NURS 3210 CH 26 PPT

Prevent the lysis of fibrin, resulting in promoting clot formation.

MI and strokes.

Internal, intracranial, and superficial bleeding.

<p>It is a synthetic polypeptide that mimics the action of vasopressin, an antidiuretic hormone.</p> Signup and view all the answers

<p>IV doses should be double-checked with another nurse.</p> Signup and view all the answers

<p>It prevents and controls excessive bleeding resulting from surgery or overactivity of the fibrinolytic system.</p> Signup and view all the answers

<p>To identify contraindications and potential drug interactions.</p> Signup and view all the answers

<p>To prevent bleeding complications.</p> Signup and view all the answers

<p>Dabigatran is an oral direct thrombin inhibitor, while argatroban is only given IV.</p> Signup and view all the answers

<p>Prevention of strokes and thrombosis.</p> Signup and view all the answers

<p>Both have a predictable pharmacological effect and do not require lab monitoring.</p> Signup and view all the answers

<p>Measurement of aPTT is necessary to ensure therapeutic effects.</p> Signup and view all the answers

<p>Enoxaparin has a longer elimination half-life compared to heparin.</p> Signup and view all the answers

<p>Bleeding and GI bleeding.</p> Signup and view all the answers

<p>Percutaneous coronary intervention procedures.</p> Signup and view all the answers

<p>Greater affinity for factor Xa than for factor IIa.</p> Signup and view all the answers

<p>Antiplatelet drugs work to prevent platelet adhesion by preventing platelet activation and aggregation.</p> Signup and view all the answers

<p>Aspirin, Cilostazol (Pletal), and Clopidogrel (Plavix)</p> Signup and view all the answers

<p>Aspirin is contraindicated for flu-like symptoms in children and teenagers due to the risk of Reye's syndrome.</p> Signup and view all the answers

<p>Thrombolytic drugs activate the fibrinolytic system to break down the clot in the blood vessel quickly, reestablishing blood flow to the heart muscle.</p> Signup and view all the answers

<p>Acute myocardial infarction (MI), arterial thrombolysis, deep vein thrombosis (DVT), occlusion of shunts or catheters, pulmonary embolus, and acute ischemic stroke.</p> Signup and view all the answers

<p>Bleeding (internal, intracranial, superficial), nausea, vomiting, hypotension, anaphylactoid reactions, cardiac dysrhythmias.</p> Signup and view all the answers

<p>Eptifibatide is a GP Iib/IIIa inhibitor, which prevents platelet aggregation and thrombus formation.</p> Signup and view all the answers

<p>Acute coronary syndrome, including unstable angina and non-ST-segment elevation myocardial infarction (NSTEMI).</p> Signup and view all the answers

<p>anaphylaxis</p> Signup and view all the answers

<p>Idarucizumab (Praxbind); reverses anticoagulant effects for emergency surgery or in life-threatening or uncontrolled bleeding</p> Signup and view all the answers

<p>Warfarin is a vitamin K antagonist, which means it inhibits the synthesis of vitamin K-dependent clotting factors</p> Signup and view all the answers

<p>Andexxa (Coagulation Factor Xa [recombinant] Inactivated-zhzo); risk of thromboembolic events, including MI, ischemic stroke, cardiac arrest, and sudden death</p> Signup and view all the answers

<p>Transfusions of human plasma or clotting factor concentrates, and potential administration of Kcentra and Profiline; expected outcome is reversal of bleeding</p> Signup and view all the answers

<p>Warfarin resistance; up to 7 days</p> Signup and view all the answers

<p>ALWAYS question an order if two anticoagulants are ordered; to prevent adverse effects and bleeding complications</p> Signup and view all the answers

<p>Enzyme inhibition of metabolism, displacement of the drug from inactive protein-binding sites, decrease in vitamin K absorption or synthesis, alteration in the platelet count or activity; increased risk of bleeding or thrombosis</p> Signup and view all the answers

<p>Vitamin K antagonists, such as warfarin, inhibit vitamin K synthesis by bacteria in the gastrointestinal tract, thereby inhibiting the production of vitamin K-dependent clotting factors II, VII, IX, and X, which are synthesized in the liver, preventing clot formation.</p> Signup and view all the answers

<p>The primary indication for anticoagulant therapy in patients with atrial fibrillation is to prevent stroke and systemic embolism.</p> Signup and view all the answers

<p>Factor Xa inhibitors, such as rivaroxaban, prevent thrombosis by inhibiting the activity of factor Xa, a key enzyme in the coagulation cascade, thereby preventing the formation of thrombin and the subsequent formation of a blood clot.</p> Signup and view all the answers

<p>The primary adverse effect of anticoagulant therapy is bleeding, which is monitored by measuring the international normalized ratio (INR) or activated partial thromboplastin time (aPTT) to assess the degree of anticoagulation.</p> Signup and view all the answers

<p>Direct thrombin inhibitors, such as dabigatran, prevent thrombosis by directly inhibiting the activity of thrombin, which is a key enzyme in the coagulation cascade, thereby preventing the formation of a blood clot.</p> Signup and view all the answers

<p>The primary indication for anticoagulant therapy in patients undergoing major orthopedic surgery is to prevent venous thromboembolism (VTE) and pulmonary embolism (PE).</p> Signup and view all the answers

<p>The contraindication for anticoagulant therapy in patients with a history of bleeding disorders is the risk of exacerbating bleeding, which can be life-threatening.</p> Signup and view all the answers

<p>Fondaparinux is a factor Xa inhibitor that prevents thrombosis by inhibiting the activity of factor Xa, a key enzyme in the coagulation cascade, thereby preventing the formation of thrombin and the subsequent formation of a blood clot.</p> Signup and view all the answers