IMMUNOHEMA MIDTERMS
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IMMUNOHEMA MIDTERMS

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What is the main reason for donor screening?

  • To protect the safety of the blood supply. (correct)
  • To determine the donor's eligibility for compensation.
  • To identify the blood type of the donor.
  • To prevent the donor from getting sick.

    • What is the main reason for donor screening?

  • To protect the safety of the blood supply. (correct)
  • To determine the donor's eligibility for compensation.
  • To identify the blood type of the donor.
  • To prevent the donor from getting sick.

    • Which blood group system includes high and low incidence antigens?

  • Oka
  • Joseph
  • Gerbich (correct)
  • Augustine

    • Which blood group system includes antigens carried by the integral membrane protein AQP1 in the kidneys?

    <p>Gerbich</p> Signup and view all the answers

    Which blood group system includes high and low incidence antigens?

    <p>Gerbich</p> Signup and view all the answers

    Which blood group system includes antigens carried by the integral membrane protein AQP1 in the kidneys?

    <p>Gerbich</p> Signup and view all the answers

    What does the donor screening process identify?

    <p>Elements of medical history and behavior that put a person at risk for transmissible disease or personal medical risk.</p> Signup and view all the answers

    What does the donor screening process identify?

    <p>Elements of medical history and behavior that put a person at risk for transmissible disease or personal medical risk.</p> Signup and view all the answers

    Which antigen is carried by the integral membrane protein AQP1 in the kidneys?

    <p>Co</p> Signup and view all the answers

    Which antibodies are associated with moderate transfusion reactions?

    <p>Anti-Coa and anti-Cob</p> Signup and view all the answers

    Which antibodies are associated with moderate transfusion reactions?

    <p>Anti-Coa and anti-Cob</p> Signup and view all the answers

    Which antigen is carried by the integral membrane protein AQP1 in the kidneys?

    <p>Co</p> Signup and view all the answers

    Which of the following is NOT a type of blood donor?

    Signup and view all the answers

    Which antibody is associated with severe HDFN?

    <p>Anti-CO3</p> Signup and view all the answers

    Which antigen is carried by intracellular adhesion molecule 4?

    <p>LW</p> Signup and view all the answers

    Which antibody is associated with severe HDFN?

    <p>Anti-CO3</p> Signup and view all the answers

    Which antigen is carried by intracellular adhesion molecule 4?

    <p>LW</p> Signup and view all the answers

    Which of the following is NOT a type of blood donor?

    Signup and view all the answers

    What information is included in donor registration?

    <p>Date and time of donation, name, address, telephone, gender, age or date of birth, and record of reasons for previous deferrals.</p> Signup and view all the answers

    Which antigen is carried by intracellular adhesion molecule 4?

    <p>LW</p> Signup and view all the answers

    Which antigen is carried by intracellular adhesion molecule 4?

    <p>LW</p> Signup and view all the answers

    What information is included in donor registration?

    <p>Date and time of donation, name, address, telephone, gender, age or date of birth, and record of reasons for previous deferrals.</p> Signup and view all the answers

    Which antibody is associated with severe HDFN?

    <p>Anti-CO3</p> Signup and view all the answers

    Which antibody is associated with severe HDFN?

    <p>Anti-CO3</p> Signup and view all the answers

    Which antibody agglutinates Rh(+) and Rh(-) cells except Rhnull?

    <p>Anti-LW</p> Signup and view all the answers

    Which blood group system includes low-incidence antigens with an incidence of less than 1%?

    <p>Wright</p> Signup and view all the answers

    What are the basic qualifications of a potential donor?

    <p>General appearance, age, body weight, maximum amount of blood to be drawn, temperature, pulse, and blood pressure</p> Signup and view all the answers

    Which blood group system includes low-incidence antigens with an incidence of less than 1%?

    <p>Wright</p> Signup and view all the answers

    Which antibody agglutinates Rh(+) and Rh(-) cells except Rhnull?

    <p>Anti-LW</p> Signup and view all the answers

    What are the basic qualifications of a potential donor?

    <p>General appearance, age, body weight, maximum amount of blood to be drawn, temperature, pulse, and blood pressure</p> Signup and view all the answers

    Which antibodies are implicated in transfusion reactions?

    <p>Anti-Cs, Anti-Ge2, Anti-Ge3</p> Signup and view all the answers

    What criteria are used for whole blood donors?

    <p>Age, hemoglobin, hematocrit, temperature, venipuncture site, and bacterial infection.</p> Signup and view all the answers

    What criteria are used for whole blood donors?

    <p>Age, hemoglobin, hematocrit, temperature, venipuncture site, and bacterial infection.</p> Signup and view all the answers

    Which antibodies are implicated in transfusion reactions?

    <p>Anti-Cs, Anti-Ge2, Anti-Ge3</p> Signup and view all the answers

    Which antigens have an incidence of less than 1%?

    <p>Wright</p> Signup and view all the answers

    Which antigens have an incidence of less than 1%?

    <p>Wright</p> Signup and view all the answers

    What is autologous transfusion?

    <p>Blood drawn from the patient for their own future use</p> Signup and view all the answers

    Which type of antibodies exhibit weak agglutination at any dilution?

    <p>HTLA</p> Signup and view all the answers

    Which blood group system includes Chido/Rodgers antigens associated with the HLA system?

    <p>Joseph</p> Signup and view all the answers

    Which type of antibodies exhibit weak agglutination at any dilution?

    <p>HTLA</p> Signup and view all the answers

    Which blood group system includes Chido/Rodgers antigens associated with the HLA system?

    <p>Joseph</p> Signup and view all the answers

    What is autologous transfusion?

    <p>Blood drawn from the patient for their own future use</p> Signup and view all the answers

    Which phenotype presents with elliptocytosis?

    <p>Leach</p> Signup and view all the answers

    Which blood group antigen is associated with neonatal alloimmune neutropenia and post-transfusion purpura?

    <p>HPA</p> Signup and view all the answers

    Which blood group antigen is associated with neonatal alloimmune neutropenia and post-transfusion purpura?

    <p>HPA</p> Signup and view all the answers

    What methods are used for HGB determination?

    <p>Copper sulfate density, acceptable drop of blood, spum microhematocrit, and spectrophotometric</p> Signup and view all the answers

    Which phenotype presents with elliptocytosis?

    <p>Leach</p> Signup and view all the answers

    What methods are used for HGB determination?

    <p>Copper sulfate density, acceptable drop of blood, spum microhematocrit, and spectrophotometric</p> Signup and view all the answers

    Which antibodies exhibit weak agglutination at any dilution?

    <p>HTLAs</p> Signup and view all the answers

    Which blood group system includes Triantigens?

    <p>Augustine</p> Signup and view all the answers

    What replaced the Blood Banking Law of 1956?

    <p>The National Blood Services Act of 1994.</p> Signup and view all the answers

    Which blood group system includes Triantigens?

    <p>Augustine</p> Signup and view all the answers

    Which antibodies exhibit weak agglutination at any dilution?

    <p>HTLAs</p> Signup and view all the answers

    What replaced the Blood Banking Law of 1956?

    <p>The National Blood Services Act of 1994.</p> Signup and view all the answers

    Which blood group antigens include granulocyte antigens and human neutrophil antigens (HNA) and human platelet antigens (HPA)?

    <p>Gerbich</p> Signup and view all the answers

    Which type of antibodies are not detected with enzyme treatment?

    <p>Some antibodies</p> Signup and view all the answers

    Which donors are deferred?

    <p>Donors with indications of drug use, infectious skin disease or scars, or bacteremia</p> Signup and view all the answers

    Which donors are deferred?

    <p>Donors with indications of drug use, infectious skin disease or scars, or bacteremia</p> Signup and view all the answers

    Which blood group antigens include granulocyte antigens and human neutrophil antigens (HNA) and human platelet antigens (HPA)?

    <p>Gerbich</p> Signup and view all the answers

    Which type of antibodies are not detected with enzyme treatment?

    <p>Some antibodies</p> Signup and view all the answers

    Which antibodies are not detected with enzyme treatment?

    <p>Natural occurring IgG immunoglobulins</p> Signup and view all the answers

    Which antibodies are not detected with enzyme treatment?

    <p>Natural occurring IgG immunoglobulins</p> Signup and view all the answers

    Which blood group antigen is associated with elliptocytosis?

    <p>Gerbich</p> Signup and view all the answers

    Which blood group antigen is associated with elliptocytosis?

    <p>Gerbich</p> Signup and view all the answers

    What is the clinical significance of HPA?

    <p>All of the above</p> Signup and view all the answers

    What is the clinical significance of HPA?

    <p>All of the above</p> Signup and view all the answers

    Which blood group antigen is associated with the HLA system?

    <p>Chido/Rodgers</p> Signup and view all the answers

    Which blood group antigen is associated with the HLA system?

    <p>Chido/Rodgers</p> Signup and view all the answers

    Study Notes

    • Co antigens are carried by the integral membrane protein AQP1 in the kidneys
    • Anti-Coa and anti-Cob are associated with moderate transfusion reactions
    • Anti-CO3 is associated with severe HDFN
    • LW antigen is carried by intracellular adhesion molecule 4
    • Anti-LW agglutinates Rh(+) and Rh(-) cells except Rhnull
    • Chido/Rodgers antigens are associated with the HLA system
    • Gerbich phenotype includes high and low incidence antigens
    • Leach phenotype presents with elliptocytosis
    • Anti-Ge2 and anti-Ge3 are implicated in transfusion reactions
    • Natural occurring IgG immunoglobulins and autoantibodies are associated with transfusion reactions.
    1. There are several blood group systems, including Augustine, Gregory, Langereis, Cromer, Holley, Oka, Ena, Jacobs, VEL, Gerbich, and Joseph.
    2. Low-incidence antigens have an incidence of less than 1% and include the Wright blood group system, Swann, By, Mta, and Triantigens.
    3. High-titer, low-avidity (HTLA) antibodies are clinically benign and exhibit weak agglutination at any dilution.
    4. Antibodies formed are classified as HTLAs due to similar serologic reactivity, but some may be significant.
    5. Antigens such as Anti-Cha, Anti-JMH, Anti-McCa, Anti-Rga, Anti-Yka, Anti-Kn, and Anti-Cs have different antibody characteristics.
    6. Antibody characteristics include clinically significant or insignificant, naturally occurring, warm or cold antibodies, and can react in any phase of testing.
    7. Detection is enhanced by enzyme treatment of test cells, while some antibodies are not detected with enzyme treatment.
    8. Other blood group antigens include granulocyte antigens and human neutrophil antigens (HNA) and human platelet antigens (HPA).
    9. Clinical significance of HPA includes neonatal alloimmune neutropenia, autoimmune neutropenia, and post-transfusion purpura.
    10. Clinical significance of HPA includes neonatal alloimmune thrombocytopenia and post-transfusion purpura.

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    Description

    Test your knowledge of blood antigens and antibodies with this quiz! From Co antigens to Gerbich phenotypes, this quiz covers a variety of topics related to blood group systems. Learn about the clinical significance of HTLA antibodies, the characteristics of different blood group antigens, and the detection methods used to identify them. You'll also explore other blood group antigens and their clinical significance, including HNA and HPA. Challenge yourself and see how much you know about blood antigens and antibodies

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