and view all the answers

What arterial blood gas reading will HCO3 be in an uncompensated scenario?

<p>Normal (B)</p> Signup and view all the answers

List five reasons a patient can experience fluid and electrolyte imbalance.

<p>Excessive fluid losses: Vomiting, diarrhea, high output fistulas or drains, excessive sweating, burns, or polyuria can lead to dehydration and electrolyte deficits. -Inadequate fluid intake: Poor oral intake due to nausea, dysphagia, altered mental status, or limited access to fluids. -Kidney disease: Impaired ability to regulate fluid and electrolyte levels. -Endocrine disorders: Conditions like diabetes insipidus, SIADH, Addison's disease, etc. disrupt fluid/electrolyte homeostasis. -Medications: Diuretics, chemotherapy, steroids, and others can cause fluid/electrolyte shifts.</p> Signup and view all the answers

List five procedures a nurse can take for determining a patient's fluid balance.

<ol> <li>Measure and record accurate intake and output (I&amp;O)</li> <li>Weigh the patient daily at the same time using the same scale and clothing.</li> <li>Assess skin turgor, mucous membranes, and capillary refill for signs of dehydration.</li> <li>Monitor vital signs like blood pressure, pulse, and respiratory rate which can indicate fluid shifts.</li> <li>Review laboratory values like serum electrolytes, BUN, creatinine, and osmolality for imbalances, ABG's</li> </ol> Signup and view all the answers

The RESPIRATORY SYSTEM compensates the fastest for altered arterial blood gases. Describe 3 health outcomes for older adults at an increased risk for fluid and electrolyte imbalances.

<p>-Dehydration - Decreased thirst perception, limited mobility, cognitive impairment, and medications like diuretics increase dehydration risk. Dehydration can lead to confusion, constipation, acute kidney injury, and increased risk of falls. -Hypernatremia - Impaired kidney function and hormonal regulation make it difficult to conserve water and dilute sodium. Hypernatremia can cause neurological symptoms like lethargy and seizures. -Hypokalemia - Diuretic use, poor dietary intake, and gastrointestinal losses contribute to low potassium levels. Hypokalemia increases arrhythmia risk and can cause muscle weakness.</p> Signup and view all the answers

Older adults are less prone to experiencing fluid volume excess.

<p>False (B)</p> Signup and view all the answers

An older adult can develop a fluid deficit due to various factors. Please list them.

<p>Decreased thirst perception, reduced kidney function impairing water conservation, insensible fluid losses, and inadequate fluid intake. Factors like immobility, cognitive impairment, and medication side effects contribute to dehydration risk.</p> Signup and view all the answers

What is the fastest-acting body system that compensates for the altered arterial blood gases?

<p>RESPIRATORY SYSTEM</p> Signup and view all the answers

Name the three different typed of lung sounds.

<p>Vesicular, crackles (Rales), Rhonchi.</p> Signup and view all the answers

Define vesicular breath sounds.

<p>Vesicular (Normal) Soft, low-pitched, rustling sounds Heard over most lung areas Normal breath sounds</p> Signup and view all the answers

Describe what crackles, or rales, breath sounds indicate.

<p>-Crackles (Rales) (Fluid) Popping, crackling sounds (like rice crispy cereal) Caused by fluid in the lungs (e.g., pneumonia, heart failure) Heard more during inspiration</p> Signup and view all the answers

Describe what rhonchi sounds indicate.

<p>-Rhonchi (Mucus) Low-pitched, snoring or gurgling sounds Caused by mucus or secretions in larger airways Clears with coughing (common in bronchitis)</p> Signup and view all the answers

Give the cause and intervention for pneumothorax, tension thorax, and hemothorax.

<p>-Pneumothorax is caused by air entering the pleural space due to a rupture in the lung (visceral pleura) or chest wall (parietal pleura). Intervention involves inserting a chest tube to remove the air and re-expand the lung.</p> <p>-Tension pneumothorax occurs when air enters the pleural space but cannot escape, increasing pressure and shifting the mediastinum. Emergent decompression with needle thoracostomy or chest tube is required.</p> <p>-Hemothorax is bleeding into the pleural space, often from chest trauma or surgery. A chest tube is inserted to drain the blood and re-expand the lung. Blood products may be needed for significant bleeding.</p> Signup and view all the answers

Flashcards

Intracellular Fluid (ICF)

Fluid inside cells; about 2/3 of body water.

Extracellular Fluid (ECF)

Fluid outside cells, divided into interstitial, intravascular, and transcellular fluid.

Third Spacing

Abnormal fluid shift from intravascular space to interstitial space or body cavities.

Normal Sodium (Na+) Range

135-145 mEq/L; abnormal S/S: confusion, seizures

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Normal Calcium (Ca2+) Range

8.5-10.2 mg/dL; abnormal S/S: kidney stones.

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Normal Potassium (K+) Range

3.5-5.0 mEq/L; abnormal S/S: muscle paralysis, peaked T-waves.

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Normal Magnesium (Mg2+) Range

1.8-2.4 mg/dL; abnormal S/S: lethargy, respiratory depression.

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Normal Bicarbonate (HCO3-) Range

22-28 mEq/L. Low: Metabolic acidosis. High: Metabolic alkalosis

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Normal Albumin Range

3.5-5.0 g/dL. Hypoalbuminemia: dehydration

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Isotonic Solutions

Solutions with the same osmotic pressure as blood plasma.

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Hypertonic Solutions

Solutions with higher osmotic pressure than blood plasma; pull water out of cells.

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Hypotonic Solutions

Solutions with lower osmotic pressure than blood plasma; cause water to move into cells.

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When to use Isotonic Solutions

replace fluid losses, maintain intravascular volume

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When to use hypertonic Solutions

used to treat severe hyponatremia (low sodium levels) by raising the sodium concentration in the extracellular fluid and pulling water out of cells

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When to use hypotonic solutions

used to treat hypernatremia (high sodium levels) by diluting the extracellular fluid and allowing water to move into cells

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Crystalloids

Aqueous solutions of electrolytes or water-soluble molecules; replace fluid losses and maintain balance.

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Colloids

Contain large insoluble molecules; expand plasma volume.

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Albumin's Volume Expansion

Albumin pulls fluid into the vascular space, expanding the plasma volume.

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How albumin affects BP

Expanding plasma volume increases BP. If excessive fluid moves to lungs, this causes pulmonary edema and increases urine

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Signs of Fluid Volume Deficit

Thirst, dry membranes, decreased skin turgor, tachycardia, hypotension.

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Signs of Fluid Volume Excess

Edema, distended neck veins, shortness of breath, increased BP.

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Edema

Excess fluid accumulation in interstitial spaces.

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Main Types of Edema

Localized, generalized, pitting, non-pitting, pulmonary, cerebral.

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Hormonal Regulators of Fluids

ADH, aldosterone, RAA system, ANP.

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ADH (Antidiuretic Hormone)

Posterior pituitary gland: increases water reabsorption by kidneys.

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Aldosterone

Adrenal cortex: increases sodium and water reabsorption by kidneys.

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Renin-Angiotensin-Aldosterone (RAA) System

Combats hypovolemia, increases sodium/water retention.

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ANP (Atrial Natriuretic Peptide)

Produced by the heart; promotes excretion of sodium and water.

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Fluid & Electrolyte Diagnostic Tests

Electrolytes, hematocrit, BUN, creatinine, osmolality, ABGs.

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Medications Causing Electrolyte Problems

Diuretics, steroids, antibiotics, laxatives.

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Diuretics

Monitor, weight, fluid replacement

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Steroids

Increased BP , Monitor K

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Calcium carbonate (Tums)

electrolyte balance, constipation

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Laxatives - (Kayexalate)

electrolyte imbalance, constipation, and fluid/water intake

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Nurse's Assessment of Electrolyte Imbalance

Assess respiratory, circulatory, integumentary systems; monitor intake/output, weight, labs.

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Causes of Acidosis

Metabolic (DKA, lactic, Renal), Respiratory (hypoventilation)

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Causes of Alkalosis

Vomiting, diuretics, hyperventilation

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Signs and symptoms of acidosis.

Headache, lethargy, and confusion

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Signs and symptoms of alkalosis.

Dizziness, headache, Tetany

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Reasons for Fluid/Electrolyte Imbalance

Excessive fluid losses, inadequate fluid intake, kidney disease, medications.

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Nurse's Fluid Balance Procedures

Measure I&O, daily weights, assess skin/mucous membranes, monitor vital signs and labs.

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Fluid/Electrolyte Outcomes in Older Adults

Dehydration, hypernatremia, hypokalemia, fluid overload.

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Study Notes

Body Fluid Compartments

  • Intracellular fluid comprises about two-thirds of total body water and contains solutes like electrolytes and glucose.
  • Extracellular fluid makes up about one-third of total body water and is divided into interstitial, intravascular, and transcellular fluids.
  • Interstitial fluid is the fluid between cells, excluding blood vessels.
  • Intravascular fluid is the fluid inside blood vessels, also known as blood plasma.
  • Transcellular fluids are contained in epithelial-lined cavities like cerebrospinal, synovial, pleural, and peritoneal fluids.
  • Distribution and composition are regulated to maintain cellular function, nutrient transport, waste removal, and internal environment optimization.

Third Spacing

  • An abnormal shift of fluid from the intravascular space to the interstitial space or body cavities.
  • Can occur in conditions like ascites, pleural effusions, intestinal obstructions, and severe burns.
  • Leads to a relative decrease in intravascular volume, potentially causing hypovolemic shock.
  • Clinically presents as edema or fluid accumulation in areas like the abdomen or extremities.

Electrolyte Normal Ranges and Abnormal Signs/Symptoms

  • Sodium Normal Range: 135-145 mEq/L
    • Hyponatremia (145 mEq/L): Extreme thirst, confusion, muscle twitches, seizures.
  • Calcium Normal Range: 8.5-10.2 mg/dL
    • Hypocalcemia (10.2 mg/dL): Nausea, vomiting, confusion, kidney stones.
  • Potassium Normal Range: 3.5-5.0 mEq/L
    • Hypokalemia (5.0 mEq/L): Muscle paralysis, peaked T-waves on ECG, arrhythmias.
  • Magnesium Normal Range: 1.8-2.4 mg/dL
    • Hypomagnesemia (2.4 mg/dL): Nausea, vomiting, lethargy, respiratory depression.
  • Bicarbonate Normal Range: 22-28 mEq/L
    • Low levels: Metabolic acidosis - nausea, fatigue, Kussmaul respirations.
    • High levels: Metabolic alkalosis - confusion, arrhythmias, muscle twitching.
  • Albumin Normal Range: 3.5-5.0 g/dL
    • Hypoalbuminemia (5.0 g/dL): Dehydration, rarely symptomatic.

Intravenous Solutions

  • Isotonic solutions have the same osmotic pressure as blood plasma and cells, causing no fluid shift between compartments. Examples include 0.9% normal saline, Lactated Ringers and D5W.
  • Hypertonic solutions have higher osmotic pressure than blood plasma and cells, pulling water out of cells and causing cellular dehydration and shrinkage. Examples include 3-5% saline solution, D10W, D5 in 0.9% NS, D5 in 0.45% NS, and D5 in LR.
  • Hypotonic solutions have lower osmotic pressure than blood plasma and cells, causing water to move into cells, potentially leading to cellular rupture. Examples include 0.45% saline and LR.

Clinical Use of Intravenous Solutions

  • Isotonic solutions are used to replace fluid losses and maintain intravascular volume without disrupting fluid balance.
  • Hypertonic solutions treat severe hyponatremia by raising extracellular sodium concentration and pulling water out of cells, administered cautiously.
  • Hypotonic solutions treat hypernatremia by diluting extracellular fluid and allowing water to move into cells, also used for fluid replacement with elevated sodium levels.

Crystalloids

  • Aqueous solutions of electrolytes or water-soluble molecules.
  • Used to replace fluid losses, maintain fluid balance, and deliver medications.
  • Examples include normal saline, Ringer's lactate, and dextrose solutions.
  • Administered for fluid resuscitation in conditions like dehydration, hypovolemia, and shock.

Colloids

  • Contain larger insoluble molecules like proteins or starches suspended in a crystalloid solution.
  • Used when plasma volume expansion such as in hypovolemic shock, burns, or during surgery is needed.
  • Examples include albumin, dextran, and hydroxyethyl starches.
  • Pull fluid into the vascular space from the interstitial space due to higher oncotic pressure.

Albumin

  • It has a higher oncotic pressure than blood plasma, causing fluid from the interstitial spaces to be pulled into the vascular space, effectively expanding the plasma volume by approximately 4 times the volume of albumin infused.
  • Can increase blood pressure by expanding the plasma volume with increased venous return, cardiac output, and blood pressure.
  • Can potentially cause pulmonary edema if too much fluid enters the pulmonary vasculature.
  • Draws fluid from the interstitial spaces into the vascular space, increasing renal perfusion, the glomerular filtration rate, and urination.

Fluid Volume Deficit - Signs and Symptoms

  • Thirst and dry mucous membranes.
  • Decreased skin turgor and dry skin.
  • Sunken eyeballs.
  • Orthostatic hypotension (dizziness upon standing).
  • Oliguria (decreased urine output).
  • Tachycardia (rapid heart rate).
  • Fatigue and weakness.
  • Headache.
  • Muscle cramps.
  • Concentrated urine with high specific gravity.
  • Elevated BUN and hematocrit levels.
  • Weight loss.
  • Hypovolemic shock with cool, clammy skin, altered mental status, oliguria or anuria, and hypotension may result.

Fluid Volume Excess - Signs and Symptoms

  • Weight gain.
  • Edema (swelling) in the legs, feet, hands.
  • Distended neck veins.
  • Shortness of breath.
  • Crackles or wheezing in the lungs.
  • Jugular venous distension.
  • Ascites (fluid accumulation in the abdomen).
  • Increased blood pressure.
  • Decreased hematocrit and plasma protein levels.
  • Oliguria (decreased urine output).
  • Pulmonary edema with pink, frothy sputum, congestive heart failure possible in severe cases.

Edema Types

  • Edema is the accumulation of excessive fluid in the interstitial spaces.
  • Localized edema: Swelling confined to a specific area, often due to injury, inflammation, or obstruction.
  • Generalized edema: Widespread swelling throughout the body, often seen in conditions like heart, liver, or kidney disease (called anasarca).
  • Pitting edema: Edema that leaves an indentation or pit after pressing on the swollen area.
  • Non-pitting edema: Firm swelling that does not indent with pressure, seen in conditions like lymphedema.
  • Peripheral edema: Swelling in the extremities like legs, ankles, and feet due to fluid accumulation.
  • Pulmonary edema: Fluid buildup in the lungs, causing breathing difficulties.
  • Cerebral edema: Excess fluid in the brain tissue, potentially life-threatening.

Hormonal Regulators

  • Hormones regulate fluid intake through various mechanisms.
  • ADH (Antidiuretic Hormone): Stored in and released from the posterior pituitary gland in response to changes in blood osmolarity; increases water reabsorption by the kidneys.
  • Aldosterone: Released by the adrenal cortex; acts as a sodium conserver, causing the kidneys to reabsorb more sodium and water.
  • RAAS (Renin-Angiotensin-Aldosterone System): Combats hypovolemia and low blood pressure by increasing sodium and water retention through angiotensin II and aldosterone effects.
  • ANP (Atrial Natriuretic Peptide): Released by the heart; promotes excretion of sodium and water by the kidneys, helping reduce blood volume and blood pressure.

Hormonal Regulator Production

  • Hypothalamus: Produces antidiuretic hormone (ADH) and is stored/released from the posterior pituitary gland.
  • Kidneys: Release renin which converts angiotensinogen to angiotensin I, further converted to angiotensin II which stimulates aldosterone release.
  • Adrenal Cortex: Releases aldosterone in response to angiotensin II, causing the kidneys to reabsorb more sodium and water.
  • Heart Atria: Releases atrial natriuretic peptide (ANP) which counters RAAS.

Fluid and Electrolyte Diagnostic Test Evaluation & Assessment

  • Serum electrolyte tests help measure imbalances: sodium, potassium, chloride, bicarbonate levels.
  • Serum hematocrit can indicate hydration status.
  • Hemoglobin: Low levels suggest anemia or fluid imbalance.
  • BUN: Elevated levels indicate dehydration or kidney dysfunction.
  • Creatinine: Rising levels signal impaired kidney function.
  • Renal function tests: Assess kidney's ability to filter and maintain balance
  • Liver function tests: Evaluate fluid regulation/protein production.
  • Serum osmolality measures total solute concentration.
  • Urinalysis checks for abnormalities that can alter fluid balance.
  • Arterial blood gases assess acid-base status.
  • Monitor Fluid intake via Diet, Fluids, and Food
  • -Monitor fluid output via Urine, Stool, and Sweat

Medications Causing Electrolyte Disturbances

  • Diuretics: Hypokalemia or hyperkalemia and metabolic alkalosis.
  • Steroids: Metabolic alkalosis.
  • Potassium Supplements: Gastrointestinal upset, ulcers, or diarrhea.
  • Respiratory Depressants: Respiratory acidosis.
  • Antibiotics: Nephrotoxicity, hyperkalemia, or hypernatremia.
  • Calcium Carbonate Antacids: Mild metabolic alkalosis.
  • Magnesium Hydroxide Laxatives: Deplete potassium.
  • Stimulant Laxatives disturb fluid/electrolyte balance if overused.

Specific Medications and Nursing Interventions

Diuretics (Furosemide/Lasix)

  • Loop diuretic class. Increases excretion of sodium, chloride, and water; inhibits reabsorption in kidney tubules.
  • Causes hypokalemia, hyponatremia, dehydration, and metabolic alkalosis.
  • Monitor intake/output, weight, electrolytes; encourage fluid/electrolyte replacement; educate the patient about daily weight monitoring, reporting excessive thirst/urination, and potassium supplements.

Steroids (Prednisone)

  • Glucocorticoid class; anti-inflammatory, immunosuppressive.
  • Causes fluid retention, hypokalemia, hyperglycemia, and osteoporosis.
  • Monitor weight, blood glucose, and potassium levels; administer potassium supplements if ordered; educate the patient about reporting swelling, muscle weakness, diet and increased thirst/urination.

Calcium Carbonate Antacids (Tums)

  • Antacid class; neutralizes stomach acid.
  • Causes constipation, metabolic alkalosis, and hypercalcemia.
  • Monitor bowel movements, encourage fluids, and check calcium levels; educate the patient to take it with food/milk and to report signs of nausea or vomiting.

Laxatives (Kayexalate)

  • Sodium polystyrene sulfonate class; binds potassium in intestines for elimination.
  • Causes hypokalemia, constipation, and intestinal impaction.
  • Monitor potassium levels and bowel movements; encourage fluids; educate the patient to take with plenty of water and to report constipation or pain.
  • Respiratory Assessment: Monitor RR, SpO2, breath sounds for signs of respiratory distress.
  • Circulatory Assessment: Monitor heart rate, BP, peripheral pulses for signs of hypovolemia or hypervolemia.
  • Integumentary Assessment: Check skin turgor, edema, mucous membranes for hydration status.
  • Assessment Considerations: Hypo or hypervolemia, labs, I&O, medication, elimination, and nutrition.

Acidosis and Alkalosis Causes

Acidosis

  • Metabolic Causes: Diabetic ketoacidosis, lactic acidosis, renal failure, ingestion of acidic substances.
  • Respiratory Causes: Hypoventilation and carbon dioxide retention.

Alkalosis

  • Metabolic Causes: Vomiting, diuretic use, hypokalemia, excessive bicarbonate intake.
  • Respiratory Causes: Hyperventilation and excessive carbon dioxide loss.

Acidosis - Signs and Symptoms

  • Headache, lethargy, confusion, coma.
  • Kussmaul respirations.
  • Anorexia, nausea, vomiting, diarrhea, abdominal discomfort.
  • Dysrhythmias, hypotension.
  • Muscle weakness, cramping.
  • Fatigue, restlessness.

Alkalosis - Signs and Symptoms

  • Dizziness, headache, confusion, seizures, Tetany (muscle twitching/cramping).
  • Shallow, slow breathing.
  • Arrhythmias, hypotension.
  • Nausea, vomiting
  • Muscle cramps, weakness, hyperreflexia.
  • Paresthesias (numbness/tingling around mouth and extremities).

Interpreting Arterial Blood Gases

  • Compensated: pH is normal.
    • PaCO₂ and HCO₃⁻ are BOTH abnormal.
  • Uncompensated: HCO3- NORMAL RANGE
    • pH is abnormal (acidic < 7.35 or alkaline > 7.45). One system (respiratory or metabolic) is abnormal.
  • Partially Compensated Acidosis: pH is low, PaCO2 is low, HCO3 is low
  • Partially Compensated Alkalosis: pH is high, PaCO2 is high, HCO3 is High .

Causes of Fluid and Electrolyte Imbalance

  • Excessive fluid losses from vomiting, diarrhea, fistulas, sweating, burns, or polyuria.
  • Inadequate fluid intake due to nausea, dysphagia, altered mental status, or limited access to fluids.
  • Kidney disease impairing the regulation of fluid and electrolyte levels.
  • Endocrine disorders like diabetes insipidus, SIADH, or Addison's disease that disrupt homeostasis.
  • Medications such as diuretics, chemotherapy, or steroids that cause fluid/electrolyte shifts.
  • Severe injuries or illnesses such as major trauma, pancreatitis, or sepsis that increase needs.
  • Liver disease, which impairs the regulation of fluid balance and protein production.

Nurse's Procedures for Determining a Patient's Fluid Balance

  1. Measure and record accurate intake and output
  2. Weigh the patient daily
  3. Assess skin turgor
  4. Monitor vital signs
  5. Review laboratory values
  6. Inspect for edema
  7. Collaborate with the healthcare team and patient/family

Fluid and Electrolyte Balance in Older Adults

  • Older adults are at increased is risk for fluid and electrolyte imbalances due to age-related physiologic changes
  • Potential health outcomes:
    • Dehydration: Decreased thirst perception, dehydration symptoms, cognitive impairment, medications, and falls.
    • Hypernatremia: Impaired kidney function and hormonal regulation can cause lethargy and sz.
    • Hypokalemia: Diuretic use, poor dietary intake, lead to arrhythmia risk and increases muscle weakness.
    • Fluid Overload: Heart failure, liver and kidney diseases can manifest as peripheral edema, pulmonary edema, and exacerbate underlying conditions.
  • Monitoring intake/output, daily weights, and early intervention are imperative.

Fluid Deficit and Fluid Volume Excess

  • Older adults develop fluid deficits due to decrease in thirst, reducing kidney function, insensible fluid loses, and inadequate fluid intake.
  • Fluid volume excess occurs due to heart, liver and kidney diseases leading to sodium and water and edema.

Body Systems - Compensation for Altered Arterial Blood Gasses

  • The respiratory system compensates faster for altered arterial blood gases.

Lung Sounds - Types

  • Vesicular (Normal)
  • Crackles (Rales) (Fluid)
  • Rhonchi (Mucus)

Lung Sounds - Explanations

  • Vesicular (Normal)
    • Soft, low-pitched, rustling sounds heard over most lung areas during inhalation and exhalation.
    • Indicates air is moving freely through the airways.
  • Crackles (Rales) (Fluid)
    • Popping, crackling sounds (like rice crispy cereal) caused by fluid in the lungs, which is heard more during inspiration.
    • Discontinuous, interrupted sounds that can be fine or coarse.
    • Fine crackles sound like hair rubbing together, while coarse crackles are louder, lower-pitched popping sounds.
    • Indicates airway secretions or abnormal opening of small airways.
  • Rhonchi (Mucus)
    • Low-pitched, snoring or gurgling sounds caused by mucus or secretions in larger airways.
    • Continuous, low-pitched, snoring or wheezing sounds caused by air moving through obstructed or compressed larger airways.
    • Can clear with coughing but often indicate mucus plugging or bronchospasm.

Pneumothorax, Tension Thorax, and Hemothorax

  • Pneumothorax: Air entering the pleural space
    • Intervention: Inserting a chest tube in order to have the air removed, thus re-expanding the lung.
  • Tension pneumothorax: Air enters the space but becomes trapped and cannot escape
    • Emergent decompression: Needle thoracostomy or chest tube needed.
  • Hemothorax: Bleeding into the pleural space
    • Intervention: Chest tube needs to be inserted in order to drain the blood, thus re-expanding the lung.

Asthma - Initial Signs and Symptoms

  • Wheezing
  • Dyspnea
  • Coughing
  • Increased sputum/mucus
  • Increased respiratory rate
  • Rapid breathing
  • Elevated heart rate
  • Nasal flaring
  • Chest Tightness
  • SOB

Asthma Medical Management

  • Medical Management - Diagnosis
    • Medical history
    • Pulmonary function tests,
    • Chest x-ray
    • Pulse oximetry
    • Arterial blood gases
  • Medical Management - Treatment
    • Assessment of respiratory status.
    • Monitoring for complications -Control of environmental factors -Pharmacological treatment: Anti-inflammatories & Bronchodilators(Albuterol and corticosteroids), and Anticholinergics
  • Medical Management-Non-Pharmacological: Breathing exercises, incentive spirometry use, and adequate hydration, Emotional support, and Education.
  • Nursing Management-Assessment and analysis: Vitals Signs, Oxygen saturation, Arterial Blood Gases, Level of Consciousness, ect...

Patient Education for Asthma

  • Self-Management: Monitor respiratory status, recognize symptoms, and adjust medication, track peak flow monitoring and symptoms.
  • Teaching: Correct inhaler technique and having the patient demonstrate.
  • Trigger Avoidance: ID triggers, decrease exposure, environmental measures.
  • Self-Management, Teach about Asthma action plans
  • Lifestyle Guidance: Encourage exercise strategies to prevent exercise-induced symptoms.

Medications for Asthma

  • A SABA short-acting beta-agonist (SABA) like albuterol always; provides quick relief.

Asthma and Inflammation

  • Inhaled corticosteroids (ICS) reduce airway inflammation
  • Combination inhalers: Breo Ellipta (fluticasone/vilanterol)

Status Asthmaticus - Signs and Symptoms

  • Breathlessness at rest, unable to speak in full sentences
  • Respiratory rate > 30 breaths/minute
  • Unresponsive to typical rescue treatment with bronchodilators
  • Bronchospasm, inflammation, mucus plugging
  • Chest tightness, wheezing, dry cough, shortness of breath
  • Use of accessory muscles
  • Distended neck veins
  • Decreasing oxygen saturation levels
  • Rising PaCO2 levels, potential respiratory acidosis
  • Silent chest with no audible air movement

Types of Medications used to treat Asthma

Prednisone (Steroid)

  • Reduces airway inflammation.
  • Causes: Weight gain, fluid retention, mood changes, hyperglycemia.
  • How to help pt: Take with food, do not stop abruptly, watch for signs of infection.

Albuterol (Bronchodilator)

  • Relaxes airway muscles.
  • Causes: Tremors, rapid heartbeat, headache. -How to help pt: Use before exercise, do not exceed recommended doses.

Ipratropium Inhalant (Anticholinergic)

  • Blocks acetylcholine effects, dilates airways.
  • Causes: Dry mouth, constipation, urinary retention.
  • How to help pt: Use with bronchodilator for better effect, rinse mouth.
  • Can also use: Tiotropium (Long acting muscarinic antagonist)

Theophylline (Xanthine)

  • Anti-inflammatory (Bronchodilator)
  • Causes: Nausea, vomiting, insomnia, seizures with high levels.
  • How to help pt: Have levels monitored, avoid certain foods/drugs.

COPD Oxygenation Complications in Older Adults

  • Hypoxemia
  • Hypercapnia.
  • Pulmonary hypertension
  • Polycythemia
  • Respiratory Failure

Emphysema - Oxygen Delivery Equipment

  • Delivery equipment:
    • Oxygen tanks with an H cylinder (stationary) or E tanks (portable).
    • Portable containers liquid oxygen, oxygen concentrators with back up oxygen options.

COPD - Risk Factors

  • 80-90% of COPD cases exposure to tobacco smoke (Active or passive)
  • Occupational exposure.
  • Elderly (Pneumonia, immune system, physiological changes, medications,)
  • HIV
  • Air pollution.
  • Deficiency of alpha1-antitrypsin enzyme.

COPD - Signs and Symptoms

  • Main Symptoms* (C=cough, S=sputum, D=Dyspnea)
  1. Cough.
  2. Sputum.
  3. Dyspnea

Definitions of Terms

  • Pleuritis - Inflammation of the lining around the lungs with causing pain.
  • Cyanosis - Bluish skin or lips due to low oxygen levels in the blood.
  • Pleuritic - Pain - Sharp chest pain, with breathing or due to pleuritis.
  • Hemoptysis - Coughing up blood from the lungs.
  • Pleural Effusion - Fluid buildup between the lungs and chest wall.
  • Atelectasis - Collapsed lung.
  • Lung Abscess - Pocket of pus in the lung due to infection.
  • Empyema - Pus buildup between the in lungs from infection .
  • Thoracentesis - Procedure to remove fluid
  • Dyspnea - SOB

Thoracentesis Treatment

  • Thoracentesis procedure used to remove excess fluid.
    • It may treat: Pneumonia, Tuberculosis, Pleurisy, Emyema.

Thoracentesis Complications

  • Pneumothorax (3-30%)
  • Hemopneumothorax
  • Hemorrhage, Vasovagal response
  • Hypotension, Pulmonary edema
  • Spleen, liver puncture
  • Air embolism
  • Introducing an infection

Chronic Bronchitis - Signs and Symptoms

  • Persistent coughing with large amounts of sputum.
  • Purulent (pus-containing) Sputum
  • Hemoptysis
  • Cyanosis
  • Obese
  • Mild dyspnea initially

Emphysema - Signs and Symptoms

  • Dyspnea with minimal coughing.
  • Pink skin coloring
  • Barrel Chest
  • Weight Loss
  • Minimal cough, increased minute ventilation. Pursed-lip breathing
  • Cachexia, Accessory muscle use
  • Tachypnea with hyperinflation

Cor Pulmonale -Signs and Symptoms

  • Enlarged tender liver, warm feet cyanotic hands
  • Distended neck veins, enlargement.
  • Hypoxia, & increasing dyspnea

Findings and Interventions for Chronic Bronchitis and Emphysema

Lab Results

  • Increased WBC count during exacerbations.
  • Sputum cultures to identify bacterial infections.
  • ABG (Arterial Blood Gases) may show hypoxemia and hypercapnia.
  • Sputum Gram Stain, testing, Complete blood count, Serology testing.

Diagnostic Results

  • Pulmonary function tests to measure airflow limitation (hx spirometry)
  • Chest X-ray assess lung hyperinflation
  • CT scan/ MRI, ECG.

Medications

Bronchodilators is theophylline) & Inhaled corticosteroids/glucocorticoids), Mucolytics antibiotics. (Same as asthma but add azithromycin)

Nursing Interventions

  • Oxygenate and encourage to quit smoking
  • Teach breathing excersies
  • Advocate rehab programs.
  • Suplimental oxigen

Patient Education

  • Regular exercise
  • Encourage, explain the disease,
  • explain medication use. provide info on oxigen when perscribed.

Special Note About Anti-Infective - Azithromycin

  • Classification = semisynthetic macrolide antibiotic.
  • Patients teachings need to include taking with or without food / Complete the dose and report allergies.
  • Notify provider about diarrhea that is severe or doesn't resolve.
  • Disclose use of herbal products or dietary supplements.

Asthma - Signs and Symptoms

  • Wheezing, Cough.

Nursing Note

  • Elevated heart rate due to compensation for diminished oxygen perfusion, nasal flaring =SOB

Pneumonia signs and symptoms

  • Fever and chills/skin skin clammy and cyanosis.
  • Malaise, fatigue
  • SOB/Hemoptysis
  • Productive cough

Chronic Bronchitis - Sign and Symptoms repeat information

  • Chronic, productive cough.
  • mild dyspnea
  • Obese
  • Cyanosis
  • purulent spetum
  • Cracckles/weezes

Emphysema-Sign&Symptoms * repeat information*

  • Tachypnea/Dyspena
  • Pink skin and purses lips
  • Barrel chest
  • Increase minute ventilation
  • Decreased breath sounds

Obstructive Sleep Apnea - causes

  • Central nervous system control dysfunction
  • Upper airway collapse increases air flow resistance/sleep causes muscles to relax with no air movement. Also, there is hypoxemia and hypercapnia present.
  • Factors include soft tissue and craniofacial: obesity, genetics narrow jaw , nose polops/septums enlarged

Prevention of airway obstruction by interventions for Sleep Apnea.

  • Use of an oral appliance, called maxillomandibular advancement & Noninvasive positive-pressure ventilation via continuous positive airway pressure (CPAP).
  • Manage weight/ Administer Medications

Sleep Apnea- Signs and Symptoms for Air Obstruction

  • Insomnia.
  • Hypoxia Hyercapnia, Gasps of air,
  • Head aches and dry mouth,
  • Depression and irritability, fatigue,
  • Decreased libido/ Difficulty concentrating/ Nighttime waking with gasping or choking sensation

Positioning of a SNoring -Sleep Apnea Victim?

1 Teach the patient to elevate the head of the bed and use a side or prone position for sleep. 2 - Use pillows to prevent a supine position/elevate head of bed

Continuous Positive Airway Pressure CPAP)Machine VS Bilevel Positive Airway BiPAP Machine

  • CPAP- set pressure throughout breathing
  • BiPAP.- two levels-high pressure breath vs low
  • BiPAP alternating pressure improves lung air volume reducing SOB than PAP.

Nurse Intervention Using CPAP/BIPAP ON PATIENT.

  • Maintain a tight face to mouth seal during breathing over device/ Explain purpose feelings when used/ Provide the patient time to breathe before turning switch power on/ monitor, set pressure , comfort, tubing,oxygen saturation/ adjust bed head angle with pillows for comfort

Paitent Education CPAP/BIPAP

  • Teach clean compressor

  • teach clean mask and t tubes to prevent infection,

  • use distilled water only and

  • do not share equipment/ report signs of irritations.

  • Emphasize consist,nightly use a perscribed sleep.

  • Bring Home PAP, BIPPa Equipment when hospitalized with correct setup.

Tuberculosis - Spread of infection

  • Mycobacterium cough aerosolized. ( bacteria in active PT from coughs, sneezes) can invade lungs spreading infection immunity in health bodies prevents further development, initial spread infects upper lungs Cell mediated immunity against TB results in pos reaction 2-10 weeks later. Pt not conatgious until symptoms occur.

Main Body System Affected By Tuberculosis

  • The upper lungs are mostly affected/ the granuloma formation is how bacteria is spread by breathing the air causing droplet infection from coughs and sneezes.

Tuberculosis - Signs and Symptoms

  • Fatigue
  • night sweats
  • cough with blood
  • Low grade fever
  • Chest Tightness
  • Lethargy Anorexia/ Weight Loss

Isolation Precaustions For Tuberculosis

  • Air- Borne contact = use filter mask

Pneumonia Signs

  • 2 Types skin test/ Blood rest results as ( Mantoux & Acid Fast Bacilli Smear)

  • Diagnostic = Chest X-Rays and Testing on blood

Treatment For Diagnosed Tuberculosis

  • Meds = [ Isoniazid and rifampin.] also combination is ETHAMBUTOL AND PYRAZINAMIED

  • Patient teaching / Home precautions=

  • Test Family Mbrs and teach use and covering for hygene.

  • Remind family not needed avoid infection.

  • Teach skin results meds , hygene with support systems around.

Pneumonia - Different ways to transfer

  • Spread from airborne through coughs/sneezes with weakened immune systems. Pneumonia is from all types of germs like bacterium & can also be spread by aspariation inhalation.

Kinds of Pneumonia for Categories

  • Community Based: (spread tru coughs from contaminated surfaces )

  • Hospital Based: ( VAP =Ventilator)

Risk of developing Pheumonia

  • Being young [under 2yrs ], Old [over 64years] and immunity diseases with lungs

  • Smoking as well as other pollution

Elderly Pneunomias - 1st Signs

  • Confusion then fatigue
  • elevated heart rate
  • only small temp changes

Complications of pneumonia

  • ARDS failure and Sepsis
  • Hypotension: and bronchitis

Diagnostics And Pneumonia

  • LAB TESTS platelets and CAT scan (pt & INR)

  • Oximeter (blood test) (ABG and LACTATE)

Complications Of Bronchoscopy

  • Bleeding and cardic stressers

HYPOXIC is a lung that collapses

What Are Nursing Diagonostics With Pneumonia

  • Disturbed Air and obstruction
  • Deficient lung voume and nutritional deficiency

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Overview of body fluid compartments including intracellular and extracellular fluids. Discussion of third spacing, its causes such as ascites and burns, and its impact on intravascular volume. Focus on distribution, composition, and regulation.

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