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What are the three primary properties of platelets? (Select all that apply)
What are the three primary properties of platelets? (Select all that apply)
Platelets are always active, constantly participating in blood clotting.
Platelets are always active, constantly participating in blood clotting.
False (B)
What two substances are responsible for the stickiness of platelets?
What two substances are responsible for the stickiness of platelets?
ADP and thromboxane A2
The ______ of platelets is responsible for the formation of intrinsic prothrombin activator, initiating the blood clotting process.
The ______ of platelets is responsible for the formation of intrinsic prothrombin activator, initiating the blood clotting process.
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What is the primary role of contractile proteins within platelets during clot retraction?
What is the primary role of contractile proteins within platelets during clot retraction?
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Match the following substances with their primary roles in platelet function:
Match the following substances with their primary roles in platelet function:
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What are the three main stages of hemostasis?
What are the three main stages of hemostasis?
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The process of hemostasis is primarily controlled by the nervous system.
The process of hemostasis is primarily controlled by the nervous system.
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What is the main component of blood plasma?
What is the main component of blood plasma?
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Blood is composed of 55% plasma and 45% cell fraction.
Blood is composed of 55% plasma and 45% cell fraction.
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What is the most abundant plasma protein?
What is the most abundant plasma protein?
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The primary function of globulins in blood is to act as __________.
The primary function of globulins in blood is to act as __________.
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Which of the following substances are considered waste products in plasma?
Which of the following substances are considered waste products in plasma?
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Match the following plasma components to their functions:
Match the following plasma components to their functions:
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Inorganic salts in plasma are essential only for muscle contractions.
Inorganic salts in plasma are essential only for muscle contractions.
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What role do clotting factors play in the blood?
What role do clotting factors play in the blood?
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What is the primary function of erythrocytes?
What is the primary function of erythrocytes?
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Erythrocytes contain a nucleus.
Erythrocytes contain a nucleus.
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What shape do erythrocytes have that aids in gas exchange?
What shape do erythrocytes have that aids in gas exchange?
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The life span of an erythrocyte is approximately ______ days.
The life span of an erythrocyte is approximately ______ days.
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What does oxyhaemoglobin release readily?
What does oxyhaemoglobin release readily?
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Match the following components with their respective functions:
Match the following components with their respective functions:
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Blood with lower oxygen levels appears bright red.
Blood with lower oxygen levels appears bright red.
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Each haemoglobin molecule contains ______ globin chains.
Each haemoglobin molecule contains ______ globin chains.
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What substance is secreted by activated platelets to cause constriction of blood vessels?
What substance is secreted by activated platelets to cause constriction of blood vessels?
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The von Willebrand factor acts as a bridge between platelets and fibrin.
The von Willebrand factor acts as a bridge between platelets and fibrin.
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What is the process called where a temporary loose plug is formed by aggregating platelets?
What is the process called where a temporary loose plug is formed by aggregating platelets?
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After a clot has formed, the process of removing it is called ______.
After a clot has formed, the process of removing it is called ______.
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Which cells are responsible for secreting platelet activating factor (PAF)?
Which cells are responsible for secreting platelet activating factor (PAF)?
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Match the blood groups with their respective characteristics:
Match the blood groups with their respective characteristics:
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Plasminogen is converted to plasmin by activators released from damaged endothelial cells.
Plasminogen is converted to plasmin by activators released from damaged endothelial cells.
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Identify the two blood group systems discovered by Landsteiner.
Identify the two blood group systems discovered by Landsteiner.
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Which blood group is considered the universal donor?
Which blood group is considered the universal donor?
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Individuals with blood group AB can receive blood from any other blood type.
Individuals with blood group AB can receive blood from any other blood type.
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What antigen determines whether a person is Rh positive or Rh negative?
What antigen determines whether a person is Rh positive or Rh negative?
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If a Rh negative person is exposed to Rh positive blood for the first time, they will form __________.
If a Rh negative person is exposed to Rh positive blood for the first time, they will form __________.
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When cross matching blood for transfusion, what is primarily observed?
When cross matching blood for transfusion, what is primarily observed?
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Why can 'O' group blood be safely transfused to individuals with any blood group?
Why can 'O' group blood be safely transfused to individuals with any blood group?
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Match the following blood groups with their characteristics:
Match the following blood groups with their characteristics:
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The person who receives the blood during transfusion is known as the __________.
The person who receives the blood during transfusion is known as the __________.
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What is formed when haemoglobin binds oxygen?
What is formed when haemoglobin binds oxygen?
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Erythropoiesis is primarily stimulated by hyperoxia.
Erythropoiesis is primarily stimulated by hyperoxia.
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What hormone is primarily responsible for stimulating erythrocyte formation during hypoxia?
What hormone is primarily responsible for stimulating erythrocyte formation during hypoxia?
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The main sites of erythrocyte breakdown, or haemolysis, are the spleen, bone marrow, and the ______.
The main sites of erythrocyte breakdown, or haemolysis, are the spleen, bone marrow, and the ______.
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Match the following terms with their definitions:
Match the following terms with their definitions:
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Which condition leads to an increase in erythropoiesis?
Which condition leads to an increase in erythropoiesis?
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When erythropoietin levels are low, red cell formation can occur in the presence of hypoxia.
When erythropoietin levels are low, red cell formation can occur in the presence of hypoxia.
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What is the primary role of the kidneys in erythropoiesis?
What is the primary role of the kidneys in erythropoiesis?
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Flashcards
What is blood?
What is blood?
Blood is a fluid connective tissue that continuously circulates throughout the body, driven by the heart's pumping action.
What is plasma?
What is plasma?
Plasma is the clear, straw-colored fluid component of blood, primarily composed of water (90-92%).
What are plasma proteins?
What are plasma proteins?
Plasma proteins are a significant component of plasma, encompassing about 7% of its volume. They are too large to pass through capillary walls and play crucial roles in blood volume regulation and carrying substances.
What is albumin?
What is albumin?
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What are globulins?
What are globulins?
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What are clotting factors?
What are clotting factors?
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What is fibrinogen?
What is fibrinogen?
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What are inorganic salts in blood?
What are inorganic salts in blood?
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What are erythrocytes?
What are erythrocytes?
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Why are erythrocytes biconcave?
Why are erythrocytes biconcave?
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Why don't erythrocytes have a nucleus?
Why don't erythrocytes have a nucleus?
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What is haemoglobin?
What is haemoglobin?
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How does haemoglobin carry oxygen?
How does haemoglobin carry oxygen?
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Why is oxygen-rich blood red?
Why is oxygen-rich blood red?
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Why is oxygen-poor blood bluish?
Why is oxygen-poor blood bluish?
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How does acidity affect oxygen release in tissues?
How does acidity affect oxygen release in tissues?
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Erythropoiesis
Erythropoiesis
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Hypoxia
Hypoxia
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Erythropoietin
Erythropoietin
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Hemolysis
Hemolysis
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Biliverdin
Biliverdin
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Bilirubin
Bilirubin
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Oxyhemoglobin Formation
Oxyhemoglobin Formation
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Oxygen Release
Oxygen Release
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Platelet Agglutination
Platelet Agglutination
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Platelet Plug Formation
Platelet Plug Formation
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Platelet Role in Vasoconstriction
Platelet Role in Vasoconstriction
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Platelet Adhesion
Platelet Adhesion
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Platelet Role in Clot Retraction
Platelet Role in Clot Retraction
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Platelet Role in Blood Vessel Repair
Platelet Role in Blood Vessel Repair
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Platelet Role in Defense Mechanism
Platelet Role in Defense Mechanism
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Haemostasis
Haemostasis
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What is blood group O?
What is blood group O?
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What is blood group AB?
What is blood group AB?
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What is Rh-positive?
What is Rh-positive?
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What is Rh-negative?
What is Rh-negative?
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Who are universal donors?
Who are universal donors?
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Who are universal recipients?
Who are universal recipients?
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What is cross-matching and why is it important?
What is cross-matching and why is it important?
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What is agglutination?
What is agglutination?
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Vasoconstriction in Hemostasis
Vasoconstriction in Hemostasis
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Role of von Willebrand Factor
Role of von Willebrand Factor
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Formation of Platelet Plug
Formation of Platelet Plug
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Coagulation in Hemostasis
Coagulation in Hemostasis
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Thrombolysis
Thrombolysis
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Antigens on Red Blood Cells
Antigens on Red Blood Cells
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ABO and Rh Blood Group Systems
ABO and Rh Blood Group Systems
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Classifying Blood Types
Classifying Blood Types
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Study Notes
Cardiovascular System: Blood
- Blood is a fluid connective tissue
- It circulates constantly throughout the body, propelled by the heart's pumping action
- Transports oxygen, nutrients, hormones, heat, antibodies, immune system cells, clotting factors, and waste products
- Composed of plasma (55% of total blood) and cell fraction (45%)
- Plasma is a clear, straw-colored, watery fluid
- Cellular components include erythrocytes, leukocytes, and platelets
- Erythrocytes (red blood cells): 45% of total blood volume
- Leukocytes (white blood cells): less than 1% of total blood volume
- Platelets are less than 1% of total blood volume
Plasma Proteins
- Make up about 7% of plasma
- Retained within blood due to their large size, preventing escape through capillary pores
- Primarily albumin and fibrinogen
- Formed in the liver
- Function:
- Creating osmotic pressure in the blood
- Maintaining plasma viscosity (thickness)
- Reduced plasma proteins lead to fluid shifting into tissues (edema)
Plasma Constituents
- Main constituent of plasma is water (90-92%)
- Dissolved and suspended substances:
- Plasma proteins (e.g., albumin, globulins)
- Inorganic salts (electrolytes)
- Nutrients
- Waste products
- Hormones
- Gases
Albumin
- Most abundant plasma protein
- Function:
- Maintains normal plasma osmotic pressure
- Acts as a carrier molecule for free fatty acids, some drugs, and steroid hormones.
Globulins
- Primarily found in the liver and lymphoid tissue
- Function:
- Antibodies (immunoglobulins), binding to and neutralizing foreign materials (microorganisms)
- Transporting hormones and mineral salts (e.g., thyroglobulin carries thyroxine)
- Inhibiting some proteolytic enzymes (e.g., a2 macroglobulin inhibits trypsin)
Clotting Factors
- Essential for blood coagulation
- Serum is plasma with clotting factors removed
- Fibrinogen, synthesized in the liver, is crucial for blood coagulation
Inorganic Salts (Minerals)
- Involved in various bodily functions, including:
- Muscle contractions
- Nerve impulse transmission
- Secretion formation
- Acid-base balance maintenance
- Blood is slightly alkaline (pH 7.35-7.45)
Nutrients
- Food is broken into smaller molecules (e.g., monosaccharides, amino acids, fatty acids, glycerol) in the alimentary tract and absorbed.
- Required by all body cells to:
- Provide energy
- Produce heat
- Provide materials for repair and replacement
- Synthesize blood components and body secretions
Waste Products
- Urea, creatinine, and uric acid are waste products of protein metabolism
- Formed in the liver and carried to the kidneys for excretion
- Carbon dioxide from tissue metabolism is transported to the lungs for excretion
Hormones
- Chemical messengers synthesized by endocrine glands
- Secreted into the blood and transported to target tissues/organs
Gases
- Oxygen is not very soluble in water; requires a transport mechanism
- Oxygen is primarily bound to hemoglobin in red blood cells (98% blood oxygen)
- Hemoglobin also binds some carbon dioxide
- Most carbon dioxide is converted to bicarbonate ion in red blood cells and transported in the plasma
Cellular Content of Blood
- Stem cells are primitive cells in bone marrow that give rise to blood cells
- A stem cell can produce different types of blood cells(pluripotent hemopoietic stem cells (PHSC))
- Early stage - uncommitted pluripotent hemopoietic stem cells
- Committed pluripotent hemopoietic stem cells
- Lymphoid stem cells (LCS)-give rise to lymphocytes
- Colony forming blastocytes-blood cells
- Erythrocytes
- Granulocytes/monocytes
- Megakaryocytes
- Three types of blood cells:
- Erythrocytes (red blood cells)
- Leukocytes (white blood cells)
- Platelets (thrombocytes)
- Most blood cells are synthesized in red bone marrow
- Some lymphocytes are produced in lymphoid tissue
- Blood cells originate from pluripotent stem cells and undergo several development stages before entering the bloodstream
- Different blood cell types follow separate lines of development
- The process of blood cell formation is called hemopoiesis
- Fatty yellow marrow replaces red marrow over time
- Hemopoiesis in the skeleton is confined to flat bones, irregular bones and ends of long bones
Erythropoiesis
- Process of red blood cell origin, development, and maturation
- Changes during erythropoiesis:
- Reduction in cell size
- Disappearance of nucleoli and nucleus
- Appearance of hemoglobin
- Change in the staining properties of the cytoplasm
- Stages of erythropoiesis:
- Proerythroblast
- Early normoblast
- Intermediate normoblast
- Late normoblast
- Reticulocyte (immature RBC)
- Mature erythrocyte
- Reticulocytes: immature red blood cells with a reticular network in the cytoplasm
- Slightly larger than mature red blood cells
- In newborn babies, reticulocytes are 2-6% of total red blood cells
- Number of reticulocytes decreases in the first week after birth and remains below 1% of red blood cells later
- Number increases with increased red blood cell production
- Important for monitoring red blood cell production (e.g., in anemia)
Erythrocytes
- Most abundant blood cell type (99%)
- Function: transporting gases (primarily oxygen and some carbon dioxide)
- Characteristics:
- Biconcave discs (increases surface area for gas exchange)
- No nucleus
- Diameter of about 7 µm
- Flexible cells, squeezing through narrow capillaries
- Contain no intracellular organelles
- Large pigmented protein (hemoglobin) responsible for gas transport
- Flattened shape for stacking in bloodstream (reduces turbulence)
- Lifespan of 120 days
Hemoglobin
- Large, complex molecule containing a globular protein and a pigmented iron-containing complex (heme)
- Each hemoglobin molecule has four globin chains and four heme units, each with one iron atom
- Iron is transported bound to its transport protein transferrin and stored in the liver
- Oxygen transport:
- Saturated hemoglobin: all four oxygen-binding sites are filled
- Hemoglobin reversibly binds to oxygen to form oxyhemoglobin
- Oxygen transport is influenced by pH and temperature
Control of Erythropoiesis
- Erythropoiesis is stimulated by hypoxia (low oxygen supply to body tissues):
- Hypoxia increases erythropoietin production, mainly by the kidneys
- Erythropoietin stimulates an increase in the production of proerythroblasts and the release of increased numbers of reticulocytes
- Hypoxia increase erythrocyte formation
- Erythropoietin stimulates the increment in erythropoiesis
- Decrease in erythropoietin levels result in decrease in red cell formation
Destruction of Erythrocytes
- Lifespan of erythrocytes: about 120 days
- Breakdown (hemolysis) is carried out by phagocytic reticuloendothelial cells (mainly spleen, bone marrow, and liver)
- Released components are retained in the body and reused to build new hemoglobin molecules
- Biliverdin is formed from heme
- Bilirubin (a yellow pigment) is formed from biliverdin
- Bilirubin is converted in the liver and becomes water-soluble; is excreted as a bile constituent
White Blood Cells (Leukocytes)
- Colorless, nucleated formed elements
- Crucial to the body's defense mechanism
- Classified into two types based on presence or absence of granules:
- Granulocytes: neutrophils, eosinophils, basophils
- Agranulocytes: monocytes, lymphocytes, mast cells
Neutrophils
- Play a vital role in defense and are the first line of defense against invading microorganisms.
- Free cells in the body; actively wander through tissues.
- Granules contain enzymes (e.g., proteases, myeloperoxidases, elastases, and metalloproteinases) and antimicrobial peptides (defensins).
- The membrane contains an enzyme called NADPH oxidase, activated by toxic metabolites from infected tissues
Eosinophils
- Important in detoxification, disintegration, and removal of foreign proteins.
- Specifically involved in combating parasites and active during parasitic infestations and allergic conditions.
- Granules contain substances that become cytotoxic upon release.
Basophils
- Crucial to post-inflammation tissue healing and acute hypersensitivity reactions (allergies).
- Number increases during post-inflammation healing
- Involved in the release of important substances from granules: histamine, heparin, and hyaluronic acid.
Monocytes
- Important in the body's defense, acting as phagocytes
- Motile
- Related to interleukin-1 production
- Colony stimulating factors (CSF)
- Platelet activating factor (PAF)
- Precursors of tissue macrophages
- Stay in the blood for a short time before entering tissues
Lymphocytes
- Classified into two categories:
- T lymphocytes (cellular immunity)
- B lymphocytes (humoral immunity)
Platelets
- Small, colorless, non-nucleated fragments of cytoplasm
- Function:
- Blood clotting (hemostasis):
- Forming a temporary plug to stop blood loss.
- Secreting substances to initiate and accelerate the clotting process
- Repair of ruptured blood vessels: promoting the repair and regeneration of blood vessel structures
- Defense mechanism: surrounding and destroying foreign bodies by phagocytosis (engulfing and digesting foreign materials)
- Blood clotting (hemostasis):
Hemostasis
- Arrest of bleeding (stopping bleeding).
- 3 Main Stages:
- Vasoconstriction
- Platelet plug formation
- Coagulation of blood
Blood Groups
- Red blood cell membranes carry antigens, triggering immune responses if mismatched
- ABO blood group system (A, B, AB, O) determined by inherited antigens for transfusions
- Rh blood group system significant in transfusions
- Antigens determine the blood group
- Cross-matching is done to determine compatibility before transfusions
- O blood group can be given to all blood groups (Universal donor); AB blood group can receive from any blood groups (Universal recipient)
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Description
Test your knowledge on blood physiology, focusing on the properties of platelets, hemostasis, and plasma components. This quiz covers essential concepts related to blood clotting, the roles of different substances, and the composition of blood. Perfect for students studying biology or health sciences.