Podcast
Questions and Answers
What is the primary function of fibrinogen within the plasma?
What is the primary function of fibrinogen within the plasma?
- Forming blood clots (correct)
- Buffering pH levels
- Transporting oxygen
- Providing immunity
Which of the following is NOT a formed element of blood?
Which of the following is NOT a formed element of blood?
- Erythrocytes
- Thrombocytes
- Globulin (correct)
- Leukocytes
What percentage of total blood volume do formed elements comprise?
What percentage of total blood volume do formed elements comprise?
- 10%
- 55%
- 45% (correct)
- 90%
What is the clinical significance of a low hematocrit (HCT) value?
What is the clinical significance of a low hematocrit (HCT) value?
Which adaptation of red blood cells (RBCs) directly facilitates their passage through narrow capillaries?
Which adaptation of red blood cells (RBCs) directly facilitates their passage through narrow capillaries?
What is the primary function of neutrophils?
What is the primary function of neutrophils?
Which type of white blood cell is primarily involved in combating parasitic infections and plays a role in allergic reactions?
Which type of white blood cell is primarily involved in combating parasitic infections and plays a role in allergic reactions?
Which of the following best describes the role of basophils?
Which of the following best describes the role of basophils?
What is the role of platelets (thrombocytes) in hemostasis?
What is the role of platelets (thrombocytes) in hemostasis?
Where does the formation of platelets (thrombocytes) primarily occur?
Where does the formation of platelets (thrombocytes) primarily occur?
What immunological characteristic defines the universal donor blood type?
What immunological characteristic defines the universal donor blood type?
Which of the following blood types is considered the universal recipient?
Which of the following blood types is considered the universal recipient?
What is the role of erythropoietin (EPO) in regulating hemopoiesis?
What is the role of erythropoietin (EPO) in regulating hemopoiesis?
In what anatomical location is the heart primarily situated?
In what anatomical location is the heart primarily situated?
Which of the following vessels carries oxygenated blood from the heart to the body?
Which of the following vessels carries oxygenated blood from the heart to the body?
What is the main function of the atrioventricular (AV) valves?
What is the main function of the atrioventricular (AV) valves?
Which heart chamber receives deoxygenated blood from the systemic circulation?
Which heart chamber receives deoxygenated blood from the systemic circulation?
What is the primary purpose of the pulmonary circulation?
What is the primary purpose of the pulmonary circulation?
Which vessel(s) directly supply blood to the heart muscle itself?
Which vessel(s) directly supply blood to the heart muscle itself?
Which of the following is a unique structural feature of cardiac muscle tissue?
Which of the following is a unique structural feature of cardiac muscle tissue?
What is the functional role of the sinoatrial (SA) node in the intrinsic conduction system of the heart?
What is the functional role of the sinoatrial (SA) node in the intrinsic conduction system of the heart?
Which component of the intrinsic conduction system is responsible for delaying the impulse to allow atrial contraction to complete before ventricular contraction?
Which component of the intrinsic conduction system is responsible for delaying the impulse to allow atrial contraction to complete before ventricular contraction?
In the intrinsic conduction system, what is the function of the Purkinje fibers?
In the intrinsic conduction system, what is the function of the Purkinje fibers?
What does the QRS complex represent on an electrocardiogram (ECG)?
What does the QRS complex represent on an electrocardiogram (ECG)?
What does the T wave on an electrocardiogram (ECG) represent?
What does the T wave on an electrocardiogram (ECG) represent?
Which of the following best describes the sequence of electrical events in the heart?
Which of the following best describes the sequence of electrical events in the heart?
If a patient has blood type A+, which antigens are present on their red blood cells?
If a patient has blood type A+, which antigens are present on their red blood cells?
A patient's lab results show an elevated hematocrit level. Which condition is most likely indicated by this result?
A patient's lab results show an elevated hematocrit level. Which condition is most likely indicated by this result?
Which heart chamber is characterized by having the thickest wall and why?
Which heart chamber is characterized by having the thickest wall and why?
Damage to the anterior interventricular artery would primarily affect blood supply to which region of the heart?
Damage to the anterior interventricular artery would primarily affect blood supply to which region of the heart?
A cardiologist observes an absent P wave on a patient's ECG. What does this likely indicate?
A cardiologist observes an absent P wave on a patient's ECG. What does this likely indicate?
How would a drug that selectively blocks desmosomes in cardiac intercalated discs affect heart function?
How would a drug that selectively blocks desmosomes in cardiac intercalated discs affect heart function?
Which of the following correctly pairs a blood component with its approximate percentage in whole blood and primary function?
Which of the following correctly pairs a blood component with its approximate percentage in whole blood and primary function?
During a blood transfusion, agglutination occurs. This reaction is directly caused by:
During a blood transfusion, agglutination occurs. This reaction is directly caused by:
A researcher is studying the effects of a drug on erythrocyte production. Which of the following locations would be the most appropriate for observing the direct impact of this drug?
A researcher is studying the effects of a drug on erythrocyte production. Which of the following locations would be the most appropriate for observing the direct impact of this drug?
A patient is diagnosed with a condition that impairs the flexibility of their erythrocytes. Which of the following physiological consequences is most likely to occur?
A patient is diagnosed with a condition that impairs the flexibility of their erythrocytes. Which of the following physiological consequences is most likely to occur?
A new drug is developed that inhibits the function of the AV node. What would be the most likely effect on the ECG?
A new drug is developed that inhibits the function of the AV node. What would be the most likely effect on the ECG?
Consider an individual with blood type O negative who requires a blood transfusion. What is the underlying immunological reason making O negative the universal donor in such scenarios?
Consider an individual with blood type O negative who requires a blood transfusion. What is the underlying immunological reason making O negative the universal donor in such scenarios?
Imagine a hypothetical scenario where the hormone erythropoietin (EPO) receptors are genetically modified to have a tenfold increase in affinity for EPO. What is the most likely long-term physiological consequence of this modification?
Imagine a hypothetical scenario where the hormone erythropoietin (EPO) receptors are genetically modified to have a tenfold increase in affinity for EPO. What is the most likely long-term physiological consequence of this modification?
Which of the following structures is part of the upper respiratory tract?
Which of the following structures is part of the upper respiratory tract?
What is the primary role of the nasal cavity in respiration?
What is the primary role of the nasal cavity in respiration?
Which type of epithelium primarily forms the structure of the alveoli?
Which type of epithelium primarily forms the structure of the alveoli?
During inhalation, the contraction of the diaphragm leads to which of the following?
During inhalation, the contraction of the diaphragm leads to which of the following?
Which of the following processes primarily occurs during exhalation?
Which of the following processes primarily occurs during exhalation?
Which of the following muscles contract during active inspiration?
Which of the following muscles contract during active inspiration?
What is the approximate volume of air exchanged during a normal breath, also known as the tidal volume (TV)?
What is the approximate volume of air exchanged during a normal breath, also known as the tidal volume (TV)?
In alveolar gas exchange, which gas diffuses from the alveoli into the capillaries?
In alveolar gas exchange, which gas diffuses from the alveoli into the capillaries?
What effect does a decrease in pH (more acidic conditions) have on the affinity of hemoglobin for oxygen?
What effect does a decrease in pH (more acidic conditions) have on the affinity of hemoglobin for oxygen?
How is the majority of carbon dioxide transported in the blood?
How is the majority of carbon dioxide transported in the blood?
Which region of the brain sets the basic rhythm for respiration?
Which region of the brain sets the basic rhythm for respiration?
Which of the following stimuli is detected by peripheral chemoreceptors to regulate respiratory rate?
Which of the following stimuli is detected by peripheral chemoreceptors to regulate respiratory rate?
Which of the following is a characteristic of restrictive lung diseases?
Which of the following is a characteristic of restrictive lung diseases?
What is the functional consequence of the large surface area in the alveoli?
What is the functional consequence of the large surface area in the alveoli?
Which of the following changes would result in increased oxygen unloading from hemoglobin?
Which of the following changes would result in increased oxygen unloading from hemoglobin?
If a patient has damage to the apneustic center in the pons, what aspect of respiration is most likely to be affected?
If a patient has damage to the apneustic center in the pons, what aspect of respiration is most likely to be affected?
In systemic tissues, what causes oxygen to exit the blood and enter the cells?
In systemic tissues, what causes oxygen to exit the blood and enter the cells?
Which scenario would result in the highest affinity of hemoglobin for oxygen?
Which scenario would result in the highest affinity of hemoglobin for oxygen?
What is the primary mechanism by which the medulla oblongata regulates the basic rhythm of respiration?
What is the primary mechanism by which the medulla oblongata regulates the basic rhythm of respiration?
In the context of carbon dioxide transport, what role does carbonic anhydrase play?
In the context of carbon dioxide transport, what role does carbonic anhydrase play?
How do central chemoreceptors in the medulla respond to increased carbon dioxide levels?
How do central chemoreceptors in the medulla respond to increased carbon dioxide levels?
Which of the following characteristics distinguishes obstructive lung diseases from restrictive lung diseases?
Which of the following characteristics distinguishes obstructive lung diseases from restrictive lung diseases?
How does the warming of inspired air in the nasal cavity benefit the respiratory system?
How does the warming of inspired air in the nasal cavity benefit the respiratory system?
What is the extra air that can be forcefully exhaled after the end of a normal tidal volume called?
What is the extra air that can be forcefully exhaled after the end of a normal tidal volume called?
In systemic tissues, the exchange of gases results in:
In systemic tissues, the exchange of gases results in:
An increase in carbon dioxide levels leads to greater unloading of $O_2$ from hemoglobin. What is the underlying chemical mechanism that directly explains this?
An increase in carbon dioxide levels leads to greater unloading of $O_2$ from hemoglobin. What is the underlying chemical mechanism that directly explains this?
Which of the following physiological responses would occur if chemoreceptors detect an increase in carbon dioxide ($CO_2$) and a decrease in oxygen ($O_2$) levels in the blood?
Which of the following physiological responses would occur if chemoreceptors detect an increase in carbon dioxide ($CO_2$) and a decrease in oxygen ($O_2$) levels in the blood?
A patient with pulmonary fibrosis would likely exhibit which of the following?
A patient with pulmonary fibrosis would likely exhibit which of the following?
What is the primary function of the pneumotaxic center located in the pons?
What is the primary function of the pneumotaxic center located in the pons?
A person standing at sea level quickly ascends to the top of a high mountain. How will this change affect the affinity of hemoglobin for oxygen in their blood?
A person standing at sea level quickly ascends to the top of a high mountain. How will this change affect the affinity of hemoglobin for oxygen in their blood?
Which of the following best describes the process of humidification within the nasal cavity?
Which of the following best describes the process of humidification within the nasal cavity?
How does increased temperature affect oxygen unloading at the tissues?
How does increased temperature affect oxygen unloading at the tissues?
A man with chronic obstructive pulmonary disease (COPD) is admitted to the hospital. Which arterial blood gas finding is most expected?
A man with chronic obstructive pulmonary disease (COPD) is admitted to the hospital. Which arterial blood gas finding is most expected?
Which of the following compensatory mechanisms is most likely to occur in a person with chronic bronchitis to maintain oxygen delivery to tissues?
Which of the following compensatory mechanisms is most likely to occur in a person with chronic bronchitis to maintain oxygen delivery to tissues?
A researcher is studying the effect of altitude on minute ventilation (the volume of gas inhaled or exhaled from a person's lungs per minute). Which of the following scenarios would result in the greatest increase in minute ventilation?
A researcher is studying the effect of altitude on minute ventilation (the volume of gas inhaled or exhaled from a person's lungs per minute). Which of the following scenarios would result in the greatest increase in minute ventilation?
A patient is diagnosed with a rare condition that selectively impairs the function of type II alveolar cells. Which of the following is the most likely consequence of this condition?
A patient is diagnosed with a rare condition that selectively impairs the function of type II alveolar cells. Which of the following is the most likely consequence of this condition?
Consider a scenario where a person's body temperature drops significantly due to extreme cold exposure. How would this hypothermia directly influence the oxygen-hemoglobin dissociation curve and oxygen delivery to tissues?
Consider a scenario where a person's body temperature drops significantly due to extreme cold exposure. How would this hypothermia directly influence the oxygen-hemoglobin dissociation curve and oxygen delivery to tissues?
During strenuous exercise, the body produces lactic acid, which lowers the blood pH. How does this change in pH affect oxygen unloading from hemoglobin in the working muscles?
During strenuous exercise, the body produces lactic acid, which lowers the blood pH. How does this change in pH affect oxygen unloading from hemoglobin in the working muscles?
Flashcards
Plasma
Plasma
Liquid component of blood (55%), mostly water (90%) + proteins, electrolytes, nutrients, hormones, gases.
Formed Elements
Formed Elements
Cellular components of blood (45%) including red blood cells (RBCs), white blood cells (WBCs), and platelets.
Plasma Function: Transport
Plasma Function: Transport
Transport of nutrients, hormones, waste, and gases.
Plasma Function: Homeostasis
Plasma Function: Homeostasis
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Plasma Function: Clotting
Plasma Function: Clotting
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Plasma Function: Immunity
Plasma Function: Immunity
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Formed Elements Definition
Formed Elements Definition
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Erythrocytes
Erythrocytes
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Leukocytes
Leukocytes
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Thrombocytes
Thrombocytes
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Hematocrit (HCT)
Hematocrit (HCT)
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Red Blood Cells (RBCs)
Red Blood Cells (RBCs)
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Neutrophils Function
Neutrophils Function
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Eosinophils Function
Eosinophils Function
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Basophils Function
Basophils Function
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Lymphocytes Function
Lymphocytes Function
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Monocytes Function
Monocytes Function
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Platelets Function
Platelets Function
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Platelets Formation
Platelets Formation
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Antigens (Agglutinogens)
Antigens (Agglutinogens)
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Antibodies (Agglutinins)
Antibodies (Agglutinins)
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Transfusion Reactions
Transfusion Reactions
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Universal Donor
Universal Donor
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Universal Recipient
Universal Recipient
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Hemopoiesis (Hematopoiesis)
Hemopoiesis (Hematopoiesis)
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Hemopoiesis Location
Hemopoiesis Location
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Hemopoiesis Regulation
Hemopoiesis Regulation
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Cardiac Muscle Histology
Cardiac Muscle Histology
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Cardiac Muscle Function
Cardiac Muscle Function
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SA Node (sinoatrial)
SA Node (sinoatrial)
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AV Node (atrioventricular)
AV Node (atrioventricular)
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Bundle of His
Bundle of His
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Bundle Branches
Bundle Branches
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Purkinje Fibers
Purkinje Fibers
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ECG: P wave
ECG: P wave
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ECG: QRS complex
ECG: QRS complex
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ECG: T wave
ECG: T wave
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Upper Respiratory Tract
Upper Respiratory Tract
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Lower Respiratory Tract
Lower Respiratory Tract
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Nasal Cavity Role
Nasal Cavity Role
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Alveoli
Alveoli
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Diaphragm function in ventilation
Diaphragm function in ventilation
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External Intercostals
External Intercostals
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Negative Pressure in Lungs
Negative Pressure in Lungs
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Relaxation in Ventilation
Relaxation in Ventilation
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Inspiration Mechanism
Inspiration Mechanism
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Expiration Mechanism
Expiration Mechanism
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Tidal Volume (TV)
Tidal Volume (TV)
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Inspiratory Reserve Volume (IRV)
Inspiratory Reserve Volume (IRV)
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Expiratory Reserve Volume (ERV)
Expiratory Reserve Volume (ERV)
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Alveolar Exchange - Oxygen
Alveolar Exchange - Oxygen
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Alveolar Exchange - CO2
Alveolar Exchange - CO2
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Systemic Tissues - Oxygen
Systemic Tissues - Oxygen
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Systemic Tissues - CO2
Systemic Tissues - CO2
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Hemoglobin (Hb)
Hemoglobin (Hb)
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Bohr Effect
Bohr Effect
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Temperature's Effect on Hemoglobin
Temperature's Effect on Hemoglobin
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CO2 Levels Effect on Hemoglobin
CO2 Levels Effect on Hemoglobin
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Bicarbonate (HCO3-)
Bicarbonate (HCO3-)
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Medulla Oblongata Function
Medulla Oblongata Function
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Pons (Apneustic & Pneumotaxic Centers)
Pons (Apneustic & Pneumotaxic Centers)
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Peripheral Chemoreceptors
Peripheral Chemoreceptors
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Central Chemoreceptors
Central Chemoreceptors
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Chemoreceptor Signals
Chemoreceptor Signals
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Restrictive Lung Disease
Restrictive Lung Disease
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Obstructive Lung Disease
Obstructive Lung Disease
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Study Notes
- RESPIRATORY PHYSIOLOGY
Upper vs. Lower Respiratory Tract Structures
- Upper respiratory tract includes the nose, nasal cavity, sinuses, and pharynx.
- Lower respiratory tract includes the larynx, trachea, bronchi, bronchioles, and alveoli.
Nasal Cavity Role
- Conditions air by filtering via mucous membranes, humidifying to prevent dryness, and warming with a rich capillary supply.
Alveoli Function & Structure
- Function: Site of gas exchange.
- Structure: Single layer of simple squamous epithelium surrounded by capillaries, providing a large surface area and thin diffusion distance.
Ventilation Mechanics
- Diaphragm contraction moves it downward, expanding the thoracic cavity.
- External intercostals elevate ribs.
- Negative pressure is created, causing air to rush in during inhalation.
- Relaxation causes lungs to recoil, and air exits during exhalation.
Inspiration vs. Expiration
- Inspiration: Active; the diaphragm and intercostal muscles contract.
- Expiration: Passive (at rest); muscles relax, pressure pushes air out.
Lung Volumes
- Tidal Volume (TV): Normal breath (~500 mL).
- Inspiratory Reserve Volume (IRV): Extra air inhaled after TV.
- Expiratory Reserve Volume (ERV): Extra air exhaled after TV.
Gas Exchange at Alveoli & Tissues
- Alveolar Exchange:
- O2 diffuses into capillaries (high → low).
- CO2 diffuses into alveoli.
- Systemic Tissues:
- O2 exits blood → into cells.
- CO2 produced by cells → enters blood.
Hemoglobin & Oxygen
- Hemoglobin (Hb) carries O2 (up to 4 molecules).
- Affinity is influenced by:
- pH (Bohr effect): low pH = less affinity.
- Temperature: ↑ temp = less affinity.
- CO2 levels: ↑ CO2 = more O2 unloading.
Carbon Dioxide Transport
- Form and percentage in blood:
- Bicarbonate (HCO3-): ~70% (via carbonic anhydrase reaction).
- Bound to hemoglobin: ~20-23%.
- Dissolved in plasma: ~7-10%.
Respiratory Control Centers
- Medulla Oblongata: Sets basic rhythm via inspiratory neurons.
- Pons (Apneustic & Pneumotaxic Centers): Modulate rhythm and depth of breathing.
Chemoreceptor Regulation
- Peripheral (carotid & aortic bodies): Detect ↓ O2, ↑ CO2, ↓ pH.
- Central (medulla): Sensitive to ↑ CO2 (via H+ in CSF).
- Send signals to increase respiratory rate & depth.
Restrictive vs. Obstructive Lung Diseases
- Restrictive: Caused by decreased lung expansion (e.g., pulmonary fibrosis, scoliosis).
- Obstructive: Caused by airflow obstruction (e.g., asthma, COPD, chronic bronchitis, emphysema).
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