Opioids

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Questions and Answers

What is the capital of France? (example question)

Paris (correct)
London
Berlin
Madrid

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What are the common 7 full MOR agonists?

Morphine
Heroin
Codeine
Oxycontin
Hydrocodone
Fentanyl
Methadone

Capital of France (example flashcard)

Paris

A pt presents to your clinic with a history of heroine abuse. The team is looking for a plan to treat his opioid dependence - what is a good tx option that is a full MOR agonist?

Methadone

Partial MOR agonist

Buprenorphine

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T or F: Buprenorphine is safer than methadone

TRUE - buprenorphine provides enough pain relief but it has a ceiling effect that doesn't depress the pt's respiration as much as methadone (since methadone is a full agonist)

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MOR antagonists

Naloxone
Naltrexone

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A cancer pt has been using daily morphine infusions for her terminal illness. You are consulted for her severe constipation side effects. What drug are you prescribing her?

Naltrexone - doesn't cross the BBB and so it inhibits the MORs in the gut (thus helping with constipation) without crossing the BBB and dampening the pain relieving effects that the morphine has been having at the level of the brain

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