Drugs affecting blood Coagulation Quiz
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Questions and Answers

What is the main cause of clot formation within the blood vessels or the heart?

  • Platelet activation and aggregation (correct)
  • Production of fibrin
  • Formation of Thrombin
  • Blood Coagulation
  • Which type of clot adheres to a vessel wall?

  • Thrombin
  • Thrombus (correct)
  • Embolus
  • Fibrin
  • What is the main function of fibrin in the clot formation process?

  • Activating platelets
  • Preventing platelet activation
  • Cross-linking and stabilizing the clot (correct)
  • Dissolving the clot
  • Why are both thrombi and emboli considered dangerous?

    <p>They may occlude blood vessels</p> Signup and view all the answers

    What is the role of platelets in response to vascular trauma?

    <p>Adhesion to the site of injury, release of intracellular contents, and aggregation</p> Signup and view all the answers

    What is the first step in the response of platelets to vascular trauma?

    <p>Adhesion to the site of injury</p> Signup and view all the answers

    What happens during the second step of platelet response to vascular trauma?

    <p>Release of intracellular contents</p> Signup and view all the answers

    What is the final step in the response of platelets to vascular trauma?

    <p>Aggregation</p> Signup and view all the answers

    What is the role of thrombin in the coagulation cascade?

    <p>Conversion of fibrinogen to fibrin</p> Signup and view all the answers

    Which factor catalyzes the conversion of fibrinogen to fibrin in clot formation?

    <p>Thrombin</p> Signup and view all the answers

    What is the result of the coagulation cascade in the formation of the clot?

    <p>Conversion of fibrinogen to fibrin</p> Signup and view all the answers

    What is the primary function of factor Xa in the coagulation cascade?

    <p>Activation of prothrombin</p> Signup and view all the answers

    Which of the following is NOT a mechanism by which endothelial cells maintain a nonthrombogenic lining in blood vessels?

    <p>The release of plasminogen activators</p> Signup and view all the answers

    What is the role of Heparin like proteoglycans in the prevention of thrombosis?

    <p>They inhibit coagulation</p> Signup and view all the answers

    Which phenomenon is important in preventing the adhesion of circulating platelets to the blood vessel lining?

    <p>The maintenance of transmural negative electrical charge</p> Signup and view all the answers

    What activates the fibrinolytic pathway to prevent thrombosis?

    <p>The production of plasminogen activators</p> Signup and view all the answers

    What is the primary function of platelet aggregation inhibitors?

    <p>Blocking GPIIb,IIIa receptors</p> Signup and view all the answers

    How do antiplatelet drugs contribute to thrombolytic therapy?

    <p>By maintaining perfusion and limiting infarction size</p> Signup and view all the answers

    What is the role of heparin when administered as an adjunct to antiplatelet therapy?

    <p>Serving as a potent anticoagulant</p> Signup and view all the answers

    Which signals do platelet aggregation inhibitors interfere with?

    <p>Signals promoting platelet aggregation</p> Signup and view all the answers

    What is the mechanism of action of aspirin in low doses?

    <p>Inhibiting thromboxane synthesis in platelets</p> Signup and view all the answers

    What is a therapeutic use of aspirin according to the text?

    <p>Prophylactic treatment of transient cerebral ischemia</p> Signup and view all the answers

    Which adverse effect is associated with aspirin therapy?

    <p>Gastrointestinal ulceration</p> Signup and view all the answers

    What is the goal of therapy with aspirin according to the text?

    <p>To inhibit the synthesis of platelet thromboxane A2</p> Signup and view all the answers

    What is the most serious side effect associated with the use of ticlopidine?

    <p>Neutropenia</p> Signup and view all the answers

    How does clopidogrel exert its effect on platelet activation?

    <p>By inhibiting glycoprotein (GP IIb/IIIa receptors</p> Signup and view all the answers

    Which hepatic enzyme inhibitor can diminish the action of clopidogrel?

    <p>Omeprazole</p> Signup and view all the answers

    What is the alternative prophylactic therapy to aspirin in the secondary prevention of stroke and myocardial infarction?

    <p>Clopidogrel</p> Signup and view all the answers

    Which of the following drugs is a murine monoclonal antibody against the GP IIb IIIa?

    <p>Abciximab</p> Signup and view all the answers

    What is the primary prophylactic use of Dipyridamole in combination with warfarin?

    <p>To prevent thrombosis in patients with prosthetic heart valves</p> Signup and view all the answers

    Which drug is a coronary vasodilator that increases CAMP and decreases thromboxane A2 synthesis?

    <p>Dipyridamole</p> Signup and view all the answers

    What is the main disadvantage associated with the use of Eptifibatide?

    <p>Oral toxicity</p> Signup and view all the answers

    What is the primary difference between standard heparin and low molecular weight heparin?

    <p>Low molecular weight heparin has greater bioavailability than standard heparin</p> Signup and view all the answers

    How does heparin exert its anticoagulant effect?

    <p>By inhibiting the action of antithrombin III</p> Signup and view all the answers

    What is the primary advantage of low molecular weight heparin over standard heparin?

    <p>It is more effective in preventing thromboembolism</p> Signup and view all the answers

    Which type of administration is available for low molecular weight heparin?

    <p>Subcutaneous administration</p> Signup and view all the answers

    What is the primary therapeutic use of heparin according to the given text?

    <p>Treating myocardial infarction</p> Signup and view all the answers

    Why is intramuscular heparin contraindicated according to the given text?

    <p>It may cause hematoma formation</p> Signup and view all the answers

    What is the maximal anticoagulant effect of intravenous heparin according to the text?

    <p>Within minutes after injection</p> Signup and view all the answers

    In which condition is heparin contraindicated according to the text?

    <p>Recent surgery</p> Signup and view all the answers

    What is the mechanism of action of warfarin?

    <p>Induces the formation of structurally incomplete clotting factors</p> Signup and view all the answers

    Where does warfarin primarily induce hypocoagulability?

    <p>In vivo</p> Signup and view all the answers

    In which condition is warfarin contraindicated?

    <p>Presence of active or past gastrointestinal ulceration</p> Signup and view all the answers

    What is a therapeutic use of warfarin?

    <p>Prevention of thromboembolism in atrial fibrillation</p> Signup and view all the answers

    What is the purpose of thrombolytic therapy?

    <p>To rapidly destroy already formed clots</p> Signup and view all the answers

    Which drug is superior to streptokinase and urokinase in dissolving older clots?

    <p>Alteplase</p> Signup and view all the answers

    What is the mechanism of action of plasmin in thrombolytic therapy?

    <p>Catalyzing the degradation of fibrin</p> Signup and view all the answers

    When is alteplase administered for ischemic stroke?

    <p>Within 3 hours of onset</p> Signup and view all the answers

    Which drug is contraindicated in pregnancy, metastatic cancers, and history of cerebrovascular accidents?

    <p>Anistreolase</p> Signup and view all the answers

    What is the primary therapeutic use of Urokinase according to the given text?

    <p>Severe pulmonary emboli</p> Signup and view all the answers

    Which drug is a third-generation thrombolytic?

    <p>Reteplase</p> Signup and view all the answers

    What are the adverse effects associated with Streptokinase?

    <p>Bleeding, hypersensitivity</p> Signup and view all the answers

    Which drug is used to reverse the effect of heparin?

    <p>Vitamin K</p> Signup and view all the answers

    What is the primary function of Aprotinin?

    <p>Inhibits streptokinase bleeding</p> Signup and view all the answers

    What is the therapeutic use of Sodium bicarbonate according to the given text?

    <p>Treating aspirin toxicity</p> Signup and view all the answers

    What is the primary adverse effect associated with the use of Protamine sulfate?

    <p>Bradycardia</p> Signup and view all the answers

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