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Questions and Answers
What is the primary function of blood?
What is the primary function of blood?
- Storage of energy
- Immune response only
- Hormone production
- Transportation of substances (correct)
Blood accounts for 8% of the total body weight in an average adult.
Blood accounts for 8% of the total body weight in an average adult.
True (A)
What are the three main components of the formed elements in blood?
What are the three main components of the formed elements in blood?
Erythrocytes, leukocytes, platelets
The liquid extracellular matrix of blood is called plasma_.
The liquid extracellular matrix of blood is called plasma_.
Match the following blood components with their functions:
Match the following blood components with their functions:
What percentage of blood is made up of plasma?
What percentage of blood is made up of plasma?
Leukocytes have organelles that help them perform their functions.
Leukocytes have organelles that help them perform their functions.
What is the pH range of blood?
What is the pH range of blood?
What is the adult average percent volume of blood occupied by erythrocytes?
What is the adult average percent volume of blood occupied by erythrocytes?
High hematocrit levels can lead to an increased number of white blood cells.
High hematocrit levels can lead to an increased number of white blood cells.
What is the process of blood cell formation called?
What is the process of blood cell formation called?
Erythropoietin (EPO) is synthesized in the __________.
Erythropoietin (EPO) is synthesized in the __________.
Match the types of blood cells with their characteristics:
Match the types of blood cells with their characteristics:
Which of the following is true about mature erythrocytes?
Which of the following is true about mature erythrocytes?
Erythrocytes can carry a significant portion of the body's carbon dioxide.
Erythrocytes can carry a significant portion of the body's carbon dioxide.
What part of hemoglobin binds oxygen?
What part of hemoglobin binds oxygen?
The life cycle of an erythrocyte is approximately __________ days.
The life cycle of an erythrocyte is approximately __________ days.
What is the main stimulus for erythropoiesis?
What is the main stimulus for erythropoiesis?
Cytokines are responsible for increasing the proliferation of leukocytes.
Cytokines are responsible for increasing the proliferation of leukocytes.
What cell types are produced from lymphoid stem cells?
What cell types are produced from lymphoid stem cells?
The globin part of hemoglobin is ___________ and the heme part is ___________.
The globin part of hemoglobin is ___________ and the heme part is ___________.
What hormone stimulates platelet formation?
What hormone stimulates platelet formation?
Which type of leukocyte defends against parasites?
Which type of leukocyte defends against parasites?
Basophils have granules that stain with acidic dyes.
Basophils have granules that stain with acidic dyes.
What is the primary role of neutrophils?
What is the primary role of neutrophils?
The nucleus of eosinophils usually has two lobes connected by a thin, tubular __________.
The nucleus of eosinophils usually has two lobes connected by a thin, tubular __________.
What do lymphocytes primarily do?
What do lymphocytes primarily do?
Monocytes are derived from the myeloid stem cell lineage.
Monocytes are derived from the myeloid stem cell lineage.
What chemical do basophils release that increases the leakiness of blood vessels?
What chemical do basophils release that increases the leakiness of blood vessels?
Hemostasis is a process that prevents __________.
Hemostasis is a process that prevents __________.
Which leukocyte arrives at the site of infection later than the others?
Which leukocyte arrives at the site of infection later than the others?
Match the leukocyte type with its primary function:
Match the leukocyte type with its primary function:
Agranular leukocytes have visible granules under a compound light microscope.
Agranular leukocytes have visible granules under a compound light microscope.
What are the three general steps of hemostasis?
What are the three general steps of hemostasis?
The process of blood clot formation is called __________.
The process of blood clot formation is called __________.
Which of the following is NOT a role of eosinophils?
Which of the following is NOT a role of eosinophils?
Platelets are formed from megakaryocytes.
Platelets are formed from megakaryocytes.
What substance is responsible for initiating the intrinsic pathway of blood clotting?
What substance is responsible for initiating the intrinsic pathway of blood clotting?
The extrinsic pathway of blood clotting involves the activation of factor XII.
The extrinsic pathway of blood clotting involves the activation of factor XII.
What is the disease characterized by insufficient clotting factors?
What is the disease characterized by insufficient clotting factors?
The clumping of erythrocytes upon contact with agglutinins is known as _____
The clumping of erythrocytes upon contact with agglutinins is known as _____
Match the blood diseases to their descriptions:
Match the blood diseases to their descriptions:
Which factor is activated by tissue factor in the blood coagulation process?
Which factor is activated by tissue factor in the blood coagulation process?
Individuals with blood type O make antibodies against both A and B antigens.
Individuals with blood type O make antibodies against both A and B antigens.
What happens to the second Rh+ child if the mother has anti-Rh antibodies?
What happens to the second Rh+ child if the mother has anti-Rh antibodies?
Blood clots are regulated to prevent unnecessary _____
Blood clots are regulated to prevent unnecessary _____
What is the primary role of thrombin in blood coagulation?
What is the primary role of thrombin in blood coagulation?
Sickle cell disease is primarily caused by a vitamin deficiency.
Sickle cell disease is primarily caused by a vitamin deficiency.
What is the function of RhoGam during pregnancy?
What is the function of RhoGam during pregnancy?
Individuals with at least one sickle cell allele have increased resistance to _____
Individuals with at least one sickle cell allele have increased resistance to _____
What is one main cause of anemia?
What is one main cause of anemia?
Flashcards
Extracellular fluids
Extracellular fluids
Fluids outside of cells, including blood, interstitial fluid, and lymph.
Blood composition
Blood composition
Blood is composed of blood plasma (liquid matrix) and formed elements (cells).
Blood plasma
Blood plasma
The liquid portion of blood, primarily water with dissolved substances like proteins, electrolytes, nutrients, and hormones.
Formed elements
Formed elements
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Erythrocytes/Red blood cells
Erythrocytes/Red blood cells
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Hemoglobin
Hemoglobin
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Leukocytes/White blood cells
Leukocytes/White blood cells
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Platelets
Platelets
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Blood function - Transportation
Blood function - Transportation
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Blood function - Regulation
Blood function - Regulation
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Blood function - Protection
Blood function - Protection
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Albumin
Albumin
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Globulins
Globulins
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Fibrinogen
Fibrinogen
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Hematocrit
Hematocrit
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Low Hematocrit
Low Hematocrit
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High Hematocrit
High Hematocrit
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Hemopoiesis
Hemopoiesis
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Red Bone Marrow
Red Bone Marrow
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Pluripotent Stem Cells
Pluripotent Stem Cells
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Myeloid Stem Cells
Myeloid Stem Cells
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Lymphoid Stem Cells
Lymphoid Stem Cells
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Erythropoietin (EPO)
Erythropoietin (EPO)
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Thrombopoietin (TPO)
Thrombopoietin (TPO)
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Erythrocytes (RBCs)
Erythrocytes (RBCs)
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Biconcave Discs
Biconcave Discs
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Anucleate
Anucleate
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Hemoglobin
Hemoglobin
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Carbonic Anhydrase
Carbonic Anhydrase
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Nitric Oxide (NO)
Nitric Oxide (NO)
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Vasodilation
Vasodilation
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Erythrocyte Life Cycle
Erythrocyte Life Cycle
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Macrophages
Macrophages
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Hypoxia
Hypoxia
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Erythropoiesis
Erythropoiesis
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Leukocytes
Leukocytes
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Granular Leukocytes
Granular Leukocytes
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Neutrophils
Neutrophils
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Intrinsic Pathway of Clotting
Intrinsic Pathway of Clotting
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Extrinsic Pathway of Clotting
Extrinsic Pathway of Clotting
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Common Pathway of Clotting
Common Pathway of Clotting
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Blood Clotting Regulation
Blood Clotting Regulation
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Thrombosis
Thrombosis
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Embolism
Embolism
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ABO Blood Groups
ABO Blood Groups
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Agglutinins
Agglutinins
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Agglutination
Agglutination
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Hemolytic Disease of the Newborn (HDN)
Hemolytic Disease of the Newborn (HDN)
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Rh Factor
Rh Factor
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Anemia
Anemia
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Sickle Cell Disease
Sickle Cell Disease
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Sickle Cell Alleles
Sickle Cell Alleles
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Hemophilia
Hemophilia
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Polycythemia
Polycythemia
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Neutrophilic Granules
Neutrophilic Granules
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Polymorphonuclear Leukocytes (PMNs)
Polymorphonuclear Leukocytes (PMNs)
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Eosinophils
Eosinophils
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Acidic Dyes
Acidic Dyes
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Basophils
Basophils
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Basic Dyes
Basic Dyes
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Agranular Leukocytes
Agranular Leukocytes
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Lymphocytes
Lymphocytes
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Myeloid Stem Cell Lineage
Myeloid Stem Cell Lineage
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Lymphoid Stem Cell Lineage
Lymphoid Stem Cell Lineage
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Monocytes
Monocytes
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Macrophages
Macrophages
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Neutrophils
Neutrophils
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Lysozyme
Lysozyme
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Defensins
Defensins
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Parasitic Infections
Parasitic Infections
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Histaminase
Histaminase
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Signaling
Signaling
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Inflammation
Inflammation
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Hypersensitivity
Hypersensitivity
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Heparin
Heparin
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Histamine
Histamine
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Serotonin
Serotonin
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Lymphatic System
Lymphatic System
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B Lymphocytes
B Lymphocytes
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T Lymphocytes
T Lymphocytes
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Wandering Macrophages
Wandering Macrophages
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Cellular Debris
Cellular Debris
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Inflammation; steps
Inflammation; steps
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Emigration
Emigration
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Rolling
Rolling
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Chemotaxis
Chemotaxis
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Hemostasis
Hemostasis
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Hemorrhage
Hemorrhage
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Vascular Spasm
Vascular Spasm
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Platelet Plug Formation
Platelet Plug Formation
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Platelet Adhesion
Platelet Adhesion
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Platelet Activation
Platelet Activation
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Platelet Aggregation
Platelet Aggregation
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Blood Clot Formation
Blood Clot Formation
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Coagulation
Coagulation
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Clotting factors
Clotting factors
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Calcium ions (Ca2+)
Calcium ions (Ca2+)
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Megakaryoblast
Megakaryoblast
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Megakaryocytes
Megakaryocytes
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Damaged Smooth Muscle
Damaged Smooth Muscle
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Study Notes
Blood Composition and Function
- Blood is a specialized connective tissue, comprising formed elements (cells) suspended in a liquid extracellular matrix called blood plasma.
- Blood accounts for about 8% of body mass. Males typically have 5-6 liters, females 4-5 liters.
- Blood is more viscous than water, with a temperature around 38°C and pH 7.35-7.45.
Blood Functions
- Transportation: Carries oxygen, nutrients, hormones, heat, and waste products.
- Regulation: Maintains pH, body temperature, and osmotic pressure.
- Protection: Against blood loss and infection/disease.
Composition of Blood
- Blood Plasma (55%):
- Pale yellow liquid, mostly water (91.5%) with dissolved solutes.
- Contains proteins like albumin (osmotic pressure), globulins (antibodies/transport), and fibrinogen (clotting).
- Also includes electrolytes, nutrients, enzymes, hormones, and gases.
- Formed Elements (45%):
- Erythrocytes (Red Blood Cells): Most prevalent, transport oxygen (O2) and carbon dioxide (CO2). Mature RBCs lack organelles, filled with hemoglobin.
- Leukocytes (White Blood Cells): Various types, fight infections and invaders.
- Platelets (Thrombocytes): Cell fragments involved in blood clotting.
Blood Cell Formation (Hemopoiesis)
- Occurs in red bone marrow.
- Initiated by pluripotent stem cells developing into myeloid and lymphoid stem cells.
- Precursor cells differentiate and mature into formed elements.
- Only WBCs divide after leaving the bone marrow.
Regulation of Blood Cell Formation
- Hematopoietic growth factors (hormones) regulate formation.
- Erythropoietin (EPO) increases erythrocyte production (made by kidneys).
- Thrombopoietin (TPO) stimulates platelet production (made by liver).
- Cytokines stimulate leukocyte and lymphocyte proliferation (made in bone marrow).
Erythrocytes (RBCs): Structure and Function
- Biconcave discs for large surface area and flexibility (to pass capillaries).
- Anucleate and lack most organelles at maturity, replaced by hemoglobin for O2 transport.
- No mitochondria, to maximize hemoglobin space.
- Per microliter: ~4.8 million in females, ~5.4 million in males.
- Can carry up to 23% of the body’s carbon dioxide.
- RBCs contain carbonic anhydrase which converts CO2 into carbonic acid, crucial for blood buffering.
- Nitric oxide (NO) acts as a hormone, released by endothelial cells in response to muscle stress. NO binding to hemoglobin causes vasodilation.
Erythrocyte Life Cycle
- ~120 days lifespan.
- Worn-out/damaged RBCs are destroyed by macrophages (in the liver, spleen, or bone marrow).
- Hemoglobin is broken down, globin recycled into amino acids, and iron is salvaged for reuse in erythropoiesis.
Leukocytes (WBCs): Structure and Function
- All have organelles, no hemoglobin.
- Classified as granular or agranular.
- Granular Leukocytes:
- Neutrophils (phagocytic, multi-lobed nuclei): primary responders to bacterial infections.
- Eosinophils (parasite defense, bi-lobed nuclei): fight parasites, especially worms.
- Basophils (inflammation, bi-lobed nuclei): release histamine.
- Agranular Leukocytes:
- Lymphocytes (immunity, varied sizes): crucial for the lymphatic system; B cells secrete antibodies. T cells attack virus-infected and cancerous cells. Monocytes(phagocytosic, kidney shape nuclei)
- Monocytes differentiate into macrophages (clean up debris) and osteoclasts (bone-resorbing).
Leukocyte Function in Inflammation and Immunity
- WBCs defend against infection and invasion, identify as "self".
- WBCs exit the bloodstream and accumulate at infection sites.
- Chemotaxis: WBCs are recruited by chemicals released by invaders and damaged tissues.
- Neutrophils are initial responders, releasing lysosomal enzymes, oxidizing chemicals, and defensins for killing bacteria.
Platelets and Hemostasis
- Platelets (thrombocytes) are cell fragments originating from megakaryocytes in bone marrow.
- Essential for blood clotting (hemostasis).
- Hemostasis is NOT homeostasis. It is the process that prevents bleeding.
- Three steps in hemostasis
- Vascular spasm (vasoconstriction).
- Platelet plug formation.
- Blood clotting(coagulation).
Blood Clotting (Coagulation)
- Blood clots reinforce platelet plugs, crucial for stopping excessive bleeding.
- Involves various clotting factors and enzymatic reactions, typically Ca2+ ions and enzymes made in the liver, initiated by either the intrinsic or extrinsic pathways, ultimately leading to fibrin formation.
- Blood clotting is controlled to prevent thrombosis(abnormal clots) or bleeding.
Blood Groups and Transfusions
- ABO blood groups are based on glycolipid antigens on RBCs, which stimulate the formation of agglutinins (antibodies).
- Individuals produce antibodies against foreign antigens.
- Hemolytic Disease of the newborn(HDN): A risk when an Rh- mother carries an Rh+ fetus; if mixing happens when the baby is born, antibodies can harm the fetus.
- Proactive treatment is available with anti-gamma globulins (RhoGam).
Anemia
- A condition where there's insufficient red blood cells or oxygen-carrying capacity of the red blood cells causing reduced oxygen supply to tissues.
Sickle Cell Disease
- Genetic mutation in hemoglobin protein causes misshaped red blood cells.
- The mutated cells are less flexible and have a shorter lifespan, and sickle-cell trait confers resistance to malaria.
Other Blood Disorders
- Hemophilia: insufficient clotting factors, leading to excessive bleeding. More commonly found in males.
- Polycythemia: too many red blood cells, thickening the blood.
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