Blood Composition and Function

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Questions and Answers

If a patient's blood work indicates a high white blood cell count, what condition might a doctor suspect?

  • An infection (correct)
  • Impaired lung function
  • A broken tissue
  • A structural damage in bones

The sinoatrial node in the heart is responsible for initiating the heartbeat. If this node malfunctions, which of the following would be directly affected?

  • The liver blood filtration
  • Muscle contractions in the arms
  • Systemic blood circulation (correct)
  • The lungs oxygenation

If a patient is experiencing edema (swelling) due to fluid imbalance, which plasma protein might be deficient?

  • Globulins
  • Albumin (correct)
  • Fibrinogen
  • Myosin

A patient has a wound that is not clotting properly. Which plasma protein is most likely deficient?

<p>Fibrinogen (A)</p> Signup and view all the answers

How does the unique biconcave shape of erythrocytes (RBCs) enhance their primary function?

<p>Increasing surface area for gas exchange (C)</p> Signup and view all the answers

If a patient's lab results show a significantly low hematocrit level, which condition is most likely?

<p>Anemia (D)</p> Signup and view all the answers

In carbon monoxide poisoning, carbon monoxide binds more strongly to hemoglobin than oxygen does; what is the immediate physiological consequence?

<p>Reduced oxygen-carrying capacity of blood (B)</p> Signup and view all the answers

Erythropoietin (EPO) is released in response to hypoxia, and the main effect of EPO is to:

<p>Stimulate red bone marrow to produce more red blood cells (D)</p> Signup and view all the answers

Someone with polycythemia is at risk for:

<p>Clotting disorders due to increased blood viscosity (D)</p> Signup and view all the answers

In sickle cell anemia, the altered shape of red blood cells leads to:

<p>Reduced blood flow due to clumped cells (B)</p> Signup and view all the answers

What is the primary role of neutrophils during an infection?

<p>Phagocytizing and digesting bacteria (D)</p> Signup and view all the answers

In an allergic reaction, basophils release histamine, leading to what immediate effect?

<p>Increased inflammation and vasodilation (C)</p> Signup and view all the answers

What is the role of lymphocytes in the immune response?

<p>To launch targeted attacks on infected or cancerous cells (A)</p> Signup and view all the answers

What is the role of monocytes?

<p>Differentiate into macrophages and phagocytize pathogens (D)</p> Signup and view all the answers

During hemostasis, what is the immediate response to blood vessel injury?

<p>Vascular spasm to reduce blood loss (A)</p> Signup and view all the answers

In leukemia, the cancerous cells primarily affect:

<p>White blood cells (D)</p> Signup and view all the answers

What is the main function of red bone marrow in adults?

<p>Blood cell formation (D)</p> Signup and view all the answers

The hemocytoblast stem cell is responsible for:

<p>Producing all types of blood cells (C)</p> Signup and view all the answers

A person with type O blood has which of the following antibodies in their plasma?

<p>Both anti-A and anti-B antibodies (B)</p> Signup and view all the answers

An Rh-negative mother is pregnant with an Rh-positive fetus. What immunological concern arises during the pregnancy or delivery?

<p>The mother may develop Rh antibodies that could harm subsequent Rh+ fetuses (B)</p> Signup and view all the answers

Flashcards

What type of tissue is blood?

A type of connective tissue

What are blood tests used for?

Identifying infections, diseases, and nutrient levels.

Initiating blood circulation

The heart

Major blood components?

Plasma, erythrocytes, leukocytes, and platelets

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What is the buffy coat composed of?

Leukocytes and platelets

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Function of albumin in plasma

Osmotic pressure regulation

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Plasma protein for immunity

Globulins

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Fibrinogen's importance

Blood clotting

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Shape of erythrocytes (RBCs)

Biconcave disc

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What do RBCs lack?

Nucleus and mitochondria

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What is hematocrit?

The percentage of RBCs in blood

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Hemoglobin's role

Oxygen transport

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Hemoglobin composition

4 globin chains and 4 heme groups

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Oxygen molecules per hemoglobin?

4

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What is erythropoiesis?

The production of red blood cells

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Hormone for erythropoiesis

Erythropoietin (EPO)

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Stimulus for erythropoietin

Low blood oxygen

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Erythrocyte's end of life

It's broken down in the spleen/liver

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What is polycythemia?

An excess of RBCs

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Definition of anemia?

A lack of hemoglobin or RBCs

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Study Notes

Blood Composition and Function

  • Blood is classified as a connective tissue.
  • Blood tests aid in identifying infections, diseases, and nutrient levels.
  • The heart is responsible for initiating blood circulation.
  • Major blood components: plasma, erythrocytes (red blood cells), leukocytes (white blood cells), and platelets.
  • The buffy coat consists of leukocytes and platelets.

Plasma and Proteins

  • Albumin in plasma regulates osmotic pressure.
  • Globulins are plasma proteins that assist in immunity.
  • Fibrinogen is essential for blood clotting.

Erythrocytes and Hemoglobin

  • Erythrocytes (RBCs) are biconcave discs.
  • RBCs lack a nucleus and mitochondria.
  • Hematocrit refers to the percentage of RBCs in blood.
  • Hemoglobin transports oxygen.
  • Hemoglobin comprises 4 globin chains and 4 heme groups.
  • One hemoglobin molecule can carry four oxygen molecules.

RBC Life Cycle and Disorders

  • Erythropoiesis is the production of red blood cells.
  • Erythropoietin (EPO) regulates erythropoiesis.
  • Low blood oxygen stimulates erythropoietin production.
  • At the end of their lifespan, erythrocytes are broken down in the spleen/liver.
  • Polycythemia refers to an excess of RBCs.
  • Anemia is characterized by a lack of hemoglobin or RBCs.
  • Sickle cell disease causes crescent-shaped RBCs that carry less oxygen.

Leukocytes and Platelets

  • Leukocytes are also known as white blood cells.
  • Monocytes are not granulocytes.
  • Neutrophils digest bacteria.
  • Eosinophils fight parasitic infections and allergens.
  • Basophils release histamine in allergic reactions.
  • Lymphocytes attack infected cells or make antibodies.
  • Monocytes become macrophages and phagocytize pathogens.
  • B cells and T cells are types of lymphocytes.
  • B cells make antibodies.
  • T cells attack infected or cancerous cells.
  • Leukocyte abundance order: Neutrophils, lymphocytes, monocytes, eosinophils, basophils ("Never Let Monkeys Eat Bananas").
  • Integrins and selectins are adhesion molecules that help with white blood cell emigration.

Platelets and Hemostasis

  • Platelets are cell fragments involved in clotting.
  • Hemostasis is the process that stops bleeding.
  • Mechanisms of hemostasis: vascular spasm, platelet plug, and coagulation.

Hematopoiesis and Blood Typing

  • Leukemia is cancer of white blood cells (WBCs).
  • Thrombocytopenia is characterized by a low platelet count.
  • Hematopoiesis is the formation of blood cells.
  • Red marrow makes blood cells.
  • Yellow marrow stores fat.
  • All blood cells arise from hemocytoblasts (hematopoietic stem cells).
  • B cells and T cells come from lymphoid stem cells.
  • All blood cells, except lymphocytes, come from myeloid stem cells.

Blood Types

  • Type A blood has A antigens and anti-B antibodies.
  • Type B blood has B antigens and anti-A antibodies.
  • Type AB blood has A and B antigens, but no antibodies.
  • Type O blood has no antigens, but both anti-A and anti-B antibodies.
  • Type AB blood is the universal recipient (no Rh considered).
  • Type O blood is the universal donor (no Rh considered).
  • Rh+ blood has the Rh antigen.
  • Rh- blood lacks the Rh antigen.
  • Type A- blood has the A antigen only.
  • Type A+ blood has both A and Rh antigens.
  • An Rh- mother carrying an Rh+ baby will produce Rh antibodies that can attack future Rh+ babies.

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