Blood Physiology Quiz
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Questions and Answers

What are the three primary properties of platelets? (Select all that apply)

  • Adhesion
  • Activation (correct)
  • Agglutination (correct)
  • Aggregation (correct)
  • Platelets are always active, constantly participating in blood clotting.

    False (B)

    What two substances are responsible for the stickiness of platelets?

    ADP and thromboxane A2

    The ______ of platelets is responsible for the formation of intrinsic prothrombin activator, initiating the blood clotting process.

    <p>activation</p> Signup and view all the answers

    What is the primary role of contractile proteins within platelets during clot retraction?

    <p>Contracting fibrin threads to tighten the clot (B)</p> Signup and view all the answers

    Match the following substances with their primary roles in platelet function:

    <p>ADP = Causes platelet activation and aggregation Thromboxane A2 = Causes vasoconstriction of blood vessels PDGF = Promotes repair of damaged blood vessels 5-HT (Serotonin) = Causes vasoconstriction of blood vessels</p> Signup and view all the answers

    What are the three main stages of hemostasis?

    <p>Vasoconstriction, platelet plug formation, coagulation of blood</p> Signup and view all the answers

    The process of hemostasis is primarily controlled by the nervous system.

    <p>False (B)</p> Signup and view all the answers

    What is the main component of blood plasma?

    <p>Water (A)</p> Signup and view all the answers

    Blood is composed of 55% plasma and 45% cell fraction.

    <p>True (A)</p> Signup and view all the answers

    What is the most abundant plasma protein?

    <p>Albumin</p> Signup and view all the answers

    The primary function of globulins in blood is to act as __________.

    <p>antibodies</p> Signup and view all the answers

    Which of the following substances are considered waste products in plasma?

    <p>Carbon dioxide (D)</p> Signup and view all the answers

    Match the following plasma components to their functions:

    <p>Albumin = Maintains osmotic pressure Globulins = Acts as antibodies Fibrinogen = Essential for blood coagulation Electrolytes = Involved in muscle contractions</p> Signup and view all the answers

    Inorganic salts in plasma are essential only for muscle contractions.

    <p>False (B)</p> Signup and view all the answers

    What role do clotting factors play in the blood?

    <p>They are essential for coagulation of blood.</p> Signup and view all the answers

    What is the primary function of erythrocytes?

    <p>Transport gas, mainly oxygen (C)</p> Signup and view all the answers

    Erythrocytes contain a nucleus.

    <p>False (B)</p> Signup and view all the answers

    What shape do erythrocytes have that aids in gas exchange?

    <p>Biconcave discs</p> Signup and view all the answers

    The life span of an erythrocyte is approximately ______ days.

    <p>120</p> Signup and view all the answers

    What does oxyhaemoglobin release readily?

    <p>Oxygen (C)</p> Signup and view all the answers

    Match the following components with their respective functions:

    <p>Haemoglobin = Oxygen transport Transferrin = Iron transport in blood Erythrocyte = Gas exchange Liver = Iron storage</p> Signup and view all the answers

    Blood with lower oxygen levels appears bright red.

    <p>False (B)</p> Signup and view all the answers

    Each haemoglobin molecule contains ______ globin chains.

    <p>four</p> Signup and view all the answers

    What substance is secreted by activated platelets to cause constriction of blood vessels?

    <p>Serotonin (A)</p> Signup and view all the answers

    The von Willebrand factor acts as a bridge between platelets and fibrin.

    <p>False (B)</p> Signup and view all the answers

    What is the process called where a temporary loose plug is formed by aggregating platelets?

    <p>Formation of platelet plug</p> Signup and view all the answers

    After a clot has formed, the process of removing it is called ______.

    <p>thrombolysis</p> Signup and view all the answers

    Which cells are responsible for secreting platelet activating factor (PAF)?

    <p>Neutrophils, monocytes, and platelets (D)</p> Signup and view all the answers

    Match the blood groups with their respective characteristics:

    <p>Group A = Contains ß antibody Group B = Contains α antibody Group AB = No antibodies Group O = Universal donor</p> Signup and view all the answers

    Plasminogen is converted to plasmin by activators released from damaged endothelial cells.

    <p>True (A)</p> Signup and view all the answers

    Identify the two blood group systems discovered by Landsteiner.

    <p>ABO system and Rh system</p> Signup and view all the answers

    Which blood group is considered the universal donor?

    <p>O (B)</p> Signup and view all the answers

    Individuals with blood group AB can receive blood from any other blood type.

    <p>True (A)</p> Signup and view all the answers

    What antigen determines whether a person is Rh positive or Rh negative?

    <p>D antigen</p> Signup and view all the answers

    If a Rh negative person is exposed to Rh positive blood for the first time, they will form __________.

    <p>anti D</p> Signup and view all the answers

    When cross matching blood for transfusion, what is primarily observed?

    <p>Antibody of the donor and antigen of the recipient (C)</p> Signup and view all the answers

    Why can 'O' group blood be safely transfused to individuals with any blood group?

    <p>It has no antigens.</p> Signup and view all the answers

    Match the following blood groups with their characteristics:

    <p>O group = Universal donor AB group = Universal recipient Rh positive = Has D antigen Rh negative = Lacks D antigen</p> Signup and view all the answers

    The person who receives the blood during transfusion is known as the __________.

    <p>recipient</p> Signup and view all the answers

    What is formed when haemoglobin binds oxygen?

    <p>Oxyhaemoglobin (A)</p> Signup and view all the answers

    Erythropoiesis is primarily stimulated by hyperoxia.

    <p>False (B)</p> Signup and view all the answers

    What hormone is primarily responsible for stimulating erythrocyte formation during hypoxia?

    <p>Erythropoietin</p> Signup and view all the answers

    The main sites of erythrocyte breakdown, or haemolysis, are the spleen, bone marrow, and the ______.

    <p>liver</p> Signup and view all the answers

    Match the following terms with their definitions:

    <p>Erythropoiesis = Process of red blood cell formation Hypoxia = Deficient oxygen supply to tissues Bilirubin = Yellow pigment resulting from hem breakdown Haemolysis = Breakdown of red blood cells</p> Signup and view all the answers

    Which condition leads to an increase in erythropoiesis?

    <p>Hypoxia (D)</p> Signup and view all the answers

    When erythropoietin levels are low, red cell formation can occur in the presence of hypoxia.

    <p>False (B)</p> Signup and view all the answers

    What is the primary role of the kidneys in erythropoiesis?

    <p>Producing erythropoietin</p> Signup and view all the answers

    Flashcards

    What is blood?

    Blood is a fluid connective tissue that continuously circulates throughout the body, driven by the heart's pumping action.

    What is plasma?

    Plasma is the clear, straw-colored fluid component of blood, primarily composed of water (90-92%).

    What are plasma proteins?

    Plasma proteins are a significant component of plasma, encompassing about 7% of its volume. They are too large to pass through capillary walls and play crucial roles in blood volume regulation and carrying substances.

    What is albumin?

    Albumin, the most abundant plasma protein, is crucial for maintaining normal osmotic pressure, which directly impacts fluid balance within the body.

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    What are globulins?

    Globulins are essential for fighting infections, transporting hormones and minerals, and inhibiting certain enzymes.

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    What are clotting factors?

    Clotting factors are substances vital for blood clotting. When these factors are removed from plasma, the remaining fluid is called serum.

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    What is fibrinogen?

    Fibrinogen, a key protein in blood clotting, is synthesized in the liver.

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    What are inorganic salts in blood?

    Inorganic salts (electrolytes) are essential for various bodily functions, including muscle contractions, nerve impulses, and maintaining acid-base balance.

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    What are erythrocytes?

    Red blood cells are disc-shaped cells that carry oxygen throughout the body.

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    Why are erythrocytes biconcave?

    Erythrocytes are biconcave, meaning they have a flattened, disc-like shape with a depressed center. This increases their surface area for efficient gas exchange.

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    Why don't erythrocytes have a nucleus?

    Erythrocytes lack a nucleus, which allows for more space to carry oxygen and makes them more flexible to navigate through narrow blood vessels.

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    What is haemoglobin?

    Haemoglobin is a protein found in red blood cells that binds and carries oxygen.

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    How does haemoglobin carry oxygen?

    Haemoglobin binds to oxygen, forming oxyhaemoglobin, allowing for the transport of oxygen throughout the body.

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    Why is oxygen-rich blood red?

    Blood rich in oxygen is bright red due to the presence of oxyhaemoglobin.

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    Why is oxygen-poor blood bluish?

    Blood low in oxygen is darker, appearing bluish, because it contains less oxyhaemoglobin.

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    How does acidity affect oxygen release in tissues?

    Active tissues release acidic waste products, which increase the breakdown of oxyhaemoglobin, releasing more oxygen to those tissues.

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    Erythropoiesis

    The process of red blood cell production, involving their origin, development, and maturation. It occurs primarily in the bone marrow.

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    Hypoxia

    The primary stimulus for erythropoiesis; it's a state of deficient oxygen supply to body cells.

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    Erythropoietin

    A hormone primarily produced by the kidneys that stimulates erythropoiesis.

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    Hemolysis

    The breakdown of red blood cells, primarily carried out by phagocytic reticuloendothelial cells in the spleen, bone marrow, and liver.

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    Biliverdin

    A green pigment formed from heme (a component of hemoglobin) during hemolysis. It is almost completely reduced to bilirubin.

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    Bilirubin

    A yellow pigment formed from biliverdin during hemolysis. It is transported to the liver and excreted as a component of bile.

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    Oxyhemoglobin Formation

    The process of red blood cells binding with oxygen in the lungs. It is favored by lower temperatures and higher oxygen concentrations.

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    Oxygen Release

    The release of oxygen from oxyhemoglobin in tissues. It is favored by higher temperatures and lower oxygen concentrations.

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    Platelet Agglutination

    The clumping together of platelets, caused by platelet agglutinins.

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    Platelet Plug Formation

    The process by which platelets form a temporary plug to seal a damaged blood vessel.

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    Platelet Role in Vasoconstriction

    Platelets secrete serotonin, which constricts blood vessels, reducing blood loss.

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    Platelet Adhesion

    Platelets stick to exposed collagen in damaged blood vessels, initiating the clotting cascade.

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    Platelet Role in Clot Retraction

    Contractile proteins in platelets, such as actin, myosin, and thrombosthenin, cause clot retraction.

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    Platelet Role in Blood Vessel Repair

    Platelet-derived growth factor (PDGF) helps repair damaged blood vessels, promoting healing.

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    Platelet Role in Defense Mechanism

    Platelets encircle foreign bodies, engulfing and destroying them through phagocytosis.

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    Haemostasis

    The process of stopping bleeding, involving three stages: vasoconstriction, platelet plug formation, and blood coagulation.

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    What is blood group O?

    Blood group O individuals lack both A and B antigens on their red blood cells, but have both anti-A and anti-B antibodies in their plasma.

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    What is blood group AB?

    Individuals with blood group AB possess both A and B antigens on their red blood cells and have no antibodies in their plasma.

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    What is Rh-positive?

    Rh-positive individuals possess the D antigen on their red blood cells.

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    What is Rh-negative?

    Rh-negative individuals lack the D antigen on their red blood cells. This can lead to complications during pregnancy or blood transfusion.

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    Who are universal donors?

    Universal donors are individuals with blood group O, as their red blood cells lack antigens and can be safely transfused to individuals with any blood group.

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    Who are universal recipients?

    Universal recipients are individuals with blood group AB, as their plasma lacks antibodies and can receive blood from individuals with any blood group.

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    What is cross-matching and why is it important?

    Cross-matching is a crucial step before blood transfusion, where the recipient's serum is mixed with the donor's red blood cells. If agglutination occurs, the donor's blood is not suitable for transfusion.

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    What is agglutination?

    Agglutination is the clumping together of red blood cells due to an antigen-antibody reaction. It can occur during blood transfusion if incompatible blood types are mixed.

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    Vasoconstriction in Hemostasis

    Platelets, when activated by collagen exposure, release serotonin and other vasoconstrictors, causing blood vessels to constrict, which helps slow down bleeding.

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    Role of von Willebrand Factor

    The adherence of platelets to collagen is accelerated by von Willebrand factor, acting as a bridge between specific platelet glycoproteins and collagen fibrils.

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    Formation of Platelet Plug

    Platelets activated by collagen release ADP and thromboxane A2. These attract more platelets and activate them. This aggregation forms a loose plug, temporarily closing the vessel and stopping bleeding.

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    Coagulation in Hemostasis

    Fibrinogen converts to fibrin, forming threads that attach to the platelet plug, solidifying it and completely blocking the vessel to stop bleeding.

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    Thrombolysis

    The process of removing the clot and repairing the damaged blood vessel. Plasminogen converts to plasmin, breaking down fibrin and allowing the vessel to heal.

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    Antigens on Red Blood Cells

    Proteins on red blood cell membranes act as antigens, triggering immune responses if incompatible blood is transfused.

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    ABO and Rh Blood Group Systems

    Landsteiner's ABO and Rh systems classify blood groups based on the presence or absence of antigens A and B. These systems are vital for safe blood transfusions.

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    Classifying Blood Types

    Blood types A, B, AB, and O are defined by the presence or absence of antigens A and B. Each type carries specific antibodies in the serum.

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    Study Notes

    Cardiovascular System: Blood

    • Blood is a fluid connective tissue
    • It circulates constantly throughout the body, propelled by the heart's pumping action
    • Transports oxygen, nutrients, hormones, heat, antibodies, immune system cells, clotting factors, and waste products
    • Composed of plasma (55% of total blood) and cell fraction (45%)
    • Plasma is a clear, straw-colored, watery fluid
    • Cellular components include erythrocytes, leukocytes, and platelets
    • Erythrocytes (red blood cells): 45% of total blood volume
    • Leukocytes (white blood cells): less than 1% of total blood volume
    • Platelets are less than 1% of total blood volume

    Plasma Proteins

    • Make up about 7% of plasma
    • Retained within blood due to their large size, preventing escape through capillary pores
    • Primarily albumin and fibrinogen
    • Formed in the liver
    • Function:
      • Creating osmotic pressure in the blood
      • Maintaining plasma viscosity (thickness)
      • Reduced plasma proteins lead to fluid shifting into tissues (edema)

    Plasma Constituents

    • Main constituent of plasma is water (90-92%)
    • Dissolved and suspended substances:
      • Plasma proteins (e.g., albumin, globulins)
      • Inorganic salts (electrolytes)
      • Nutrients
      • Waste products
      • Hormones
      • Gases

    Albumin

    • Most abundant plasma protein
    • Function:
      • Maintains normal plasma osmotic pressure
      • Acts as a carrier molecule for free fatty acids, some drugs, and steroid hormones.

    Globulins

    • Primarily found in the liver and lymphoid tissue
    • Function:
      • Antibodies (immunoglobulins), binding to and neutralizing foreign materials (microorganisms)
      • Transporting hormones and mineral salts (e.g., thyroglobulin carries thyroxine)
      • Inhibiting some proteolytic enzymes (e.g., a2 macroglobulin inhibits trypsin)

    Clotting Factors

    • Essential for blood coagulation
    • Serum is plasma with clotting factors removed
    • Fibrinogen, synthesized in the liver, is crucial for blood coagulation

    Inorganic Salts (Minerals)

    • Involved in various bodily functions, including:
      • Muscle contractions
      • Nerve impulse transmission
      • Secretion formation
      • Acid-base balance maintenance
    • Blood is slightly alkaline (pH 7.35-7.45)

    Nutrients

    • Food is broken into smaller molecules (e.g., monosaccharides, amino acids, fatty acids, glycerol) in the alimentary tract and absorbed.
    • Required by all body cells to:
      • Provide energy
      • Produce heat
      • Provide materials for repair and replacement
      • Synthesize blood components and body secretions

    Waste Products

    • Urea, creatinine, and uric acid are waste products of protein metabolism
    • Formed in the liver and carried to the kidneys for excretion
    • Carbon dioxide from tissue metabolism is transported to the lungs for excretion

    Hormones

    • Chemical messengers synthesized by endocrine glands
    • Secreted into the blood and transported to target tissues/organs

    Gases

    • Oxygen is not very soluble in water; requires a transport mechanism
    • Oxygen is primarily bound to hemoglobin in red blood cells (98% blood oxygen)
    • Hemoglobin also binds some carbon dioxide
    • Most carbon dioxide is converted to bicarbonate ion in red blood cells and transported in the plasma

    Cellular Content of Blood

    • Stem cells are primitive cells in bone marrow that give rise to blood cells
    • A stem cell can produce different types of blood cells(pluripotent hemopoietic stem cells (PHSC))
    • Early stage - uncommitted pluripotent hemopoietic stem cells
    • Committed pluripotent hemopoietic stem cells
      • Lymphoid stem cells (LCS)-give rise to lymphocytes
      • Colony forming blastocytes-blood cells
        • Erythrocytes
        • Granulocytes/monocytes
        • Megakaryocytes
    • Three types of blood cells:
      • Erythrocytes (red blood cells)
      • Leukocytes (white blood cells)
      • Platelets (thrombocytes)
    • Most blood cells are synthesized in red bone marrow
    • Some lymphocytes are produced in lymphoid tissue
    • Blood cells originate from pluripotent stem cells and undergo several development stages before entering the bloodstream
    • Different blood cell types follow separate lines of development
    • The process of blood cell formation is called hemopoiesis
    • Fatty yellow marrow replaces red marrow over time
    • Hemopoiesis in the skeleton is confined to flat bones, irregular bones and ends of long bones

    Erythropoiesis

    • Process of red blood cell origin, development, and maturation
    • Changes during erythropoiesis:
      • Reduction in cell size
      • Disappearance of nucleoli and nucleus
      • Appearance of hemoglobin
      • Change in the staining properties of the cytoplasm
    • Stages of erythropoiesis:
      • Proerythroblast
      • Early normoblast
      • Intermediate normoblast
      • Late normoblast
      • Reticulocyte (immature RBC)
      • Mature erythrocyte
    • Reticulocytes: immature red blood cells with a reticular network in the cytoplasm
    • Slightly larger than mature red blood cells
    • In newborn babies, reticulocytes are 2-6% of total red blood cells
    • Number of reticulocytes decreases in the first week after birth and remains below 1% of red blood cells later
    • Number increases with increased red blood cell production
    • Important for monitoring red blood cell production (e.g., in anemia)

    Erythrocytes

    • Most abundant blood cell type (99%)
    • Function: transporting gases (primarily oxygen and some carbon dioxide)
    • Characteristics:
      • Biconcave discs (increases surface area for gas exchange)
      • No nucleus
      • Diameter of about 7 µm
    • Flexible cells, squeezing through narrow capillaries
    • Contain no intracellular organelles
    • Large pigmented protein (hemoglobin) responsible for gas transport
    • Flattened shape for stacking in bloodstream (reduces turbulence)
    • Lifespan of 120 days

    Hemoglobin

    • Large, complex molecule containing a globular protein and a pigmented iron-containing complex (heme)
    • Each hemoglobin molecule has four globin chains and four heme units, each with one iron atom
    • Iron is transported bound to its transport protein transferrin and stored in the liver
    • Oxygen transport:
      • Saturated hemoglobin: all four oxygen-binding sites are filled
      • Hemoglobin reversibly binds to oxygen to form oxyhemoglobin
    • Oxygen transport is influenced by pH and temperature

    Control of Erythropoiesis

    • Erythropoiesis is stimulated by hypoxia (low oxygen supply to body tissues):
      • Hypoxia increases erythropoietin production, mainly by the kidneys
      • Erythropoietin stimulates an increase in the production of proerythroblasts and the release of increased numbers of reticulocytes
    • Hypoxia increase erythrocyte formation
    • Erythropoietin stimulates the increment in erythropoiesis
    • Decrease in erythropoietin levels result in decrease in red cell formation

    Destruction of Erythrocytes

    • Lifespan of erythrocytes: about 120 days
    • Breakdown (hemolysis) is carried out by phagocytic reticuloendothelial cells (mainly spleen, bone marrow, and liver)
    • Released components are retained in the body and reused to build new hemoglobin molecules
    • Biliverdin is formed from heme
    • Bilirubin (a yellow pigment) is formed from biliverdin
    • Bilirubin is converted in the liver and becomes water-soluble; is excreted as a bile constituent

    White Blood Cells (Leukocytes)

    • Colorless, nucleated formed elements
    • Crucial to the body's defense mechanism
    • Classified into two types based on presence or absence of granules:
      • Granulocytes: neutrophils, eosinophils, basophils
      • Agranulocytes: monocytes, lymphocytes, mast cells

    Neutrophils

    • Play a vital role in defense and are the first line of defense against invading microorganisms.
    • Free cells in the body; actively wander through tissues.
    • Granules contain enzymes (e.g., proteases, myeloperoxidases, elastases, and metalloproteinases) and antimicrobial peptides (defensins).
    • The membrane contains an enzyme called NADPH oxidase, activated by toxic metabolites from infected tissues

    Eosinophils

    • Important in detoxification, disintegration, and removal of foreign proteins.
    • Specifically involved in combating parasites and active during parasitic infestations and allergic conditions.
    • Granules contain substances that become cytotoxic upon release.

    Basophils

    • Crucial to post-inflammation tissue healing and acute hypersensitivity reactions (allergies).
    • Number increases during post-inflammation healing
    • Involved in the release of important substances from granules: histamine, heparin, and hyaluronic acid.

    Monocytes

    • Important in the body's defense, acting as phagocytes
    • Motile
    • Related to interleukin-1 production
    • Colony stimulating factors (CSF)
    • Platelet activating factor (PAF)
    • Precursors of tissue macrophages
    • Stay in the blood for a short time before entering tissues

    Lymphocytes

    • Classified into two categories:
      • T lymphocytes (cellular immunity)
      • B lymphocytes (humoral immunity)

    Platelets

    • Small, colorless, non-nucleated fragments of cytoplasm
    • Function:
      • Blood clotting (hemostasis):
        • Forming a temporary plug to stop blood loss.
        • Secreting substances to initiate and accelerate the clotting process
      • Repair of ruptured blood vessels: promoting the repair and regeneration of blood vessel structures
      • Defense mechanism: surrounding and destroying foreign bodies by phagocytosis (engulfing and digesting foreign materials)

    Hemostasis

    • Arrest of bleeding (stopping bleeding).
    • 3 Main Stages:
      • Vasoconstriction
      • Platelet plug formation
      • Coagulation of blood

    Blood Groups

    • Red blood cell membranes carry antigens, triggering immune responses if mismatched
    • ABO blood group system (A, B, AB, O) determined by inherited antigens for transfusions
    • Rh blood group system significant in transfusions
    • Antigens determine the blood group
    • Cross-matching is done to determine compatibility before transfusions
    • O blood group can be given to all blood groups (Universal donor); AB blood group can receive from any blood groups (Universal recipient)

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    Test your knowledge on blood physiology, focusing on the properties of platelets, hemostasis, and plasma components. This quiz covers essential concepts related to blood clotting, the roles of different substances, and the composition of blood. Perfect for students studying biology or health sciences.

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