Blood Clot & Antithrombotics

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Questions and Answers

What is the mechanism by which elevated cAMP levels affect thromboxane A2 activity?

  • Blocking the release of arachidonic acid (correct)
  • Enhancing the release of arachidonic acid
  • Attenuating platelet aggregation
  • Increasing the activity of thromboxane A2

Which of the following substances is greatly attenuated by Cilostazol in platelet aggregation?

  • Vitamin K
  • Epinephrine
  • Collagen
  • ADP (correct)

What is a therapeutic application of Vitamin K?

  • Improving endothelial cell function
  • Reducing platelet aggregation
  • Enhancing thromboxane A2 activity
  • Correcting bleeding tendency due to its deficiency (correct)

Which of the following can result in Vitamin K deficiency?

<p>Inadequate intake of Vitamin K (B)</p> Signup and view all the answers

How are Phylloquinone derivatives like Aquamephyton, Konakion, Mephyton typically administered?

<p>Intravenously as injections (D)</p> Signup and view all the answers

What is the primary function of the system of fibrinolysis when intravascular thrombus occurs?

<p>To restore blood fluidity (D)</p> Signup and view all the answers

In healthy conditions, what is essential to prevent both thrombosis and hemorrhage?

<p>Maintaining a balance between pro-coagulants and anticoagulants (A)</p> Signup and view all the answers

Which category of antithrombotics includes drugs that inhibit platelet function?

<p>Antiplatelet agents (A)</p> Signup and view all the answers

What is the primary therapeutic goal of administering an anticoagulant?

<p>Prevent blood clot formation (B)</p> Signup and view all the answers

What adverse effect can be observed when overdosing on an anticoagulant?

<p>Excessive bleeding (A)</p> Signup and view all the answers

Which antithrombotic drug is a glycosaminoglycan found in the secretory granules of mast cells?

<p>Heparin (B)</p> Signup and view all the answers

Which drug is classified as a platelet aggregation inhibitor?

<p>Clopidogrel (C)</p> Signup and view all the answers

What is the mechanism of action of thienopyridines like Ticlopidine?

<p>Inhibiting adenosine diphosphate-induced platelet aggregation (A)</p> Signup and view all the answers

Which of the following drugs is a protease-activated receptor-1 antagonist?

<p>Vorapaxar (B)</p> Signup and view all the answers

What is the main target of glycoprotein platelet inhibitors like Abciximab?

<p>Glycoprotein IIb/IIIa receptors (B)</p> Signup and view all the answers

Among the thienopyridines mentioned, which drug is known for being the most potent with a rapid onset of action?

<p>Prasugrel (D)</p> Signup and view all the answers

What is the main inhibitory effect of Dipyridamole on platelet function?

<p>Inhibiting phosphodiesterase type 3 (B)</p> Signup and view all the answers

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