Blood Composition and Functions Quiz

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Questions and Answers

What is the primary function of blood?

  • Storage of energy
  • Immune response only
  • Hormone production
  • Transportation of substances (correct)

Blood accounts for 8% of the total body weight in an average adult.

True (A)

What are the three main components of the formed elements in blood?

Erythrocytes, leukocytes, platelets

The liquid extracellular matrix of blood is called plasma_.

<p>plasma</p> Signup and view all the answers

Match the following blood components with their functions:

<p>Erythrocytes = Transport O2 and CO2 Leukocytes = Fight infection Platelets = Blood clotting Plasma = Liquid ECM containing solutes</p> Signup and view all the answers

What percentage of blood is made up of plasma?

<p>55% (B)</p> Signup and view all the answers

Leukocytes have organelles that help them perform their functions.

<p>True (A)</p> Signup and view all the answers

What is the pH range of blood?

<p>7.35-7.45</p> Signup and view all the answers

What is the adult average percent volume of blood occupied by erythrocytes?

<p>47 (D)</p> Signup and view all the answers

High hematocrit levels can lead to an increased number of white blood cells.

<p>False (B)</p> Signup and view all the answers

What is the process of blood cell formation called?

<p>Hemopoiesis</p> Signup and view all the answers

Erythropoietin (EPO) is synthesized in the __________.

<p>kidneys</p> Signup and view all the answers

Match the types of blood cells with their characteristics:

<p>Erythrocytes = Transport oxygen Leukocytes = Fight infections Platelets = Participate in blood clotting Stem cells = Give rise to all blood cells</p> Signup and view all the answers

Which of the following is true about mature erythrocytes?

<p>They lack organelles. (C)</p> Signup and view all the answers

Erythrocytes can carry a significant portion of the body's carbon dioxide.

<p>True (A)</p> Signup and view all the answers

What part of hemoglobin binds oxygen?

<p>Heme</p> Signup and view all the answers

The life cycle of an erythrocyte is approximately __________ days.

<p>120</p> Signup and view all the answers

What is the main stimulus for erythropoiesis?

<p>Reduced oxygen transport (B)</p> Signup and view all the answers

Cytokines are responsible for increasing the proliferation of leukocytes.

<p>True (A)</p> Signup and view all the answers

What cell types are produced from lymphoid stem cells?

<p>Lymphocytes</p> Signup and view all the answers

The globin part of hemoglobin is ___________ and the heme part is ___________.

<p>organic; inorganic</p> Signup and view all the answers

What hormone stimulates platelet formation?

<p>Thrombopoietin (B)</p> Signup and view all the answers

Which type of leukocyte defends against parasites?

<p>Eosinophils (B)</p> Signup and view all the answers

Basophils have granules that stain with acidic dyes.

<p>False (B)</p> Signup and view all the answers

What is the primary role of neutrophils?

<p>To respond rapidly to bacterial infections and phagocytize pathogens.</p> Signup and view all the answers

The nucleus of eosinophils usually has two lobes connected by a thin, tubular __________.

<p>linker</p> Signup and view all the answers

What do lymphocytes primarily do?

<p>Fight viral-infected and cancerous cells (C)</p> Signup and view all the answers

Monocytes are derived from the myeloid stem cell lineage.

<p>True (A)</p> Signup and view all the answers

What chemical do basophils release that increases the leakiness of blood vessels?

<p>Histamine</p> Signup and view all the answers

Hemostasis is a process that prevents __________.

<p>hemorrhage</p> Signup and view all the answers

Which leukocyte arrives at the site of infection later than the others?

<p>Monocytes (A)</p> Signup and view all the answers

Match the leukocyte type with its primary function:

<p>Neutrophils = Phagocytosis of bacteria Eosinophils = Defense against parasites Basophils = Release histamine Lymphocytes = Adaptive immunity</p> Signup and view all the answers

Agranular leukocytes have visible granules under a compound light microscope.

<p>False (B)</p> Signup and view all the answers

What are the three general steps of hemostasis?

<p>Vascular spasm, platelet plug formation, blood clotting.</p> Signup and view all the answers

The process of blood clot formation is called __________.

<p>coagulation</p> Signup and view all the answers

Which of the following is NOT a role of eosinophils?

<p>Fight viral infections (B)</p> Signup and view all the answers

Platelets are formed from megakaryocytes.

<p>True (A)</p> Signup and view all the answers

What substance is responsible for initiating the intrinsic pathway of blood clotting?

<p>Collagen (B)</p> Signup and view all the answers

The extrinsic pathway of blood clotting involves the activation of factor XII.

<p>False (B)</p> Signup and view all the answers

What is the disease characterized by insufficient clotting factors?

<p>Hemophilia</p> Signup and view all the answers

The clumping of erythrocytes upon contact with agglutinins is known as _____

<p>agglutination</p> Signup and view all the answers

Match the blood diseases to their descriptions:

<p>Anemia = Condition with insufficient red blood cells Sickle Cell Disease = Genetic mutation affecting hemoglobin Polycythemia = Excessive number of erythrocytes Hemophilia = Mutation leading to insufficient clotting factors</p> Signup and view all the answers

Which factor is activated by tissue factor in the blood coagulation process?

<p>Factor X (B)</p> Signup and view all the answers

Individuals with blood type O make antibodies against both A and B antigens.

<p>True (A)</p> Signup and view all the answers

What happens to the second Rh+ child if the mother has anti-Rh antibodies?

<p>The second child may suffer from hemolytic disease of the newborn (HDN).</p> Signup and view all the answers

Blood clots are regulated to prevent unnecessary _____

<p>thrombosis</p> Signup and view all the answers

What is the primary role of thrombin in blood coagulation?

<p>Converting fibrinogen to fibrin (D)</p> Signup and view all the answers

Sickle cell disease is primarily caused by a vitamin deficiency.

<p>False (B)</p> Signup and view all the answers

What is the function of RhoGam during pregnancy?

<p>To neutralize anti-Rh antibodies in the Rh- mother.</p> Signup and view all the answers

Individuals with at least one sickle cell allele have increased resistance to _____

<p>malaria</p> Signup and view all the answers

What is one main cause of anemia?

<p>Iron deficiency (B)</p> Signup and view all the answers

Flashcards

Extracellular fluids

Fluids outside of cells, including blood, interstitial fluid, and lymph.

Blood composition

Blood is composed of blood plasma (liquid matrix) and formed elements (cells).

Blood plasma

The liquid portion of blood, primarily water with dissolved substances like proteins, electrolytes, nutrients, and hormones.

Formed elements

The cellular components of blood, including red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes).

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Erythrocytes/Red blood cells

Cells that transport oxygen and carbon dioxide throughout the body.

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Hemoglobin

The protein in red blood cells that carries oxygen.

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Leukocytes/White blood cells

Cells that fight infection and disease.

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Platelets

Cell fragments involved in blood clotting.

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Blood function - Transportation

Blood carries nutrients, oxygen, hormones, heat, and waste products throughout the body.

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Blood function - Regulation

Blood regulates pH, body temperature, and osmotic pressure.

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Blood function - Protection

Blood protects against blood loss and invasion/disease.

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Albumin

A protein in blood plasma that helps maintain osmotic pressure.

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Globulins

Proteins in blood plasma that include antibodies and transport proteins for various substances.

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Fibrinogen

A protein in blood plasma that plays a role in blood clotting.

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Hematocrit

The percentage of blood volume occupied by red blood cells.

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Low Hematocrit

A hematocrit value below the normal range (typically < 40).

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High Hematocrit

A hematocrit value above the normal range (typically > 65).

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Hemopoiesis

The process of blood cell formation.

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Red Bone Marrow

The tissue in bones where blood cells are formed.

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Pluripotent Stem Cells

Stem cells that can differentiate into many different types of cells.

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Myeloid Stem Cells

A type of stem cell that produces various blood cells.

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Lymphoid Stem Cells

A lineage of stem cells that produce lymphocytes.

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Erythropoietin (EPO)

A hormone that stimulates red blood cell production.

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Thrombopoietin (TPO)

A hormone that stimulates platelet production.

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Erythrocytes (RBCs)

Red blood cells that transport oxygen and carbon dioxide.

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Biconcave Discs

The shape of red blood cells, providing a large surface area for gas exchange.

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Anucleate

Lacking a nucleus.

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Hemoglobin

Protein in red blood cells that carries oxygen.

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Carbonic Anhydrase

An enzyme involved in CO2 transport.

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Nitric Oxide (NO)

Gas that acts as a hormone, affecting blood vessel diameter.

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Vasodilation

Widening of Blood vessels.

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Erythrocyte Life Cycle

The lifespan and destruction of red blood cells, approximately 120 days.

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Macrophages

Immune cells that destroy worn-out or damaged cells.

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Hypoxia

Low oxygen levels in the body.

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Erythropoiesis

The process of red blood cell production

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Leukocytes

White blood cells that function in the immune system.

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Granular Leukocytes

White blood cells containing granules, including neutrophils, eosinophils, and basophils.

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Neutrophils

Phagocytic white blood cells that fight infection.

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Intrinsic Pathway of Clotting

Blood clotting initiated by damage within blood vessels.

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Extrinsic Pathway of Clotting

Blood clotting triggered by external substances entering blood.

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Common Pathway of Clotting

The shared final steps in blood clotting, regardless of activation method.

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Blood Clotting Regulation

Tight control over blood clotting is vital for preventing thrombosis and hemorrhage.

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Thrombosis

Formation of harmful blood clots in blood vessels.

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Embolism

A blood clot moving through the circulatory system that can obstruct blood flow.

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ABO Blood Groups

Blood groups determined by glycolipid antigens on red blood cells.

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Agglutinins

Antibodies that cause clumping of red blood cells.

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Agglutination

Clumping of red blood cells.

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Hemolytic Disease of the Newborn (HDN)

Fetal red blood cell destruction due to maternal antibodies.

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Rh Factor

Protein antigen on red blood cells, determining Rh positive or negative status.

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Anemia

A condition with insufficient healthy red blood cells reducing oxygen carrying capacity.

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Sickle Cell Disease

Genetic disorder causing misshapen red blood cells.

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Sickle Cell Alleles

Gene variants that differ by mutation.

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Hemophilia

Inherited blood disorder with insufficient clotting factors.

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Polycythemia

Overproduction of red blood cells, causing thickened blood.

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Neutrophilic Granules

Granules in cells that do not retain acidic or basic dyes.

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Polymorphonuclear Leukocytes (PMNs)

White blood cells with a multi-lobed nucleus.

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Eosinophils

White blood cells that defend against parasites, through phagocytosis.

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Acidic Dyes

Dyes that attract negatively charged molecules.

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Basophils

White blood cells involved in inflammation and allergies.

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Basic Dyes

Dyes that attract positively charged molecules.

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Agranular Leukocytes

White blood cells that lack granules (small particles).

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Lymphocytes

Agranular leukocytes that function in the immune response.

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Myeloid Stem Cell Lineage

Stem cells that give rise to monocytes (and other related cells).

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Lymphoid Stem Cell Lineage

Stem cells that give rise to lymphocytes.

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Monocytes

White blood cells that differentiate into macrophages or osteoclasts.

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Macrophages

Phagocytic cells that clean up cellular debris.

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Neutrophils

White blood cells that are fast responders to bacterial infections.

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Lysozyme

An enzyme that disrupts bacterial cell membranes.

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Defensins

Antimicrobial peptides that disrupt bacterial membranes.

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Parasitic Infections

Infections caused by parasites.

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Histaminase

An enzyme that breaks down histamine.

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Signaling

Process of communicating between cells, via chemical signals.

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Inflammation

Body's response to tissue damage or infection.

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Hypersensitivity

Exaggerated immune response that can harm the body.

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Heparin

An anticoagulant, preventing blood clotting.

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Histamine

Substance that increases blood vessel permeability.

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Serotonin

A chemical signal that has role in blood clotting

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Lymphatic System

Network of vessels and organs involved in immune responses.

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B Lymphocytes

Lymphocytes that produce antibodies.

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T Lymphocytes

Lymphocytes that directly kill infected or cancerous cells.

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Wandering Macrophages

Specialized macrophages that migrate through the tissues.

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Cellular Debris

Dead or damaged cells and their components.

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Inflammation; steps

5 step response to tissue damage and infection

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Emigration

Movement of cells from one tissue to another.

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Rolling

Process where cells adhere to and detach from vessel walls.

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Chemotaxis

Movement of cells toward a chemical signal.

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Hemostasis

Process to stop bleeding

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Hemorrhage

Excessive bleeding.

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Vascular Spasm

Narrowing of blood vessels to reduce blood flow.

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Platelet Plug Formation

Formation of a temporary plug to stop bleeding at site of injury

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Platelet Adhesion

Platelets attach to sites of injury.

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Platelet Activation

Platelets become more responsive.

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Platelet Aggregation

Platelets clump together.

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Blood Clot Formation

Formation of insoluble protein fibers that reinforce plug.

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Coagulation

Process whereby blood clots are formed.

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Clotting factors

Proteins required for blood clotting.

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Calcium ions (Ca2+)

Essential ions for blood clotting.

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Megakaryoblast

Immature cell that matures into megakaryocytes.

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Megakaryocytes

Large cells that splinter into platelets during maturation.

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Damaged Smooth Muscle

Smooth muscle cells that have been harmed.

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Study Notes

Blood Composition and Function

  • Blood is a specialized connective tissue, comprising formed elements (cells) suspended in a liquid extracellular matrix called blood plasma.
  • Blood accounts for about 8% of body mass. Males typically have 5-6 liters, females 4-5 liters.
  • Blood is more viscous than water, with a temperature around 38°C and pH 7.35-7.45.

Blood Functions

  • Transportation: Carries oxygen, nutrients, hormones, heat, and waste products.
  • Regulation: Maintains pH, body temperature, and osmotic pressure.
  • Protection: Against blood loss and infection/disease.

Composition of Blood

  • Blood Plasma (55%):
    • Pale yellow liquid, mostly water (91.5%) with dissolved solutes.
    • Contains proteins like albumin (osmotic pressure), globulins (antibodies/transport), and fibrinogen (clotting).
    • Also includes electrolytes, nutrients, enzymes, hormones, and gases.
  • Formed Elements (45%):
    • Erythrocytes (Red Blood Cells): Most prevalent, transport oxygen (O2) and carbon dioxide (CO2). Mature RBCs lack organelles, filled with hemoglobin.
    • Leukocytes (White Blood Cells): Various types, fight infections and invaders.
    • Platelets (Thrombocytes): Cell fragments involved in blood clotting.

Blood Cell Formation (Hemopoiesis)

  • Occurs in red bone marrow.
  • Initiated by pluripotent stem cells developing into myeloid and lymphoid stem cells.
  • Precursor cells differentiate and mature into formed elements.
  • Only WBCs divide after leaving the bone marrow.

Regulation of Blood Cell Formation

  • Hematopoietic growth factors (hormones) regulate formation.
    • Erythropoietin (EPO) increases erythrocyte production (made by kidneys).
    • Thrombopoietin (TPO) stimulates platelet production (made by liver).
    • Cytokines stimulate leukocyte and lymphocyte proliferation (made in bone marrow).

Erythrocytes (RBCs): Structure and Function

  • Biconcave discs for large surface area and flexibility (to pass capillaries).
  • Anucleate and lack most organelles at maturity, replaced by hemoglobin for O2 transport.
  • No mitochondria, to maximize hemoglobin space.
  • Per microliter: ~4.8 million in females, ~5.4 million in males.
  • Can carry up to 23% of the body’s carbon dioxide.
  • RBCs contain carbonic anhydrase which converts CO2 into carbonic acid, crucial for blood buffering.
  • Nitric oxide (NO) acts as a hormone, released by endothelial cells in response to muscle stress. NO binding to hemoglobin causes vasodilation.

Erythrocyte Life Cycle

  • ~120 days lifespan.
  • Worn-out/damaged RBCs are destroyed by macrophages (in the liver, spleen, or bone marrow).
  • Hemoglobin is broken down, globin recycled into amino acids, and iron is salvaged for reuse in erythropoiesis.

Leukocytes (WBCs): Structure and Function

  • All have organelles, no hemoglobin.
  • Classified as granular or agranular.
  • Granular Leukocytes:
    • Neutrophils (phagocytic, multi-lobed nuclei): primary responders to bacterial infections.
    • Eosinophils (parasite defense, bi-lobed nuclei): fight parasites, especially worms.
    • Basophils (inflammation, bi-lobed nuclei): release histamine.
  • Agranular Leukocytes:
    • Lymphocytes (immunity, varied sizes): crucial for the lymphatic system; B cells secrete antibodies. T cells attack virus-infected and cancerous cells. Monocytes(phagocytosic, kidney shape nuclei)
    • Monocytes differentiate into macrophages (clean up debris) and osteoclasts (bone-resorbing).

Leukocyte Function in Inflammation and Immunity

  • WBCs defend against infection and invasion, identify as "self".
  • WBCs exit the bloodstream and accumulate at infection sites.
  • Chemotaxis: WBCs are recruited by chemicals released by invaders and damaged tissues.
  • Neutrophils are initial responders, releasing lysosomal enzymes, oxidizing chemicals, and defensins for killing bacteria.

Platelets and Hemostasis

  • Platelets (thrombocytes) are cell fragments originating from megakaryocytes in bone marrow.
  • Essential for blood clotting (hemostasis).
    • Hemostasis is NOT homeostasis. It is the process that prevents bleeding.
  • Three steps in hemostasis
    • Vascular spasm (vasoconstriction).
    • Platelet plug formation.
    • Blood clotting(coagulation).

Blood Clotting (Coagulation)

  • Blood clots reinforce platelet plugs, crucial for stopping excessive bleeding.
  • Involves various clotting factors and enzymatic reactions, typically Ca2+ ions and enzymes made in the liver, initiated by either the intrinsic or extrinsic pathways, ultimately leading to fibrin formation.
  • Blood clotting is controlled to prevent thrombosis(abnormal clots) or bleeding.

Blood Groups and Transfusions

  • ABO blood groups are based on glycolipid antigens on RBCs, which stimulate the formation of agglutinins (antibodies).
  • Individuals produce antibodies against foreign antigens.
  • Hemolytic Disease of the newborn(HDN): A risk when an Rh- mother carries an Rh+ fetus; if mixing happens when the baby is born, antibodies can harm the fetus.
  • Proactive treatment is available with anti-gamma globulins (RhoGam).

Anemia

  • A condition where there's insufficient red blood cells or oxygen-carrying capacity of the red blood cells causing reduced oxygen supply to tissues.

Sickle Cell Disease

  • Genetic mutation in hemoglobin protein causes misshaped red blood cells.
  • The mutated cells are less flexible and have a shorter lifespan, and sickle-cell trait confers resistance to malaria.

Other Blood Disorders

  • Hemophilia: insufficient clotting factors, leading to excessive bleeding. More commonly found in males.
  • Polycythemia: too many red blood cells, thickening the blood.

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